摘要：
Osteoarthritis (OA) is an aging-related joint disease, pathologically featured with degenerated articular cartilage and deformation of subchondral bone. OA has become the fourth major cause of disability in the world, imposing a huge economic burden. At present, the pathogenesis and pathophysiology of OA are still unclear. Complex regulating networks containing different biochemical signaling pathways are involved in OA pathogenesis and progression. The p38MAPK signaling pathway is a member of the MAPK signaling pathway family, which participates in the induction of cellular senescence, the differentiation of chondrocytes, the synthesis of matrix metalloproteinase (MMPs) and the production of pro-inflammatory factors. In recent years, studies on the regulating role of p38MAPK signaling pathway and the application of its inhibitors have attracted growing attention, with an increasing number of in vivo and in vitro studies. One interesting finding is that the inhibition of p38MAPK could suppress chondrocyte inflammation and ameliorate OA, indicating its therapeutic role in OA treatment. Based on this, we reviewed the mechanisms of p38MAPK signaling pathway in the pathogenesis of OA, hoping to provide new ideas for future research and OA treatment.
作者机构：
[Zhai, X. M.; Yang, H.; Lin, S. Y.; Ding, B. J.; Zhang, X. J.; Wu, Z. G.; Liu, L.; Yan, G. H.; Gong, X. Z.; Yan, N.; Zang, Q.; Zhao, H. L.; Wang, M.; Wu, C. B.; Zhao, L. M.; Li, M. H.; Huang, J.] Chinese Acad Sci, Inst Plasma Phys, Hefei 230031, Peoples R China.;[Baek, S. G.; Bonoli, P. T.; Wallace, G. M.] MIT, Plasma Sci & Fus Ctr, Cambridge, MA 02139 USA.;[Li, X. X.] Univ South China, Dept Nucl Phys, Hengyang 421001, Peoples R China.
通讯机构：
[B.J. Ding; M. Wang] I;Institute of Plasma Physics, Chinese Academy of Sciences, Hefei 230031, China
摘要：
Lower hybrid current drive (LHCD) experiments with line-averaged density up to similar to 5.1 x 10(19) m(-3) were performed in EAST L-mode plasmas. When the line-averaged density rises above a critical value, the hard x-ray (HXR) emission falls to the noise level, indicating that the LHCD density limit is encountered. The experimental results show that the LHCD density limit can be increased with higher wave source frequency (f (0)) and higher magnetic field (B (t)). Although a higher LHCD density limit is obtained by a higher magnetic field for both 2.45 GHz and 4.6 GHz waves, the results show a stronger dependence on the magnetic field for the 4.6 GHz case. Analysis suggests that, for normal operation with a relatively low magnetic field (1.6 T <= B (t) <= 2.5 T) on EAST, the dominant mechanisms responsible for the LHCD density limit are different between the 2.45 GHz and 4.6 GHz waves. The wave accessibility plays a more significant role during 4.6 GHz LHCD experiments, while parasitic losses due to parametric decay instability (PDIs) dominate the accessibility issue in the 2.45 GHz case. Collisional loss in the scrape-off layer (SOL) may explain the 4.6 GHz result when combined with the accessibility limit at high density and low temperature.
摘要：
Sr-doped LaMnO3 (LSM) which is the first-generation cathode for solid oxide fuel cells (SOFCs) has been tailored with Zn ions, aiming to achieve improved protonation ability for proton-conducting SOFCs (H-SOFCs). The new Sr and Zn co-doped LaMnO3 (LSMZ) can be successfully synthesized. The first-principle studies indicate that the LSMZ improves the protonation of LSM and decreases the barriers for oxygen vacancy formation, leading to high performance of the LSMZ cathode-based cells. The proposed LSMZ cell shows the highest fuel cell performance among ever reported LSM-based H-SOFCs. In addition, the superior fuel cell performance does not impair its stability. LSMZ is stable against CO2, as demonstrated by both in-situ CO2 corrosion tests and the first-principles calculations, leading to good long-term stability of the cell. The Zn-doping strategy for the traditional LSM cathode with high performance and good stability brings back the LSM cathode to intermediate temperatures and paves a new way for the research on the LSM-based materials as cathodes for SOFCs.
期刊：
Journal of Controlled Release,2022年347:270-281 ISSN：0168-3659
通讯作者：
Yin, Tinghui;Wang, Ping;Liu, Li-Han
作者机构：
[Chen, Yi; Shu, Xian; Xiang, Yun; Wang, Ping] Southern Med Univ, Acad Orthoped, Dept Ultrasonog, Affiliated Hosp 3, Guangzhou 510630, Guangdong, Peoples R China.;[Yan, Ping] Univ South China, Dept Radiol, Affiliated Hosp 1, Hengyang Med Sch, Hengyang 421001, Hunan, Peoples R China.;[Liu, Li-Han; Shi, Qun-Ying] Southern Med Univ, Sch Pharmaceut Sci, Guangdong Key Lab New Drug Screening, Guangzhou 510515, Peoples R China.;[Yin, Tinghui] Sun Yat Sen Univ, Dept Med Ultrason, Lab Novel Optoacoust Ultrason Imaging, Affiliated Hosp 3, 600 Tianhe Rd, Guangzhou 510630, Peoples R China.;[Shuai, Xintao] Sun Yat Sen Univ, PCFM Lab, Minist Educ, Sch Mat Sci & Engn, Guangzhou 510275, Peoples R China.
通讯机构：
[Liu, Li-Han] G;[Wang, Ping; Yin, Tinghui] D;Department of Medical Ultrasonic, Laboratory of Novel Optoacoustic (Ultrasonic) imaging, The Third Affiliated Hospital of Sun Yat-sen University, 600 Tianhe Road, Guangzhou 510630, PR China. Electronic address:;Department of Ultrasonography, The Third Affiliated Hospital of Southern Medical University, Academy of Orthopedics, Guangdong Province, Guangzhou 510630, PR China. Electronic address:;Guangdong Key Laboratory of New Drug Screening, School of Pharmaceutical Sciences, Southern Medical University, Guangzhou 510515, PR China. Electronic address:
关键词：
Heat endurance;Heat shock proteins;Hollow mesoporous Prussian blue nanoparticles;Mild temperature photothermal therapy;Multimodal imaging
作者机构：
[Yang, Shengyuan; Tong, Xuezhi] Univ South China, Sch Publ Hlth, Hengyang Med Sch, Dept Publ Hlth Lab Sci, Hengyang 421001, Hunan, Peoples R China.;[Zeng, Dong; Feng, JiaLi; Fan, Xiang; Zhang, Hao; Chen, Dongyang] Hunan Prov Ctr Dis Control & Prevent, Changsha 410005, Hunan, Peoples R China.;[Tan, Shan] Changsha Med Univ, Sch Publ Hlth, Dept Gen Med, Changsha 410219, Hunan, Peoples R China.
通讯机构：
[Shengyuan Yang] D;[Dongyang Chen] H;Hunan Provincial Center for Disease Control and Prevention, Changsha, Hunan 410005, China<&wdkj&>Department of Public Health Laboratory Sciences, School of Public Health, Hengyang Medical School, University of South China, Hengyang, Hunan 421001, China
作者机构：
[Guo, Jian] Univ South China, Sch Mech Engn, Hengyang 421001, Peoples R China.;[Chen, Lei; Qian, Linmao; Gao, Jian; Xiao, Chen] Southwest Jiaotong Univ, Tribol Res Inst, State Key Lab Tract Power, Chengdu 610031, Peoples R China.;[Xiao, Chen] Adv Res Ctr Nanolithog ARCNL, Sci Pk 106, NL-1098XG Amsterdam, Netherlands.;[Chen, Lei; Qian, Linmao] Southwest Jiaotong Univ, Technol & Equipment Rail Transit Operat & Mainten, Chengdu 610031, Peoples R China.
通讯机构：
[Chen Xiao; Lei Chen] T;Tribology Research Institute, State Key Laboratory of Traction Power, Southwest Jiaotong University, Chengdu, China<&wdkj&>Advanced Research Center for Nanolithography (ARCNL), Amsterdam, The Netherlands<&wdkj&>Tribology Research Institute, State Key Laboratory of Traction Power, Southwest Jiaotong University, Chengdu, China<&wdkj&>Technology and Equipment of Rail Transit Operation and Maintenance Key Laboratory of Sichuan Province, Southwest Jiaotong University, Chengdu, China
期刊：
Journal of Alloys and Compounds,2022年918:165408 ISSN：0925-8388
通讯作者：
Xueping Gan<&wdkj&>Xijun Wu
作者机构：
[Wu, Xijun; Cheng, Jinjuan] Univ South China, Sch Math & Phys, Hengyang 421001, Peoples R China.;[Gan, Xueping; Zhang, Ziyan; Gao, Yi; Lei, Qian] Cent South Univ, State Key Lab Powder Met, Changsha 410083, Peoples R China.
通讯机构：
[Xueping Gan; Xijun Wu] S;State Key Laboratory of Powder Metallurgy, Central South University, Changsha 410083, China<&wdkj&>School of Mathematics and Physics, University of South China, Hengyang 421001, China
摘要：
The effects of yttrium on the cellular precipitation kinetics, grain growth behavior and mechanical properties of Cu-15Ni-8Sn alloy are investigated. Results show that the added yttrium leads to the formation of NiSnY and Ni2Y compounds, which increases the strength, refines the grains and slows the grain growth rate of the Cu-15Ni-8Sn alloy. Also, the addition of yttrium changes the nucleation rate and crystal growth type of the gamma phase, postponing cellular precipitation in the early stages of aging treatment. Compared with the peak-aged Cu-15Ni-8Sn alloy, the peak-aged Cu-15Ni-8Sn-0.2Y alloy possesses higher hardness and strength. The hardness increases from 348 HV to 372.2 HV, the yield strength increases from 960 MPa to 1098 MPa, and the ultimate tensile strength increases from 1044 MPa to 1166 MPa. (C) 2022 Published by Elsevier B.V.
通讯机构：
[Karim Khan; Chuan Li; Han Zhang] S;School of Electrical Engineering & Intelligentization, Dongguan University of Technology, Dongguan, China<&wdkj&>Shenzhen Engineering Laboratory of Phosphorene and Optoelectronics, International Collaborative Laboratory of 2D Materials for Optoelectronics Science and Technology of Ministry of Education, Institute of Microscale Optoelectronics, Engineering, Shenzhen University, Shenzhen, China<&wdkj&>Shenzhen Nuoan Environmental & Safety Inc., Shenzhen 518107,P. R. China & College of Physics and Optoelectronic Engineering, Shenzhen University, Shenzhen 518060, P. R. China<&wdkj&>School of Mechanical Engineering, Dongguan University of Technology, Dongguan 523808, China<&wdkj&>Shenzhen Engineering Laboratory of Phosphorene and Optoelectronics, International Collaborative Laboratory of 2D Materials for Optoelectronics Science and Technology of Ministry of Education, Institute of Microscale Optoelectronics, Engineering, Shenzhen University, Shenzhen, China
作者机构：
[Zhang, Miao; Peng, Jinlei; Wei, Hua; Liu, Ying; Tang, Shengsong; Li, Shuang; Zhong, Fengmin; Yu, Cui-Yun; Liu, Fangjun] Univ South China, Hunan Prov Cooperat Innovat Ctr Mol Target New Dru, Hengyang 421001, Peoples R China.;[Zhang, Miao] Sichuan Univ, Coll Polymer Sci & Engn, State Key Lab Polymer Mat Engn, Chengdu 610065, Peoples R China.;[Tang, Shengsong; Ning, Qian] Hunan Univ Med, Sch Pharmaceut Sci, Hunan Prov Key Lab Antibody Based Drug & Intellige, Huaihua 418000, Peoples R China.;[Tang, Shengsong; Ning, Qian] Hunan Agr Univ, Coll Biosci & Biotechnol, Changsha 410000, Peoples R China.
通讯机构：
[Cui-Yun Yu; Hua Wei] H;Hunan Province Cooperative Innovation Center for Molecular Target New Drug Study & Department of Pharmacy and Pharmacology, University of South China, Hengyang, 421001, China
作者机构：
[Huang, Fujin; Ning, Pengyun; Zhou, Jun; Wang, Jinling; Liao, Yang; Zeng, Yahua; Zhong, Peirui; Huang, Xiarong; Yin, Linwei; Qu, Mengjian] Univ South China, Affiliated Hosp 1, Hengyang Med Sch, Dept Rehabil,Rehabil Med Ctr,Rehabil Lab, Hengyang, Peoples R China.;[Zeng, Yahua] Univ South China, Affiliated Hosp 1, Hengyang Med Sch, Dept Rehabil, Hengyang 421001, Hunan, Peoples R China.
通讯机构：
[Yahua Zeng] D;Department of Rehabilitation, Rehabilitation Medicine Center, Rehabilitation Laboratory, The First Affiliated Hospital, Hengyang Medical School, University of South China, Hengyang, China
关键词：
bone architecture;bone loss;osteoporosis;pulsed electromagnetic field;Wnt/β-catenin signaling
期刊：
European Journal of Surgical Oncology,2022年48(10):2075-2081 ISSN：0748-7983
通讯作者：
Peng, X.;Xiao, S.;Fu, K.
作者机构：
[Peng, Xiuda; Xu, Yunhua; Xiao, Shuai; Zhang, Yiwei; Huang, Jia] Univ South China, Affiliated Hosp 1, Hengyang Med Sch, Canc Res Inst, Hengyang 421001, Hunan, Peoples R China.;[Fu, Kai; Chen, Yuqiao] Cent South Univ, Inst Mol Precis Med, Dept Gen Surg, Xiangya Hosp, Changsha 410008, Hunan, Peoples R China.;[Fu, Kai; Chen, Yuqiao] Cent South Univ, Hunan Key Lab Mol Precis Med, Dept Gen Surg, Xiangya Hosp, Changsha 410008, Hunan, Peoples R China.;[Wu, Xiaofeng; Xiao, Shuai; Tang, Rong; Huang, Qiulin] Univ South China, Affiliated Hosp 1, Hengyang Med Sch, Dept Gastrointestinal Surg, Hengyang 421001, Hunan, Peoples R China.
通讯机构：
[Xiuda Peng; Shuai Xiao] T;The First Affiliated Hospital, Cancer Research Institute, Hengyang Medical School, University of South China, Hengyang, Hunan, 421001, China<&wdkj&>The First Affiliated Hospital, Department of Gastrointestinal Surgery, Hengyang Medical School, University of South China, Hengyang, Hunan, 421001, China<&wdkj&>The First Affiliated Hospital, Cancer Research Institute, Hengyang Medical School, University of South China, Hengyang, Hunan, 421001, China
期刊：
FRONTIERS IN ONCOLOGY,2022年11:794146 ISSN：2234-943X
通讯作者：
Wang, Danling
作者机构：
[Wan, Zhengqing; Tan, Xian; Wang, Danling] Univ South China, Hengyang Med Sch, Hengyang, Peoples R China.;[Wan, Zhengqing; Wang, Danling] Univ South China, Hengyang Med Sch, Affiliated Changsha Cent Hosp, Changsha, Peoples R China.;[Wan, Zhengqing] Univ South China, Hengyang Med Sch, Postdoctoral Stn Basic Med, Hengyang, Peoples R China.;[Su, Tong; Xiong, Haofeng] Cent South Univ, Xiangya Hosp, Changsha, Peoples R China.;[Xia, Kun; Xiong, Haofeng] Cent South Univ, Sch Life Sci, Ctr Med Genet, Changsha, Peoples R China.
通讯机构：
[Wang, Danling] U;Univ South China, Hengyang Med Sch, Hengyang, Peoples R China.;Univ South China, Hengyang Med Sch, Affiliated Changsha Cent Hosp, Changsha, Peoples R China.
作者机构：
[Guo, Zifen; Wen, Xiaosha; Pu, Huijie] Univ South China, Hengyang Med Sch, Sch Pharmaceut Sci, Hunan Prov Cooperat Innovat Ctr Mol Target New Dru, Hengyang 421001, Peoples R China.;[Wen, Xiaosha; Pu, Huijie; Liu, Quan; Luo, Dixian] Huazhong Univ Sci & Technol, Union Shenzhen Hosp, Lab Med Ctr, Shenzhen 518052, Peoples R China.
通讯机构：
[Dixian Luo; Zifen Guo] A;Authors to whom correspondence should be addressed.<&wdkj&>Hunan Province Cooperative Innovation Center for Molecular Target New Drug Study, Hunan Provincial Key Laboratory of Tumor Microenvironment Responsive Drug Research, School of Pharmaceutical Science, Hengyang Medical School, University of South China, Hengyang 421001, China<&wdkj&>Authors to whom correspondence should be addressed.<&wdkj&>Laboratory Medicine Centre, Huazhong University of Science and Technology Union Shenzhen Hospital, Shenzhen 518052, China
摘要：
Simple Summary ctDNA is a small DNA fragment derived from tumor cells, which contains tumor-related genomic information, such as mutation, methylation, microsatellite instability, etc. It is an ideal biomarker for real-time monitoring of tumor development. This work mainly reviews the different sources of ctDNA, such as blood, urine, uncommon cerebrospinal fluid, ascites, etc. The most frequent mutation and methylation detection methods in ctDNA, such as the most commonly used high-throughput sequencing and innovative methods, combined with new materials in recent years, such as CRISPR-Cas system, graphene, etc. Finally, it is concluded that ctDNA has a comprehensive and accurate application value in all stages of tumor development (early screening, diagnosis, molecular typing, guiding medication, prognosis, and recurrence monitoring). Cancer is the second leading cause of death in the world and seriously affects the quality of life of patients. The diagnostic techniques for tumors mainly include tumor biomarker detection, instrumental examination, and tissue biopsy. In recent years, liquid technology represented by circulating tumor DNA (ctDNA) has gradually replaced traditional technology with its advantages of being non-invasive and accurate, its high specificity, and its high sensitivity. ctDNA may carry throughout the circulatory system through tumor cell necrosis, apoptosis, circulating exosome secretion, etc., carrying the characteristic changes in tumors, such as mutation, methylation, microsatellite instability, gene rearrangement, etc. In this paper, ctDNA mutation and methylation, as the objects to describe the preparation process before ctDNA analysis, and the detection methods of two gene-level changes, including a series of enrichment detection techniques derived from PCR, sequencing-based detection techniques, and comprehensive detection techniques, are combined with new materials. In addition, the role of ctDNA in various stages of cancer development is summarized, such as early screening, diagnosis, molecular typing, prognosis prediction, recurrence monitoring, and drug guidance. In summary, ctDNA is an ideal biomarker involved in the whole process of tumor development.
作者机构：
[Guo, Yu; Xiao, Fang; Zheng, Xing; Guo, Y] Univ South China, Inst Pharm & Pharmacol, Hunan Prov Key Lab Tumor Microenvironm Respons Dr, Hengyang 421001, Peoples R China.;[Hao, Fei; Ji-Chang Xiao; Xiao, Fang; Jin-Hong Lin; Hao, F] Chinese Acad Sci, Univ Chinese Acad Sci, Shanghai Inst Organ Chem, Key Lab Organofluorine Chem, Shanghai 200032, Peoples R China.;[Jin-Hong Lin] Shanghai Univ, Innovat Drug Res Ctr, Dept Chem, Shanghai 200444, Peoples R China.;[Hao, F; Hao, Fei] Qilu Univ Technol, Shandong Acad Sci, Shandong Prov Key Lab Mol Engn, Jinan 250353, Peoples R China.
通讯机构：
[Hao, F ] Q;[Xiao, JC ; Hao, F] C;[Zheng, X; Guo, Y ] U;Univ South China, Inst Pharm & Pharmacol, Hunan Prov Key Lab Tumor Microenvironm Respons Dr, Hengyang 421001, Peoples R China.;Chinese Acad Sci, Univ Chinese Acad Sci, Shanghai Inst Organ Chem, Key Lab Organofluorine Chem, Shanghai 200032, Peoples R China.
摘要：
A protocol for visible light mediated C–H trifluoromethylation of unactivated (hetero)arenes under blue LED irradiation has been developed. The reaction enables the rapid construction of a range of CF3-containing (hetero)arenes in moderate to high yields from the readily accessible trifluoromethylsulfonyl-pyridinium salt (TFSP). This protocol is also suitable for nitrogen-containing aromatic heterocycles, which are potentially useful in medicinal chemistry.
作者机构：
[Wang, Ji; Ning, Shunyan; Wei, Yuezhou; Jiang, Tianjiao; Yu, Tao] Univ South China, Sch Nucl Sci & Technol, Hengyang 421001, Peoples R China.;[Wei, Yuezhou; Wu, Yan] Shanghai Jiao Tong Univ, Sch Nucl Sci & Engn, Shanghai 200240, Peoples R China.;[He, Hui] China Inst Atom Energy, Dept Radiochem, Beijing 102413, Peoples R China.;[Chen, Fangqiang; Wang, Qingsong] MEE, Nucl & Radiat Safety Ctr, Beijing 102400, Peoples R China.
通讯机构：
[Ji Wang; Fangqiang Chen] A;Authors to whom correspondence should be addressed.<&wdkj&>School of Nuclear Science and Technology, University of South China, Hengyang 421001, China<&wdkj&>Authors to whom correspondence should be addressed.<&wdkj&>Nuclear and Radiation Safety Center, MEE, Beijing 102400, China
关键词：
high-level liquid waste;minor actinides;separation;R-BTP adsorbent;hot test
摘要：
To separate the long-lived minor actinides (MA = Am, Cm) from high-level liquid waste (HLLW), we have been studying an advanced separation process via selective adsorption that uses minimal amounts of organic solvent and compact equipment. The process consists of two separation columns packed with a CMPO (octyl(phenyl)-N,N-diisobutylcarbamoyl-methyl phosphine oxide) adsorbent for elemental group separation and a soft-donor named the R-BTP (2,6-bis-(5,6-dialkyl-1,2,4-triazine-3-yl) pyridine) adsorbent for the isolation of MA from lanthanides (Ln). In this work, the effects of nitrate ion (NO3−) on the adsorption behavior of Am(III) and a typical fission product Ln(III) onto the isoBu-BTP/SiO2-P adsorbent were studied experimentally. Then, the desorption properties of the adsorbed element were examined using different eluting agents. A hot test for the separation of MA from the fission product Ln in a genuine MA containing effluent from the irradiated MOX-fuel treatment process was carried out using a nBu-BTP/SiO2-P packed column. It was found that the separation factor between Am(III) and Ln(III)-FP is over 100 in the measured 0.5–4 M NO3−. The adsorbed elements could be effectively eluted off using a complexing agent such as DTPA or pure water. Complete separation between MA and Ln was achieved in the column results, indicating that the proposed MA separation process is feasible in principle.
