作者机构：
[Luo, W.; Luo, W; Zhu, Z. C.; Lan, H. Y.; Song, Y. M.; Sun, X. Y.] Univ South China, Sch Nucl Sci & Technol, Hengyang 421001, Peoples R China.;[Gao, Q. Y.] Chinese Acad Sci, Inst Modern Phys, Lanzhou 730000, Peoples R China.;[Cai, X. Z.; Chen, J. G.; Chen, JG] Chinese Acad Sci, Shanghai Inst Appl Phys, Shanghai 201800, Peoples R China.
通讯机构：
[Luo, W ] U;[Chen, JG ] C;Univ South China, Sch Nucl Sci & Technol, Hengyang 421001, Peoples R China.;Chinese Acad Sci, Shanghai Inst Appl Phys, Shanghai 201800, Peoples R China.
摘要：
Disposal of long-lived fission products (LLFPs) produced in reactors has been paid a lot attention for sustainable and clean nuclear energy. Although a few transmutation means have been proposed to address this issue, there are still scientific and/or engineering challenges to achieve efficient transmutation of LLFPs. In this study, we propose a novel concept of advanced nuclear energy system (ANES) for transmuting LLFPs efficiently without isotopic separation. The ANES comprises intense photoneutron source (PNS) and subcritical reactor, which consist of lead-bismuth (Pb-Bi) layer, beryllium (Be) layer, and fuel, LLFPs and shield assemblies. The PNS is produced by bombarding radioactive cesium and iodine target with a laser-Compton scattering (LCS) γ-ray beam. We investigate the effect of the ANES system layout on transmutation efficiency by Monte Carlo simulations. It is found that a proper combination of the Pb-Bi layer and the Be layer can increase the utilization efficiency of the PNS by a factor of ~ 10, which helps to decrease by almost the same factor the LCS γ-beam intensity required for driving the ANES. Supposing that the ANES operates over 20years at a normal thermal power of 500 MWt, five LLFPs including (99)Tc, (129)I, (107)Pd, (137)Cs and (79)Se could be transmuted by more than 30%. Their effective half-lives thus decrease drastically from ~ 10(6) to less than 10(2)years. It is suggested that this successful implementation of the ANES paves the avenue towards practical transmutation of LLFPs without isotopic separation.
通讯机构：
[Xiaofeng Tan; Qinglai Yang] C;Center for Molecular Imaging Probe, Hunan Province Key Laboratory of Tumor Cellular and Molecular Pathology, Cancer Research Institute, Hengyang Medical School, University of South China, Hengyang, Hunan421001, China
作者机构：
[Salami, Oluwabukunmi Modupe; Habimana, Olive] Univ South China, Int Coll, 28 W Changsheng Rd, Hengyang 421001, Hunan, Peoples R China.;[Yi, Guang-Hui; Peng, Jinfu] Univ South China, Inst Cardiovasc Dis, Hengyang Med Sch, Key Lab Arteriosclerol Hunan Prov, 28 W Changsheng Rd, Hengyang 421001, Hunan, Peoples R China.;[Yi, Guang-Hui; Peng, Jinfu] Univ South China, Inst Pharm & Pharmacol, Hunan Prov Cooperat Innovat Ctr Mol Target New Dru, 28 W Changsheng Rd, Hengyang 421001, Hunan, Peoples R China.;[Yi, Guang-Hui] Univ South China, Inst Cardiovasc Dis, Hengyang Med Sch, Key Lab Arteriosclerol Hunan Prov,Hunan Int Sci &, 28 W Changsheng Rd, Hengyang 421001, Hunan, Peoples R China.
通讯机构：
[Guang-Hui Yi] I;Institute of Cardiovascular Disease, Key Laboratory for Arteriosclerology of Hunan Province, Hengyang Medical School, University of South China, 28, W Changsheng Road, Hengyang, Hunan 421001, China<&wdkj&>Institute of Pharmacy and Pharmacology, Hunan Province Cooperative Innovation Center for Molecular Target New Drug Study, University of South China, 28, W Changsheng Road, Hengyang, Hunan 421001, China
摘要：
Heart failure remains a considerable clinical and public health problem, it is the dominant cause of death from cardiovascular diseases, besides, cardiovascular diseases are one of the leading causes of death worldwide. The survival of patients with heart failure continues to be low with 45-60% reported deaths within five years. Apoptosis, necrosis, autophagy, and pyroptosis mediate cardiac cell death. Acute cell death is the hallmark pathogenesis of heart failure and other cardiac pathologies. Inhibition of pyroptosis, autophagy, apoptosis, or necrosis reduces cardiac damage and improves cardiac function in cardiovascular diseases. Pyroptosis is a form of inflammatory deliberate cell death that is characterized by the activation of inflammasomes such as NOD-like receptors (NLR), absent in melanoma 2 (AIM2), interferon-inducible protein 16 (IFI-16), and their downstream effector cytokines: Interleukin IL-1β and IL-18 leading to cell death. Recent studies have shown that pyroptosis is also the dominant cell death process in cardiomyocytes, cardiac fibroblasts, endothelial cells, and immune cells. It plays a crucial role in the pathogenesis of cardiac diseases that contribute to heart failure. This review intends to summarize the therapeutic implications targeting pyroptosis in the main cardiac pathologies preceding heart failure.
期刊：
Movement Disorders,2022年37(9):1807-1816 ISSN：0885-3185
通讯作者：
Guo, J.-F.;Gao, C.-Q.
作者机构：
[Xiang, Ya-Qin; Qiao, Jiao-Jiao; Gao, Chang-Qing; Li, Jing-Jing; Huang, Juan-Juan; Wang, Shan-Ni; Wang, Mei-Mei; Zhang, Xu-Xiang; Xu, Qian; Guo, Ji-Feng; Tang, Bei-Sha; Wang, Jun-Ling; Liu, Zheng-Hua; Shen, Lu] Cent South Univ, Xiang Ya Hosp, Dept Neurol, Xiang Ya Rd 87, Changsha 410008, Peoples R China.;[Qiao, Jiao-Jiao; Gao, Chang-Qing; Li, Jing-Jing; Wang, Shan-Ni; Wang, Mei-Mei] Cent South Univ, Xiang Ya Hosp, Ctr Studies Lab Anim, Changsha, Peoples R China.;[Qiao, Jiao-Jiao] Cent South Univ, Sch Basic Med Sci, Dept Microbiol, Changsha, Peoples R China.;[Hu, Ping-An; Wang, Jian-Gang; Chen, Zhi-Heng] Cent South Univ, Xiang Ya Hosp 3, Dept Hlth Prevent, Changsha, Peoples R China.;[Lei, Li-Fang; Zhang, Ru-Xu; Song, Zhi; Gu, Shao-Juan] Cent South Univ, Xiang Ya Hosp 3, Dept Neurol, Changsha, Peoples R China.
通讯机构：
[Chang-Qing Gao ; Ji-Feng Guo ] D;Department of Neurology, Xiang-Ya Hospital, Central South University, Changsha, China<&wdkj&>Hunan International Scientific and Technological Cooperation Base of Neurodegenerative and Neurogenetic Diseases, Changsha, China<&wdkj&>Engineering Research Center of Hunan Province in Cognitive Impairment Disorders, Central South University, Changsha, China<&wdkj&>National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, Hunan, China<&wdkj&>Department of Neurology, Xiang-Ya Hospital, Central South University, Changsha, China<&wdkj&>Center for Studies in Laboratory Animals, Xiang-Ya Hospital, Central South University, Changsha, China<&wdkj&>National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, Hunan, China
通讯机构：
[Ruibin Wang; Yonggang Min] S;School of Chemistry and Chemical Engineering, University of South China, Hengyang 421001, China<&wdkj&>School of Materials and Energy, Guangdong University of Technology, Guangzhou 510006, China
摘要：
Abstract: Due to its unique physical and chemical properties, MXene has recently attracted much attention as a promising candidate for wastewater treatment. However, the low water permeation flux of MXene membrane remains a challenge that has not been fully solved. In this study, attapulgite was used to increase the flux of MXene membrane through a facile one-pot method, during which the MXene nanosheets were self-assembled while being intercalated by the attapulgite nanorods to finally form the composite membranes. Under optimal conditions, an increase of water permeation flux of 97.31% could be observed, which was attributed to the broadened nano-channel upon the adequate intercalation of attapulgite nanorods. Its permeation flux and rejection rate for methylene blue (MB) were further studied for diverse applications. In contrast to bare MXene, the permeation flux increased by 61.72% with a still high rejection rate of 90.67%, owing to the size rejection. Overcoming a key technique barrier, this work successfully improved the water permeability of MXene by inserting attapulgite nanorods, heralding the exciting prospects of MXene-based lamellar membrane in dye wastewater treatment. Keywords: MXene; attapulgite; methylene blue; permeation flux; rejection
期刊：
World Journal of Microbiology and Biotechnology,2022年38(10):1-10 ISSN：0959-3993
通讯作者：
Guowen Peng
作者机构：
[Shu, Yangzhen; Peng, Guowen] Univ South China, Sch Resources Environm & Safety Engn, Hengyang 421001, Hunan, Peoples R China.;[Xie, Jingxi; Peng, Guowen] Univ South China, Sch Chem & Chem Engn, Hengyang 421001, Hunan, Peoples R China.;[Chen, Luyao; Cheng, Conghui; Guo, Kexin] Univ South China, Sch Publ Hlth, Hengyang 421001, Hunan, Peoples R China.
通讯机构：
[Guowen Peng] S;School of Resources Environment and Safety Engineering, University of South China, Hengyang, People’s Republic of China<&wdkj&>School of Chemistry and Chemical Engineering, University of South China, Hengyang, People’s Republic of China
关键词：
Biological;Genetic engineering;Uranyl;Protein DSR A
期刊：
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES,2022年18(6):2484-2496 ISSN：1449-2288
通讯作者：
Luo, X.
作者机构：
[Quan, Jing; Liao, Weihua; Cao, Ya; Luo, Xiangjian; Liao, Chaoliang; Cheng, Can] Cent South Univ, Xiangya Hosp, Dept Radiol, Key Lab Carcinogenesis & Invas,Chinese Minist Edu, Changsha 410078, Hunan, Peoples R China.;[Quan, Jing; Cao, Ya; Luo, Xiangjian; Liao, Chaoliang; Cheng, Can] Cent South Univ, Sch Basic Med, Canc Res Inst, Changsha 410078, Hunan, Peoples R China.;[Tan, Yue] Univ South China, Hengyang Med Coll, Hengyang 421001, Hunan, Peoples R China.;[Jiang, Nian] Cent South Univ, Xiangya Hosp, Dept Neurosurg, Changsha 410078, Hunan, Peoples R China.;[Luo, Xiangjian] Cent South Univ, Hunan Canc Hosp, Hunan Key Lab Oncotarget Gene, Changsha 410078, Hunan, Peoples R China.
通讯机构：
Key Laboratory of Carcinogenesis and Invasion, Chinese Ministry of Education, Department of Radiology, Xiangya Hospital, Central South University, Hunan, Changsha, China
作者机构：
[Zhou, Shuai; Duan, Yi] Univ South China, Hunan Prov Key Lab Pollut Control & Resources Reu, Hengyang 421001, Peoples R China.;[Liu, Boyang; Zhou, Shuai; Duan, Yi; Xiong, Cong] Univ South China, Sch Civil Engn, Hengyang 421001, Peoples R China.;[Gao, Yuanyuan; Zhou, Shuai; Tang, Zhenping] Univ South China, Hunan Prov Key Lab Rare Met Minerals Exploitat &, Hengyang 421001, Peoples R China.;[Su, Yinglong] East China Normal Univ, Sch Ecol & Environm Sci, Shanghai 200241, Peoples R China.;[Wang, Yayi] Tongji Univ, Coll Environm Sci & Engn, Shanghai Inst Pollut Control & Ecol Secur, State Key Lab Pollut Control & Resources Reuse, Siping Rd, Shanghai 200092, Peoples R China.
通讯机构：
[Yi Duan] H;Hunan Province Key Laboratory of Pollution Control and Resources Reuse Technology, University of South China, Hengyang, 421001, China<&wdkj&>School of Civil Engineering, University of South China, Hengyang, 421001, China
摘要：
Schedule exercise therapy (SET) is a novel nonpharmacological intervention for the treatment of chronic insomnia disorder (CID). The aim of this study was to explore the effects of SET on CID. Methods: One hundred and eighteen CID were recruited and randomized into medication (MED) or medication combined with SET (MSET) groups. Over 12 observational weeks, sleep and mood status were evaluated using the Pittsburgh Sleep Quality Index (PSQI), Insomnia Severity Index (ISI), Epworth Sleepiness Scale (ESS), Self-rating Depression Scale (SDS), and Self-rating Anxiety Scale (SAS). At the end of the observational period, the rates of clinically effective hypnotic use were calculated. At 12 weeks, the PSQI progressively decreased for all subjects combined (P < .001) as well as ISI (P < .001), ESS (P < .001), SDS (P < .001), and SAS (P < .001). The decreases in PSQI (P < .05), ISI (P < .05), SDS (P < .01), and SAS (P < .05) in the MSET group were significantly larger than those in the MED group, but not the same as those in the ESS group (P > .05). At the trial endpoint, the clinically effective rate was significantly higher (P < .05) and the hypnotic usage rate was lower (P < .05) in the MSET group than in the MED group. SET may be an effective treatment for insomnia in patients with CID.
作者：
Ablikim, M.;Achasov, M. N.;Adlarson, P.;Albrecht, M.;Aliberti, R.;...
期刊：
PHYSICAL REVIEW D,2022年106(5) ISSN：2470-0010
作者机构：
[Yu, B. X.; Yu, G.; Li, Xiaoyu; Hu, T.; Ning, Z.; Zhang, P.; Wen, S. P.; Shi, X.; Sun, G. X.; Ma, M. M.; Zhao, Ling; Chen, T.; Zhu, Z. A.; Xu, G. F.; Wang, K.; Zhou, L. P.; Heng, Y. K.; Ji, Q.; Zhang, J. W.; Rong, G.; Batozskaya, V; Guan, C. Y.; Qi, F. Z.; Wang, Y. F.; Wang, L. L.; Ouyang, Q.; Zhang, A. Q.; Ji, X. B.; Qian, S.; Dong, M. Y.; Zhang, Jiawei; Fang, S. S.; Chang, J. F.; Liu, Z. A.; Wu, J. F.; Wang, Yaqian; Sun, S. S.; Fu, C. D.; Lou, X. C.; Lin, T.; Zhang, B. X.; Xing, T. Y.; Cao, G. F.; Wu, L. H.; Zhao, Y. B.; Zheng, J. P.; Jiang, X. S.; Kiuchi, R.; Gu, M. H.; Lu, Y. P.; Dong, L. Y.; Zhao, G.; Wu, L. J.; Li, L. J.; Yang, Yifan; Yuan, Y.; Lu, X. L.; Wu, Z.; Fang, Y.; Luo, X. L.; Ji, X. L.; Zhang, X. M.; Li, L. K.; Li, H. B.; Liang, H.; Huang, Y. P.; Zhang, J. Y.; Yin, J. H.; Liu, Huanhuan; Song, W. M.; Chen, X. T.; Zhang, J. Z.; He, K. L.; Chen, G.; Ablikim, M.; Liu, C. X.; Chang, W. L.; Zhu, K.; Zhao, J. Z.; Yang, Tao; Mao, Z. P.; Zhao, Q.; Xiao, S. Y.; Lu, J. G.; Liu, P. L.; Jing, M. Q.; Sun, H. K.; Chen, Y. B.; Wang, Z.; Liu, Fang; Zhao, J. Y.; Dong, J.; Liu, K.; Shi, J. Y.; Wang, H. P.; Yuan, C. Z.; Tang, G. Y.; Yuan, S. C.; Zhang, H. Y.; Chen, M. L.; Zhang, Z. H.; Hou, G. Y.; Shen, H. F.; Shao, L. G.; Hou, Z. L.; Sun, Y. Z.; Liu, B. J.; Li, Ke; Zhu, K. J.; Liu, H. M.; Xu, C. F.; Ma, H. L.; Sun, T.; Ye, M.; Xie, Y. G.; Zou, B. S.; Chen, H. S.; Cao, N.; Deng, Z. Y.; Ma, Q. M.; Wang, Z. Y.; Cai, X.; Yuan, X. Q.; Zhang, Y. H.; Ma, R. Q.; Shi, R. S.; Zou, J. H.; Zhang, Yao; Liu, J. Y.; Li, W. G.; Wang, Y. Q.; Mo, X. H.; Fang, J.; Shen, X. Y.; Ma, X. Y.; Hu, H. M.; Gong, W. X.; Hu, Y.; Wang, B.; Zhang, B. L.; Wang, Meng; Yang, Y. X.; Zhang, Jianyu; Miao, H.; Li, F.; Pathak, A.; Lu, Z. H.; Yang, H. X.; Qin, Z. H.; Li, G.; Ping, R. G.; Qiu, J. F.; Dai, H. L.; Li, W. D.; Fang, W. X.] Inst High Energy Phys, Beijing 100049, Peoples R China.;[Yuan, L.] Beihang Univ, Beijing 100191, Peoples R China.;[Li, Lei] Beijing Inst Petrochem Technol, Beijing 102617, Peoples R China.;[Jaeger, S.; Fritsch, M.; Heinsius, F. H.; Kuessner, M.; Pelizaeus, M.; Kopf, B.; Keshk, I. K.; Wollenberg, L.; Albrecht, M.; Schnier, C.; de Boer, R. E.; Feldbauer, F.; Wiedner, U.; Kuemmel, M.; Li, J. Q.; Maldaner, S.] Bochum Ruhr Univ, D-44780 Bochum, Germany.;[Briere, R. A.] Carnegie Mellon Univ, Pittsburgh, PA 15213 USA.
摘要：
Using data samples collected with the BESIII detector operating at the BEPCII storage ring, we measure the cross sections of the e(+)e(-) -> pi(+)pi-D+D- process at center-of-mass energies from 4.190 to 4.946 GeV with a partial reconstruction method. Resonance structures are seen and the cross section line shape can be described by the coherent sum of either two Breit-Wigner functions or a Breit-Wigner function and a phase space term. The mass and width of the resonance at about 4.4 GeV are determined to be (4371.6 +/- 2.5 +/- 9.2) MeV/c(2) and (167 +/- 4 +/- 29) MeV, respectively, which are in agreement with those of the psi(4360) or Y(4390) state. The spin-3D-wave charmonium state X(3842) is searched for through the e(+)e(-) -> pi(+)pi X-(3842) -> pi(+)pi-D+D- process, and evidence with a significance of 4.2 sigma is found in the data samples with center-of-mass energies from 4.6 to 4.7 GeV.
摘要：
Indoor photovoltaic is one of the most important applications of organic solar cells (OSCs). As different from AM1.5G sunlight with broad spectra from the visible to near-infrared region, the spectra of indoor light are usually located in the visible region. Therefore, a special material design for the photoactive layer to meet the requirement of indoor light is required for application in indoor photovoltaics. Herein, a wide-bandgap double-cable conjugated polymer is intentionally selected, which has the well-matched absorption spectra with indoor light for use in indoor OSCs. This double-cable polymer is used as a single photoactive layer in OSCs, providing a high power conversion efficiency of 19.44% under indoor light, which is comparable with the bulk-heterojunction solar cells using near-infrared electron acceptors. Moreover, the double-cable polymer-based indoor OSCs exhibit high storage stability. These results indicate that single-component OSCs based on double-cable polymers have promising applications in indoor OSCs.
期刊：
AMERICAN JOURNAL OF TRANSLATIONAL RESEARCH,2022年14(11):7985-7993 ISSN：1943-8141
通讯作者：
Zhou, JL;Wang, SY
作者机构：
[Zhou, Jianliang; Luo, Hongying] Univ South China, Sch Nucl Sci & Technol, Hengyang 421001, Hunan, Peoples R China.;[Lou, Jianlin] Chinese Acad Sci, Inst Basic Med & Canc IBMC, Zhejiang Canc Hosp, Dept Head & Neck Surg,Canc Hosp,Univ Chinese Acad, Hangzhou 310022, Zhejiang, Peoples R China.;[Wang, Shengyu; Feng, Wei; Shan, Guoping; Yang, Yiwei; Shao, Kainan] Chinese Acad Sci, Inst Basic Med & Canc IBMC, Zhejiang Canc Hosp, Dept Radiat Phys,Canc Hosp,Univ Chinese Acad Sci, Hangzhou 310022, Zhejiang, Peoples R China.
通讯机构：
[Wang, SY ] C;[Zhou, JL ] U;Univ South China, Sch Nucl Sci & Technol, Hengyang 421001, Hunan, Peoples R China.;Chinese Acad Sci, Inst Basic Med & Canc IBMC, Zhejiang Canc Hosp, Dept Radiat Phys,Canc Hosp,Univ Chinese Acad Sci, Hangzhou 310022, Zhejiang, Peoples R China.
关键词：
Robust optimization;postoperative left breast cancer;flatten filter free mode;volumetric modulated arc therapy;dosimetric characteristics
摘要：
Objective: By comparing the target dose distribution with or without the robust optimization, the dosimetric advantages of robust optimization and flattening filter free (FFF) in radiation therapy for postmastectomy cancer of the left breast was explored when part of the chest wall target was moved out in case of respiratory motion. Materials and methods: This is a retrospective study. The data of 21 postmastectomy patients with cancer of the left breast from 2019 to 2020 were retrospectively collected. The planned target volume (PTV) dose was prescribed 50 Gy/25 fractions and the treatment plans were designed using 6 MV FFF X ray and volumetric modulated arc therapy (VMAT) technology in RayStation treatment planning system (TPS), with and without robust optimization. The movement of the target area of the internal chest wall (0.50 cm) caused by respiratory movement was simulated by moving the isocenter of the beams. Results: When the chest wall target moved outward, the PTV target area D-98, D-95, D-2, conformity index (CI) and homogeneity index (HI) with robust optimization were better than those without robust optimization. The coverage rate of Planned Target Volume-Chest (PTV-T) V-50 with robust optimization was significantly higher than that with no-robust optimization (P<0.001). Clinical target volume (CTV) V-50 coverage with robust optimization was 14.49% higher than that with no-robust optimization. In terms of organ-at-risk parameters, the average spinal cord dose of the plan with robust optimization was 13.19% lower than that of the plan with norobust optimization, and the Lung-L V5 of the plan with no-robust optimization was slightly (1.94%) lower than that of the plan with robust optimization. There was no significant difference in machine execution efficiency between the two groups (P>0.05). Conclusions: Robust optimization could be adopted in the postoperative radiotherapy planning for cancer in the left breast, for it ensures that the target dose coverage and the dose limit of organ-at-risk still meet the clinical requirements under condition of chest wall displacement caused by respiratory movement.
通讯机构：
[Yan Zhang] I;Institute of Pathogenic Biology, Hengyang Medical College, University of South China;Hunan Provincial Key Laboratory for Special Pathogens Prevention and Control;Hunan Province Innovative Training Base for Postgraduates, University of South China and Nanyue Biopharmaceutical Co. Ltd. , Hengyang 421001, Hunan, China
关键词：
Helicobacter pylori;Tipα;gastric cancer stem cells;EMT;Wnt/β-catenin pathway
摘要：
Tumor necrosis factor-α-inducing protein (Tipα) is a newly identified toxin that promotes the inflammation and carcinogenesis caused by Helicobacter pylori. However, its mechanism of pathogenesis is still unclear. To investigate the carcinogenic mechanisms of Tipα, SGC7901 cells and SGC7901-derived cancer stem-like cells (CSCs) were stimulated by recombinant Tipα with or without Wnt/β-catenin signaling inhibitor XAV939. qRT-PCR and Western blotting were employed to detect expression of epithelial-mesenchymal transition (EMT), CSCs markers and downstream target genes of this signaling pathway. The cell migration ability was measured by wound healing assay and transwell assay. Our results indicated that Tipα promoted CSC properties of SGC7901 spheroids, including increased expression of CSC specific surface markers CD44, Oct4 and Nanog and an increased capacity for self-renewal. Tipα activated Wnt/β-catenin signaling in both SGC7901 cells or CSCs. Furthermore, Tipα induced the EMT and increased the expressions of downstream target genes of this signaling, including c-myc, cyclin D1 and CD44. However, XAV939 pretreatment inhibited Tipα-induced EMT and CSC properties in SGC7901 cells or CSCs. These results suggest that Tipα promotes EMT and CSC-like properties in gastric cancer cells through activation of Wnt/β-catenin signaling pathway, thereby accelerating the progression of gastric cancer.
