Biomimetic nanoparticles for effective mild temperature photothermal therapy and multimodal imaging

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成果类型：

期刊论文

作者：

Shu, Xian;Chen, Yi;Yan, Ping;Xiang, Yun;Shi, Qun-Ying;...

通讯作者：

Yin, Tinghui;Wang, Ping;Liu, Li-Han

作者机构：

[Chen, Yi; Shu, Xian; Xiang, Yun; Wang, Ping] Southern Med Univ, Acad Orthoped, Dept Ultrasonog, Affiliated Hosp 3, Guangzhou 510630, Guangdong, Peoples R China.

[Yan, Ping] Univ South China, Dept Radiol, Affiliated Hosp 1, Hengyang Med Sch, Hengyang 421001, Hunan, Peoples R China.

[Liu, Li-Han; Shi, Qun-Ying] Southern Med Univ, Sch Pharmaceut Sci, Guangdong Key Lab New Drug Screening, Guangzhou 510515, Peoples R China.

[Yin, Tinghui] Sun Yat Sen Univ, Dept Med Ultrason, Lab Novel Optoacoust Ultrason Imaging, Affiliated Hosp 3, 600 Tianhe Rd, Guangzhou 510630, Peoples R China.

[Shuai, Xintao] Sun Yat Sen Univ, PCFM Lab, Minist Educ, Sch Mat Sci & Engn, Guangzhou 510275, Peoples R China.

通讯机构：

[Liu, Li-Han] G

[Wang, Ping; Yin, Tinghui] D

Department of Medical Ultrasonic, Laboratory of Novel Optoacoustic (Ultrasonic) imaging, The Third Affiliated Hospital of Sun Yat-sen University, 600 Tianhe Road, Guangzhou 510630, PR China. Electronic address:

Department of Ultrasonography, The Third Affiliated Hospital of Southern Medical University, Academy of Orthopedics, Guangdong Province, Guangzhou 510630, PR China. Electronic address:

Guangdong Key Laboratory of New Drug Screening, School of Pharmaceutical Sciences, Southern Medical University, Guangzhou 510515, PR China. Electronic address:

语种：

英文

关键词：

Heat endurance;Heat shock proteins;Hollow mesoporous Prussian blue nanoparticles;Mild temperature photothermal therapy;Multimodal imaging

期刊：

Journal of Controlled Release

ISSN：

0168-3659

年：

2022

卷：

347

页码：

270-281

DOI：

10.1016/j.jconrel.2022.05.010

基金类别：

CRediT authorship contribution statement Xian Shu: Investigation, Methodology, Validation, Writing – original draft, Data curation. Yi Chen: Investigation, Data curation. Ping Yan: Investigation. Yun Xiang: Investigation. Qun-Ying Shi: Investigation. Tinghui Yin: Methodology, Supervision, acquisition. Ping Wang: Conceptualization, Methodology, Writing – original draft, Supervision. Li-Han Liu: Conceptualization, Methodology, Writing – review & editing, Supervision, acquisition. Xintao Shuai: Writing – review & editing.

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本校为其他机构

摘要：

Downregulation of adenosine triphosphate (ATP)-dependent heat shock proteins (HSPs) can significantly reduce the tumorigenicity of cancer cells and overcome heat endurance to achieve high-performance mild temperature (≤45 °C) photothermal therapy (PTT). Herein, we designed and constructed 4T1 cancer cell membrane-coated, lonidamine (LN)-loaded and DL-menthol (DLM)-loaded hollow mesoporous Prussian blue nanoparticles ([email protected] NPs). DLM with mild phase change characteristics served as a plugging agent to avoid early leakage and allow ...

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Biomimetic nanoparticles for effective mild temperature photothermal therapy and multimodal imaging

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