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Integrative Multi−Omics Analysis Reveals Candidate Biomarkers for Oral Squamous Cell Carcinoma

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成果类型:
期刊论文
作者:
Wan, Zhengqing;Xiong, Haofeng;Tan, Xian;Su, Tong;Xia, Kun;...
通讯作者:
Wang, Danling
作者机构:
[Wan, Zhengqing; Tan, Xian; Wang, Danling] Univ South China, Hengyang Med Sch, Hengyang, Peoples R China.
[Wan, Zhengqing; Wang, Danling] Univ South China, Hengyang Med Sch, Affiliated Changsha Cent Hosp, Changsha, Peoples R China.
[Wan, Zhengqing] Univ South China, Hengyang Med Sch, Postdoctoral Stn Basic Med, Hengyang, Peoples R China.
[Su, Tong; Xiong, Haofeng] Cent South Univ, Xiangya Hosp, Changsha, Peoples R China.
[Xia, Kun; Xiong, Haofeng] Cent South Univ, Sch Life Sci, Ctr Med Genet, Changsha, Peoples R China.
通讯机构:
[Wang, Danling] U
Univ South China, Hengyang Med Sch, Hengyang, Peoples R China.
Univ South China, Hengyang Med Sch, Affiliated Changsha Cent Hosp, Changsha, Peoples R China.
语种:
英文
关键词:
DEGs;DMGs;MeDEGs;multi-omics;oral squamous cell carcinoma
期刊:
FRONTIERS IN ONCOLOGY
ISSN:
2234-943X
年:
2022
卷:
11
页码:
794146
基金类别:
This work is funded by The Science and Technology Innovation Program of Hunan Province, grant number 2019SK2124 and 2020RC2070. The funders had no role in the design of the study; in the collection, analyses, or interpretation of data; in the writing of the manuscript, or in the decision to publish the results.
机构署名:
本校为第一且通讯机构
摘要:
Oral squamous cell carcinoma (OSCC) is one of the most common types of cancer worldwide. Due to the lack of early detection and treatment, the survival rate of OSCC remains poor and the incidence of OSCC has not decreased during the past decades. To explore potential biomarkers and therapeutic targets for OSCC, we analyzed differentially expressed genes (DEGs) associated with OSCC using RNA sequencing technology. Methylation−regulated and differentially expressed genes (MeDEGs) of OSCC were further identified via an integrative approach by exa...

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