通讯机构：
[Xiaofeng Tan; Qinglai Yang] C;Center for Molecular Imaging Probe, Hunan Province Key Laboratory of Tumor Cellular and Molecular Pathology, Cancer Research Institute, Hengyang Medical School, University of South China, Hengyang, Hunan421001, China
作者机构：
[Guo, Xinxun; Guo, Yongli; Fang, Yaochu; Zhang, Wenlong; Wu, Wentao; Luo, Yaoge; Sun, Bing] Univ South China, Sch Civil Engn, Hengyang 421001, Hunan, Peoples R China.;[Fang, Yaochu; Sun, Bing] Hunan Prov Key Lab High Performance Special Concre, Hengyang 421001, Hunan, Peoples R China.;[Fang, Yaochu; Sun, Bing] China Nucl Construction Key Lab High Performance C, Hengyang 421001, Hunan, Peoples R China.;[Wu, Wentao] JZFZ Architectural Design Co LTD, Xian Branch Chengdu, Xian 710000, Peoples R China.;[Zhu, Xiang] Shanxi Univ, Sch Elect Power, Civil Engn & Architecture, Taiyuan 030013, Shanxi, Peoples R China.
通讯机构：
[Yaochu Fang] S;School of Civil Engineering, University of South China, Hunan, Hengyang 421001, China<&wdkj&>Hunan Provincial Key Laboratory of High Performance Special Concrete, Hunan, Hengyang 421001, China<&wdkj&>China Nuclear Construction Key Laboratory of High Performance Concrete, Hunan, Hengyang 421001, China
摘要：
Based on the elastic thin plate theory, the mechanical properties and failure pattern are studied, considering the local failure defects, and the nominal positive stress expression of the hierarchical sandwich structures with a second-order core were presented. Moreover, the dominant relationship of each failure mode was compared, and the structure failure mechanism diagram is constructed by MATLAB, then the influence law of different local failure defects on the structure-dominant failure mode was discussed. However, for the failure mode of the structure, the emergence of the dominant failure mode of the secondary transmission path component may not be used as the failure criterion of the structure. Only when the failure mode of the structure appears on the main transmission path components, the failure mode can be used as the failure criterion of the hierarchical sandwich structure with a second-order core. In the failure mechanism diagram of the hierarchical sandwich structure with a second-order core, the single dominant failure mode of the structure can be accurately predicted, and for the junction of multiple mixed dominant failure modes, the structure is more prone to structural/component stability failure. At the same time, in order to test the correctness of the theoretical prediction, the verification experiment models were made with photosensitive resin 9000 material and 3D printing technology. Through the uniaxial compression test on the experimental model and numerical simulation, the correctness of the theoretical pre-diction of structural failure mode and ultimate bearing capacity is verified. The results show that the failure mode of the structure can be accurately predicted by the theoretical analysis, and the relative error is about 20% when calculating the bearing capacity. The experimental and simulation results agree well with the theoretical prediction.
期刊：
AMERICAN JOURNAL OF TRANSLATIONAL RESEARCH,2022年14(11):7985-7993 ISSN：1943-8141
通讯作者：
Zhou, JL;Wang, SY
作者机构：
[Zhou, Jianliang; Luo, Hongying] Univ South China, Sch Nucl Sci & Technol, Hengyang 421001, Hunan, Peoples R China.;[Lou, Jianlin] Chinese Acad Sci, Inst Basic Med & Canc IBMC, Zhejiang Canc Hosp, Dept Head & Neck Surg,Canc Hosp,Univ Chinese Acad, Hangzhou 310022, Zhejiang, Peoples R China.;[Wang, Shengyu; Feng, Wei; Shan, Guoping; Yang, Yiwei; Shao, Kainan] Chinese Acad Sci, Inst Basic Med & Canc IBMC, Zhejiang Canc Hosp, Dept Radiat Phys,Canc Hosp,Univ Chinese Acad Sci, Hangzhou 310022, Zhejiang, Peoples R China.
通讯机构：
[Wang, SY ] C;[Zhou, JL ] U;Univ South China, Sch Nucl Sci & Technol, Hengyang 421001, Hunan, Peoples R China.;Chinese Acad Sci, Inst Basic Med & Canc IBMC, Zhejiang Canc Hosp, Dept Radiat Phys,Canc Hosp,Univ Chinese Acad Sci, Hangzhou 310022, Zhejiang, Peoples R China.
关键词：
Robust optimization;postoperative left breast cancer;flatten filter free mode;volumetric modulated arc therapy;dosimetric characteristics
摘要：
Objective: By comparing the target dose distribution with or without the robust optimization, the dosimetric advantages of robust optimization and flattening filter free (FFF) in radiation therapy for postmastectomy cancer of the left breast was explored when part of the chest wall target was moved out in case of respiratory motion. Materials and methods: This is a retrospective study. The data of 21 postmastectomy patients with cancer of the left breast from 2019 to 2020 were retrospectively collected. The planned target volume (PTV) dose was prescribed 50 Gy/25 fractions and the treatment plans were designed using 6 MV FFF X ray and volumetric modulated arc therapy (VMAT) technology in RayStation treatment planning system (TPS), with and without robust optimization. The movement of the target area of the internal chest wall (0.50 cm) caused by respiratory movement was simulated by moving the isocenter of the beams. Results: When the chest wall target moved outward, the PTV target area D-98, D-95, D-2, conformity index (CI) and homogeneity index (HI) with robust optimization were better than those without robust optimization. The coverage rate of Planned Target Volume-Chest (PTV-T) V-50 with robust optimization was significantly higher than that with no-robust optimization (P<0.001). Clinical target volume (CTV) V-50 coverage with robust optimization was 14.49% higher than that with no-robust optimization. In terms of organ-at-risk parameters, the average spinal cord dose of the plan with robust optimization was 13.19% lower than that of the plan with norobust optimization, and the Lung-L V5 of the plan with no-robust optimization was slightly (1.94%) lower than that of the plan with robust optimization. There was no significant difference in machine execution efficiency between the two groups (P>0.05). Conclusions: Robust optimization could be adopted in the postoperative radiotherapy planning for cancer in the left breast, for it ensures that the target dose coverage and the dose limit of organ-at-risk still meet the clinical requirements under condition of chest wall displacement caused by respiratory movement.
作者：
Du, Meng;Wang, Ting;Yang, Yaozhang;Zeng, Fengyi;Li, Yue;...
期刊：
Contrast Media & Molecular Imaging,2022年2022 ISSN：1555-4309
作者机构：
[Du, Meng; Wang, Ting; Yang, Yaozhang; Zeng, Fengyi; Li, Yue; Chen, Zhiyi] Univ South China, Hengyang Med Sch, Med Imaging Ctr, Affiliated Hosp 1, Hengyang 421001, Hunan, Peoples R China.;[Du, Meng; Wang, Ting; Yang, Yaozhang; Zeng, Fengyi; Li, Yue; Chen, Zhiyi] Univ South China, Hengyang Med Sch, Inst Med Imaging, Hengyang 421001, Hunan, Peoples R China.;[Yang, Yaozhang; Zeng, Fengyi; Li, Yue] Guangzhou Med Univ, Lab Ultrasound Mol Imaging, Affiliated Hosp 3, Guangzhou 510000, Guangdong, Peoples R China.
摘要：
In recent years, imaging technology has made rapid progress to improve the sensitivity of tumor diagnostic. With the development of genetic engineering and synthetic biology, various genetically encoded molecular imaging probes have also been extensively developed. As a biomedical imaging method with excellent detectable sensitivity and spatial resolution, genetically encoded molecular imaging has great application potential in the visualization of cellular and molecular functions during tumor development. Compared to chemosynthetic dyes and nanoparticles with an imaging function, genetically encoded molecular imaging probes can more easily label specific cells or proteins of interest in tumor tissues and have higher stability and tissue contrast in vivo. Therefore, genetically encoded molecular imaging probes have attracted increasing attention from researchers in engineering and biomedicine. In this review, we aimed to introduce the genetically encoded molecular imaging probes and further explained their applications in tumor imaging.
作者机构：
[Peng, Yunchi; Chen, Jiayi; Zhou, Jiahuan; Xie, Yafeng; Xiao, Yongjian] Univ South China, Affiliated Hosp 2, Hengyang Med Sch, Dept Clin Lab, Hengyang 421001, Peoples R China.
通讯机构：
[Yongjian Xiao] D;Department of Clinical Laboratory, The Second Affiliated Hospital, Hengyang Medical School, University of South China, Hengyang 421001, China<&wdkj&>Author to whom correspondence should be addressed.
摘要：
Infectious diseases, caused by various pathogens in the clinic, threaten the safety of human life, are harmful to physical and mental health, and also increase economic burdens on society. Infections are a complex mechanism of interaction between pathogenic microorganisms and their host. Identification of the causative agent of the infection is vital for the diagnosis and treatment of diseases. Etiological laboratory diagnostic tests are therefore essential to identify pathogens. However, due to its rapidity and automation, the serological diagnostic test is among the methods of great significance for the diagnosis of infections with the basis of detecting antigens or antibodies in body fluids clinically. Epitopes, as a special chemical group that determines the specificity of antigens and the basic unit of inducing immune responses, play an important role in the study of immune responses. Identifying the epitopes of a pathogen may contribute to the development of a vaccine to prevent disease, the diagnosis of the corresponding disease, and the determination of different stages of the disease. Moreover, both the preparation of neutralizing antibodies based on useful epitopes and the assembly of several associated epitopes can be used in the treatment of disease. Epitopes can be divided into B cell epitopes and T cell epitopes; B cell epitopes stimulate the body to produce antibodies and are therefore commonly used as targets for the design of serological diagnostic experiments. Meanwhile, epitopes can fall into two possible categories: linear and conformational. This article reviews the role of B cell epitopes in the clinical diagnosis of infectious diseases.
摘要：
We consider a one-dimensional classical Poisson-Nernst-Planck model with two ion species, one positively charged and one negatively charged, and a simple profile of nonzero permanent charges. Of particular interest is to examine the effect from boundary layers on zero-current ionic flows in terms of reversal potentials and reversal permanent charges through membrane channels. This is important because boundary layers of charge are particularly likely to create artifacts over long distances, and this could dramatically affect the behavior of ionic flows. With boundary layers, the existence of reversal potentials and reversal permanent charges is established. Particularly, the reversal potentials are further compared with those identified under electroneutrality boundary conditions, and their orders are provided, which sensitively depends on the complicated nonlinear interaction among system parameters, particularly, boundary layers, boundary concentrations and channel geometry.
作者机构：
[Cai, Jinhui; Yang, Rong; Cen, Kaili; Shen, Wangzhen] Univ South China, Coll Chem & Chem Engn, Hengyang 421001, Peoples R China.;[Usman, Muhammad] Zhejiang Univ, Coll Pharmaceut Sci, Hangzhou 310058, Peoples R China.;[Liu, Meijing] Univ South China, Coll Pharmaceut Sci, Hengyang 421001, Hunan, Peoples R China.
通讯机构：
[Jinhui Cai] C;College of Chemistry and Chemical Engineering, University of South China, Hengyang 421001, China
摘要：
In recent years, many methods for the facile synthesis of pyridines and their derivatives have been developed. The [2 + 2 + 2] cycloaddition reaction of alkynes and nitriles catalyzed by transition metals has emerged as the most straightforward and efficient method to obtain pyridine derivatives. Recently, Earth-abundant cobalt has been employed as a versatile and economical catalyst for the synthesis of functionalized molecules, as compared to other transition metals. This review mainly focuses on the recent research and development of the Co-catalyzed intramolecular [2 + 2 + 2] cycloaddition of diynes–nitriles or intermolecular [2 + 2 + 2] cycloaddition reaction of alkynes or diynes with nitriles for the construction of chiral or achiral multi-substituted pyridines. Meanwhile, brief mechanistic insights are also discussed here to explain the observed regioselectivity.
作者：
Ablikim, M.;Achasov, M. N.;Adlarson, P.;Albrecht, M.;Aliberti, R.;...
期刊：
Journal of High Energy Physics,2022年2022(12):1-22 ISSN：1029-8479
通讯作者：
H. Xiao
作者机构：
[Yu, B. X.; Yu, G.; Li, Xiaoyu; Hu, T.; Ning, Z.; Zhang, P.; Wen, S. P.; Shi, X.; Sun, G. X.; Ma, M. M.; Zhao, Ling; Chen, T.; Zhu, Z. A.; Xu, G. F.; Wang, K.; Zhou, L. P.; Heng, Y. K.; Ji, Q.; Zhang, J. W.; Rong, G.; Batozskaya, V; Guan, C. Y.; Qi, F. Z.; Wang, Y. F.; Wang, L. L.; Ouyang, Q.; Zhang, A. Q.; Ji, X. B.; Qian, S.; Dong, M. Y.; Zhang, Jiawei; Fang, S. S.; Chang, J. F.; Liu, Z. A.; Wu, J. F.; Wang, Yaqian; Sun, S. S.; Fu, C. D.; Lou, X. C.; Lin, T.; Zhang, B. X.; Xing, T. Y.; Cao, G. F.; Wu, L. H.; Zhao, Y. B.; Zheng, J. P.; Jiang, X. S.; Kiuchi, R.; Gu, M. H.; Lu, Y. P.; Dong, L. Y.; Zhao, G.; Wu, L. J.; Li, L. J.; Yang, Yifan; Yuan, Y.; Lu, X. L.; Wu, Z.; Fang, Y.; Luo, X. L.; Ji, X. L.; Zhang, X. M.; Li, L. K.; Li, H. B.; Liang, H.; Huang, Y. P.; Zhang, J. Y.; Yin, J. H.; Liu, Huanhuan; Song, W. M.; Chen, X. T.; Zhang, J. Z.; He, K. L.; Chen, G.; Ablikim, M.; Liu, C. X.; Chang, W. L.; Zhu, K.; Zhao, J. Z.; Yang, Tao; Mao, Z. P.; Zhao, Q.; Xiao, S. Y.; Lu, J. G.; Liu, P. L.; Jing, M. Q.; Sun, H. K.; Chen, Y. B.; Zhang, Shuihan; Wang, Z.; Liu, Fang; Zhao, J. Y.; Dong, J.; Liu, K.; Shi, J. Y.; Wang, H. P.; Yuan, C. Z.; Tang, G. Y.; Yuan, S. C.; Zhang, H. Y.; Chen, M. L.; Zhang, Z. H.; Hou, G. Y.; Shen, H. F.; Shao, L. G.; Hou, Z. L.; Sun, Y. Z.; Liu, B. J.; Li, Ke; Zhu, K. J.; Liu, H. M.; Xu, C. F.; Ma, H. L.; Sun, T.; Ye, M.; Xie, Y. G.; Zou, B. S.; Chen, H. S.; Cao, N.; Deng, Z. Y.; Ma, Q. M.; Wang, Z. Y.; Cai, X.; Yuan, X. Q.; Zhang, Y. H.; Ma, R. Q.; Shi, R. S.; Zou, J. H.; Zhang, Yao; Liu, J. Y.; Li, W. G.; Wang, Y. Q.; Mo, X. H.; Fang, J.; Shen, X. Y.; Ma, X. Y.; Hu, H. M.; Gong, W. X.; Hu, Y.; Wang, B.; Zhang, B. L.; Wang, Meng; Yang, Y. X.; Zhang, Jianyu; Miao, H.; Li, F.; Lu, Z. H.; Yang, H. X.; Qin, Z. H.; Li, G.; Ping, R. G.; Qiu, J. F.; Dai, H. L.; Li, W. D.; Fang, W. X.] Inst High Energy Phys, Beijing 100049, Peoples R China.;[Yuan, L.] Beihang Univ, Beijing 100191, Peoples R China.;[Li, Lei] Beijing Inst Petrochem Technol, Beijing 102617, Peoples R China.;[Jaeger, S.; Fritsch, M.; Heinsius, F. H.; Kuessner, M.; Pelizaeus, M.; Kopf, B.; Keshk, I. K.; Wollenberg, L.; Albrecht, M.; Schnier, C.; de Boer, R. E.; Feldbauer, F.; Wiedner, U.; Kuemmel, M.; Li, J. Q.; Maldaner, S.] Bochum Ruhr Univ, D-44780 Bochum, Germany.;[Briere, R. A.] Carnegie Mellon Univ, Pittsburgh, PA 15213 USA.
通讯机构：
[H. Xiao] F;Fudan University, Shanghai, People’s Republic of China<&wdkj&>Key Laboratory of Nuclear Physics and Ion-beam Application (MOE) and Institute of Modern Physics, Fudan University, Shanghai, People’s Republic of China
关键词：
Charm Physics;e(+)-e(-) Experiments
摘要：
Using data samples with an integrated luminosity of 19 fb(-1) at twenty-eight center-of-mass energies from 3.872 GeV to 4.700 GeV collected with the BESIII detector at the BEPCII electron-positron collider, the process e(+)e(-) -> eta(+)pi(-) and the intermediate process e(+)e(-) -> eta rho(0) are studied for the first time. The Born cross sections are measured. No significant resonance structure is observed in the cross section lineshape.
