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Metabolic Labeling Strategy Boosted Antibacterial Efficiency for Photothermal and Photodynamic Synergistic Bacteria-Infected Wound Therapy

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成果类型:
期刊论文
作者:
Li, Na;Wu, Guilong;Tang, Li;Zhou, Wei;Yang, Sha;...
通讯作者:
Tan, Xiaofeng(tanxiaofeng@usc.edu.cn);Yang, Qinglai(qingyu513@usc.edu.cn)
作者机构:
[Xiao, Hao; Pan, Qi; Tang, Li; Yang, Qinglai; Li, Na; Wu, Guilong; Tan, Xiaofeng; Zhou, Wei; Wang, Minghui; He, Yuxuan; Wu, Peixian; Yang, Sha] Univ South China, Ctr Mol Imaging Probe, Hunan Prov Key Lab Tumor Cellular & Mol Pathol, Canc Res Inst,Hengyang Med Sch, Hengyang 421001, Hunan, Peoples R China.
通讯机构:
[Xiaofeng Tan; Qinglai Yang] C
Center for Molecular Imaging Probe, Hunan Province Key Laboratory of Tumor Cellular and Molecular Pathology, Cancer Research Institute, Hengyang Medical School, University of South China, Hengyang, Hunan421001, China
语种:
英文
关键词:
antibacterial therapy;metabolic labeling strategy;photothermal therapy (PTT);photodynamic therapy (PDT);bacterial biofilm
期刊:
ACS Applied Materials & Interfaces
ISSN:
1944-8244
年:
2022
卷:
14
期:
41
页码:
46362-46373
基金类别:
This work was financially supported by the National Science Foundation of China (81801749), the Science and Technology Innovation Program of Hunan Province “Huxiang Young Talents Plan” (2021RC3106), and the Key Research and Development Program of Hunan Province, China (no. 2022SK2053). The authors would also like to thank Shiyanjia Lab (www.shiyanjia.com) for the support with the fluorescence tests.
机构署名:
本校为第一机构
院系归属:
医学院
摘要:
Pathogenic bacteria infections bring about a substantial risk to human health. Given the development of antibiotic-resistance bacteria, alternative antibacterial strategies with great inactivation efficiency and bacteria-binding ability are extremely attractive. In this work, a metabolic labeling photosensitizer, prepared by the coupling of commercial IR820 and d-propargylglycine (a type of d-amino acid, DAA) via a straightforward one-step incubation (IR820-DAA), could metabolically be incorporated into the bacterial wall via enzymatic reaction...

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