Multivalent cyclic template-directed synthesis of polycyclodextrin-based nanocarriers for enhanced chemotherapy

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成果类型：

期刊论文

作者：

Zhang, Miao;Li, Shuang;Peng, Jinlei;Liu, Ying;Liu, Fangjun;...

通讯作者：

Cui-Yun Yu<&wdkj&>Hua Wei

作者机构：

[Zhang, Miao; Peng, Jinlei; Wei, Hua; Liu, Ying; Tang, Shengsong; Li, Shuang; Zhong, Fengmin; Yu, Cui-Yun; Liu, Fangjun] Univ South China, Hunan Prov Cooperat Innovat Ctr Mol Target New Dru, Hengyang 421001, Peoples R China.

[Zhang, Miao] Sichuan Univ, Coll Polymer Sci & Engn, State Key Lab Polymer Mat Engn, Chengdu 610065, Peoples R China.

[Tang, Shengsong; Ning, Qian] Hunan Univ Med, Sch Pharmaceut Sci, Hunan Prov Key Lab Antibody Based Drug & Intellige, Huaihua 418000, Peoples R China.

[Tang, Shengsong; Ning, Qian] Hunan Agr Univ, Coll Biosci & Biotechnol, Changsha 410000, Peoples R China.

通讯机构：

[Cui-Yun Yu; Hua Wei] H

Hunan Province Cooperative Innovation Center for Molecular Target New Drug Study & Department of Pharmacy and Pharmacology, University of South China, Hengyang, 421001, China

语种：

英文

关键词：

Chemotherapy;Crosslinked nanocarriers;Multivalent cyclic template;Polycyclodextrin

期刊：

Materials Today Chemistry

ISSN：

2468-5194

年：

2022

卷：

页码：

100996

DOI：

10.1016/j.mtchem.2022.100996

基金类别：

National Natural Science Foundation of China [51473072, 21504035]; Thousand Young Talent Program; general project of scientific research project of Hunan Provincial Education Department [19C1597]; University of South China Innovation Foundation for Postgraduate [213YXC011]

机构署名：

本校为第一机构

摘要：

Nanocarriers with reversibly crosslinked structures provide one solution to the in vivo stability versus high therapeutic efficiency dilemma, however, generally suffer from a diluted condition-required synthetic approach for crosslinking. To address this issue, we reported herein multivalent cyclic template-directed synthesis of polycyclodextrin (polyCD)-based nanocarriers. The adopted multivalent cyclic template with great stability and steric hindrance resulted in a relatively high preparation concentration of 1.0 mg/mL for crosslinking. The ...

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Multivalent cyclic template-directed synthesis of polycyclodextrin-based nanocarriers for enhanced chemotherapy

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