Aryl acyl peroxides for visible-light induced decarboxylative arylation of quinoxalin-2(1H)-ones under additive-, metal catalyst-, and external photosensitizer-free and ambient conditions
作者：
Xie, Long-Yong;Peng, Sha;Yang, Li-Hua;Peng, Cun;Lin, Ying-Wu;...
期刊：
Green Chemistry ,2021年23(1):374-378 ISSN：1463-9262
通讯作者：
He, Wei-Min
作者机构：
[Yang, Li-Hua; He, Wei-Min; Xie, Long-Yong; Peng, Sha; Peng, Cun] Hunan Univ Sci & Engn, Dept Chem & Bioengn, Yongzhou 425100, Peoples R China.;[Lin, Ying-Wu] Univ South China, Sch Chem & Chem Engn, Hengyang 421001, Peoples R China.;[Yu, Xianyong] Hunan Univ Sci & Technol, Sch Chem & Chem Engn, Xiangtan 411201, Peoples R China.;[Peng, Yu-Yu; Cao, Zhong] Changsha Univ Sci & Technol, Hunan Prov Key Lab Mat Protect Elect Power & Tran, Changsha 410114, Peoples R China.
通讯机构：
[He, Wei-Min] H;Hunan Univ Sci & Engn, Dept Chem & Bioengn, Yongzhou 425100, Peoples R China.
摘要：
Aryl radicals were generated for the first time from cheap and easily available aryl acyl peroxides in eco-friendly ethyl acetate under ambient conditions and visible-light illumination in the absence of any additive, metal catalyst, or external photosensitizer. The present arylation of quinoxalin-2(1H)-ones was chemo- and regioselective, and provided good access to various 3-arylquinoxalin-2(1H)-ones. This journal is © The Royal Society of Chemistry.
语种：
英文
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A facile gelator based on phenylalanine derivative is capable of forming fluorescent Zn-metallohydrogel, detecting Zn2+ in aqueous solutions and imaging Zn2+ in living cells
作者：
Wang, Hai-Xia;Wei, Chuan-Wan;Wang, Xiao-Juan* ;Xiang, Heng-Fang;Yang, Xin-Zhi;...
期刊：
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY ,2021年250:119378 ISSN：1386-1425
通讯作者：
Wang, Xiao-Juan;Lin, Ying-Wu
作者机构：
[Wei, Chuan-Wan; Wang, Hai-Xia; Lin, Ying-Wu; Wang, Xiao-Juan; Xiang, Heng-Fang; Wang, XJ] Univ South China, Sch Chem & Chem Engn, Hengyang 421001, Peoples R China.;[Wu, Gui-Long; Yang, Xin-Zhi; Lin, Ying-Wu] Univ South China, Lab Prot Struct & Funct, Med Sch, Hengyang 421001, Peoples R China.
通讯机构：
[Wang, XJ; Lin, YW] U;Univ South China, Sch Chem & Chem Engn, Hengyang 421001, Peoples R China.
关键词：
Metallohydrogel;Phenylalanine derivative;Fluorescence;Chemosensor;Image
摘要：
Supramolecular hydrogels are attracting soft materials with potential applications. In this study, we synthesized a facile gelator (named 2-QF) based on phenylalanine derivative with a Quinoline group. 2-QF can assemble to form hydrogels at room temperature in different colors under low pH values. Moreover, 2-QF was triggered to form a yellow metallohydrogel (2-QF-Zn) at high pH by the coordination between 2-QF and Zn2+. 2-QF-Zn metallohydrogel showed excellent multi-stimuli responsiveness, especially the reversible ``on-off" luminescence switching, as induced by base/acid. In addition, at a low concentration, 2-QF can selectively and visibly identify Zn2+ through fluorescence enhancement, and can detect Zn2+ at physiological pH as a chemosensor. Remarkably, 2-QF and 2-QF-Zn exhibited an excellent biocompatibility without cell cytotoxicity, and 2-QF is able to penetrate live HeLa cells and image intracellular Zn2+ by a turn-on fluorescent response, which makes it a potential candidate for biomedical applications. (C) 2020 Elsevier B.V. All rights reserved.
语种：
英文
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Nitriles as radical acceptors in radical cascade reactions
作者：
Sun, Kai;Lv, Qi-Yan;Lin, Ying-Wu;Yu, Bing* ;He, Wei-Min*
期刊：
Organic Chemistry Frontiers ,2021年8(3):445-465 ISSN：2052-4110
通讯作者：
Yu, Bing;He, Wei-Min
作者机构：
[Lv, Qi-Yan; Sun, Kai; Yu, Bing] Zhengzhou Univ, Coll Chem, Green Catalysis Ctr, Zhengzhou 450001, Peoples R China.;[Lv, Qi-Yan; He, Wei-Min] Changsha Univ Sci & Technol, Hunan Prov Key Lab Mat Protect Elect Power & Tran, Changsha 410114, Peoples R China.;[Lin, Ying-Wu] Univ South China, Sch Chem & Chem Engn, Hengyang 421001, Peoples R China.;[He, Wei-Min] Hunan Univ Sci & Engn, Dept Chem, Yongzhou 425100, Peoples R China.
通讯机构：
[Yu, Bing] Z;[He, Wei-Min] C;[He, Wei-Min] H;Zhengzhou Univ, Coll Chem, Green Catalysis Ctr, Zhengzhou 450001, Peoples R China.;Changsha Univ Sci & Technol, Hunan Prov Key Lab Mat Protect Elect Power & Tran, Changsha 410114, Peoples R China.
关键词：
Ketones;Cascade process;Cascade reactions;Functional molecules;Molecular complexity;Radical acceptors;Radical cascade reactions;Synthetic strategies;Versatile tools;Amines
摘要：
The cyano group is a valuable and readily available functional group for the preparation of various functional groups, such as amines, carboxylic acids, and ketones. In recent decades, the radical cascade reaction has emerged as a versatile tool to prepare a large variety of functional molecules. The application of the cyano group as a radical acceptor in cascade reactions provides diverse opportunities for the convenient construction of various important heterocycles and carbocycles. Such synthetic strategies will open new ways for the rapid buildup of molecular complexity. The focus of this review is the summary of the dynamic field of radical cascade processes using the cyano group as a radical acceptor, which has not been well documented so far.
语种：
英文
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In vitro measurement of superoxide dismutase-like nanozyme activity: a comparative study
作者：
Liu, Yufeng;Zhang, Yihong;Liu, Quanyi;Wang, Quan;Lin, Anqi;...
期刊：
ANALYST ,2021年146(6):1872-1879 ISSN：0003-2654
通讯作者：
Wei, Hui
作者机构：
[Liu, Yufeng; Wei, Hui; Lin, Anqi; Zhang, Yihong; Wang, Quan] Nanjing Univ, Coll Engn & Appl Sci, Dept Biomed Engn, Nanjing 210023, Jiangsu, Peoples R China.;[Liu, Quanyi; Du, Yan] Chinese Acad Sci, Changchun Inst Appl Chem, State Key Lab Electroanalyt Chem, Changchun 130022, Jilin, Peoples R China.;[Luo, Jie; Lin, Ying-Wu] Univ South China, Lab Prot Struct & Anct, Sch Chem & Chem Engn, Hengyang 421001, Hunan, Peoples R China.;[Wei, Hui] Nanjing Univ, Nanjing Natl Lab Microstruct, Jiangsu Key Lab Artificial Funct Mat, Nanjing 210093, Jiangsu, Peoples R China.;[Wei, Hui] Nanjing Univ, State Key Lab Analyt Chem Life Sci, Sch Chem & Chem Engn, Chem & Biomed Innovat Ctr ChemBIC, Nanjing 210023, Jiangsu, Peoples R China.
通讯机构：
[Wei, Hui] N;Nanjing Univ, Coll Engn & Appl Sci, Dept Biomed Engn, Nanjing 210023, Jiangsu, Peoples R China.;Nanjing Univ, Nanjing Natl Lab Microstruct, Jiangsu Key Lab Artificial Funct Mat, Nanjing 210093, Jiangsu, Peoples R China.;Nanjing Univ, State Key Lab Analyt Chem Life Sci, Sch Chem & Chem Engn, Chem & Biomed Innovat Ctr ChemBIC, Nanjing 210023, Jiangsu, Peoples R China.
关键词：
measurement;superoxide;dismutase-like
摘要：
Analyzing the SOD-like activity of nanozymes in vitro is of great importance for identifying new nanozymes and predicting their potential biological effects in vivo. However, false negative or positive results occasionally occur due to the mismatch between the detection methods and nanozymes. Here, five typical SOD-like nanozymes, including CeO2, Mn3O4, Prussian blue (PB), PCN222-Mn, and Pt NPs, have been used to evaluate the sensitivity and accuracy of several commonly used in vitro detection methods. By systematically analyzing the detection results, several precautions have been taken. (1) The hydroethidine (HE) probe could be disturbed by the nanozyme with oxidative ability. (2) The nitro blue tetrazolium (NBT) probe has a moderate sensitivity due to the poor water solubility of its reduced product. (3) The water-soluble tetrazolium salt (WST)-8 probe has a higher sensitivity than both NBT and iodonitrotetrazolium chloride (INT). (4) The detection system using the irradiation of riboflavin to produce O2- might be interfered by the nanozyme with photosensibility. (5) Both the quality of DMPO and incubation time are important factors for electron paramagnetic resonance (EPR) measurement. This study will be useful for choosing more suitable in vitro detection methods of SOD-like activity for nanozymes in the future. This journal is © The Royal Society of Chemistry.
语种：
英文
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Practical and sustainable approach for clean preparation of 5-organylselanyl uracils
作者：
Chen, Jin-Yang;Zhong, Chun-Tao;Gui, Qing-Wen;Zhou, Yuan-Ming;Fang, Yang-Yang;...
期刊：
中国化学快报：英文版 ,2021年32(1):475-479 ISSN：1001-8417
通讯作者：
He, Wei-Min
作者机构：
[Zhong, Chun-Tao; Fang, Yang-Yang; Chen, Jin-Yang; Zhou, Yuan-Ming] Yangtze Normal Univ, Coll Chem & Chem Engn, Chongqing 408000, Peoples R China.;[Liu, Kai-Jian; He, Wei-Min] Hunan Univ Sci & Engn, Dept Chem, Yongzhou 425100, Peoples R China.;[Gui, Qing-Wen; Cao, Zhong] Changsha Univ Sci & Technol, Hunan Prov Key Lab Mat Protect Elect Power & Tran, Changsha 410114, Peoples R China.;[Lin, Ying-Wu] Univ South China, Sch Chem & Chem Engn, Hengyang 421001, Peoples R China.
通讯机构：
[He, Wei-Min] H;Hunan Univ Sci & Engn, Dept Chem, Yongzhou 425100, Peoples R China.
关键词：
Selenylation;Electrochemistry;Diorganyl diselenides;Atom-economy;Recyclability
摘要：
An eco-friendly,sustainable and practical method for the efficient preparation of 5-organylselanyl uracils through the electrochemical selenylation of uracils and dio rganyl diselenides at room temperature under oxidant-and external electrolvte-free conditions was developed.
语种：
英文
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Conversion of Human Neuroglobin into a Multifunctional Peroxidase by Rational Design
作者：
Chen, Shun-Fa;Liu, Xi-Chun;Xu, Jia-Kun;Li, Lianzhi* ;Lang, Jia-Jia;...
期刊：
INORGANIC CHEMISTRY ,2021年60(4):2839-2845 ISSN：0020-1669
通讯作者：
Lin, Ying-Wu;Li, Lianzhi
作者机构：
[Chen, Shun-Fa; Liu, Xi-Chun; Lin, Ying-Wu] Univ South China, Sch Chem & Chem Engn, Hengyang 421001, Peoples R China.;[Xu, Jia-Kun] Chinese Acad Fishery Sci, Yellow Sea Fisheries Res Inst, Key Lab Sustainable Dev Polar Fisheries,Minist Ag, Lab Marine Drugs & Byprod,Pilot Natl Lab Marine S, Qingdao 266071, Peoples R China.;[Wen, Ge-Bo; Lang, Jia-Jia; Lin, Ying-Wu] Univ South China, Lab Prot Struct & Funct, Med Sch, Hengyang 421001, Peoples R China.;[Li, Lianzhi] Liaocheng Univ, Sch Chem & Chem Engn, Liaocheng 252059, Shandong, Peoples R China.
通讯机构：
[Lin, Ying-Wu] U;[Li, Lianzhi] L;Univ South China, Sch Chem & Chem Engn, Hengyang 421001, Peoples R China.;Univ South China, Lab Prot Struct & Funct, Med Sch, Hengyang 421001, Peoples R China.;Liaocheng Univ, Sch Chem & Chem Engn, Liaocheng 252059, Shandong, Peoples R China.
摘要：
Protein design has received much attention in the last decades. With an additional disulfide bond to enhance the protein stability, human A15C neuroglobin (Ngb) is an ideal protein scaffold for heme enzyme design. In this study, we rationally converted A15C Ngb into a multifunctional peroxidase by replacing the heme axial His64 with an Asp residue, where Asp64 and the native Lys67 at the heme distal site were proposed to act as an acid-base catalytic couple for H2O2 activation. Kinetic studies showed that the catalytic efficiency of A15C/H64D Ngb was much higher (∼50-80-fold) than that of native dehaloperoxidase, which even exceeds (∼3-fold) that of the most efficient native horseradish peroxidase. Moreover, the dye-decolorizing peroxidase activity was also comparable to that of some native enzymes. Electron paramagnetic resonance, molecular docking, and isothermal titration calorimetry studies provided valuable information for the substrate-protein interactions. Therefore, this study presents the rational design of an efficient multifunctional peroxidase based on Ngb with potential applications such as in bioremediation for environmental sustainability. © 2021 American Chemical Society.
语种：
英文
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Synergistic cooperative effect of CF3SO2Na and bis(2-butoxyethyl)ether towards selective oxygenation of sulfides with molecular oxygen under visible-light irradiation
作者：
Liu, Kai-Jian;Wang, Zheng;Lu, Ling-Hui;Chen, Jin-Yang;Zeng, Fei;...
期刊：
Green Chemistry ,2021年23(1):496-500 ISSN：1463-9262
通讯作者：
He, Wei-Min
作者机构：
[Zeng, Fei; Liu, Kai-Jian; Wang, Zheng; He, Wei-Min; Lu, Ling-Hui] Hunan Univ Sci & Engn, Dept Chem & Bioengn, Yongzhou 425100, Peoples R China.;[Lin, Ying-Wu; Chen, Jin-Yang] Univ South China, Sch Chem & Chem Engn, Hengyang 421001, Peoples R China.;[Cao, Zhong] Changsha Univ Sci & Technol, Hunan Prov Key Lab Mat Protect Elect Power & Duns, Changsha 410114, Peoples R China.;[Yu, Xianyong] Hunan Univ Sci & Technol, Sch Chem & Chem Engn, Xiangtan 411201, Peoples R China.
通讯机构：
[He, Wei-Min] H;Hunan Univ Sci & Engn, Dept Chem & Bioengn, Yongzhou 425100, Peoples R China.
摘要：
A safe, practical and eco-friendly method for the switchable synthesis of sulfoxides and sulfones through visible-light-initiated oxygenation of sulfides at ambient temperature under transition-metal-, additives-free and minimal solvent conditions. The synergistic catalytic efforts between CF3SO2Na and 2-butoxyethyl ether represents the key promoting factor for the reaction. This journal is © The Royal Society of Chemistry.
语种：
英文
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Selective oxidation of (hetero)sulfides with molecular oxygen under clean conditions
作者：
Liu, Kai-Jian;Deng, Ji-Hui;Yang, Jie;Gong, Shao-Feng;Lin, Ying-Wu;...
期刊：
Green Chemistry ,2020年22(2):433-438 ISSN：1463-9262
通讯作者：
He, Wei-Min
作者机构：
[Liu, Kai-Jian; He, Wei-Min; Yang, Jie; Gong, Shao-Feng; Deng, Ji-Hui] Hunan Univ Sci & Engn, Dept Chem, Yongzhou 425100, Peoples R China.;[Lin, Ying-Wu] Univ South China, Sch Chem & Chem Engn, Hengyang 421001, Peoples R China.;[He, Jun-Yi; Cao, Zhong] Changsha Univ Sci & Technol, Hunan Prov Key Lab Mat Protect Elect Power & Tran, Changsha 410114, Peoples R China.
通讯机构：
[He, Wei-Min] H;Hunan Univ Sci & Engn, Dept Chem, Yongzhou 425100, Peoples R China.
摘要：
The development of eco-friendly and switchable catalytic systems for the conversion of a sole raw-material into distinct high-value products is a particularly attractive concept and a daunting synthetic challenge. In the present work, the first example of efficient and selective oxidation of sulfides to sulfones and sulfoxides using molecular oxygen under clean conditions was established. © The Royal Society of Chemistry.
语种：
英文
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Uranyl Binding to Proteins and Structural-Functional Impacts
作者：
Lin, Ying-Wu*
期刊：
Biomolecules ,2020年10(3):457 ISSN：2218-273X
通讯作者：
Lin, Ying-Wu
作者机构：
[Lin, Ying-Wu] Univ South China, Sch Chem & Chem Engn, Hengyang 421001, Peoples R China.;[Lin, Ying-Wu] Univ South China, Lab Prot Struct & Funct, Hengyang 421001, Peoples R China.;[Lin, Ying-Wu] Univ South China, Hunan Key Lab Design & Applicat Actinide Complexe, Hengyang 421001, Peoples R China.
通讯机构：
[Lin, Ying-Wu] U;Univ South China, Sch Chem & Chem Engn, Hengyang 421001, Peoples R China.;Univ South China, Lab Prot Struct & Funct, Hengyang 421001, Peoples R China.;Univ South China, Hunan Key Lab Design & Applicat Actinide Complexe, Hengyang 421001, Peoples R China.
关键词：
metal-binding site;metalloproteins;structure-function;toxicity;uranyl
摘要：
The widespread use of uranium for civilian purposes causes a worldwide concern of its threat to human health due to the long-lived radioactivity of uranium and the high toxicity of uranyl ion (UO2 2+). Although uranyl–protein/DNA interactions have been known for decades, fewer advances are made in understanding their structural-functional impacts. Instead of focusing only on the structural information, this article aims to review the recent advances in understanding the binding of uranyl to proteins in either potential, native, or artificial metal-binding sites, and the structural-functional impacts of uranyl–protein interactions, such as inducing conformational changes and disrupting protein-protein/DNA/ligand interactions. Photo-induced protein/DNA cleavages, as well as other impacts, are also highlighted. These advances shed light on the structure-function relationship of proteins, especially for metalloproteins, as impacted by uranyl–protein interactions. It is desired to seek approaches for biological remediation of uranyl ions, and ultimately make a full use of the double-edged sword of uranium. © 2020 by the author. Licensee MDPI, Basel, Switzerland.
语种：
英文
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VISIBLE-LIGHT-INDUCED DECARBOXYLATIVE ACYLATION OF QUINOXALIN-2(1H )-ONES WITH ?-OXO CARBOXYLIC ACIDS UNDER METAL-, STRONG OXIDANT- AND EXTERNAL PHOTOCATALYST-FREE CONDITIONS
作者：
Xie, Long-Yong;Bai, You-Shu;Xu, Xiang-Qin;Peng, Xia;Tang, Hai-Shan;...
期刊：
Green Chemistry ,2020年22(5):1720-1725 ISSN：1463-9262
通讯作者：
He, Wei-Min
作者机构：
[Bai, You-Shu; He, Wei-Min; Tang, Hai-Shan; Xu, Xiang-Qin; Peng, Xia; Xie, Long-Yong] Hunan Univ Sci & Engn, Dept Chem, Yongzhou 425100, Peoples R China.;[Huang, Ying; Cao, Zhong] Changsha Univ Sci & Technol, Hunan Prov Key Lab Mat Protect Elect Power & Tran, Changsha 410114, Peoples R China.;[Lin, Ying-Wu] Univ South China, Sch Chem & Chem Engn, Hengyang 421001, Peoples R China.
通讯机构：
[He, Wei-Min] H;Hunan Univ Sci & Engn, Dept Chem, Yongzhou 425100, Peoples R China.
摘要：
A mild and eco-friendly visible-light-induced decarboxylative acylation of quinoxalin-2(1H)-ones and α-oxo carboxylic acids with ambient air as the sole oxidant at room temperature was established. The reaction proceeded efficiently without any metal catalysts, strong oxidants or external-photosensitizers, ultimately reducing the generation of waste. This journal is © The Royal Society of Chemistry.
语种：
英文
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血红素蛋白的亚硝酸盐还原酶功能及其生物学意义
作者：
林英武
期刊：
中国动脉硬化杂志 ,2020年28(12):1020-1025 ISSN：1007-3949
作者机构：
南华大学,化学化工学院,湖南省衡阳市421001;南华大学,衡阳医学院蛋白质结构与功能实验室,湖南省衡阳市421001;[林英武] 南华大学
关键词：
血红素蛋白;亚硝酸盐还原酶;生物催化;一氧化氮;心血管系统
摘要：
血红素蛋白在生物体系中执行重要的生物功能。在乏氧状态下,一系列血红素蛋白,如血红蛋白（Hb）、肌红蛋白（Mb）、细胞色素C（CytC）、神经红蛋白（Ngb）和胞红蛋白（Cgb）等,表现出不同的亚硝酸盐还原酶（NIR）活性,催化NO-2还原成NO,这与生物体在常氧状态下由L-精氨酸氧化产生NO的通路形成互补。研究表明:蛋白质构象、血红素的配位状态、分子内二硫键以及氢键网络等,可以调控其NIR催化活性,同时受生物体内微环境的影响,如NO-2浓度和pH等。文章对不同血红素蛋白的NIR催化活性进行了分析比较,探讨了其生物学意义,特别是NO-3-NO-2-NO通路在调节心血管系统内稳态平衡中的重要作用。
语种：
中文
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Electrochemical Synthesis of α-Ketoamides under Catalyst-, Oxidant-, and Electrolyte-Free Conditions
作者：
Chen, Jin-Yang;Wu, Hong-Yu;Gui, Qing-Wen;Han, Xiao-Ran;Wu, Yan;...
期刊：
Organic Letters ,2020年22(6):2206-2209 ISSN：1523-7060
通讯作者：
He, Wei-Min
作者机构：
[Du, Kui; Han, Xiao-Ran; Wu, Yan; Chen, Jin-Yang; Wu, Hong-Yu] Yangtze Normal Univ, Coll Chem & Chem Engn, Chongqing 408000, Peoples R China.;[Gui, Qing-Wen; He, Wei-Min; Cao, Zhong] Changsha Univ Sci & Technol, Hunan Prov Key Lab Mat Protect Elect Power & Tran, Changsha 410114, Peoples R China.;[Gui, Qing-Wen] Hunan Univ Sci & Technol, Sch Chem & Chem Engn, Xiangtan 411201, Peoples R China.;[Lin, Ying-Wu] Univ South China, Sch Chem & Chem Engn, Hengyang 421001, Peoples R China.
通讯机构：
[He, Wei-Min] C;Changsha Univ Sci & Technol, Hunan Prov Key Lab Mat Protect Elect Power & Tran, Changsha 410114, Peoples R China.
摘要：
A catalyst-, oxidant-, electrolyte-free method for the preparation of α-ketoamides through the direct electrochemical amidation of α-ketoaldehydes and amines with innocuous hydrogen as the sole byproduct at ambient temperature was developed. The present reaction features clean and mild conditions, excellent functional-group tolerance, and high atom economy and scalability, enabling facile applications in pharmaceutical chemistry. Copyright © 2020 American Chemical Society.
语种：
英文
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1,2-Diethoxyethane catalyzed oxidative cleavage of gem-disubstituted aromatic alkenes to ketones under minimal solvent conditions
作者：
Liu, Kai-Jian;Deng, Ji-Hui;Zeng, Tang-Yu;Chen, Xin-Jie;Huang, Ying;...
期刊：
中国化学快报：英文版 ,2020年31(7):1868-1872 ISSN：1001-8417
通讯作者：
He, Wei-Min
作者机构：
[Zeng, Tang-Yu; Liu, Kai-Jian; He, Wei-Min; Deng, Ji-Hui] Hunan Univ Sci & Engn, Dept Chem, Yongzhou 425100, Peoples R China.;[Huang, Ying; Cao, Zhong] Changsha Univ Sci & Technol, Hunan Prov Key Lab Mat Protect Elect Power & Tran, Changsha 410114, Peoples R China.;[Chen, Xin-Jie] Hunan Univ Sci & Technol, Sch Chem & Chem Engn, Xiangtan 411201, Peoples R China.;[Lin, Ying-Wu] Univ South China, Sch Chem & Chem Engn, Hengyang 421001, Peoples R China.
通讯机构：
[He, Wei-Min] H;Hunan Univ Sci & Engn, Dept Chem, Yongzhou 425100, Peoples R China.
关键词：
Ketone;Oxidation;Ambient air;Oxidative cleavage
摘要：
Aerobic oxidation using pure dioxygen gas as the oxidant has attracted much attention,but its application in synthetic chemistry has been significantly hampered by the complexity of catalytic system and potential risk of high-energy dioxygen gas.By employing 1,2-diethoxyethane as a catalyst and ambient air as an oxidant,an efficient protocol for the construction of various aryl-alkyl and diaryl ketones through oxidative cleavage of gem-disubstituted aromatic alkenes under minimal solvent conditions has been achieved.
语种：
英文
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Molecular iodine-catalyzed multicomponent synthesis of α-cyanopyrrolines with ambient air as the oxidant under neat conditions
作者：
Gui, Qing-Wen;Teng, Fan;Li, Zhou-Chao;Jin, Xue-Feng;Zhang, Mei;...
期刊：
Organic Chemistry Frontiers ,2020年7(24):4026-4030 ISSN：2052-4110
通讯作者：
He, Wei-Min
作者机构：
[Teng, Fan; Jin, Xue-Feng; Gui, Qing-Wen; Li, Zhou-Chao; Zhang, Mei; Dai, Jia-Ni] Hunan Agr Univ, Coll Chem & Mat Sci, Changsha 410128, Peoples R China.;[Lin, Ying-Wu] Univ South China, Sch Chem & Chem Engn, Hengyang 421001, Peoples R China.;[He, Wei-Min; Cao, Zhong] Changsha Univ Sci & Technol, Hunan Prov Key Lab Mat Protect Elect Power & Tran, Changsha 410114, Peoples R China.
通讯机构：
[He, Wei-Min] C;Changsha Univ Sci & Technol, Hunan Prov Key Lab Mat Protect Elect Power & Tran, Changsha 410114, Peoples R China.
关键词：
Iodine;Oxidants;Transition metals;Ambient air;Chemo-selectivity;Formamides;Molecular iodine;Multicomponent synthesis;Tandem reaction;Catalysis
摘要：
In this work, a variety of α-cyanopyrrolines were efficiently synthesized from alkenes, TMSCN and N,N-disubstituted formamides via molecular iodine-catalyzed tandem reaction under neat and mild conditions. This method applies ambient air as the sole oxidant and circumvents the use of transition metals and extra solvents to afford a broad range of final products with good regio- A nd chemo-selectivity. © 2020 the Partner Organisations.
语种：
英文
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A hybrid hydrogel within situformed Ag-nanoparticles within 3D networks that exhibits broad antibacterial activities
作者：
Wei, Chuan-Wan;Gong, Xiao-Qing;Wang, Xiao-Juan* ;Yang, Xin-Zhi;Gao, Shu-Qin;...
期刊：
NEW JOURNAL OF CHEMISTRY ,2020年44(18):7265-7269 ISSN：1144-0546
通讯作者：
Wang, Xiao-Juan;Lin, Ying-Wu
作者机构：
[Wei, Chuan-Wan; Gong, Xiao-Qing; Lin, Ying-Wu; Wang, Xiao-Juan; Wang, XJ] Univ South China, Sch Chem & Chem Engn, Hengyang 421001, Peoples R China.;[Wei, Chuan-Wan; Lin, Ying-Wu; Wang, Xiao-Juan; Wang, XJ] Univ South China, Hunan Key Lab Design & Applicat Actinide Complexe, Hengyang 421001, Peoples R China.;[Gao, Shu-Qin; Yang, Xin-Zhi; Lin, Ying-Wu] Univ South China, Lab Prot Struct & Funct, Hengyang 421001, Peoples R China.
通讯机构：
[Wang, XJ; Lin, YW; Lin, Ying-Wu] U;Univ South China, Sch Chem & Chem Engn, Hengyang 421001, Peoples R China.;Univ South China, Hunan Key Lab Design & Applicat Actinide Complexe, Hengyang 421001, Peoples R China.;Univ South China, Lab Prot Struct & Funct, Hengyang 421001, Peoples R China.
关键词：
Amino acids;Hydrogels;Irradiation;Medical applications;Metal nanoparticles;Ag nanoparticle;Anti-bacterial activity;Biomedical applications;Capping reagents;Hybrid hydrogels;Natural light;Silver nanoparticles (AgNps);UV irradiation;Silver nanoparticles;benzyl alcohol derivative;hydrogel;silver nanoparticle;tryptophan derivative;absorption;antibacterial activity;Article;cell viability;chemical structure;chirality;circular dichroism;controlled study;electron transport;Escherichia coli;gelation;human;human cell;MCF-7 cell line;nonhuman;oxidation reduction reaction;particle size;pH;priority journal;racemic mixture;room temperature;scanning electron microscopy;Staphylococcus aureus;Streptomyces albus;thermogravimetry;thermostability;thixotropy;transmission electron microscopy;ultrasound;ultraviolet irradiation;X ray photoemission spectroscopy
摘要：
A new hybrid hydrogel was constructed byin situforming silver nanoparticles (Ag NPs) within the 3D network of a hydrogel based on a tryptophan derivative containing a phenylcarbinol side group (HAIP), which was triggered by natural light, without the need of UV-irradiation or the addition of capping reagents. Remarkably, in addition to excellent thixotropy and injectability, the hybrid Ag NPs-HAIP hydrogel exhibits broad antibacterial activities without cell cytotoxicity, which makes it a potential candidate for various biomedical applications. © The Royal Society of Chemistry and the Centre National de la Recherche Scientifique 2020.
语种：
英文
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“双万计划”建设背景下精细化工工艺学课程教学改革
作者：
杜可杰;林英武;王宏青;侯三英;贺楚华
期刊：
现代职业教育 ,2020年(18):43-45 ISSN：2096-0603
作者机构：
南华大学化学化工学院,湖南 衡阳421001;[王宏青; 贺楚华; 杜可杰; 林英武; 侯三英] 南华大学
关键词：
精细化工工艺学;化工教学改革;“双万计划”
摘要：
南华大学化学化工学院化学工程与工艺专业列入湖南省一流建设专业,并第二次进行了工程教育认证.在此背景下,为提升其作为核心课程对本专业建设的专业支撑能力,对精细化工工艺学教学思路、教学内容等进行设计改革非常必要.基于本课程特点及本专业建设实际情况,从课堂教学体系、实验设计、教学方法、产学研结合等方面进行系列修订,以期达到一流专业建设要求.
语种：
中文
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Uranyl photocatalysis:precisely controlled oxidation of sulfides with ground-state oxygen
作者：
Wei-Min He* ;Ying-Wu Lin;Dong-Hong Yu
期刊：
中国科学：化学英文版 ,2020年63(3):291-293 ISSN：1674-7291
通讯作者：
Wei-Min He
作者机构：
Department of Chemistry, Hunan University of Science and Engineering, Yongzhou, China;Hunan Provincial Key Laboratory of Materials Protection for Electric Power and Transportation, Changsha University of Science and Technology, Changsha, China;[Ying-Wu Lin] School of Chemistry and Chemical Engineering, University of South China, Hengyang, China;[Dong-Hong Yu] Department of Chemistry and Bioscience, Aalborg University, Aalborg, East, Denmark;[Wei-Min He] Department of Chemistry, Hunan University of Science and Engineering, Yongzhou, China<&wdkj&>Hunan Provincial Key Laboratory of Materials Protection for Electric Power and Transportation, Changsha University of Science and Technology, Changsha, China
通讯机构：
[Wei-Min He] D;Department of Chemistry, Hunan University of Science and Engineering, Yongzhou, China<&wdkj&>Hunan Provincial Key Laboratory of Materials Protection for Electric Power and Transportation, Changsha University of Science and Technology, Changsha, China
关键词：
URANYL;OXIDATION;GROUND-STATE;OXYGEN
摘要：
Sulfur-containing organic compounds such as sulfides,sulfoxides and sulfones, have played significant roles in the fields of organic synthesis, pharmaceuticals, and agrochemicals.The selective oxidation of the parent sulfides has been considered as one of the most straightforward methods for the construction of sulfoxides and sulfones.Therefore, a plethora of oxidative systems have been developed for the selective oxidation of sulfides, in which strong oxidants like organic/inorganic peroxides, hypervalent iodines, highpressure oxygen, were required with/without the catalysis of transition metals.In the point view of green chemistry, the application of atmospheric molecular oxygen as an oxidant for the selective oxidation of sulfides under mild conditions is highly desired.
语种：
英文
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Metal-free synthesis of 1,2,3-benzotriazines
作者：
Chen, Jin-Yang;Lin, Ying-Wu;He, Wei-Min*
期刊：
中国化学快报：英文版 ,2020年31(12):2989-2990 ISSN：1001-8417
通讯作者：
He, Wei-Min
作者机构：
[Chen, Jin-Yang] Yangtze Normal Univ, Coll Chem & Chem Engn, Chongqing 408000, Peoples R China.;[He, Wei-Min] Changsha Univ Sci & Technol, Hunan Prov Key Lab Mat Protect Elect Power & Tran, Changsha 410114, Peoples R China.;[Chen, Jin-Yang] Hunan Univ Sci & Technol, Sch Chem & Chem Engn, Xiangtan 411201, Peoples R China.;[Lin, Ying-Wu] Univ South China, Sch Chem & Chem Engn, Hengyang 421001, Peoples R China.
通讯机构：
[He, Wei-Min] C;Changsha Univ Sci & Technol, Hunan Prov Key Lab Mat Protect Elect Power & Tran, Changsha 410114, Peoples R China.
关键词：
Iodine;Metal-free;Rearrangement reaction;1,2,3-Benzotriazines
摘要：
The recent molecular iodine catalyzed [1,2]-rearrangement of aryl amines and 3-amino-1H-indazolesfor the synthesis of 1,2,3-benzotriazines is highlighted.
语种：
英文
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可见光激发醛还原Minisci反应构筑功能化氮杂环化合物
作者：
彭莎;林英武;何卫民
期刊：
有机化学 ,2020年40(2):541-542 ISSN：0253-2786
通讯作者：
He, W.
作者机构：
[何卫民] Department of Chemistry, Hunan University of Science and Engineering, Yongzhou, Hunan 425100, China;Hunan Provincial Key Laboratory of Materials Protection for Electric Power and Transportation, Changsha University of Science and Technology, Changsha, 410114, China;[林英武] School of Chemistry and Chemical Engineering, University of South China, Hengyang, Hunan 421001, China;[彭莎] Department of Chemistry, Hunan University of Science and Engineering, Yongzhou, Hunan 425100, China, Hunan Provincial Key Laboratory of Materials Protection for Electric Power and Transportation, Changsha University of Science and Technology, Changsha, 410114, China
通讯机构：
[He, W.] D;Department of Chemistry, China
关键词：
氮杂环化合物;合成策略;芳基化;有机光电材料;含氮杂环;强氧化剂;苄基化反应;氧化条件
摘要：
众所周知,氮杂环类化合物是许多药物、天然产物以及有机光电材料的核心骨架,研究氮杂环类化合物的官能团化反应对化工、医药及材料等领域的发展具有重要意义.鉴于其独特的生理活性和功能,开发新型高效的氮杂环合成策略,构建结构多样的含氮杂环一直是合成化学家追求的目标[1].Minisci反应,即含氮杂环的自由基加成反应,于20世纪60年代被发现.约半个世纪以来,该反应得到了广泛的研究,为构建功能化氮杂芳烃提供了一条重要路径.尽管如此,该反应仍然存在一些问题,比如通常要使用过量的强氧化剂来实现自由基的形成.另外,相比被广泛报道的Minisci烷基化、芳基化和酰基化反应,Minisci苄基化反应鲜有报道,这可能是因为在较高温度的强氧化条件下,苄基自由基很容易被氧化而不能参与反应.在已往报道中,醛参与的Minisci反应主要集中在加热条件下过量氧化剂促进的酰基化和脱羰烷基反应.
语种：
中文
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A Catalytic Binding Site Together with a Distal Tyr in Myoglobin Affords Catalytic Efficiencies Similar to Natural Peroxidases
作者：
Zhang, Ping;Yuan, Hong;Xu, Jiakun;Wang, Xiao-Juan;Gao, Shu-Qin;...
期刊：
ACS CATALYSIS ,2020年10(1):891-896 ISSN：2155-5435
通讯作者：
Lin, Ying-Wu
作者机构：
[Lin, Ying-Wu; Wang, Xiao-Juan; Zhang, Ping] Univ South China, Sch Chem & Chem Engn, Hengyang 421001, Peoples R China.;[Yuan, Hong; Tan, Xiangshi] Fudan Univ, Dept Chem, Shanghai 200433, Peoples R China.;[Yuan, Hong; Tan, Xiangshi] Fudan Univ, Inst Biomed Sci, Shanghai 200433, Peoples R China.;[Xu, Jiakun] Chinese Acad Fishery Sci, Yellow Sea Fisheries Res Inst, Key Lab Sustainable Dev Polar Fisheries, Qngdao 266071, Peoples R China.;[Gao, Shu-Qin; Lin, Ying-Wu] Univ South China, Lab Prot Struct & Funct, Hengyang 421001, Peoples R China.
通讯机构：
[Lin, Ying-Wu] U;Univ South China, Sch Chem & Chem Engn, Hengyang 421001, Peoples R China.;Univ South China, Lab Prot Struct & Funct, Hengyang 421001, Peoples R China.
关键词：
protein design;peroxidase;substrate binding site;X-ray crystallography;EPR;molecular docking
摘要：
Functional enzyme design has made tremendous progress, but designer enzymes with activities comparable to those of natural enzymes are still limited. In this study, we rationally engineered a functional peroxidase with a catalytic binding site of guaiacol in a model protein, myoglobin (Mb), by replacing Phe46 with a serine (F46S mutation), together with a distal Tyr in the heme pocket (F43Y mutation). The double mutant F43Y/F46S Mb exhibited an overall catalytic efficiency that exceeds most natural peroxidases and is similar to the most efficient horseradish peroxidase. The catalytic substrate binding site was further confirmed by X-ray crystallography, EPR spectroscopy, and inhibition studies, as well as molecular docking simulations. Remarkably, this study reports an artificial peroxidase with an engineered catalytic binding site whose structure was solved both in the absence and presence of the substrate.
语种：
英文
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