期刊论文

Lin, Ying-Wu

英文

Biomolecules

2218-273X

2020

10

3

457

10.3390/biom10030457

Funding: The work on uranyl–protein interactions and the structure-function of heme proteins from my group was supported by the National Natural Science Foundation of China (21101091, 31370812 and 21977042), Open Project Fund of Key Laboratory of Sustainable Development of Polar Fishery, Ministry of Agriculture and Rural Affairs of PRC (No. 2019OPF01), and the double first class construct program of University of South China.

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The widespread use of uranium for civilian purposes causes a worldwide concern of its threat to human health due to the long-lived radioactivity of uranium and the high toxicity of uranyl ion (UO2 2+). Although uranyl–protein/DNA interactions have been known for decades, fewer advances are made in understanding their structural-functional impacts. Instead of focusing only on the structural information, this article aims to review the recent advances in understanding the binding of uranyl to proteins in either potential, native, or artificial m...