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Rational design of heme enzymes for biodegradation of pollutants toward a green future

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成果类型:
期刊论文
作者:
Lin, Ying-Wu*
通讯作者:
Lin, Ying-Wu
作者机构:
[Lin, Ying-Wu] Univ South China, Sch Chem & Chem Engn, Hengyang 421001, Peoples R China.
[Lin, Ying-Wu] Univ South China, Lab Prot Struct & Funct, Hengyang, Peoples R China.
[Lin, Ying-Wu] Univ South China, Hunan Key Lab Design & Applict Actinide Complexes, Hengyang, Peoples R China.
通讯机构:
[Lin, Ying-Wu] U
Univ South China, Sch Chem & Chem Engn, Hengyang 421001, Peoples R China.
语种:
英文
关键词:
biodegradation;dehaloperoxidase;dye-decolorizing peroxidase;heme enzyme;protein design
期刊:
Biotechnology and Applied Biochemistry
ISSN:
0885-4513
年:
2020
卷:
67
期:
4
页码:
484-494
基金类别:
I thank all coworkers for their studies described in this review. The research on heme protein design from my group was supported by the National Natural Science Foundation of China (21807058, 21701081, 31370812, and 21101091) and the double first-class construct program of University of South China.
机构署名:
本校为第一且通讯机构
院系归属:
化学化工学院
摘要:
Environmental pollutants, such as industrial dyes and halophenols, are harmful to human health, which urgently demand degradation. Bioremediation has been shown to be a cost-effective and ecofriendly approach. As reviewed herein, significant progress has been made in the last decade for biodegradation of both industrial dyes and halophenols, by engineering of native dye-decolorizing peroxidases (DyPs) and dehaloperoxidases (DHPs), and by design of artificial heme enzymes in both native and de novo protein scaffolds. The catalytic efficiency of ...

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