摘要：
The supercritical carbon dioxide (S-CO 2 ) Brayton cycle is an advanced energy conversion system with many advantages including high power conversion efficiency, system compactness and high flexibility. The coupling of Liquid Metal-cooled Reactor (LMR) with the S-CO 2 Brayton cycle represents a promising direction in the development of nuclear energy systems, fully leveraging the strengths of both technologies. However, the coupled system is in the preliminary design stage. This paper carries out an integrated review of research activities about the coupled systems, with a focus on coupled system design, the Liquid Metal (LM)-S-CO 2 coupled heat transfer experiment and numerical simulation, and the LM-S-CO 2 Heat eXchanger Tube Rupture (HXTR) accident. This review summarizes the achievements and shortcomings of the existing studies, which can provide a valuable reference for the future research in this domain.
The supercritical carbon dioxide (S-CO 2 ) Brayton cycle is an advanced energy conversion system with many advantages including high power conversion efficiency, system compactness and high flexibility. The coupling of Liquid Metal-cooled Reactor (LMR) with the S-CO 2 Brayton cycle represents a promising direction in the development of nuclear energy systems, fully leveraging the strengths of both technologies. However, the coupled system is in the preliminary design stage. This paper carries out an integrated review of research activities about the coupled systems, with a focus on coupled system design, the Liquid Metal (LM)-S-CO 2 coupled heat transfer experiment and numerical simulation, and the LM-S-CO 2 Heat eXchanger Tube Rupture (HXTR) accident. This review summarizes the achievements and shortcomings of the existing studies, which can provide a valuable reference for the future research in this domain.
摘要：
The rapid and selective identification of microorganisms is of great significance for clinical therapy applications. To develop high performance probes for microbe determination, we systemically constructed series aggregation-induced emission (AIE) luminogens by modulating the structural planarity, the basicity of functional group, the length of linker moiety and the hydrophobicity based on our previous work. The detail structure-property relationship study based on experimental and theoretical observation revealed that: i) the planar skeleton is essential for probe insertion towards the cell wall via van n der Waals' force. ii) the basic function group enable the anchoring on the membrane by binding with acidic biomolecules. iii) the shortened alkyl chain is in favor of the efficient binding of basic groups with microbes and endows the desirable hydrophobicity. Based on the developed probes, the successful detection of the pathogens in clinic samples was achieved in highly sensitive and simple way. This work provides a reliable strategy for designing intelligent luminogens for microorganism discrimination and identification in efficient and sensitive way for in vitro diagnosis applications, especially point-of-care testing (POCT).
The rapid and selective identification of microorganisms is of great significance for clinical therapy applications. To develop high performance probes for microbe determination, we systemically constructed series aggregation-induced emission (AIE) luminogens by modulating the structural planarity, the basicity of functional group, the length of linker moiety and the hydrophobicity based on our previous work. The detail structure-property relationship study based on experimental and theoretical observation revealed that: i) the planar skeleton is essential for probe insertion towards the cell wall via van n der Waals' force. ii) the basic function group enable the anchoring on the membrane by binding with acidic biomolecules. iii) the shortened alkyl chain is in favor of the efficient binding of basic groups with microbes and endows the desirable hydrophobicity. Based on the developed probes, the successful detection of the pathogens in clinic samples was achieved in highly sensitive and simple way. This work provides a reliable strategy for designing intelligent luminogens for microorganism discrimination and identification in efficient and sensitive way for in vitro diagnosis applications, especially point-of-care testing (POCT).
期刊：
EXPERIMENTAL AND THERAPEUTIC MEDICINE,2025年29(3):56 ISSN：1792-0981
通讯作者：
Tang, J
作者机构：
[Cao, Chuangjie] Univ South China, Affiliated Hosp 1, Hengyang Med Sch, Dept Pathol, Hengyang 421001, Hunan, Peoples R China.;[Xie, Haitao] Univ South China, Affiliated Hosp 1, Inst Microbiol & Infect Dis, Dept Clin Lab Med,Hengyang Med Sch, Hengyang 421001, Hunan, Peoples R China.;[Dou, Chengyun; Tang, Jian; Tang, J; Guo, Ruohan] Univ South China, Affiliated Hosp 1, Hengyang Med Sch, Dept Infect Dis, 69 Chuanshan Rd, Hengyang 421001, Hunan, Peoples R China.
通讯机构：
[Tang, J ] U;Univ South China, Affiliated Hosp 1, Hengyang Med Sch, Dept Infect Dis, 69 Chuanshan Rd, Hengyang 421001, Hunan, Peoples R China.
关键词：
coronavirus disease 2019;distinction;eosinophil;influenza A;neutrophil-to-lymphocyte ratio
摘要：
Coronavirus disease 2019 (COVID-19) and influenza A outbreaks have spread rapidly in China. It is difficult to accurately differentiate these two different respiratory tract infections on the basis of their similar early-stage symptoms and lymphocytopenia. In the present study, the age, sex and white blood cell, neutrophil, lymphocyte, monocyte and eosinophil counts, as well as the neutrophil-to-lymphocyte ratio (NLR) of 201 outpatients with confirmed COVID-19 and 246 outpatients with influenza A were investigated and compared. A receiver operating characteristic curve was drawn to determine the thresholds in distinguishing COVID-19 from influenza A Our study found that the monocyte count and NLR were significantly elevated, while the eosinophil count/percentage was higher in outpatients with COVID-19 than in those with influenza A (0.06±0.07 vs. 0.04±0.09, P=0.002; 0.95±1.12 vs. 0.56±0.95, P<0.001, respectively). Logit(P)=-1.11 + 1.29 x eosinophil percentage -12.07 x eosinophil count +1.10 x monocyte count, deduced from the eosinophil count/percentage and monocyte count, had the largest area under the curve at 0.67, with high specificity (80.1%) and a sensitivity of 47.3%. The present study demonstrated that a higher eosinophil count/percentage may be a potential biomarker to significantly differentiate early COVID-19 from influenza A.
摘要：
Laser cladding rapid solidification technique is an effective strategy for manufacturing ultra-high-strength martensitic stainless steels (UHS-MSS). Due to super-saturation solution strengthening of interstitial atoms (IAs), martensitic stainless steels containing IAs exhibit excellent ultra-high strength and toughness and have high tolerance for oxygen impurities. Hence, studying the specific speciation and structural characteristics of IAs is of great significance for guiding laser cladding of ultra-high-strength steels. Herein, we use density functional theory (DFT) computations to analyze the stable occupancies of IAs and their interactions in body-centered cubic iron (BCC Fe). The findings show that single IAs prefer to occupy octahedral sites over tetrahedral sites. Therefore, octahedral sites are selected as the optimal sites for the following double IAs study. For homo IAs, C-C and N-N configurations exhibit greater stability at long-range distances, whereas O-O demonstrate optimal stability at intermediate distances. Crucially, hetero IAs configurations are more stable compared to single IAs and homo IAs, exhibiting a synergistic effect. Especially, the C-O combination shows the highest stability and strongest bonding character. Meanwhile, the dissociation behavior of O indicates that C-O and N-O have higher dissociation temperatures than single O, further verifying the synergistic effect of hetero IAs. This provides a theoretical basis for understanding the interstitial solution strengthening of laser cladding UHS-MSS.
摘要：
Ruthenium removal from complex solutions (highly saline effluents, seawater) is a critical challenge. Herein, the sorption capacity of chitosan/SiO2 composite beads (Ch-Si) for ruthenium nitrosyl is increased three-fold after phosphoramidate grafting (DPA-Ch-Si, 1.6 mmol Ru g−1) at pH 5. Uptake kinetics and sorption isotherms are compared at pH0: 3, 5 and 10; playing with the mode of agitation (mechanical, MA, vs. ultrasonic treatment, UT). The sorbent maintains good sorption capacities at pH 3 and 10. Uptake kinetics modeled by pseudo-first order rate equation is boosted by functionalization. For Ch-Si, sorption isotherms are modeled by the Langmuir or Sips equations (depending on the pH), while for DPA-Ch-Si the best fits depend on pH, temperature and mode of agitation. Ruthenium sorption is spontaneous and endothermic for the two sorbents. For DPA-Ch-Si, the sorption capacity increases from 1.62 to 1.70 mmol Ru g−1 to 2.23–2.32 mmol Ru g−1 (T increasing from 21 to 50 °C). Nitric acid solution (0.3 M) reveals highly efficient for back extraction; ruthenium is completely released in <15 min. The functionalized sorbent can be reused for a minimum of 10 cycles, with limited loss in performance. Phosphoramidation improves sorption selectivity for the treatment of equimolar multicomponent solutions (Na, Ca, Mg, Fe, Al, U, and Nd). The effect of pH on sorption selectivity is evaluated in simple multi-metal solutions and complex environment. In seawater, the selective recovery of ruthenium is favored at pH close to 10. These tests confirm the promising perspectives offered for ruthenium removal from complex environments. Physicochemical characterizations of the sorbent (and their modes of interaction with ruthenium nitrosyl) included SEM, BET, TGA, FTIR, XPS, and elemental analyses.
Ruthenium removal from complex solutions (highly saline effluents, seawater) is a critical challenge. Herein, the sorption capacity of chitosan/SiO2 composite beads (Ch-Si) for ruthenium nitrosyl is increased three-fold after phosphoramidate grafting (DPA-Ch-Si, 1.6 mmol Ru g−1) at pH 5. Uptake kinetics and sorption isotherms are compared at pH0: 3, 5 and 10; playing with the mode of agitation (mechanical, MA, vs. ultrasonic treatment, UT). The sorbent maintains good sorption capacities at pH 3 and 10. Uptake kinetics modeled by pseudo-first order rate equation is boosted by functionalization. For Ch-Si, sorption isotherms are modeled by the Langmuir or Sips equations (depending on the pH), while for DPA-Ch-Si the best fits depend on pH, temperature and mode of agitation. Ruthenium sorption is spontaneous and endothermic for the two sorbents. For DPA-Ch-Si, the sorption capacity increases from 1.62 to 1.70 mmol Ru g−1 to 2.23–2.32 mmol Ru g−1 (T increasing from 21 to 50 °C). Nitric acid solution (0.3 M) reveals highly efficient for back extraction; ruthenium is completely released in <15 min. The functionalized sorbent can be reused for a minimum of 10 cycles, with limited loss in performance. Phosphoramidation improves sorption selectivity for the treatment of equimolar multicomponent solutions (Na, Ca, Mg, Fe, Al, U, and Nd). The effect of pH on sorption selectivity is evaluated in simple multi-metal solutions and complex environment. In seawater, the selective recovery of ruthenium is favored at pH close to 10. These tests confirm the promising perspectives offered for ruthenium removal from complex environments. Physicochemical characterizations of the sorbent (and their modes of interaction with ruthenium nitrosyl) included SEM, BET, TGA, FTIR, XPS, and elemental analyses.
作者机构：
[Pei, Yanfang; Zhou, Wei; Cao, Yan; Han, Xiaotong; Liu, Xin; Yan, Xiquan; Hu, Conglong] Hunan Normal Univ, Hunan Prov Peoples Hosp, Affiliated Hosp 1, Dept Emergency Med, Changsha, Peoples R China.;[Cao, Yan] Hunan Normal Univ, Hunan Prov Peoples Hosp, Affiliated Hosp 1, Sepsis Res Ctr Hunan Prov Geriatr Inst, Changsha, Peoples R China.;[Hu, Bangqi] Hunan Normal Univ, Affiliated Hosp 1, Dept Emergency Med, Changsha, Peoples R China.;[Liu, Zhengyu] Hunan Normal Univ, Hunan Prov Peoples Hosp, Affiliated Hosp 1, Dept Cardiol, Changsha, Peoples R China.;[Liu, Zhengyu] Hunan Normal Univ, Affiliated Hosp 1, Clin Med Res Ctr Heart Failure Hunan Prov, Hunan Prov Peoples Hosp, Changsha, Peoples R China.
通讯机构：
[Ding, N ; He, LD] U;Univ South China, Affiliated Changsha Cent Hosp, Hengyang Med Sch, Dept Emergency Med, 161 Shaoshan South Rd, Changsha 410004, Hunan, Peoples R China.
关键词：
E. coli sepsis;Serum magnesium;Mortality;MIMIC-IV database
摘要：
OBJECTIVE: Escherichia coli (E.coli) is the leading pathogen for deaths associated with antimicrobial resistance, making it the most problematic bacteria for human infections. This study aimed to investigate the association between serum magnesium levels and clinical outcomes in patients with E.coli sepsis. METHOD: Data of E.coli septic patients were collected from the MIMIC-IV database. Patients were divided into three groups based on tertiles of serum magnesium levels. Three models were utilized, including the raw model (unadjusted), Model I (adjusted for age and gender), and Model II (adjusted for all potential confounding factors). Linear model and two-segment nonlinear model were established to examine the relationship between serum magnesium and 30-day, 60-day, and 90-day mortality rates. Kaplan-Meier survival curve analysis was performed to assess cumulative hazard of mortalities at 30-day, 60-day, 90-day based on tertiles of serum magnesium levels. RESULTS: A total of 421 E.coli septic patients were included and classified into tertiles: Q1(< 1.6mg/dL), Q2 (1.6-1.9mg/dL), Q3(> 1.9mg/dL). In the Model adjusting for all potential confounders, for every 1mg/dL increase in serum magnesium, there was a significant increase in 30-day, 60-day, and 90-day mortality rates, with odds ratios of 4.01 (95% CI 1.22-13.19, P = 0.022), 4.81 (95% CI 1.59-14.53, P = 0.005), and 4.45 (95% CI 1.52-12.96, P = 0.006) respectively. And linear model is more suitable for describing the relationship between serum magnesium levels and clinical outcomes. Kaplan-Meier analysis revealed that the cumulative hazard of mortalities at 30-day, 60-day, 90-day increased with the prolongation of hospital stay, particularly in the group with the highest serum magnesium level. CONCLUSION: Increased level of serum magnesium is significantly associated with increased risk of 30-day, 60-day and 90-day mortality in a population of septic patients with E.coli infection.
摘要：
Brain tumor segmentation is crucial for diagnosing tumors and assessing clinical conditions. Diffusion models have become highly popular in medical image segmentation. However, current diffusion-based methods seldom fuse multi-modality images from a multi-scale perspective. Furthermore, removing the effect of noise in brain tumor images remains a significant challenge for brain tumor segmentation. In this paper, we propose a multi-scale diffusion model with an attention mechanism for brain tumor segmentation to address these challenges. Our method reduces the effects of noise and irrelevant background data in brain tumor images to enhance the capture of subtle differences and features across various tumor regions, improving segmentation performance. We incorporate an axial attention mechanism module (AAMM) into the denoising encoder to establish global long-range dependency, overcoming the limitations of convolutions and improving model’s interpretability. To use texture and contextual information from multi-scale features, we propose a multi-scale feature fusion module (MSFFM) in the decoder to adaptively fuse features from various scales and enhance the feature extraction ability of the model. We evaluate the proposed method on two public brain tumor segmentation datasets. The experimental results demonstrate that our method outperformed state-of-the-art brain tumor segmentation methods due to the effective denoising capability of the diffusion model.
Brain tumor segmentation is crucial for diagnosing tumors and assessing clinical conditions. Diffusion models have become highly popular in medical image segmentation. However, current diffusion-based methods seldom fuse multi-modality images from a multi-scale perspective. Furthermore, removing the effect of noise in brain tumor images remains a significant challenge for brain tumor segmentation. In this paper, we propose a multi-scale diffusion model with an attention mechanism for brain tumor segmentation to address these challenges. Our method reduces the effects of noise and irrelevant background data in brain tumor images to enhance the capture of subtle differences and features across various tumor regions, improving segmentation performance. We incorporate an axial attention mechanism module (AAMM) into the denoising encoder to establish global long-range dependency, overcoming the limitations of convolutions and improving model’s interpretability. To use texture and contextual information from multi-scale features, we propose a multi-scale feature fusion module (MSFFM) in the decoder to adaptively fuse features from various scales and enhance the feature extraction ability of the model. We evaluate the proposed method on two public brain tumor segmentation datasets. The experimental results demonstrate that our method outperformed state-of-the-art brain tumor segmentation methods due to the effective denoising capability of the diffusion model.
作者机构：
[Wei, Wenxuan; Kang, Xiaomei; Liu, Yujia; Guo, Qian; He, Qun; Bu, Weifeng; Bu, WF; Liu, Yilin] Lanzhou Univ, Key Lab Nonferrous Met Chem & Resources Utilizat G, State Key Lab Appl Organ Chem, Lanzhou 730000, Peoples R China.;[Wei, Wenxuan; Kang, Xiaomei; Liu, Yujia; Guo, Qian; He, Qun; Bu, Weifeng; Bu, WF; Liu, Yilin] Lanzhou Univ, Coll Chem & Chem Engn, Lanzhou 730000, Peoples R China.;[Wei, Wenxuan; Zhou, Jin Yuan] Lanzhou Univ, Sch Phys Sci & Technol, Lanzhou 730000, Peoples R China.;[Zhu, Shoujun; Du, Yijing; Zhu, SJ] First Hosp Jilin Univ, Joint Lab Optofunct Theranost Med & Chem, Changchun 130021, Peoples R China.;[Zhu, Shoujun; Du, Yijing; Zhu, SJ] Jilin Univ, Coll Chem, Ctr Supramol Chem Biol, State Key Lab Supramol Struct & Mat, Changchun 130012, Peoples R China.
通讯机构：
[Bu, WF ] L;[Zhu, SJ ] F;[Wang, J ] U;Lanzhou Univ, Key Lab Nonferrous Met Chem & Resources Utilizat G, State Key Lab Appl Organ Chem, Lanzhou 730000, Peoples R China.;Lanzhou Univ, Coll Chem & Chem Engn, Lanzhou 730000, Peoples R China.
关键词：
rhodium(I)-based nanoMOFs;NIR-II luminescence;Rh(I)Rh(I) interaction;vascular and tumorimaging
摘要：
Although luminescent metal-organic frameworks (MOFs) have been widely reported, rare examples were found to emit in the second near-infrared (NIR-II, 1000-1700 nm) window. In this work, two nanoscale rhodium(I)-based MOFs (Rh-1@SDS and Rh-1@DSPE-PEG) have been controllably constructed in the aqueous dispersions of sodium dodecyl sulfate (SDS) and 1,2-distearoyl-sn-glycero-3-phosphoethanolamine-N-methoxy-poly(ethylene glycol) (DSPE-PEG), wherein micelle- and vesicle-like aggregates form, respectively, with high colloidal stability. The vesicular dispersion of Rh-1@DSPE-PEG exhibits intense NIR-II luminescence at 1125 (1245, shoulder) nm. Consequently, this nanoMOF was used as an NIR-II luminescence probe, indicative of high-resolution systemic and local vascular imaging, where the postoperative recovery process of flap transplantation was clearly visualized. Meanwhile, it also demonstrates superior tumor targeting in the NIR-II window. To the best of our knowledge, this research represents the first example of nanoMOFs having intense NIR-II luminescence and excellent imaging capabilities.
摘要：
A multifunctional electrochemiluminescence (ECL) coreaction accelerator, AuAgPt nanoframes (NFs), is described for use in an ECL aptasensor for highly sensitive aflatoxin B1 (AFB1) detection. As a signal quencher, the broad UV-vis absorption spectrum of AuAgPt nanosheets (NSs) overlaps the ECL emission spectrum of g-C(3)N(4)@Au, triggering an ECL resonance energy transfer (ECL-RET). By the adjustment of the dosage of hydrogen peroxide (H(2)O(2)), the AuAgPt NSs are transformed into AuAgPt NFs because H(2)O(2) etches Ag in AuAgPt NSs into Ag(+), which disrupts the RET process. The as-formed AuAgPt NFs act as a coreaction accelerator to enhance the ECL response of the g-C(3)N(4)@Au/K(2)S(2)O(8) system. Without AFB1, the Ag-dependent DNAzyme is inactive, and a strong ECL signal is observed. After AFB1 is added, the AFB1 aptamer targets AFB1 and the DNAzyme active site is exposed. As-generated Ag(+) further activates DNAzyme to cut the substrate strand (S-DNA), which causes AuAgPt NFs to detach from the electrode surface and the ECL signal to significantly decrease. Under optimal conditions, the proposed ECL aptasensor exhibits high sensitivity with a limit of detection (LOD) of 0.11 fg/mL in the range of 1 fg/mL to 1 μg/mL for AFB1 detection.
作者：
Ablikim, M.;Achasov, M. N.;Adlarson, P.;Afedulidis, O.;Ai, X. C.;...
期刊：
Journal of High Energy Physics,2025年2025(2):1-24 ISSN：1029-8479
通讯作者：
Ablikim, M
作者机构：
[Yu, B. X.; Yu, G.; Hu, T.; Ning, Z.; Zhang, P.; Wen, S. P.; Shi, X.; Sun, G. X.; Ma, M. M.; Chen, T.; Hou, X. T.; Zhu, Z. A.; Xu, G. F.; Wang, K.; Zhou, L. P.; Heng, Y. K.; Ji, Q.; Zhang, J. W.; Chen, Z. Y.; Rong, G.; Guan, C. Y.; Qi, F. Z.; Wang, Y. F.; Wang, L. L.; Ouyang, Q.; Jiang, D.; Liao, Y. P.; Zhang, A. Q.; Ji, X. B.; Qian, S.; Dong, M. Y.; Fang, S. S.; Chang, J. F.; Liu, Z. A.; Yang, T.; Yan, X. Q.; Sun, Z. Q.; Han, T. T.; Wu, J. F.; Sun, S. S.; Ding, B.; Fu, C. D.; Zhang, Y.; Lou, X. C.; Lin, T.; Zhang, B. X.; Xing, T. Y.; Cao, G. F.; Ji, W.; Wu, L. H.; Zhao, Y. B.; Fu, Y. W.; Zheng, J. P.; Jiang, X. S.; Kiuchi, R.; Fang, Y. Q.; Gu, M. H.; Lu, Y. P.; Dong, L. Y.; Zhang, H. Q.; Zhao, G.; Wu, L. J.; Li, L. J.; Yuan, Y.; Lu, X. L.; Wu, Z.; Fang, Y.; Luo, X. L.; Ji, X. L.; Zhang, X. M.; Li, X. Y.; Li, L. K.; Li, H. B.; Liu, F.; Liang, H.; Huang, Y. P.; Zhang, J. Y.; Zhao, L.; Yin, J. H.; Yang, Y. F.; Batozskaya, V.; Song, W. M.; Chen, X. T.; Zhang, J. Z.; He, K. L.; Chen, G.; Ablikim, M.; Liu, C. X.; Li, X.; Zhu, K.; Liu, H. H.; Zhao, J. Z.; Mao, Z. P.; Xiao, S. Y.; Lu, J. G.; Liu, P. L.; Jing, M. Q.; Sun, H. K.; Chen, Y. B.; Du, M. C.; Wang, Z.; Ablikim, M; Zhao, J. Y.; Dong, J.; Shi, J. Y.; Yuan, C. Z.; Tang, G. Y.; Yuan, S. C.; Zhang, H. Y.; Chen, M. L.; Zhang, Z. H.; Hou, G. Y.; Shen, H. F.; Shao, L. G.; Hou, Z. L.; Sun, Y. Z.; Liu, B. J.; Xiang, B. H.; Zhu, K. J.; Liu, H. M.; Xu, C. F.; Ma, H. L.; Ye, M.; Xie, Y. G.; Chen, H. S.; Cao, N.; Ma, X. T.; Deng, Z. Y.; Ma, Q. M.; Wang, Z. Y.; Cai, X.; Zhang, Y. H.; Ma, R. Q.; Zheng, W. J.; Zou, J. H.; Liu, J. Y.; Wang, X. N.; Kui, X.; Li, W. G.; Wang, Y. Q.; Mo, X. H.; Fang, J.; Li, Q. M.; Shen, X. Y.; Ma, X. Y.; Hu, H. M.; Li, K.; Gong, W. X.; Xu, W.; Hu, Y.; Wang, B.; Zhang, B. L.; Ma, J. L.; Yang, Y. X.; Miao, H.; Zhang, S. H.; Li, F.; Lu, Z. H.; Yang, H. X.; Qin, Z. H.; Li, G.; Ping, R. G.; Qiu, J. F.; Zhang, Z. D.; Zhang, H. C.; Dai, H. L.; Li, W. D.; Fang, W. X.; Zeng, Y. J.] Inst High Energy Phys, Beijing 100049, Peoples R China.;[Xu, H. Y.; Yuan, L.] Beihang Univ, Beijing 100191, Peoples R China.;[Afedulidis, O.; Fritsch, M.; Heinsius, F. H.; Kuessner, M.; Hanisch, F.; Pelizaeus, M.; Kopf, B.; Wollenberg, L.; Holtmann, T.; de Boer, R. E.; Feldbauer, F.; Wiedner, U.; Hoelzken, F.] Bochum Ruhr Univ, D-44780 Bochum, Germany.;[Achasov, M. N.; Nikolaev, I. B.; Muchnoi, N. Yu.] Budker Inst Nucl Phys SB RAS BINP, Novosibirsk 630090, Russia.;[Briere, R. A.] Carnegie Mellon Univ, Pittsburgh, PA 15213 USA.
通讯机构：
[Ablikim, M ] I;Inst High Energy Phys, Beijing 100049, Peoples R China.
关键词：
e(+)-e(-) Experiments;Branching fraction;Particle and Resonance Production;QCD
摘要：
Based on a sample of (2712.4 ± 14.3) × 106 ψ(3686) events collected with the BESIII detector, a partial wave analysis of the decay
$$ \psi (3686)\to \Lambda {\overline{\Sigma}}^0{\pi}^0 $$
+ c.c. is performed to investigate Λ* and Σ* resonances in the
$$ {\pi}^0{\overline{\Sigma}}^0 $$
and π0Λ invariant mass distributions. Significant contributions are found from the Λ(1405), Λ(1520), Λ(1600), Λ(1670), Λ(1690), Λ(1800), Λ(1890), Λ(2325), Σ(1385), Σ(1660), Σ(1670), Σ(1750), and Σ(1910). The masses, widths, and production branching fractions for each component are determined. In addition, the branching fraction of
$$ \psi (3686)\to \Lambda {\overline{\Sigma}}^0{\pi}^0 $$
+ c.c. is measured to be (1.544 ± 0.013 ± 0.071) × 10−4 for the first time, where the first uncertainty is statistical and the second systematic.
摘要：
BACKGROUND: Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease that impairs both upper and lower motor neurons. Mutations in the neurofilament heavy (NEFH) gene are associated with a higher risk for ALS. This study aimed to evaluate the brain metabolism in patients with ALS and NEFH gene mutations (NEFH-ALS) and assess its correlation with emotional and cognitive changes. METHODS: This prospective study enrolled 119 patients with ALS and 128 age- and gender-matched health controls. Study assessments included demographic data collection, questionnaires for motor function, cognition, and depression, and brain F-18 FDG PET/CT (18F-fluorodeoxyglucose positron emission tomography (PET)/computed tomography (CT)) scan. Correlation between brain metabolism and clinical questionnaire scores was performed. Chain-mediation model analysis for the NEFH-ALS group was conducted. Cox regression and Kaplan-Meier survival analysis were also performed. RESULTS: There were 26 NEFH-ALS patients. Patients with NEFH-ALS showed brain glucose hypometabolism in the cortex-striatum/limbic system-brainstem circuit when compared with healthy controls (p < 0.05). Decreased brain glucose metabolism was correlated with impairments of motor function (r = 0.477, p = 0.014, FDR corrected p = 0.014), cognitive scores (r = 0.549, p = 0.004, FDR corrected p = 0.009), and depression (r = -0.523, p = 0.009, FDR corrected p = 0.009). This study showed that brain glucose hypometabolism could lead to impairment of motor function, which was mediated by cognition and depression. Survival analysis showed that brain glucose metabolism was an independent prognostic factor for patients with ALS. CONCLUSIONS: Reduced brain glucose metabolism in the cortex-striatum/limbic system-brainstem circuit may potentially serve as an independent prognostic factor for patients with ALS and NEFH mutation.
摘要：
Endothelial cells (ECs) are interior surface cells covering blood vessels, which play a crucial role in maintaining vascular homeostasis. In vascular pharmacology and toxicology, ECs directly contact drugs or toxicants entering circulation. Therefore, the bio-effects of pharmacological/toxicological substances on ECs have gained extensive research interest, which needs to be evaluated by reliable models. Human umbilical vein endothelial cells (HUVECs) have been served as versatile platforms to mimic diverse pathophysiological processes in vitro, stemming from their unique fetal arterial-like exposure microenvironment, expression of key EC markers, and comparable EC responses to various pathophysiological stimuli. This review provides an overview of the application of HUVECs in pharmacology and toxicology, with a focus on their utility and limitations. HUVECs have been widely used to model the effects of pharmacological or toxicological substances on material exchange, barrier functions, cell death, endothelial nitric oxide synthase (eNOS) uncoupling, and EC dysfunction, angiogenesis, and thrombosis. However, their applicability is constrained primarily due to vascular-type and organ-specific heterogeneity. The review highlights key mechanisms investigated using HUVECs, including oxidative stress, inflammation, organelle damage, and autophagy, metabolic reprogramming (endometabolism), and epigenetic regulation. Strategies to overcome HUVECs' limitations, such as microfluidic techniques, co-culture, and organoid models, are discussed. Finally, future directions are outlined, emphasizing the integration of HUVECs into multi-scale models, dynamic microenvironment simulations, artificial intelligence (AI)-assisted big data analysis, and patient-derived ECs for precision toxicology and personalized medicine. This review aims to guide researchers in optimizing the use of HUVECs in pharmacological and toxicological studies.
This review summarizes the pathophysiological roles of ECs, the applicable and non-applicable scopes of HUVECs in modeling ECs, and the uses of HUVECs in studying the pharmacological or toxicological effects and mechanisms. This review also discusses the strategies to overcome HUVECs' limitations and outlines future directions.
作者机构：
[Zhu, Lin; Luo, Jiekun; Yang, Xueping; Yu, Zhe; Zhang, Xindi; Jiang, Haoying; Wang, Yang; Yang, Xiya; Yang, Bo; Guo, Xin; Li, Teng] Cent South Univ, Xiangya Hosp, Inst Integrat Med, Dept Integrated Tradit Chinese & Western Med, Changsha 410008, Peoples R China.;[Zheng, Zhi] Cent South Univ, Xiangya Hosp, Jiangxi Natl Reg Ctr Neurol Dis, Dept Neurol, Nanchang 330038, Peoples R China.;[Zheng, Zhi] Jiangxi Prov Peoples Hosp, Nanchang Med Coll, Affiliated Hosp 1, Nanchang 330038, Peoples R China.;[Guo, Xin] Univ South China, Affiliated Hosp 1, Childrens Med Ctr, Hengyang Med Sch, Hengyang 421001, Hunan, Peoples R China.;[Hu, En; Tang, Tao; Hu, E] Cent South Univ, Xiangya Hosp, Inst Integrat Med, Natl Reg Ctr Neurol Dis,Dept Integrated Tradit Chi, Nanchang 330038, Peoples R China.
通讯机构：
[Tang, T; Hu, E ] C;Cent South Univ, Xiangya Hosp, Inst Integrat Med, Natl Reg Ctr Neurol Dis,Dept Integrated Tradit Chi, Nanchang 330038, Peoples R China.
关键词：
Traditional Chinese medicine;Prescription formulation;Gradient weighting strategy;Multiple targets;Intracerebral hemorrhage
摘要：
Traditional Chinese medicine (TCM) exerts integrative effects on complex diseases owing the characteristics of multiple components with multiple targets. However, the syndrome-based system of diagnosis and treatment in TCM can easily lead to bias because of varying medication preferences among physicians, which has been a major challenge in the global acceptance and application of TCM. Therefore, a standardized TCM prescription system needs to be explored to promote its clinical application. In this study, we first developed a gradient weighted disease-target-herbal ingredient-herb network to aid TCM formulation. We tested its efficacy against intracerebral hemorrhage (ICH). First, the top 100 ICH targets in the GeneCards database were screened according to their relevance scores. Then, SymMap and Traditional Chinese Medicine Systems Pharmacology (TCMSP) databases were applied to find out the target-related ingredients and ingredient-containing herbs, respectively. The relevance of the resulting ingredients and herbs to ICH was determined by adding the relevance scores of the corresponding targets. The top five ICH therapeutic herbs were combined to form a tailored TCM prescriptions. The absorbed components in the serum were detected. In a mouse model of ICH, the new prescription exerted multifaceted effects, including improved neurological function, as well as attenuated neuronal damage, cell apoptosis, vascular leakage, and neuroinflammation. These effects matched well with the core pathological changes in ICH. The multi-targets-directed gradient-weighting strategy presents a promising avenue for tailoring precise, multipronged, unbiased, and standardized TCM prescriptions for complex diseases. This study provides a paradigm for advanced achievements-driven modern innovation in TCM concepts.
Traditional Chinese medicine (TCM) exerts integrative effects on complex diseases owing the characteristics of multiple components with multiple targets. However, the syndrome-based system of diagnosis and treatment in TCM can easily lead to bias because of varying medication preferences among physicians, which has been a major challenge in the global acceptance and application of TCM. Therefore, a standardized TCM prescription system needs to be explored to promote its clinical application. In this study, we first developed a gradient weighted disease-target-herbal ingredient-herb network to aid TCM formulation. We tested its efficacy against intracerebral hemorrhage (ICH). First, the top 100 ICH targets in the GeneCards database were screened according to their relevance scores. Then, SymMap and Traditional Chinese Medicine Systems Pharmacology (TCMSP) databases were applied to find out the target-related ingredients and ingredient-containing herbs, respectively. The relevance of the resulting ingredients and herbs to ICH was determined by adding the relevance scores of the corresponding targets. The top five ICH therapeutic herbs were combined to form a tailored TCM prescriptions. The absorbed components in the serum were detected. In a mouse model of ICH, the new prescription exerted multifaceted effects, including improved neurological function, as well as attenuated neuronal damage, cell apoptosis, vascular leakage, and neuroinflammation. These effects matched well with the core pathological changes in ICH. The multi-targets-directed gradient-weighting strategy presents a promising avenue for tailoring precise, multipronged, unbiased, and standardized TCM prescriptions for complex diseases. This study provides a paradigm for advanced achievements-driven modern innovation in TCM concepts.
摘要：
Microcystin-LR (MC-LR) is a toxin that causes hepatic steatosis. Our previous study found that exposure to 60 μg/L MC-LR for 9 months resulted in liver lipid accumulation, but the underlying mechanisms remain elusive. Herein, for the first time, fatty acid-targeted metabolome and RNA-seq were combined to probe the effect and mechanism of chronic (12-month) MC-LR treatment on mice lipid metabolism at environmental-related levels (1, 60, and 120 μg/L). It was found that MC-LR dose-dependently raised serum and liver lipid levels. The total cholesterol (TC) levels in the liver were significantly increased following treatment with 1 μg/L MC-LR (equivalent to 0.004 μ/L in human). Treatment with 60 and 120 μg/L MC-LR significantly elevated TC and triglyceride (TG) levels in both serum and liver. Serum fatty acid-targeted metabolome analysis demonstrated that exposure to 1, 60, and 120 μg/L MC-LR caused significant alterations in the fatty acid profile. Chronic 1, 60, and 120 μg/L MC-LR treatment significantly increased serum polyunsaturated fatty acids (PUFAs), including conjugated linoleic acid and eicosapentaenoic acid, which positively correlated with serum or liver TG levels. Chronic exposure to 120 μg/L MC-LR led to a significant decrease in the accumulation of saturated fatty acids, including citramalic acid, pentadecanoic acid, and docosanoic acid, which were negatively correlated with serum or liver lipid levels. These findings suggested that 1 μg/L MC-LR exposure caused mild lipid metabolism disruption, while 60 and 120 μg/L MC-LR treatment resulted in pronounced hepatic steatosis in mice. Transcriptome analysis revealed that chronic environmental MC-LR treatment regulated the expression of genes involved in the phosphatidylinositol 3-kinase (PI3K) complex and fatty acid metabolism. Western blotting and RT-qPCR confirmed that chronic environmental MC-LR exposure activated the PI3K/AKT/mTOR signaling pathway, the downstream of fads3 gene that participates in fatty acid desaturation was upregulated, fatty acid degradation-related genes, including acsl1, acsl4, and ehhadh were inhibited, and lipid transport-related genes, including slc27a4 and apol7a, were promoted. Thus, chronic environmental MC-LR exposure boosts hepatic steatosis. Our work indicated that the limit concentration of 1 μg/L MC-LR in human drinking water for safety needs to be discussed. The study provides the first evidence of the fatty acid profile and gene changes and gains new insights into the mechanisms of chronic environmental MC-LR treatment-induced hepatic steatosis.
通讯机构：
[Liu, HB ] H;Hengyang Normal Univ, Sch Phys & Elect Engn, Hengyang 421008, Peoples R China.
摘要：
A numerical study of helicon wave heating and current driving for the HL-2M steady-state scenario has been performed. Numerical calculations based on fast wave theory show that the high frequency plays a significant role, which results in a predominance of electron absorption and negligible ion absorption. The calculations also show that the desired strong absorption region can be achieved when the frequency is greater than 420 MHz and the electron beta is higher than 1.8%. The helicon wave propagation and current drive have been simulated using GENRAY, CQL3D, and AORSA codes. Modeling analysis indicates that both the amplitude and location of the current drive simulated by these codes are in good agreement. These models also demonstrate that a remarkable off-axis current drive with a good efficiency can be obtained. Extensive scanning calculations of the wave frequency, the parallel refractive index (n & Vert;), and the poloidal location of the antenna have been conducted using GENRAY. Detailed analysis of the scanned data found that the current profile can be flexibly controlled by changing the wave frequency and the poloidal location. A smaller launched n(& Vert;) causes a part of the current to be on-axis and an increase in the total current. The helicon wave launched at or over the midplane with f = 500 MHz and n(& Vert;) = 3.8 may be a feasible scheme for HL-2M tokamaks. (c) 2025 Author(s). All article content, except where otherwise noted, is licensed under a Creative Commons Attribution (CC BY) license(https://creativecommons.org/licenses/by/4.0/).https://doi.org/10.1063/5.0275569
摘要：
Hepatocellular carcinoma (HCC) recurrence after liver transplantation (LT) is a major contributor to mortality. We developed a recurrence prediction system for HCC patients before and after LT. Data from patients with HCC who underwent LT were retrospectively collected from three specialist centres in China. Pre- and post-operative variables were selected using support vector machine, random forest, and logistic regression (LR). Then, pre- and post-operative models were developed using three machine learning methods: LR, stacking, and two survival-based approaches. Models were evaluated using seven assessment indices, and patients were classified as either high- or low-risk based on recurrence risk. 466 patients were included and followed for a median of 51.0 months (95% CI 47.8-54.2). The pre-DeepSurv model (pre-DSM) had a C-index of 0.790 ± 0.003 during training, 0.775 ± 0.037 during testing, and 0.765 ± 0.001 and 0.819 ± 0.002 during external validation. After incorporating clinicopathologic variables, the post-DeepSurv model (post-DSM) had a 0.835 ± 0.008C-index during training, 0.812 ± 0.082 during testing, and 0.839 ± 0.001 and 0.831 ± 0.002 during external validation. The post-DSM outperformed the Milan criteria by more accurately identifying patients at high risk of recurrence. Tumour recurrence predictions also improved significantly with DeepSurv. Both pre- and post-DSMs have the potential to guide personalised surveillance strategies for LT patients with HCC.
期刊：
BRITISH JOURNAL OF PHARMACOLOGY,2025年 ISSN：0007-1188
通讯作者：
Qiao, Xin;Li, YF
作者机构：
[Ma, Hui; Qiao, Xin; Yang, Yi-Xin; Li, Yun-Feng; Long, Qian] Beijing Inst Basic Med Sci, Beijing 100850, Peoples R China.;[Chen, Yue] Univ South China, Grad Collaborat Training Base Acad Mil Med Sci, Hengyang Med Sch, Hengyang, Peoples R China.;[Zhang, Yi-Mo] Chinese Peoples Liberat Army Gen Hosp, Med Ctr 1, Dept Neurol, Beijing, Peoples R China.;[Zhang, Yue] Capital Med Univ, Beijing Tongren Hosp, Dept Anesthesiol, Beijing, Peoples R China.;[Hou, Xiao-Juan] Hebei North Univ, Dept Postgrad, Zhangjiakou, Peoples R China.
通讯机构：
[Li, YF ; Qiao, X] B;Beijing Inst Basic Med Sci, Beijing 100850, Peoples R China.
摘要：
BACKGROUND AND PURPOSE: Ischaemic stroke is one of the most critical causes of death and disability worldwide, but its pharmacotherapies are currently lacking. This study aimed to investigate the effects of the sigma non-opioid intracellular receptor 1 agonist hypidone hydrochloride (YL-0919) on ischaemic stroke as well as the underlying mechanisms. EXPERIMENTAL APPROACH: Male mice were subjected to a middle cerebral artery occlusion (MCAO)/reperfusion (R) model to mimic ischaemic stroke injury. Neurological and cognitive functions were evaluated, and neuroinflammatory pathways in the medial prefrontal cortex and hippocampus were detected. KEY RESULTS: Mice subjected to MCAO exhibited obvious neurological and motor deficits, increased infarct volume and neuronal death in the acute phase, and severe cognitive impairment in the chronic phase. Administration of YL-0919 for seven consecutive days beginning within 7 h after MCAO significantly ameliorated the pathological changes described above. Further studies demonstrated that YL-0919 exerted its effect by suppressing absent in melanoma 2 (AIM2)-related inflammatory signals in MCAO mice and alleviated the neuronal deficits in the medial prefrontal cortex and hippocampus, thereby ameliorating chronic post-stroke cognitive impairment. This effect was eliminated by AIM2 overexpression in the medial prefrontal cortex and hippocampus. CONCLUSIONS AND IMPLICATIONS: This study highlights the extended therapeutic window for sigma non-opioid intracellular receptor 1 agonist administration during the acute phase of ischaemic stroke and further demonstrates that targeted inhibition of AIM2-mediated neuroinflammatory pathways may promote sustained cognitive rehabilitation in post-stroke survivors.
摘要：
Avatar is one of the most intuitive central components in Metaverse and faces serious security problems, particularly during the interaction with each other. In this article, we consider the problem of timely detecting the stealthy anomaly in the avatar interaction, which is crucial for security and privacy in Metaverse. With this goal, a new tensor summary statistic is proposed first to well depict the statistical discrepancy between normal and anomalous interaction volume samples, even when anomalies are stealthy. The proposed tensor summary statistic is established from the tensor linear representation residual, which naturally implies the statistical probability that an interaction volume sample lies within or deviates from the tensor lateral space. Moreover, a convex optimization programme is introduced to robustly recover the tensor lateral space in the presence of anomalous samples, thereby enhancing the robustness of our tensor summary statistic. On the basis of the tensor summary statistic, a non-parametric statistic framework is developed for the real-time detection of the stealthy interaction volume anomaly. We also provide theoretical analysis concerning its detection performance and parameter selection. Extensive experiments using synthetic and real-world datasets verify our effectiveness and superiority. Compared with benchmark methods, the proposed detection scheme achieves significantly lower detection delay and higher false alarm period, particularly in the detection of stealthy anomalies with a low change rate.
摘要：
Gastric cancer (GC) is one of the most crucial malignancies worldwide because of the high lethality. This study aims to explore the mechanism by which ubiquitin-specific protease 17 (USP17) mediates autophagic ferroptosis in GC. In the present study, we cultured human GC cell line AGS in vitro and knocked BNIP3 or NCOA4 down using specific small interfering-RNA. Erastin was chosen as a ferroptosis inducer while Ferrostatin-1 was utilized as an inhibitor of ferroptosis. Then, the levels of mitophagy-related proteins, USP17, BNIP3, mitochondrial marker proteins, NCOA4, and FTH1 were quantified through RT-qPCR and Western blot tests. Also, the JC-1 method was adopted to detect mitochondrial membrane potential. Additionally, CCK-8 cell viability test was performed. Ultimately, glutathione, reactive oxygen species, malondialdehyde, and active Fe2+ were determined as indicators related to ferroptosis using corresponding kits. The interaction between USP17 and BNIP3 was assessed through co-immunoprecipitation. Genetic inhibition of BNIP3 reduced mitophagy and increased ferroptosis in GC cells. Subsequently, upon BNIP3 silencing, we found up-regulated NCOA4 and down-regulated FTH1, with autophagy inhibition resulting in the similar changes in the NCOA4-FTH1 pathway and cellular Fe2+ levels. NCOA4 inhibition partly counteracted BNIP3 deficiency-induced ferroptosis, indicating that BNIP3-dependent autophagic ferroptosis was associated with the NCOA4-FTH1 pathway. Furthermore, it was found that USP17 stabilized BNIP3 by reducing its ubiquitination level, which was linked to the regulatory role of USP17 in ferroptosis. USP17 knockdown modulates autophagic ferroptosis in GC by affecting the stability of BNIP3 and mediating the NCOA4-FTH1 pathway.
摘要：
The rapid expansion of nuclear energy has led to increased uranium contamination in wastewater, necessitating the development of efficient, cost-effective, and recyclable materials for uranium removal. Hydroxyapatite (HAP) has emerged as a promising candidate due to its exceptional surface properties, structural tunability, and environmental compatibility. This review systematically evaluates recent progress in HAP-based materials for uranium remediation, focusing on advanced synthesis techniques and modification strategies that enhance adsorption capacity and ion selectivity. We analyze the underlying mechanisms, particularly the roles of material morphology and solution pH in optimizing uranium removal efficiency. Current limitations in practical applications are critically discussed, along with future research priorities for developing next-generation HAP composites. By establishing structure-performance relationships and addressing current challenges, this review provides fundamental insights to guide the design of high-performance radioactive wastewater treatment materials.
The rapid expansion of nuclear energy has led to increased uranium contamination in wastewater, necessitating the development of efficient, cost-effective, and recyclable materials for uranium removal. Hydroxyapatite (HAP) has emerged as a promising candidate due to its exceptional surface properties, structural tunability, and environmental compatibility. This review systematically evaluates recent progress in HAP-based materials for uranium remediation, focusing on advanced synthesis techniques and modification strategies that enhance adsorption capacity and ion selectivity. We analyze the underlying mechanisms, particularly the roles of material morphology and solution pH in optimizing uranium removal efficiency. Current limitations in practical applications are critically discussed, along with future research priorities for developing next-generation HAP composites. By establishing structure-performance relationships and addressing current challenges, this review provides fundamental insights to guide the design of high-performance radioactive wastewater treatment materials.
