摘要：
High-concentration erbium-doped WSe 2 monolayer (7.2 at%) is synthesized via in-situ CVD, enabling electric-field-tunable photoluminescence (PL) with enhanced quantum efficiency. Structural characterization results verify the homogeneous incorporation of Er 3+ into the host WSe 2 , while gate-controlled devices reveal bidirectional modulation of up/down-conversion PL. The material exhibits broadband emission from UV to visible and near-infrared under 980 nm excitation, and a distinct 780 nm visible peak under 532 nm excitation. Vertical electric fields suppress PL under positive bias but boost up-conversion efficiency under negative bias. Through first-principles calculations, this is attributed to field-induced bandgap narrowing and enhanced electron-hole symmetry. These factors together promote radiative recombination. Power-dependent PL confirms stable exciton/trion emission, supporting high-power applications. This synergy of rare-earth doping and field engineering advances tunable optoelectronics, including adaptive photodetectors, bioimaging, and energy-efficient cooling systems.
High-concentration erbium-doped WSe 2 monolayer (7.2 at%) is synthesized via in-situ CVD, enabling electric-field-tunable photoluminescence (PL) with enhanced quantum efficiency. Structural characterization results verify the homogeneous incorporation of Er 3+ into the host WSe 2 , while gate-controlled devices reveal bidirectional modulation of up/down-conversion PL. The material exhibits broadband emission from UV to visible and near-infrared under 980 nm excitation, and a distinct 780 nm visible peak under 532 nm excitation. Vertical electric fields suppress PL under positive bias but boost up-conversion efficiency under negative bias. Through first-principles calculations, this is attributed to field-induced bandgap narrowing and enhanced electron-hole symmetry. These factors together promote radiative recombination. Power-dependent PL confirms stable exciton/trion emission, supporting high-power applications. This synergy of rare-earth doping and field engineering advances tunable optoelectronics, including adaptive photodetectors, bioimaging, and energy-efficient cooling systems.
作者机构：
[Zhang, Yu; Han, Peigang; Shi, Tingshu; Liu, Zhixin; Wang, Junyu; Tang, Zeguo; Zheng, Xiaojian; Xu, Guoqiang; Khan, Danish; Lu, Di; Tang, Jun] Shenzhen Technol Univ, Coll New Mat & New Energies, Lantian Rd 3002, Shenzhen 518118, Peoples R China.;[Yan, Lei; Wang, Xingzhu; Zheng, Xiaojian; Xu, Guoqiang] Univ South China, Engn & Res Ctr Integrated New Energy Photovolta &, Hengyang 421001, Peoples R China.;[Yan, Lei; Wang, Xingzhu; Zheng, Xiaojian; Xu, Guoqiang] Univ South China, Sch Elect Engn, Hengyang 421001, Peoples R China.;[Ahmed, Shehzad] Shanghai Jiao Tong Univ, China UK Low Carbon Coll, Shanghai 201306, Peoples R China.;[Chen, Wei] Shenzhen Technol Univ, Coll Engn Phys, Shenzhen 518118, Guangdong, Peoples R China.
通讯机构：
[Liu, ZX; Khan, D; Tang, ZG ] S;[Wang, XZ ] U;Shenzhen Technol Univ, Coll New Mat & New Energies, Lantian Rd 3002, Shenzhen 518118, Peoples R China.;Univ South China, Engn & Res Ctr Integrated New Energy Photovolta &, Hengyang 421001, Peoples R China.;Univ South China, Sch Elect Engn, Hengyang 421001, Peoples R China.
关键词：
3D/2D perovskite films;Benzamidine;Amorphous passivation;2D passivation;Inverted perovskite solar cells
摘要：
The introduction of two-dimensional (2D) perovskite layers on top of three-dimensional (3D) perovskite films enhances the performance and stability of perovskite solar cells (PSCs). However, the electronic effect of the spacer cation and the quality of the 2D capping layer are critical factors in achieving the required results. In this study, we compared two fluorinated salts: 4-(trifluoromethyl) benzamidine hydrochloride (4TF-BA<middle dot>HCl) and 4-fluorobenzamidine hydrochloride (4F-BA<middle dot>HCl) to engineer the 3D/2D perovskite films. Surprisingly, 4F-BA formed a high-performance 3D/2D heterojunction, while 4TF-BA produced an amorphous layer on the perovskite films. Our findings indicate that the balanced intramolecular charge polarization, which leads to effective hydrogen bonding, is more favorable in 4F-BA than in 4TF-BA, promoting the formation of a crystalline 2D perovskite. Nevertheless, 4TF-BA managed to improve efficiency to 24%, surpassing the control device, primarily due to the natural passivation capabilities of benzamidine. Interestingly, the devices based on 4F-BA demonstrated an efficiency exceeding 25% with greater longevity under various storage conditions compared to 4TF-BA-based and the control devices.
摘要：
The supercritical carbon dioxide (S-CO 2 ) Brayton cycle is an advanced energy conversion system with many advantages including high power conversion efficiency, system compactness and high flexibility. The coupling of Liquid Metal-cooled Reactor (LMR) with the S-CO 2 Brayton cycle represents a promising direction in the development of nuclear energy systems, fully leveraging the strengths of both technologies. However, the coupled system is in the preliminary design stage. This paper carries out an integrated review of research activities about the coupled systems, with a focus on coupled system design, the Liquid Metal (LM)-S-CO 2 coupled heat transfer experiment and numerical simulation, and the LM-S-CO 2 Heat eXchanger Tube Rupture (HXTR) accident. This review summarizes the achievements and shortcomings of the existing studies, which can provide a valuable reference for the future research in this domain.
The supercritical carbon dioxide (S-CO 2 ) Brayton cycle is an advanced energy conversion system with many advantages including high power conversion efficiency, system compactness and high flexibility. The coupling of Liquid Metal-cooled Reactor (LMR) with the S-CO 2 Brayton cycle represents a promising direction in the development of nuclear energy systems, fully leveraging the strengths of both technologies. However, the coupled system is in the preliminary design stage. This paper carries out an integrated review of research activities about the coupled systems, with a focus on coupled system design, the Liquid Metal (LM)-S-CO 2 coupled heat transfer experiment and numerical simulation, and the LM-S-CO 2 Heat eXchanger Tube Rupture (HXTR) accident. This review summarizes the achievements and shortcomings of the existing studies, which can provide a valuable reference for the future research in this domain.
摘要：
The safe operation of nuclear facilities and the demand for real-time radiation monitoring have continued to increase. Active Pixel Sensor based nuclear radiation imaging technology has attracted significant attention due to its low power consumption and high integration capability. However, in high-radiation environments, APS devices are susceptible to interference from high-energy particle impacts, generating random high-amplitude noise that severely degrades video quality and reduces dose rate measurement accuracy. To address this issue, this paper proposes a real-time radiation noise suppression and dose detection method that combines time-domain minimum-value substitution with spatial median filtering with two-dimensional wavelet decomposition , implemented on a parallel FPGA architecture. The proposed method fully exploits the multi-stage pipelining and parallel processing capabilities of FPGAs to efficiently suppress radiation-induced noise in APS image streams and extract residual dose information at multiple scales. Experiments conducted using a 60 Co gamma-ray source on both a video test chart and a real-world scenario demonstrate that the method improves the peak signal-to-noise ratio by an average of approximately 11 dB after denoising , significantly outperforming Gaussian and low-pass filtering, and achieving comparable results to deep learning approaches such as DnCNN and Vision Transformer . Moreover, the hardware implementation does not require power-hungry GPUs , ensuring real-time performance for embedded applications. Further wavelet decomposition and pixel value fitting analyses confirm excellent linear correlation for dose rate estimation, with the Daubechies wavelet diagonal component achieving an R 2 as high as 0.99624. Overall, the proposed approach offers a low-power, high-efficiency engineering solution for real-time APS video denoising and dose detection in nuclear environments, providing a solid technical foundation for building FPGA-based intelligent nuclear radiation monitoring expert systems .
The safe operation of nuclear facilities and the demand for real-time radiation monitoring have continued to increase. Active Pixel Sensor based nuclear radiation imaging technology has attracted significant attention due to its low power consumption and high integration capability. However, in high-radiation environments, APS devices are susceptible to interference from high-energy particle impacts, generating random high-amplitude noise that severely degrades video quality and reduces dose rate measurement accuracy. To address this issue, this paper proposes a real-time radiation noise suppression and dose detection method that combines time-domain minimum-value substitution with spatial median filtering with two-dimensional wavelet decomposition , implemented on a parallel FPGA architecture. The proposed method fully exploits the multi-stage pipelining and parallel processing capabilities of FPGAs to efficiently suppress radiation-induced noise in APS image streams and extract residual dose information at multiple scales. Experiments conducted using a 60 Co gamma-ray source on both a video test chart and a real-world scenario demonstrate that the method improves the peak signal-to-noise ratio by an average of approximately 11 dB after denoising , significantly outperforming Gaussian and low-pass filtering, and achieving comparable results to deep learning approaches such as DnCNN and Vision Transformer . Moreover, the hardware implementation does not require power-hungry GPUs , ensuring real-time performance for embedded applications. Further wavelet decomposition and pixel value fitting analyses confirm excellent linear correlation for dose rate estimation, with the Daubechies wavelet diagonal component achieving an R 2 as high as 0.99624. Overall, the proposed approach offers a low-power, high-efficiency engineering solution for real-time APS video denoising and dose detection in nuclear environments, providing a solid technical foundation for building FPGA-based intelligent nuclear radiation monitoring expert systems .
摘要：
The RAD7 detector is widely used for measuring the radon exhalation rate from the surfaces of media such as soil, rocks, and building materials. However, during the measurement process, the accuracy of the results is prone to interference due to the instrument's inherent statistical errors and environmental noise. To reduce these measurement errors, the Kalman filtering was introduced in this study to correct the radon exhalation rate, which was obtained through data fitting of radon concentration measured by the RAD7 detector. Ten verified experiments were performed with a radon exhalation standard device. The experimental result shows that 80 % of the radon exhalation rate, corrected by Kalman filtering, significantly approached the theoretical value of the standard device, compared to the uncorrected experimental results. It confirms the effectiveness of the Kalman filtering in correcting RAD7 measurements, thereby enhancing the accuracy of radon exhalation rate measurements. The proposed method provides a reference technical pathway for improving the measurement accuracy of similar radon measurement instruments.
The RAD7 detector is widely used for measuring the radon exhalation rate from the surfaces of media such as soil, rocks, and building materials. However, during the measurement process, the accuracy of the results is prone to interference due to the instrument's inherent statistical errors and environmental noise. To reduce these measurement errors, the Kalman filtering was introduced in this study to correct the radon exhalation rate, which was obtained through data fitting of radon concentration measured by the RAD7 detector. Ten verified experiments were performed with a radon exhalation standard device. The experimental result shows that 80 % of the radon exhalation rate, corrected by Kalman filtering, significantly approached the theoretical value of the standard device, compared to the uncorrected experimental results. It confirms the effectiveness of the Kalman filtering in correcting RAD7 measurements, thereby enhancing the accuracy of radon exhalation rate measurements. The proposed method provides a reference technical pathway for improving the measurement accuracy of similar radon measurement instruments.
期刊：
Annals of Nuclear Energy,2026年226:111875 ISSN：0306-4549
通讯作者：
Zhao, PC
作者机构：
[Li, Feiyang; Liu, Zijing; Zeng, Youwei; Zhao, Pengcheng] Univ South China, Sch Nucl Sci & Technol, Hengyang 421001, Hunan, Peoples R China.;[Li, Feiyang; Liu, Zijing; Zeng, Youwei; Zhao, Pengcheng] Minist Educ, Key Lab Adv Nucl Energy Design & Safety, Hengyang 421001, Peoples R China.;[Li, Wei] Univ South China, Sch Resource Environm & Safety Engn, Hengyang 421200, Peoples R China.
通讯机构：
[Zhao, PC ] U;Univ South China, Sch Nucl Sci & Technol, Hengyang 421001, Hunan, Peoples R China.
关键词：
Lead-bismuth fast reactor;Active learning strategy;Integrated surrogate model;Passive system;Reliability analysis
摘要：
Passive residual heat removal systems ensure the safe operation of lead–bismuth fast reactors. However, the resistance of such systems is similar to natural driving forces, while small fluctuations in the surrounding environment and material parameters can cause system failure; thus, analyzing the reliability of passive residual heat removal systems is important for lead–bismuth cooling. This study utilizes the passive system in the lead–bismuth eutectic loop of the TALL-3D experimental facility and proposes a reliability analysis based on the active learning-integration (AL-I) surrogate model. The AL-I surrogate model is constructed first, and single-failure and multiple-failure region validations are performed to ensure accuracy and robustness of the model. Subsequently, the sensitivity and reliability of the TALL-3D non-energetic system is determined. The active learning ensemble surrogate model only needs 99 low-cost numerical calculations to obtain a reliable result with a failure rate of 0.0650%. This model not only significantly reduces the computational resources and time costs, but also allows high-precision failure probability assessments. Therefore, this study shows that the AL-I surrogate model is advantageous for lead–bismuth cooled non-energetic waste heat discharge systems and offers solid technical support for engineering such systems.
Passive residual heat removal systems ensure the safe operation of lead–bismuth fast reactors. However, the resistance of such systems is similar to natural driving forces, while small fluctuations in the surrounding environment and material parameters can cause system failure; thus, analyzing the reliability of passive residual heat removal systems is important for lead–bismuth cooling. This study utilizes the passive system in the lead–bismuth eutectic loop of the TALL-3D experimental facility and proposes a reliability analysis based on the active learning-integration (AL-I) surrogate model. The AL-I surrogate model is constructed first, and single-failure and multiple-failure region validations are performed to ensure accuracy and robustness of the model. Subsequently, the sensitivity and reliability of the TALL-3D non-energetic system is determined. The active learning ensemble surrogate model only needs 99 low-cost numerical calculations to obtain a reliable result with a failure rate of 0.0650%. This model not only significantly reduces the computational resources and time costs, but also allows high-precision failure probability assessments. Therefore, this study shows that the AL-I surrogate model is advantageous for lead–bismuth cooled non-energetic waste heat discharge systems and offers solid technical support for engineering such systems.
摘要：
The mechanical properties of sandstone, a common building material, are influenced by a variety of factors. In the coastal areas of China, groundwater has gradually become salinized into brine, which inevitably alters the original microstructure of rocks and affects the stability of underground structures. To clarify the evolution of the rock microstructure under brine erosion, this study used NMR technology to investigate the pore evolution characteristics of red sandstone under brine erosion. The experimental results show that the water absorption capacity of sandstone is influenced by the solution environment, with the lowest absorption rate occurring in regard to brine. The pores in red sandstone undergo significant changes after brine erosion. Factors such as the composition of the brine and soaking time affect sandstone porosity, with transformations of mini-pores and meso-pores leading to changes in porosity. In addition, XRD tests were carried out on the soaked red sandstone samples to analyze the changes in the main mineral components of the sandstone after brine erosion.
摘要：
Photocatalytic reduction is a promising way to remove radioactive uranium U(VI) in wastewater. Herein, an S-scheme ZnO@ZnS heterojunction with hollow structure and dual-vacancies of Zn and S (ZnV, SV) is developed. The hollow confined space enhances light trapping ability through multiple light scattering and reflection, while the existence of vacancies extends light absorption, further enhancing the utilization of solar spectrum. Furthermore, the density function theory (DFT) calculations demonstrate that co-sharing of metal atoms at the interface and the ZnV and SV dual-vacancies induce enhanced internal electric field (IEF), leading to facilitated S-scheme charge transfer, thereby resulting in improved retention of redox potential and suppressed carrier recombination dynamics. ZnO@ZnS shows a highest U(VI) removal rate of 96.48% along with a highest U enrichment of 514.33 mg/g, which is 3.6 and 2.7-folds enhanced compared to pristine ZnO and ZnS, respectively. Through various quenching experiments, a potential new mechanism for the catalytic reduction of U(VI) is proposed. Our findings reveal the involvement of h+ in the reaction, highlighting its significant catalytic role in the reduction process. Moreover, ZnO@ZnS performs excellent U(VI) extraction ability in open-air conditions without any sacrificial agents, revealing the great significance for practical applications.
Photocatalytic reduction is a promising way to remove radioactive uranium U(VI) in wastewater. Herein, an S-scheme ZnO@ZnS heterojunction with hollow structure and dual-vacancies of Zn and S (ZnV, SV) is developed. The hollow confined space enhances light trapping ability through multiple light scattering and reflection, while the existence of vacancies extends light absorption, further enhancing the utilization of solar spectrum. Furthermore, the density function theory (DFT) calculations demonstrate that co-sharing of metal atoms at the interface and the ZnV and SV dual-vacancies induce enhanced internal electric field (IEF), leading to facilitated S-scheme charge transfer, thereby resulting in improved retention of redox potential and suppressed carrier recombination dynamics. ZnO@ZnS shows a highest U(VI) removal rate of 96.48% along with a highest U enrichment of 514.33 mg/g, which is 3.6 and 2.7-folds enhanced compared to pristine ZnO and ZnS, respectively. Through various quenching experiments, a potential new mechanism for the catalytic reduction of U(VI) is proposed. Our findings reveal the involvement of h+ in the reaction, highlighting its significant catalytic role in the reduction process. Moreover, ZnO@ZnS performs excellent U(VI) extraction ability in open-air conditions without any sacrificial agents, revealing the great significance for practical applications.
作者机构：
[Xie, Xianshun; Xie, Changjun] Univ South China, Affiliated Hosp 2, Hengyang Med Sch, Dept Oncol Hematol, Hengyang 421001, Hunan, Peoples R China.;[Jiang, Yiling] Univ South China, Affiliated Hosp 1, Hengyang Med Sch, Dept Oncol, Hengyang, Hunan, Peoples R China.;[Liu, Sumei] Univ South China, Affiliated Hosp 2, Hengyang Med Sch, Dept Emergency, Hengyang, Hunan, Peoples R China.
通讯机构：
[Liu, SM ; Xie, CJ ] U;Univ South China, Affiliated Hosp 2, Hengyang Med Sch, Dept Oncol Hematol, Hengyang 421001, Hunan, Peoples R China.;Univ South China, Affiliated Hosp 2, Hengyang Med Sch, Dept Emergency, Hengyang, Hunan, Peoples R China.
摘要：
Non-small cell lung cancer (NSCLC) is a major cause of global mortality. This study investigated Anemarrhena asphodeloides' potential mechanisms in treating NSCLC through network pharmacology and molecular docking, offering a theoretical basis for future experimental and clinical applications of traditional Chinese medicine in lung cancer therapy. Active compounds of Anemarrhena asphodeloides and their relevant targets were identified by network pharmacology methods. Key targets influenced by Anemarrhena asphodeloides in NSCLC were analyzed using the String 11.0 database to construct a PPI network. The binding abilities of these active ingredients to core targets were validated using molecular docking and dynamics simulations. The results of the network pharmacology analysis were validated by in vitro experiments. A total of 15 active compounds from Anemarrhena asphodeloides were identified, corresponding to 432 targets. Molecular docking and dynamics simulations confirmed that kaempferol, asperglaucide, and coumaroyltyramine exhibited strong binding interactions with key proteins such as AKT1, SRC, and HSP90AA1. Additionally, in vitro experiments confirmed that the active compounds of Anemarrhena asphodeloides reduced the expression of AKT1, SRC, and HSP90AA1, thereby inhibiting the malignant characteristics of human NSCLC cells. In conclusion, this study explored the pharmacological mechanisms of Anemarrhena asphodeloides in NSCLC, offering references for further research and supporting its clinical application in NSCLC treatment.
期刊：
INTERNATIONAL JOURNAL FOR VITAMIN AND NUTRITION RESEARCH,2025年95(1):26882 ISSN：0300-9831
通讯作者：
Zhao, Sue;Yang, HZ
作者机构：
[Cao, Jing] Univ South China, Affiliated Changsha Cent Hosp, Hengyang Med Sch, Med Insurance Dept, Changsha 410004, Hunan, Peoples R China.;[Su, Yingjie] Univ South China, Affiliated Changsha Cent Hosp, Hengyang Med Sch, Dept Emergency Med, Changsha 410004, Hunan, Peoples R China.;[Zhao, Sue; Yang, Hongzhong; Xiao, Yijia] Univ South China, Affiliated Changsha Cent Hosp, Hengyang Med Sch, Dept Resp & Crit Care Med, Changsha 410004, Hunan, Peoples R China.
通讯机构：
[Zhao, S; Yang, HZ ] U;Univ South China, Affiliated Changsha Cent Hosp, Hengyang Med Sch, Dept Resp & Crit Care Med, Changsha 410004, Hunan, Peoples R China.
关键词：
NHANES;cardiovascular disease;cross-sectional study;remnant cholesterol;vitamin E
摘要：
BACKGROUND: Remnant cholesterol (RC) is a risk factor for the development of atherosclerosis. Vitamin E has antioxidant properties, making it a potentially effective management tool for preventing cardiovascular disease (CVD). However, the relationship between vitamin E intake and RC remains unclear. METHODS: We conducted a cross-sectional study using data from the National Health and Nutrition Examination Survey (NHANES) Survey 2007-2020. 11,585 participants (aged ≥20, 48% male) were included. Information on vitamin E intake (dietary vitamin E intake and total vitamin E intake) was collected. RC was defined as serum total cholesterol minus high-density lipoprotein and low-density lipoprotein cholesterol. Survey-weighted linear regression models and a restricted cubic spline (RCS) were used to test the relationship between vitamin E intake and RC. Subgroup analyses and interaction tests were also performed to verify the robustness of the results. RESULTS: After adjusting for all potential confounders (demographics, socioeconomic status, lifestyle, diet, and comorbidities), dietary vitamin E intake was negatively associated with RC (β = -0.21, 95% CI: (-0.29, -0.12), p < 0.0001), and this negative association was also present between total vitamin E intake and RC (β = -0.12, 95% CI: (-0.18, -0.06), p < 0.0001). The RCS analysis revealed a nonlinear negative association between vitamin E intake and RC. The negative correlation existed in different subgroups, with no interaction except for the "use of vitamin E supplements" subgroup. CONCLUSION: Vitamin E intake showed a protective association with RC. The results suggest that increasing dietary vitamin E intake may help reduce RC levels and CVD risk.
通讯机构：
[Dai, ZR ] U;[Han, S ] H;Hebei Univ Engn, Coll Mat Sci & Engn, Handan Key Lab Novel Nanobiomat, Handan 056000, Peoples R China.;Univ South China, Key Discipline Lab Natl Def Biotechnol Uranium Min, Hengyang 421001, Peoples R China.
摘要：
Photocatalytic removal of uranium is an efficient method for uranium removal. In this paper, a novel g-C 3 N 4 @C-PAN nanofiber membrane has been prepared by electrospinning and thermal polymerization from carbonized dicyandiamide and polyacrylonitrile fiber film, and it has been used for photocatalytic removal of U( VI ) under LED illumination. The experimental results show that the removal rate of U( VI ) by g-C 3 N 4 @C-PAN was nearly 100% in a wide concentration range of U( VI ) with great anti-interference performance. After 5 cycles, the removal rate of g-C 3 N 4 @C-PAN for uranium remains above 90%, showing excellent reusable performance. The mechanism studies show that the e − and ˙O 2 − play an important role in the photocatalytic removal of U( VI ), and they can react with U( VI ) to form (UO 2 )O 2 ·2H 2 O, thus realizing the fixation and removal of U( VI ). This work shows that the nanofiber membrane prepared by electrospinning technology has considerable application prospects for the photocatalytic treatment of uranium-containing wastewater.
摘要：
This paper presents a Respiratory Syncytial Virus (RSV) epidemic model for a continuous human population of super-spreading infected individuals. The model uses a generalized fractal-fractional derivative with the Mittag-Leffler function to analyze transmission, considering different infection stages, and demonstrates the effectiveness of certain individuals as viral spreaders. Using linear growth and Lipschitz requirements, the study determines the existence, uniqueness, positiveness, and boundedness of a proposed fractional-order system in order to assess its viability. The global stability of equilibrium points is verified by the Lyapunov function, and the effects of the model's parameters are investigated through sensitivity analysis. To comprehend the model's behavior and create preventative measures for infected people, a numerical simulation of its activity is also carried out. By offering a more realistic depiction of virus behavior at various dimensions and population effects, the fractal-fractional model enhances comprehension and forecasts. The results highlight the importance of fractional order and its fitting function in the model by demonstrating how input parameters affect the dynamic behavior of RSV infection. Such an investigation will aid in understanding the behavior of the RSV and develop prevention measures for infected individuals.
摘要：
This study aimed to investigate the relationship between the Composite Dietary Antioxidant Index (CDAI) and sarcopenia in middle-aged and older adults using data from the 1999 to 2018 National Health and Nutrition Examination Survey. The study included 6621 participants from National Health and Nutrition Examination Survey. CDAI was calculated based on dietary data from the first 24-hour dietary recall, reflecting the intake of 6 major antioxidants: vitamins C, E, and A, carotenoids, zinc, and selenium. Sarcopenia was defined using the sarcopenia index, calculated as appendicular skeletal muscle mass adjusted for body mass index, with cutoff values from the Foundation for the National Institutes of Health. Multivariable logistic regression analyses were conducted to assess the relationship between CDAI and sarcopenia risk. Among 6621 adults aged ≥ 40 years, the overall prevalence of sarcopenia was 12.3%. Participants in the highest CDAI quartile had a lower prevalence of sarcopenia (8.2%) compared to the lowest quartile (17.1%, P < .001). In multivariable analyses, CDAI was inversely associated with sarcopenia risk. Each 1-unit increase in CDAI was linked to a 7% reduction in sarcopenia odds (odds ratio = 0.93, 95% confidence interval = 0.91-0.95, P < .001). Compared with the lowest quartile, the highest CDAI quartile showed a 53 % lower odds of sarcopenia (odds ratio = 0.47, 95% confidence interval = 0.32-0.70, P < .001). Dose-dependent risk reductions were observed across CDAI quartiles. Subgroup analyses showed consistent inverse associations across various categories, with no significant interactions. Sensitivity analyses confirmed the robustness of the findings. Higher CDAI levels are associated with a lower risk of sarcopenia in middle-aged and older adults. This study highlights the potential protective role of dietary antioxidants in maintaining muscle health and preventing sarcopenia. Future research should explore causal relationships and specific mechanisms, and validate findings in diverse populations.
摘要：
Single-phase concentrated solid-solution alloys have garnered widespread attention due to their remarkable irradiation resistance properties. In this study, the molecular dynamics method was employed to investigate the collision cascade process in Ni-Fe alloys. The generation and evolution of point defects under uniaxial strain were systematically analyzed for alloys with varying Fe concentrations. It was observed that the peak number of point defects increased under tensile strain but decreased under compressive strain as the uniaxial strain magnitude rose. However, the uniaxial strain exhibited only a minor influence on the surviving number of defects. The calculated formation energies revealed that Fe vacancies possessed higher formation energies compared to Ni vacancies. Consequently, an increase in Fe concentration led to greater participation of Fe atoms in collision cascades, resulting in fewer point defects during the thermal peak stage. Owing to the elevated defect formation energies of Fe relative to Ni, the proportions of Fe vacancies and interstitials in the total point defects were consistently lower than the Fe atomic concentration. These findings indicate that higher Fe concentrations impede the formation of point defects. (c) 2025 Author(s). All article content, except where otherwise noted, is licensed under a Creative Commons Attribution (CC BY) license(https://creativecommons.org/licenses/by/4.0/).
摘要：
Strategic engineering of B-site coordination environment in K 2 NiF 4 -type oxides presents a rational pathway to optimize electrocatalytic functionality. Herein, Co substitution in La 1.2 Sr 0.8 NiO 4+δ (LSNO) induces structural reorganization that accommodates excess interstitial oxygen species, enabling dual enhancement of ionic transport with 30-fold enhanced oxygen diffusion and 3.5–11.1-fold improved proton migration. The NiO-BaZr 0.1 Ce 0.7 Y 0.2 O 3-δ |BaZr 0.1 Ce 0.7 Y 0.2 O 3-δ |La 1.2 Sr 0.8 Ni 0.5 Co 0.5 O 4+δ (LSNCO) cell demonstrates exceptional electrochemical performance with the power density of 1698 mW cm −2 and polarization resistance of 0.056 Ω cm 2 at 700 °C, outperforming both LSNO counterpart and reported Ln 2 NiO 4 -based cathodes. The synergistic integration of exceptional power generation, optimized interfacial polarization, and excellent operational stability establishes LSNCO as a benchmark cathode material for proton conducting solid oxide fuel cells. This study systematically validates a Co-mediated B-site coordination engineering strategy in K 2 NiF 4 -type lattices, providing a generalized framework for designing high electrocatalytically active electrodes with coupled ionic transport channels.
Strategic engineering of B-site coordination environment in K 2 NiF 4 -type oxides presents a rational pathway to optimize electrocatalytic functionality. Herein, Co substitution in La 1.2 Sr 0.8 NiO 4+δ (LSNO) induces structural reorganization that accommodates excess interstitial oxygen species, enabling dual enhancement of ionic transport with 30-fold enhanced oxygen diffusion and 3.5–11.1-fold improved proton migration. The NiO-BaZr 0.1 Ce 0.7 Y 0.2 O 3-δ |BaZr 0.1 Ce 0.7 Y 0.2 O 3-δ |La 1.2 Sr 0.8 Ni 0.5 Co 0.5 O 4+δ (LSNCO) cell demonstrates exceptional electrochemical performance with the power density of 1698 mW cm −2 and polarization resistance of 0.056 Ω cm 2 at 700 °C, outperforming both LSNO counterpart and reported Ln 2 NiO 4 -based cathodes. The synergistic integration of exceptional power generation, optimized interfacial polarization, and excellent operational stability establishes LSNCO as a benchmark cathode material for proton conducting solid oxide fuel cells. This study systematically validates a Co-mediated B-site coordination engineering strategy in K 2 NiF 4 -type lattices, providing a generalized framework for designing high electrocatalytically active electrodes with coupled ionic transport channels.
摘要：
As a member of the single-fluorophore genetically encoded calcium indicators (GECIs), jGCaMP7f is widely applied to investigate intracellular Ca 2+ concentrations. Here, we established an INS-jGCaMP7f knock-in H1 human embryonic stem cell (hESC) line by integrating jGCaMP7f gene into insulin locus via CRISPR/Cas9 system. The reporter cell line not only effectively labelled the insulin-producing cells induced from hESC, but also reflected the cytosolic change of Ca 2+ level in response to different stimuli. This reporter cell line is a valuable research tool for studying functional maturation of hESC-derived insulin-producing cells, conducting drug screenings, and exploring the mechanisms of diabetes.
As a member of the single-fluorophore genetically encoded calcium indicators (GECIs), jGCaMP7f is widely applied to investigate intracellular Ca 2+ concentrations. Here, we established an INS-jGCaMP7f knock-in H1 human embryonic stem cell (hESC) line by integrating jGCaMP7f gene into insulin locus via CRISPR/Cas9 system. The reporter cell line not only effectively labelled the insulin-producing cells induced from hESC, but also reflected the cytosolic change of Ca 2+ level in response to different stimuli. This reporter cell line is a valuable research tool for studying functional maturation of hESC-derived insulin-producing cells, conducting drug screenings, and exploring the mechanisms of diabetes.
摘要：
Introduction Glucosylceramidase beta 1 (GBA1) mutations are a genetic risk factor for Parkinson's disease (PD), though most carriers do not develop the disease. This study aimed to identify exposure factors linked to PD in GBA1 carriers and assess clinical features and the probability of prodromal PD in non-manifesting carriers.
Glucosylceramidase beta 1 (GBA1) mutations are a genetic risk factor for Parkinson's disease (PD), though most carriers do not develop the disease. This study aimed to identify exposure factors linked to PD in GBA1 carriers and assess clinical features and the probability of prodromal PD in non-manifesting carriers.
Methods Data from the Parkinson's Disease & Movement Disorders Multicenter Database and Collaborative Network in China was used, including 59 GBA1 non-manifesting carriers, 62 controls, and 107 GBA1-associated PD, of whom 81 were in the early stage. Exposure factors included pesticide/solvent exposure, smoking, alcohol, and tea consumption. Logistic regression assessed the association between exposure factors and PD. Clinical characteristics were evaluated using multiple scales, relevant markers were collected based on the Movement Disorders Society criteria. A naive Bayesian classifier method determined the probability of prodromal PD in GBA1 non-manifesting carriers and controls.
Data from the Parkinson's Disease & Movement Disorders Multicenter Database and Collaborative Network in China was used, including 59 GBA1 non-manifesting carriers, 62 controls, and 107 GBA1-associated PD, of whom 81 were in the early stage. Exposure factors included pesticide/solvent exposure, smoking, alcohol, and tea consumption. Logistic regression assessed the association between exposure factors and PD. Clinical characteristics were evaluated using multiple scales, relevant markers were collected based on the Movement Disorders Society criteria. A naive Bayesian classifier method determined the probability of prodromal PD in GBA1 non-manifesting carriers and controls.
Results After adjusting for sociodemographic variables, pesticide/solvent exposure was positively associated with PD in GBA1 carriers (OR 8.40; 95 % CI 2.50–28.20), while smoking was inversely associated with PD (OR 0.18; 95 % CI 0.05–0.62). Rapid eye movement sleep behavior disorder, constipation, hyposmia, and cognitive deficits were more severe in early-stage GBA1-associated PD than in carriers and controls. Clinical symptoms and the probability of prodromal PD were similar between carriers and controls.
After adjusting for sociodemographic variables, pesticide/solvent exposure was positively associated with PD in GBA1 carriers (OR 8.40; 95 % CI 2.50–28.20), while smoking was inversely associated with PD (OR 0.18; 95 % CI 0.05–0.62). Rapid eye movement sleep behavior disorder, constipation, hyposmia, and cognitive deficits were more severe in early-stage GBA1-associated PD than in carriers and controls. Clinical symptoms and the probability of prodromal PD were similar between carriers and controls.
Conclusions PD in GBA1 carriers is closely linked to exposure factors. Early-stage GBA1-associated PD shows significant prodromal symptoms, which are not evident in carriers. The probability of prodromal PD in carriers is similar to that in controls.
PD in GBA1 carriers is closely linked to exposure factors. Early-stage GBA1-associated PD shows significant prodromal symptoms, which are not evident in carriers. The probability of prodromal PD in carriers is similar to that in controls.
摘要：
Skin injury refers to the disruption of skin integrity, resulting in the loss of normal tissue, which can occur due to wounds, diseases, or surgeries. The repair of skin injuries is a highly regulated process involving cell migration, proliferation, collagen matrix deposition, and tissue remodeling, all of which are intricately linked to inflammation and angiogenesis. Angiogenesis-the formation of new blood vessels-plays a pivotal role in this process by ensuring the delivery of oxygen and nutrients that are essential for healing. Key angiogenic factors, such as vascular endothelial growth factor, fibroblast growth factor, and platelet-derived growth factor, are crucial in regulating vascular formation. Recent advances have shed light on the complex interactions between angiogenesis and inflammatory responses, emphasizing their critical roles in wound healing, scar formation, and tissue remodeling. However, effectively regulating angiogenesis in clinical settings remains challenging due to the complexity of its underlying mechanisms. This review offers a comprehensive analysis of angiogenesis in skin injury repair, focusing on its regulatory mechanisms, functional roles during different stages of healing, and therapeutic strategies aimed at optimizing vascularization for enhanced clinical outcomes. By advancing our understanding of angiogenesis, we seek to contribute to the development of innovative treatments for skin injuries.
