关键词：
Efflux pumps;Heavy metal resistance;Secretome
摘要：
Heavy metal-resistant bacteria secrete extracellular proteins (e-PNs). However, the role of e-PNs in heavy metal resistance remains elusive. Here Fourier Transform Infrared Spectroscopy implied that N-H, C=O and NH(2)-R played a crucial role in the adsorption and resistance of Ni(2+) in the model organism Cuprividus pauculus 1490 (C. pauculus). Proteinase K treatment reduced Ni(2+) resistance of C. pauculus underlining the essential role of e-PNs. Further three-dimension excitation-emission matrix fluorescence spectroscopy analysis demonstrated that tryptophan proteins as part of the e-PNs increased significantly with Ni(2+) treatment. Proteomic and quantitative real-time polymerase chain reaction data indicated that major changes were induced in the metabolism of C. pauculus in response to Ni(2+). Among those lipopolysaccharide biosynthesis, general secretion pathways, Ni(2+)-affiliated transporters and multidrug efflux play an essential role in Ni(2+) resistance. Altogether the results provide a conceptual model for comprehending how e-PNs contribute to bacterial resistance and adsorption of Ni(2+).
摘要：
'Single shot' laser-ablation split-stream (SS-LASS) technique analyzing unpolished zircon grains makes their thin rims tenable for determination, which thus offers great potential in deciphering the timing of multiple and short-lived episodes of anatexis and metamorphism in deeplysubducted continental crusts. Dominated granitic gneisses in the deeply subducted continental crust undergoing considerable fluid-melt activities persist multistage growth of zircon. Therefore, a comparative study of SS-LASS and laser ablation inductively coupled plasma mass spectrometer (LA-ICP-MS) zircon dating was conducted on the granitic gneisses from the Sulu belt in this study. Zircons mostly show a core-mantle-rim structure with CL-bright rims thinner than 5 mu m. For LA-ICP-MS dating, relict magmatic zircon cores yield protolith ages of ca. 756- 747 Ma; whereas the dark mantles record synexhumation anatexis at ca. 214 Ma. By contrast, according to the U-Pb dates, trace element features, zircon crystallization temperatures and geological context, SS-LASS zircon petrochronology deciphers three episodes of anatectic events, as follows: (i) the first episode of anatexis at ca. 218-217 Ma dominated by phengite-breakdown melting, likely facilitating the exhumation of the UHP slice from mantle depth; (ii) the second episode of anatexis at ca. 193-191 Ma indicating part of northern Dabie-Sulu belt was still "hot" because of buried in the thickened orogenic crust at that time; (iii) the third episode of anatexis (ca. 162-161 Ma) consistent with the intrusion ages (ca. 161-141 Ma) of the Jurassic to Cretaceous granitoids in this orogen, suggesting the initial collapse of the orogenic root of the Sulu belt occurred at Late Jurassic due to the Izanagi plate initially subducting beneath the margin of Eastern Asia. This study sheds new light upon the utilization of SS-LASS petrochronology deciphering multiple anatectic events in the deeply-subducted continental crust and supports us in better understanding the tectonic evolution of Dabie-Sulu Orogen.
摘要：
Tuberculosis (TB) caused by Mycobacterium tuberculosis (Mtb) persistently kills nearly 1.5 million lives per year in the world, whereas the only licensed TB vaccine BCG exhibits unsatisfactory efficacy in adults. Taking BCG as a vehicle to express Mtb antigens is a promising way to enhance its efficacy against Mtb infection. In this study, the immune efficacy of recombination BCG (rBCG-ECD003) expressing specific antigens ESAT-6, CFP-10, and nDnaK was evaluated at different time points after immunizing BALB/c mice. The results revealed that rBCG-ECD003 induced multiple Th1 cytokine secretion including IFN-γ, TNF-α, IL-2, and IL-12 when compared to the parental BCG. Under the action of PPD or ECD003, rBCG-ECD003 immunization resulted in a significant increase in the proportion of IL-2(+) and IFN-γ(+)IL-2(+) CD4(+)T cells. Importantly, rBCG-ECD003 induced a stronger long-term humoral immune response without compromising the safety of the parental BCG vaccine. By means of the protective efficacy assay in vitro, rBCG-ECD003 showed a greater capacity to inhibit Mtb growth in the long term. Collectively, these features of rBCG-ECD003 indicate long-term protection and the promising effect of controlling Mtb infection.
通讯机构：
[Xu, YS ] U;Univ South China, Sch Resource Environm & Safety Engn, Hengyang 421001, Peoples R China.
关键词：
Cathode;Proton-conducting oxides;SOFCs
摘要：
As a cathode material for proton-conducting SOFCs (H-SOFCs), a novel MnCo1.9Sb0.1O4 (MCSO) spinel material was suggested. The MCSO material was effectively produced, and it demonstrated excellent phase stability at elevated temperatures and chemical stability against CO2 and H2O. Doping Sb into the MnCo2O4 (MCO) allowed for enhanced proton diffusion and surface exchange, as evidenced by electrical conductivity relaxation tests. In addition, an oxygen-vacancy-rich surface was developed for the MCSO material, resulting in the possibility of a high cathode oxygen reduction reaction activity. The MCSO material was examined in the H-SOFC application, and the fuel cell with an MCSO cathode attained a high power density of 1380 mW cm-2 at 700 degrees C. At 700 degrees C, the cell employing the Sb-free MCO cathode, which had a comparable cell microstructure to the MCSO cell, only obtained a peak power density of 836 mW cm-2. The higher cell performance resulted from the Sbmodified MCO cathode's increased catalytic activity. In addition, the MCSO cell displayed excellent operational stability under fuel cell operating conditions, indicating that MCSO is a novel and effective spinel cathode for H-SOFCs.(c) 2023 Hydrogen Energy Publications LLC. Published by Elsevier Ltd. All rights reserved.
摘要：
Uranium, regarded as an important element in nuclear fission energy schemes, is harmful to public health owing to its high toxicity and radioactivity. Herein, a novel fluorescent probe (SC4A@Tb3+) was developed using a one-step liquid-phase method with 4-sulfocalix[4]arene (SC4A) and rare earth-metal ions (Tb3+) as precursors to realize the accurate monitoring of uranyl ion (UO22+) detection. Based on the dynamic quenching mechanism, the SC4A@Tb3+ fluorescence quenching sensor for UO22+ detection was in the linear range of 0-0.36 mu M, with a detection limit of 20 mu g center dot L-1, and successfully quantified UO22+ in water and human serum samples. These results suggest that SC4A@Tb3+ is a potential sensing material for UO22+ detection.
摘要：
How to fabricate a multifunctional coating with controllable ultralow refractive index (RI), high antifogging and anticorrosion performances by a facile method is still one of the great challenges. In this work, a simple and time-saving approach involving a microwave-assisted sol-sel process was developed to fabricate a novel core-shell structured silica nanoparticle sol by co-condensation of perfluorodecyltriethoxysilane (F-DTOS) and tetraethoxysilane (TEOS) and self-condensation of F-DTOS. Results suggest that both the co-condensations and self-condensations not only give a layer of low surface energy -C10H4F17 groups on the silica particles but also enlarge the hybrid silica particle size, providing more and larger voids to form the high porosity. After spinning the silica nanoparticles on the substrate, the obtained optical coating exhibits the controllable ultralow refractive index (RI) and outstanding transparency. The minimum RI and maximum transmittance of our developed coating is up to similar to 1.04 and similar to 100 %, respectively. Moreover, because of the high porosity and the presence of low surface energy -C10H4F17 groups in the coating, the coating has the high hydrophobicity (water contact angle similar to 108.8 degrees), which not only makes it excellent antifogging performance but also affords it high-efficient anticorrosion property. After immersion in a 3.5 wt% NaCl solution for 7 days, the R-ct value of the coating could be higher than 7.3 x 10(4) Omega cm(2). It is believed that our developed method used to fabricate such multifunctional coating does not need any costly equipments, complex steps and time-consuming, making it well suited for industrial application.
摘要：
Immunotherapy has revolutionized the cancer treatment landscape by opening up novel avenues for intervention. As the use of immune checkpoint inhibitors (ICIs) has exponentially increased, so have immune-related adverse events (irAEs). The mechanism of irAEs may involve the direct damage caused by monoclonal antibodies and a sequence of immune responses triggered by T cell activation. Common side effects include dermatologic toxicity, endocrine toxicity, gastrointestinal toxicity, and hepatic toxicity. While relatively rare, neurotoxicity, cardiotoxicity, and pulmonary toxicity can be fatal. These toxicities pose a clinical dilemma regarding treatment discontinuation since they can result in severe complications and necessitate frequent hospitalization. Vigilant monitoring of irAEs is vital in clinical practice, and the principal therapeutic strategy entails the administration of oral or intravenous glucocorticoids (GSCs). It may be necessary to temporarily or permanently discontinue the use of ICIs in severe cases. Given that irAEs can impact multiple organs and require diverse treatment approaches, the involvement of a multidisciplinary team of experts is imperative. This review aims to comprehensively examine the pathogenesis, clinical manifestations, incidence, and treatment options for various irAEs.
摘要：
Solution-phase hydrogen reduction reaction (SpHR) was introduced to overcome the problems of ammonia nitrogen pollution, high energy consumption, and long production flow of traditional reduction roasting. From phi-pH diagram, the increase of reaction temperature, vanadium concentration and H2 partial pressure is beneficial to the preparation of V2O3. High purity V2O3 could not be prepared by single addition catalysis and synchronous catalysis in SpHR process, and the Ni + NiSO4 stepwise catalysis can effectively eliminate the problem of nickel wrapped in vanadium precipitates during the precipitation process. Under the optimal conditions of Ni + NiSO4 stepwise catalysis of nickel powder dosage 5 g/L, NiSO4 dosage 8 g/L, nickel powder catalytic time 90 min, NiSO4 catalytic time 30 min, the precipitate with nickel content 11.15 % was obtained, and Ni catalyst can be separated by magnetic separation with nickel recovery ratio of 99.52 %. Ni2+ in SpHR precipitates to Ni(OH)2 and then disintegrates and reduces to Ni, and Ni + NiSO4 stepwise catalysis includes two steps of pre-catalysis and secondary catalysis. After fourth cyclic experiment, the vanadium content of V2O3 product obtained was 67.46 % (i.e. 99.21 % V2O3 purity met the requirements of GB 40301-2021), the total recovery was 98.68 %, and the vanadium loss ratio was stable at 1.22 %. The process of SpHR has no ammonia nitrogen wastewater or waste gas discharge, and the price of V2O3 with purity more than 99 % on the market is about 260,000 yen /t. The stepwise catalysis SpHR has remarkable environmental benefits and economic benefits.
摘要：
The electrocatalytic nitrogen reduction reaction (eNRR) under ambient conditions is a promising alternative to the Haber-Bosch process, but one of the primary pending issues for the eNRR is the development of efficient and stable electrocatalysts. Herein, we propose to prepare a ZIF-67-derived nitrogen-doped porous carbon-supported Co9S8 nanocomposite achieving the maximum average of 9.80 mu g h(-1) mg(cat)(-1) NH3 yield and the highest Faradaic efficiency (FE) of 9.89% in 0.1 M Na2SO4. Moreover, Co9S8/NC shows excellent electrocatalytic stability and durability for the eNRR.
作者机构：
[Wei, Hua; Cheng, Yao; Zhang, Haitao; Yu, Cui-Yun; Wei, H] Univ South China, Hunan Prov Cooperat Innovat Ctr Mol Target New Dru, 28 W Changsheng Rd, Hengyang 421001, Hunan, Peoples R China.;Univ South China, Sch Pharmaceut Sci, Hengyang Med Sch, 28 W Changsheng Rd, Hengyang 421001, Hunan, Peoples R China.
通讯机构：
[Zhang, HT; Yu, CY ; Wei, H] U;Univ South China, Hunan Prov Cooperat Innovat Ctr Mol Target New Dru, 28 W Changsheng Rd, Hengyang 421001, Hunan, Peoples R China.
摘要：
Tumor therapy continues to be a prominent field within biomedical research. The development of various drug carriers has been propelled by concerns surrounding the side effects and targeting efficacy of various chemotherapeutic drugs and other therapeutic agents. These carriers strive to enhance drug concentration at tumor sites, minimize systemic side effects, and improve therapeutic outcomes. Among the reported delivery systems, injectable hydrogels have emerged as an emerging candidate for the in vivo delivery of chemotherapeutic drugs due to their minimal invasive drug delivery properties. This review systematically summarizes the composition and preparation methodologies of injectable hydrogels and further highlights the delivery mechanisms of diverse drugs using these hydrogels for tumor therapy, along with an in-depth discussion on the optimized therapeutic efficiency of drugs encapsulated within the hydrogels. The work concludes by providing a dynamic forward-looking perspective on the potential challenges and possible solutions of the in situ injectable hydrogels for non-surgical and real-time diagnostic applications. This review summarizes composition and preparation methodologies of injectable hydrogels and highlights the delivery mechanisms of drugs for tumor therapy, along with discussion on the optimal therapeutic efficiency of drugs and provides perspective on challenges and solutions in applications.
作者：
Luo, Yi;He, Youzhi;Wang, Yongfu;Xu, Yuxia;Yang, Li
期刊：
Molecular and Cellular Biochemistry,2024年479(1):171-181 ISSN：0300-8177
通讯作者：
Yi Luo
作者机构：
[He, Youzhi; Yang, Li; Xu, Yuxia; Luo, Yi; Wang, Yongfu] Univ South China, Affiliated Changsha Cent Hosp, Hengyang Med Sch, Dept Spine Surg, 161 Shaoshan South Rd, Changsha 410007, Hunan, Peoples R China.
通讯机构：
[Yi Luo] T;The Affiliated Changsha Central Hospital, Department of Spine Surgery, Hengyang Medical School, University of South China, Changsha, Changsha, People’s Republic of China
摘要：
Intervertebral disc degeneration (IDD) causes pain in the back and neck. This study investigated the role of long non-coding RNA HLA complex group 18 (HCG18) in a cell model of IDD. An IDD model was established by stimulating nucleus pulposus (NP) cells with interleukin (IL)-1 beta. MTT assay was performed to evaluate NP cell viability. The apoptosis was detected by flow cytometry. The expressions of HCG18, microRNA (miR)-495-3p, and follistatin-like protein-1 (FSTL1) were measured by RT-qPCR. The interactions of miR-495-3p with HCG18 and FSTL1 were analyzed by luciferase reporter assay. IL-1 beta stimulation upregulated HCG18 and FSTL1, but downregulated miR-495-3p in NP cells. Silencing of HCG18 or FSTL1, as well as miR-495-3p overexpression in NP cells alleviated IL-1 beta-induced apoptosis and inflammation of NP cells. Both HCG18 and FSTL1 had binding sites for miR-495-3p. Overexpression of FSTL1 abolished the effects of HCG18 silencing on IL-1 beta-induced apoptosis and inflammation. The HCG18/miR-495-3p/FSTL1 axis is essential for IDD development. Therapeutic strategies targeting this axis may be used for IDD treatment.
摘要：
BACKGROUND: High myopia (HM) refers to an eye refractive error exceeding -5.00 D, significantly elevating blindness risk. The underlying mechanism of HM remains elusive. Given the extensive genetic heterogeneity and vast genetic base opacity, it is imperative to identify more causative genes and explore their pathogenic roles in HM. METHODS: We employed exome sequencing to pinpoint the causal gene in an HM family. Sanger sequencing was used to confirm and analyse the gene mutations in this family and 200 sporadic HM cases. Single-cell RNA sequencing was conducted to evaluate the gene's expression patterns in developing human and mouse retinas. The CRISPR/Cas9 system facilitated the gene knockout cells, aiding in the exploration of the gene's function and its mutations. Immunofluorescent staining and immunoblot techniques were applied to monitor the functional shifts of the gene mutations at the cellular level. RESULTS: A suspected nonsense mutation (c.C172T, p.Q58X) in CCDC66 was found to be co-segregated with the HM phenotype in the family. Additionally, six other rare variants were identified among the 200 sporadic patients. CCDC66 was consistently expressed in the embryonic retinas of both humans and mice. Notably, in CCDC66-deficient HEK293 cells, there was a decline in cell proliferation, microtube polymerisation rate and ace-tubulin level. Furthermore, the mutated CCDC66 failed to synchronise with the tubulin system during Hela cell mitosis, unlike its wild type counterpart. CONCLUSIONS: Our research indicates that the CCDC66 variant c.C172T is associated with HM. A deficiency in CCDC66 might disrupt cell proliferation by influencing the mitotic process during retinal growth, leading to HM.
关键词：
Nonradical oxidation;Ni-N4;Peroxymonosulfate;Charge transfer process;High-valent Ni species
摘要：
In this work, we revealed a dual -pathway nonradical oxidation (NRO) system catalyzed by Ni single atom catalyst (NiN4) accommodated in the carbon nitride substrate. The monatomic Ni coordinated with four N atoms (Ni-N4) is determined as the dynamic catalytic center for peroxymonosulfate (PMS) activation, showing an exceptional specific rate constant of 3.34 min -1 g-2 L-2 (29.7 times that of CN/PMS system) in oxidizing bisphenol A and other refractory organics. In situ Raman, X-ray absorption, and electrochemical analyses as well as theoretical simulations demonstrate that the Ni-N4 sites exhibit strong interaction with PMS benefited from the modulated electronic structures, resulting in nonradical surface -bonding active complexes (NiN4-PMS*) and deuterogenic high-valent Ni(IV)-Oxo species. The dual -pathway NRO process will spontaneously coordinate both electron transfer process via CN matrix and direct electron transfer by Ni(IV)-Oxo for selective organic oxidation with excellent anti -interference ability and adaptability.
期刊：
Naunyn-Schmiedeberg's Archives of Pharmacology,2024年397(1):627-627 ISSN：0028-1298
通讯作者：
Xiao, Junhui;Li, R
作者机构：
[Shen, Lixian; Tang, Lijing; Li, Rong; Li, R; Xiao, Junhui; Wang, Mei; Xiao, JH; Liu, Meng] Univ South China, Affiliated Hosp 2, Hengyang Med Sch, Dept Pharm, Hengyang 421001, Hunan, Peoples R China.;[Wang, Mei; Liu, Meng] Univ South China, Sch Pharmaceut Sci, Hengyang Med Sch, Dept Pharm & Pharmacol, Hengyang 421000, Hunan, Peoples R China.
通讯机构：
[Li, R ; Xiao, JH] U;Univ South China, Affiliated Hosp 2, Hengyang Med Sch, Dept Pharm, Hengyang 421001, Hunan, Peoples R China.
关键词：
Doxorubicin;Ferroptosis;Liquiritin;Solute carrier family 7 member;Glutathione peroxidase 4
摘要：
Solute carrier family 7 member (SLC7A11) and glutathione peroxidase 4 (GPX4) mediated ferroptosis in doxorubicin-induced cardiotoxicity. Based on the bioinformatics analysis, liquiritin, a flavonoid isolated from the rhizome part of Glycyrrhiza glabra with activities of anti-inflammatory and anti-oxidant, is forecasted to synchronously with ferroptosis-relevant protein. This study aims to investigate the effect of liquiritin on doxorubicin-induced cardiotoxicity and the underlying mechanisms. The C57BL/6 J mice heart or cardiomyocytes were subjected to doxorubicin in vivo or in vitro, which were treated with liquiritin at different dosages. The heart or H9c2 cell cardiotoxicity, relevant protein levels, and ferroptosis were measured by methods of biochemistry, flow cytometry, or Western blot. The mice treated with doxorubicin showed evident cardiotoxicity, concomitant with the downregulation of SLC7A11 and GPX4, and accelerate ferroptosis. Administration of liquiritin could relieve the heart injury, accompanied by restoration of the levels of SLC7A11 and GPX4, and inhibit ferroptosis. And liquiritin ameliorated similar effects in doxorubicin-treated H9c2 cells. Based on these findings, we conclude that liquiritin can protect the doxorubicin-induce mice's cardiotoxicity, and its beneficial effect is related to the reduction of ferroptosis through a mechanism involving the regulation of the SLC7A11/GPX4 pathway.
摘要：
Radiation encephalopathy (RE) refers to radiation-induced brain necrosis and is a life-threatening complication in patients with nasopharyngeal carcinoma (NPC) after radiotherapy (RT), and radiation-induced pre-symptomatic glymphatic alterations have not yet been investigated. We used diffusion tensor image analysis along the perivascular space (DTI-ALPS) index to examine the pre-symptomatic glymphatic alterations in NPC patients following RT. A total of 109 patients with NPC consisted of Pre-RT (n = 35) and Post-RT (n = 74) cohorts were included. The post-RT NPC patients, with normal-appearing brain structure at the time of MRI, were further divided into Post-RT-RE- (n = 58) and Post-RT-RE+ (n = 16) subgroups based on the detection of RE in follow-up. We observed lower DTI-ALPS (left) index, DTI-ALPS (right) index and DTI-ALPS (whole brain) index in post-RT patients than that in pre-RT patients (p < 0.05). We further found that post-RT-RE+ patients demonstrated significantly lower DTI-ALPS (right) (p = 0.013), DTI-ALPS (whole brain) (p = 0.011) and marginally lower DTI-ALPS (left) (p = 0.07) than Post-RT (non-RE) patients. Significant negative correlations were observed between the maximum dosage of radiation-treatment (MDRT) and DTI-ALPS (left) index (p = 0.003) as well as DTI-ALPS (whole brain) index (p = 0.004). Receiver operating characteristic (ROC) curve analysis showed that DTI-ALPS (whole brain) index exhibited good performance (AUC = 0.706) in identifying patients more likely developing RE. We concluded that glympathic function was impaired in NPC patients following RT and DTI-ALPS index may serve as a novel imaging biomarker for diagnosis of RE.
摘要：
Understanding the stress distribution and failure characteristics around a U-shaped cavern is vital to the stability analysis of rock structures such as tunnels and roadways. In this study, the stress distribution around a U-shaped cavern with different height-to-width (h/w) ratios under biaxial compression was first analyzed based on the complex variable theory. Then, numerical simulations were conducted using PFC2D to study the failure process and energy evolution around a U-shaped cavern with different h/w ratios. Theoretical solution shows that the maximum stress concentration factor occurs at the bottom corner of the U-shaped cavern. With the h/w ratio increasing from 0.75 to 3.0, the stress concentration factor around the sidewall shows a declining trend, while the opposite trend is observed in the vault and floor. Numerical results show that when the maximum principal stress is parallel to the vertical direction, the thin slab buckling occurs in the sidewall of the cavern with low h/w ratios (h/w = 0.75 and 1.0), accompanied by the release of relatively high kinetic energy. Instead, the wedged-shaped slab spalling occurs in the sidewall of the cavern with high h/w ratios (h/w = 1.5, 2.0 and 3.0), which can be considered as a static process. Although the U-shaped cavern with low h/w ratios has higher integrity after failure, more stain energy is accumulated in the remaining surrounding rock, which is likely to cause rockbursts under a higher stress state or dynamic disturbance. When the maximum principal stress is horizontal, the rock slab separates from the cavern floor and presents a reverse trend with the increasing h/w ratio. The above results indicate that the h/w ratio and the direction of maximum principal stress should be considered comprehensively in the design of the support system of U-shaped caverns.
摘要：
Gram-negative Bartonella species are facultative intracellular bacteria that can survive in the harsh intracellular milieu of host cells. They have evolved strategies to evade detection and degradation by the host immune system, which ensures their proliferation in the host. Following infection, Bartonella alters the initial immunogenic surface-exposed proteins to evade immune recognition via antigen or phase variation. The diverse lipopolysaccharide structures of certain Bartonella species allow them to escape recognition by the host pattern recognition receptors. Additionally, the survival of mature erythrocytes and their resistance to lysosomal fusion further complicate the immune clearance of this species. Certain Bartonella species also evade immune attacks by producing biofilms and anti-inflammatory cytokines and decreasing endothelial cell apoptosis. Overall, these factors create a challenging landscape for the host immune system to rapidly and effectively eradicate the Bartonella species, thereby facilitating the persistence of Bartonella infections and creating a substantial obstacle for therapeutic interventions. This review focuses on the effects of three human-specific Bartonella species, particularly their mechanisms of host invasion and immune escape, to gain new perspectives in the development of effective diagnostic tools, prophylactic measures, and treatment options for Bartonella infections.
期刊：
International Journal of Biological Macromolecules,2024年254(Pt 3):128008 ISSN：0141-8130
通讯作者：
Wang, HQ
作者机构：
[Wang, HQ; Wang, Hongqiang; Wang, Qingliang; Gan, Jiali; Xin, Qi; Hu, Eming; Le, Dongdong; Lei, Zhiwu] Univ South China, Sch Resource Environm & Safety Engn, Hengyang 421001, Peoples R China.;[Wang, Hongqing] Univ South China, Sch Chem & Chem Engn, Hengyang 421001, Peoples R China.
通讯机构：
[Wang, HQ ] U;Univ South China, Sch Resource Environm & Safety Engn, Hengyang 421001, Peoples R China.
关键词：
Hydrogel;Phytic acid;Uranium adsorption
摘要：
In order to improve the removal rate of uranium and reduce the harm of radioactive pollution, a physically crosslinked polyvinyl alcohol/phosphorylated chitosan (PPP) hydrogel electrode was designed by freezing thawing method. The results show that PPP hydrogel has a good adsorption effect on uranium, and 200mL of uranium tailings leachate is absorbed, and the treatment efficiency reaches 100% within 15min. PPP hydrogel can adapt to a wide range of pH conditions and exhibit excellent adsorption efficiency in the range of 3-9. At the same time, PPP hydrogel maintains an adsorption efficiency of over 85% for 950mg/L uranium solution. This lays the foundation for the practical application of PPP hydrogel. In addition, PPP hydrogel also exhibits good repeatability, after 7cycles, the material still retains 95% of its initial performance. The synergistic effect of various functional groups such as phosphate, hydroxyl, and ammonium in the material is the main mechanism of PPP's adsorption capacity for uranium. Furthermore, electrochemical adsorption method significantly enhances the adsorption performance of PPP hydrogel.
通讯机构：
[Guo, ZM ] U;Univ South China, Sch Resources Environm & Safety Engn, Hengyang 421001, Peoples R China.
关键词：
Heterocoagulation;Microhydrodynamics;DLVO theoretical calculation;Collision frequency
摘要：
Heterocoagulation between mineral particles is an important phenomenon in mineral processing. Although various characterization methods have been available for characterizing heterocoagulation, in-situ characterization techniques are still lacking. In the present work, a novel in-situ particle vision and measurement (PVM) system was developed to investigate heterocoagulation between coarse and fine particles, which is consistent with the common situation of mineral processing. The heterocoagulation between fine coal particles and coarse glass beads was observed at different pH values and stirring speeds. It was found that the heterocoagulation degree decreased with the increase of pH, which is consistent with the DLVO theoretical calculation results. The heterocoagulation degree decreased with the increase of stirring speed. This indicated that heterocoagulation can be inhibited by high intensity conditioning. Moreover, it was observed that the coated coal particles were not randomly distributed on the glass bead surface. Under certain hydrodynamic conditions, the coal particles were even more distributed at the rear of the glass bead. It is concluded that the microhydrodynamics has a significant effect on the collision frequency and heterocoagulation.
摘要：
Bladder carcinoma represents a prevalent malignancy, wherein the influence of sex extends across its incidence, biological attributes, and clinical outcomes. This scholarly exposition meticulously examines pertinent investigations, elucidating the nuanced impact of sex on bladder cancer, and posits cogent avenues for future research and intervention modalities. In the initial discourse, an exhaustive scrutiny is undertaken of the etiological underpinnings of bladder cancer, encompassing variables such as tobacco consumption, occupational exposures, and genetic aberrations. Subsequently, a comprehensive dissection unfolds, delving into the intricate biological disparities inherent in sex vis-à-vis the initiation and progression of bladder cancer. This analytical framework embraces multifaceted considerations, spanning sex hormones, sex chromosomal dynamics, metabolic enzymatic cascades, and the intricate interplay with the microbiome. Lastly, a synthesized exposition encapsulates the ramifications of gender differentials on the diagnostic and prognostic landscapes of bladder cancer, underscoring the imperative for intensified investigative endeavors directed towards elucidating gender-specific variances and the formulation of tailored therapeutic strategies.
