Recombinant BCG vaccine expressing multistage antigens of Mycobacterium tuberculosis provides long-term immunity against tuberculosis in BALB/c mice

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作者信息关键词期刊信息基础信息归属信息摘要

成果类型：

期刊论文

作者：

Fang, Danang;Wang, Ruihuan;Fan, Xueting;Li, Machao;Qian, Chenyu;...

通讯作者：

Liu, Haican;Wan, KL;Lou, YL

作者机构：

[Fang, Danang; Qian, Chenyu; Lou, Yongliang] Wenzhou Med Univ, Sch Lab Med & Life Sci, Wenzhou, Peoples R China.

[Wang, Ruihuan; Liu, Haican; Fan, Xueting; Fang, Danang; Li, Machao; Wan, Kanglin] Chinese Ctr Dis Control & Prevent, Natl Inst Communicable Dis Control & Prevent, Natl Key Lab Intelligent Tracking & Forecasting In, Beijing, Peoples R China.

[Yu, Jinjie; Cao, Bin] Univ South China, Sch Publ Hlth, Hengyang, Peoples R China.

[Liu, Haican; Liu, HC; Wan, KL; Wan, Kanglin] Chinese Ctr Dis Control & Prevent, Natl Inst Communicable Dis Control & Prevent, Natl Key Lab Intelligent Tracking & Forecasting In, Beijing 102206, Peoples R China.

[Lou, Yongliang] Wenzhou Med Univ, Sch Lab Med & Life Sci, Wenzhou 325035, Peoples R China.

通讯机构：

[Wan, KL ; Liu, HC] C

[Lou, YL ] W

Chinese Ctr Dis Control & Prevent, Natl Inst Communicable Dis Control & Prevent, Natl Key Lab Intelligent Tracking & Forecasting In, Beijing 102206, Peoples R China.

Wenzhou Med Univ, Sch Lab Med & Life Sci, Wenzhou 325035, Peoples R China.

语种：

英文

关键词：

Mycobacterium tuberculosis;Tuberculosis;cytokine;multicomponent fusion antigen;recombinant BCG vaccine

期刊：

Human Vaccines & Immunotherapeutics

ISSN：

2164-5515

年：

2024

卷：

期：

页码：

2299607

DOI：

10.1080/21645515.2023.2299607

机构署名：

本校为其他机构

院系归属：

公共卫生学院

摘要：

Tuberculosis (TB) caused by Mycobacterium tuberculosis (Mtb) persistently kills nearly 1.5 million lives per year in the world, whereas the only licensed TB vaccine BCG exhibits unsatisfactory efficacy in adults. Taking BCG as a vehicle to express Mtb antigens is a promising way to enhance its efficacy against Mtb infection. In this study, the immune efficacy of recombination BCG (rBCG-ECD003) expressing specific antigens ESAT-6, CFP-10, and nDnaK was evaluated at different time points after immunizing BALB/c mice. The results revealed that rBC...

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Recombinant BCG vaccine expressing multistage antigens of Mycobacterium tuberculosis provides long-term immunity against tuberculosis in BALB/c mice

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