Recombinant BCG vaccine expressing multistage antigens of Mycobacterium tuberculosis provides long-term immunity against tuberculosis in BALB/c mice

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成果类型：

期刊论文

作者：

Fang, Danang;Wang, Ruihuan;Fan, Xueting;Li, Machao;Qian, Chenyu;...

通讯作者：

Liu, Haican;Wan, KL;Lou, YL

作者机构：

[Fang, Danang; Qian, Chenyu; Lou, Yongliang] Wenzhou Med Univ, Sch Lab Med & Life Sci, Wenzhou, Peoples R China.

[Wang, Ruihuan; Liu, Haican; Fan, Xueting; Fang, Danang; Li, Machao; Wan, Kanglin] Chinese Ctr Dis Control & Prevent, Natl Inst Communicable Dis Control & Prevent, Natl Key Lab Intelligent Tracking & Forecasting In, Beijing, Peoples R China.

[Yu, Jinjie; Cao, Bin] Univ South China, Sch Publ Hlth, Hengyang, Peoples R China.

[Liu, Haican; Liu, HC; Wan, KL; Wan, Kanglin] Chinese Ctr Dis Control & Prevent, Natl Inst Communicable Dis Control & Prevent, Natl Key Lab Intelligent Tracking & Forecasting In, Beijing 102206, Peoples R China.

[Lou, Yongliang] Wenzhou Med Univ, Sch Lab Med & Life Sci, Wenzhou 325035, Peoples R China.

通讯机构：

[Wan, KL ; Liu, HC] C

[Lou, YL ] W

Chinese Ctr Dis Control & Prevent, Natl Inst Communicable Dis Control & Prevent, Natl Key Lab Intelligent Tracking & Forecasting In, Beijing 102206, Peoples R China.

Wenzhou Med Univ, Sch Lab Med & Life Sci, Wenzhou 325035, Peoples R China.

语种：

英文

关键词：

bacterial antigen;BCG vaccine;culture filtrate protein 10;early secretory antigenic target 6;epitope;gamma interferon;granulocyte macrophage colony stimulating factor;interleukin 10;interleukin 12;interleukin 17;interleukin 2;interleukin 4;interleukin 6;major histocompatibility antigen class 2;nDnaK antigen;rbcg ecd003;tumor necrosis factor;unclassified drug;BCG vaccine;interleukin 2;animal experiment;animal tissue;Article;assay;bacterial growth;bacterium culture;CD4+ T lymphocyte;colony forming unit;controlled study;cytokine production;cytokine release;DNA sequencing;drug safety;enzyme linked immunosorbent assay;enzyme linked immunospot assay;female;flow cytometry;growth inhibition;humoral immunity;immunity;immunization;in vitro study;luminex multiplex cytokine assay;mouse;mycobacterial growth inhibition assay;Mycobacterium bovis BCG;Mycobacterium tuberculosis;nonhuman;polymerase chain reaction;Th1 cell;vaccine immunogenicity;animal;Bagg albino mouse;tuberculosis;Animals;BCG Vaccine;Immunity, Humoral;Interleukin-2;Mice;Mice, Inbred BALB C;Mycobacterium tuberculosis;Tuberculosis

期刊：

Human Vaccines & Immunotherapeutics

ISSN：

2164-5515

年：

2024

卷：

期：

页码：

2299607

DOI：

10.1080/21645515.2023.2299607

基金类别：

This work was financially supported by the projects of 2018ZX10731301-002. The funders had no role in the study design, data collection and analysis, manuscript preparation or decision to publish. We would like to thank the collaboration of the Laboratory Animal Center, Chinese Center for Disease Control and Prevention, for their help and support in the animal experiments.

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本校为其他机构

院系归属：

公共卫生学院

摘要：

Tuberculosis (TB) caused by Mycobacterium tuberculosis (Mtb) persistently kills nearly 1.5 million lives per year in the world, whereas the only licensed TB vaccine BCG exhibits unsatisfactory efficacy in adults. Taking BCG as a vehicle to express Mtb antigens is a promising way to enhance its efficacy against Mtb infection. In this study, the immune efficacy of recombination BCG (rBCG-ECD003) expressing specific antigens ESAT-6, CFP-10, and nDnaK was evaluated at different time points after immunizing BALB/c mice. The results revealed that rBC...

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Recombinant BCG vaccine expressing multistage antigens of Mycobacterium tuberculosis provides long-term immunity against tuberculosis in BALB/c mice

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