Luo, Yi;He, Youzhi;Wang, Yongfu;Xu, Yuxia;Yang, Li
通讯作者：
Yi Luo
作者机构：
[He, Youzhi; Yang, Li; Xu, Yuxia; Luo, Yi; Wang, Yongfu] Univ South China, Affiliated Changsha Cent Hosp, Hengyang Med Sch, Dept Spine Surg, 161 Shaoshan South Rd, Changsha 410007, Hunan, Peoples R China.
通讯机构：
[Yi Luo] T
The Affiliated Changsha Central Hospital, Department of Spine Surgery, Hengyang Medical School, University of South China, Changsha, Changsha, People’s Republic of China
This work was supported by Scientific research project of Health Commission of Hunan Province (No.202204072873).
机构署名：
本校为第一机构
摘要：
Intervertebral disc degeneration (IDD) causes pain in the back and neck. This study investigated the role of long non-coding RNA HLA complex group 18 (HCG18) in a cell model of IDD. An IDD model was established by stimulating nucleus pulposus (NP) cells with interleukin (IL)-1 beta. MTT assay was performed to evaluate NP cell viability. The apoptosis was detected by flow cytometry. The expressions of HCG18, microRNA (miR)-495-3p, and follistatin-like protein-1 (FSTL1) were measured by RT-qPCR. The interactions of miR-495-3p with HCG18 and FSTL1 were analyzed by luciferase reporter assay. IL-1 ...
