期刊：
NEW JOURNAL OF CHEMISTRY,2024年48(6):2855-2865 ISSN：1144-0546
通讯作者：
Sun, YK;Sun, Yunkai;Yang, PF
作者机构：
[Ding, Yi; Sun, Yunkai] Changzhou Inst Technol, Sch Chem Engn & Mat, Changzhou 213032, Peoples R China.;[Yang, Pengfei; Liu, Cheng; Sun, Yunkai; Yin, Na] Univ South China, Sch Chem & Chem Engn, Hengyang 421001, Peoples R China.;[Ding, Yi; Sun, Yunkai] Changzhou Inst Technol, Ind Coll Carbon Fiber & New Mat, Changzhou 213032, Peoples R China.
通讯机构：
[Sun, YK ] C;[Sun, YK; Yang, PF ] U;Changzhou Inst Technol, Sch Chem Engn & Mat, Changzhou 213032, Peoples R China.;Univ South China, Sch Chem & Chem Engn, Hengyang 421001, Peoples R China.;Changzhou Inst Technol, Ind Coll Carbon Fiber & New Mat, Changzhou 213032, Peoples R China.
摘要：
Nanoscale zero-valent iron (nZVI) was cured by vulcanization and biochar functionalization to overcome the tendency of oxidation and aggregation, and the sulfurized nano-zero-valent iron functional material supported by amino biochar (SnZVI-BC-NH2) was obtained, which was used to remove U(VI) from wastewater in this study. A variety of measurements (SEM, TEM, XRD, BET, VSM, FT-IR, and XPS) were used to characterize the morphology, structure, magnetic properties, characteristic functional groups and chemical bonds of SnZVI-BC-NH2. Analysis results confirm that the aminated biochar can support sulfurized nZVI well. The good kinetics, thermodynamics, and large removal capacity data (at pH 6, T = 298 K, Q(m) = 158.1 mg g(-1)) indicate that SnZVI-BC-NH2 has excellent removal performance for U(VI), and the experimental data are in good agreement with the pseudo-second-order kinetic model. Cycling and anti-oxidation tests demonstrate that the FeSx shell plays a crucial role in enhancing the removal of SnZVI-BC-NH2 on U(VI). XPS and FT-IR analysis results show that SnZVI-BC-NH2 removes U(VI) through the synergistic effect of adsorption and reduction.
摘要：
Electrosorption holds extraordinary promise for uranium (U(VI)) capture but is still limited by the finite accessible active sites of electrode materials, poor surface wettability and its intrinsic co-ion repulsion effect. Here we originally designed KOH-etched porous graphitic carbon nitride (g-C3N4) as active material, and multi-functional crosslinked xanthan gum-polyacrylic acid (XG-PAA) as binder to fabricate g-C3N4-X electrode for U(VI) capture. The abundant in-plane nanopores on 2D g-C3N4 lamellar, rich O- and N-containing active sites, and 3D tough interconnected conductive architecture, endowed g-C3N4-X electrode with fast electron/ion transport channels, alleviated co-ions exclusion, superior electrochemical properties, and hydrophilicity. These unique structure characteristics enabled U(VI) ions to form micro electric-field attraction with negatively charged COO- groups in advance to alleviate co-ion repulsion, then to electro-migrate towards and coordinate with active sites, and eventually to be electrocatalytic reduced into U(IV) deposits. Consequently, the g-C3N4-X electrode exhibited a 1.87 times faster adsorption kinetics, a much higher removal ratio of 98.1% within 70 min than traditional PVDF-bound electrode. Meanwhile, the cumulative adsorption capacity of g-C3N4-X electrode after six cycles was up to 1459.1 mg g−1. This efficient, scalable, and cost-effective g-C3N4-X electrode represents a significant step forward toward the practical applications of U(VI) electrosorption.
作者机构：
[Li, Ye; Zhang, Yuexin; Li, Chunquan; Zhao, Yu; Huang, Xuemei; Xie, Liyuan; Zhang, Guorui; Zhao, Jun; Fan, Shifan; Song, Chao] Univ South China, Hengyang Med Sch, Affiliated Hosp 1, Hengyang 421001, Hunan, Peoples R China.;[Li, Ye; Zhang, Yuexin; Li, Chunquan; Zhao, Yu; Huang, Xuemei; Xie, Liyuan; Zhang, Guorui; Zhao, Jun; Fan, Shifan; Song, Chao] Univ South China, Hengyang Med Sch, MOE Key Lab Rare Pediat Dis, Hengyang 421001, Hunan, Peoples R China.;[Li, Ye; Zhang, Yuexin; Zhang, Qinyi; Li, Chunquan; Zhao, Yu; Huang, Xuemei; Xie, Liyuan; Zhang, Guorui; Fan, Shifan; Song, Chao] Univ South China, Sch Comp, Hengyang 421001, Hunan, Peoples R China.;[Li, Chunquan] Univ South China, Hunan Prov Maternal & Child Hlth Care Hosp, Hengyang Med Sch, Key Lab Birth Defect Res & Prevent,Natl Hlth Commi, Hengyang 421001, Hunan, Peoples R China.;[Li, Ye; Zhang, Yuexin; Li, Chunquan; Zhao, Yu; Huang, Xuemei; Xie, Liyuan; Zhang, Guorui; Fan, Shifan; Song, Chao] Univ South China, Affiliated Hosp 1, Cardiovasc Lab Big Data & Imaging ArtificialIntell, Hengyang Med Sch, Hengyang 421001, Hunan, Peoples R China.
通讯机构：
[Li, CQ ] U;Univ South China, Hengyang Med Sch, Affiliated Hosp 1, Hengyang 421001, Hunan, Peoples R China.;Univ South China, Hengyang Med Sch, MOE Key Lab Rare Pediat Dis, Hengyang 421001, Hunan, Peoples R China.;Univ South China, Sch Comp, Hengyang 421001, Hunan, Peoples R China.;Univ South China, Hunan Prov Maternal & Child Hlth Care Hosp, Hengyang Med Sch, Key Lab Birth Defect Res & Prevent,Natl Hlth Commi, Hengyang 421001, Hunan, Peoples R China.
关键词：
genes;mice;candidate disease gene;inference;multiomics;oncogenes;enhancer of transcription;cell lines;transcription factor
摘要：
Gene regulatory networks (GRNs) are interpretable graph models encompassing the regulatory interactions between transcription factors (TFs) and their downstream target genes. Making sense of the topology and dynamics of GRNs is fundamental to interpreting the mechanisms of disease etiology and translating corresponding findings into novel therapies. Recent advances in single-cell multi-omics techniques have prompted the computational inference of GRNs from single-cell transcriptomic and epigenomic data at an unprecedented resolution. Here, we present scGRN (https://bio.liclab.net/scGRN/), a comprehensive single-cell multi-omics gene regulatory network platform of human and mouse. The current version of scGRN catalogs 237 051 cell type-specific GRNs (62 999 692 TF-target gene pairs), covering 160 tissues/cell lines and 1324 single-cell samples. scGRN is the first resource documenting large-scale cell type-specific GRN information of diverse human and mouse conditions inferred from single-cell multi-omics data. We have implemented multiple online tools for effective GRN analysis, including differential TF-target network analysis, TF enrichment analysis, and pathway downstream analysis. We also provided details about TF binding to promoters, super-enhancers and typical enhancers of target genes in GRNs. Taken together, scGRN is an integrative and useful platform for searching, browsing, analyzing, visualizing and downloading GRNs of interest, enabling insight into the differences in regulatory mechanisms across diverse conditions. Graphical Abstract
作者：
Ji, Hong-Tao;Jiang, Jun;He, Wei-Bao;Lu, Yu-Han;Liu, Yuan-Yuan;...
期刊：
JOURNAL OF ORGANIC CHEMISTRY,2024年89(6):4113-4119 ISSN：0022-3263
通讯作者：
He, WM
作者机构：
[He, Wei-Bao; Lu, Yu-Han; He, Wei-Min; Li, Xiao; Ji, Hong-Tao; Liu, Yuan-Yuan; Jiang, Jun; He, WM] Univ South China, Sch Chem & Chem Engn, Hengyang 421001, Peoples R China.
通讯机构：
[He, WM ] U;Univ South China, Sch Chem & Chem Engn, Hengyang 421001, Peoples R China.
摘要：
The first example of an electrochemical multicomponent synthesis of selenium-containing compounds with inexpensive and abundant elemental selenium as the selenating reagent was developed. A variety of selenazol-2-amines were constructed in high yields with good functional group tolerance under metal-free and chemical oxidant-free conditions.
摘要：
This study proposes and develops a novel ionic concentration gradient electric generator (i‐CGEG) based on the evaporation rate difference of electrolytes. The i‐CGEG with PVA–Na electrolyte achieves a thermovoltage greater than 200 mV and an energy density of 77.94 J m−2 at a temperature of 323 K. Wearable devices and their corresponding cell modules are also developed to recycle body heat. Abstract Constructing concentration differences between anions and cations at the ends of an ionic conductor is an effective strategy in electricity generation for powering wearable devices. Temperature gradient or salinity gradient is the driving force behind such devices. But their corresponding power generation devices are greatly limited in actual application due to their complex structure and harsh application conditions. In this study, a novel ionic concentration gradient electric generator based on the evaporation difference of the electrolyte is proposed. The device can be constructed without the need for semipermeable membranes, and operation does not need to build a temperature difference. As a demonstration, a PVA–Na ionic hydrogel is prepared as an electrolyte for the device and achieved a thermovoltage of more than 200 mV and an energy density of 77.94 J m−2 at 323 K. Besides, the device exhibits the capability to sustain a continuous voltage output for a duration exceeding 1500 min, as well as enabling charging and discharging cycles for 100 iterations. For practical applications, a module comprising 16 sub‐cells is constructed and successfully utilized to directly power a light‐emitting diode. Wearable devices and their corresponding cell modules are also developed to recycle body heat.
期刊：
International Journal of Biological Macromolecules,2024年254(Pt 3):128008 ISSN：0141-8130
通讯作者：
Wang, HQ
作者机构：
[Wang, HQ; Wang, Hongqiang; Wang, Qingliang; Gan, Jiali; Xin, Qi; Hu, Eming; Le, Dongdong; Lei, Zhiwu] Univ South China, Sch Resource Environm & Safety Engn, Hengyang 421001, Peoples R China.;[Wang, Hongqing] Univ South China, Sch Chem & Chem Engn, Hengyang 421001, Peoples R China.
通讯机构：
[Wang, HQ ] U;Univ South China, Sch Resource Environm & Safety Engn, Hengyang 421001, Peoples R China.
关键词：
Hydrogel;Phytic acid;Uranium adsorption
摘要：
In order to improve the removal rate of uranium and reduce the harm of radioactive pollution, a physically crosslinked polyvinyl alcohol/phosphorylated chitosan (PPP) hydrogel electrode was designed by freezing thawing method. The results show that PPP hydrogel has a good adsorption effect on uranium, and 200mL of uranium tailings leachate is absorbed, and the treatment efficiency reaches 100% within 15min. PPP hydrogel can adapt to a wide range of pH conditions and exhibit excellent adsorption efficiency in the range of 3-9. At the same time, PPP hydrogel maintains an adsorption efficiency of over 85% for 950mg/L uranium solution. This lays the foundation for the practical application of PPP hydrogel. In addition, PPP hydrogel also exhibits good repeatability, after 7cycles, the material still retains 95% of its initial performance. The synergistic effect of various functional groups such as phosphate, hydroxyl, and ammonium in the material is the main mechanism of PPP's adsorption capacity for uranium. Furthermore, electrochemical adsorption method significantly enhances the adsorption performance of PPP hydrogel.
摘要：
Land-based uranium resources are becoming scarce because of the widespread development and use of nuclear energy. Therefore, to make up for the shortage of uranium resources, a new chitosan/carboxymethyl-β-cyclodextrin/quaternary ammonium salt-functionalized amidoxime carbon adsorbent (CSAOCF) was designed and synthesized for extracting uranium from seawater. Experimental studies show that the adsorption of uranium by CSAOCF is a spontaneous endothermic reaction and chemical adsorption. The theoretical maximum adsorption capacity of uranium can reach 726mg/g at 308K and pH=6. Moreover, the adsorption efficiency and selectivity of CSAOCF for uranium were significantly improved after the introduction of the carboxymethyl group, and the selection and partition coefficient of CSAOCF for uranium and vanadium increased from 16-fold to 30-fold under the same conditions. This indicates that there is a synergistic effect between carboxyl and amidoxime groups, which can promote the adsorption of uranium by CSAOCF. Furthermore, CSAOCF exhibits good oil resistance and can be reused more than five times. Therefore, CSAOCF containing carboxymethyl and amidoxime functional groups can considerably improve the selective adsorption of uranium and has great potential in the extraction of uranium from seawater.
期刊：
European Journal of Medicinal Chemistry,2024年263:115956 ISSN：0223-5234
通讯作者：
Mi, Pengbing;Yuan, Zhonghua;Zheng, X;Lin, YW
作者机构：
[Tan, Yan; Yuan, Zhonghua; Mi, Pengbing; Jiang, Jinhuan; Chen, Limei; Luo, Jianxiong; Zheng, Xing; Ye, Shiying; Lin, Yuqing; Zheng, X] Univ South China, Dept Pharm, Hengyang Med Sch, Hengyang 421001, Hunan, Peoples R China.;[Lang, Jia-Jia; Lin, Ying-Wu] Univ South China, Sch Chem & Chem Engn, Hengyang 421001, Hunan, Peoples R China.;[Lang, Jia-Jia; Lin, Ying-Wu; Mi, Pengbing] Univ South China, Key Lab Prot Struct & Funct Univ Hunan Prov, Hengyang 421001, Hunan, Peoples R China.;[Zheng, Xing] Hunan Vocat Coll Sci & Technol, Dept Pharm, Changsha 410004, Hunan, Peoples R China.;[Lv, You] Shaanxi Univ Sci & Technol, Coll Bioresources Chem & Mat Engn, Xian 710021, Shaanxi, Peoples R China.
通讯机构：
[Yuan, ZH; Mi, PB; Lin, YW ; Zheng, X ] U;Univ South China, Dept Pharm, Hengyang Med Sch, Hengyang 421001, Hunan, Peoples R China.;Univ South China, Sch Chem & Chem Engn, Hengyang 421001, Hunan, Peoples R China.
关键词：
Human monoamine oxidase B inhibitor;Thiochromone;Thiochromone S,S-dioxide
摘要：
Developing new scaffolds for highly potent and selective inhibitors of human Monoamine Oxidase B (hMAO-B) is a crucial objective in enhancing the efficacy and safety in the clinical treatment of neurodegenerative diseases. In this study, we have identified a series of C-3 isoxazole-substituted thiochromone S,S-dioxide derivatives that exhibit strong inhibitory activity against hMAO-B. The strategy of oxidizing thiochromone to thiochromone S,S-dioxide solves the key defect of extreme insolubility observed for thiochromone analogues. In addition, the sulfone group contributes extra hydrogen(H)-bonding interactions with Tyr435, which significantly increases the activity of thiochromone S,S-dioxide derivatives against hMAO-B. Furthermore, the presence of isoxazole group provides potential H-bonding interaction and electrostatic interaction with the residue of Tyr326, while the rigid aryl ring introduces a potential steric conflict with Phe208 of hMAO-A to improve both potency and selectivity. In our investigations, several compounds (9c, 10c, 10e, 10g, 10l and 10m) demonstrate remarkable single-digit nanomolar potency. These compounds exhibit favorable cytotoxicity profiles in both differentiated SH-SY5Y and HVSMC cells, without apparent cardiotoxic effects. Moreover, compounds 10e and 10h do not lead to an increase in ROS levels in differentiated SH-SY5Y cells, further demonstrating their potential as safe and effective hMAO-B inhibitors. These findings indicate that the C-3 isoxazole substituted thiochromone S,S-dioxide analogues are potential leading compounds for the development of selective inhibitors with high potency.
摘要：
In the classical route of synthesizing of avanafil, the last step of the reaction uses EDCI and HOBT as an acid and amine binding agent. HOBT may contain residues of hydrazine, and potential mutagenic impurities containing acylhydrazide structures may be formed. The intermediate product (M6) of avanafil was synthesized by 6 steps using diethyl ethoxylmethylmalonate and S-methyl isothiourea semisulfide as starting materials. The potentially genotoxic impurity E (Imp-E) of avanafil was given by the reaction of M6 and hydrazine sulfate acid amine, yield of 20%. The single crystal of Imp-E was cultivated by solvent volatilization method, and its structure was analyzed by high resolution mass spectrometry (HRMS) and nuclear magnetic resonance spectroscopy (NMR). The Flack parameter of Imp-E was -0.03(3) by X-ray single crystal diffraction analysis, and the absolute configuration of Imp-E was determined as S configuration. The intramolecular / intermolecular hydrogen bonds of Imp-E make the molecules maintain a stable arrangement in space.
摘要：
A novel polyvinyl alcohol-carbon nanotube containing an imidazolyl ionic liquid/chitosan composite hydrogel (termed CBCS) was prepared for highly selective uranium adsorption from seawater. The results show that CBCS has good adsorption properties for uranium within the pH range of 5.0-8.0. Kinetics and thermodynamics experiments show that the theoretical maximum adsorption capacity of CBCS to U(VI) is 496.049mg/g (288K, pH=6.0), indicating a spontaneous exothermic reaction. Mechanism analysis shows that the hydroxyl group, amino group, and CN bond on the surface of CBCS directly participate in uranium adsorption and that the dense pores on the surface of CBCS play an important role in uranium adsorption. The competitive adsorption experiment shows that CBCS has excellent uranium adsorption selectivity. In addition, CBCS exhibits good reusability. After five adsorption-desorption cycles, the uranium adsorption rate of CBCS can still reach >98%. Hence, CBCS has excellent potential for uranium extraction from seawater.
摘要：
Deinococcus radiodurans (DR) exhibits strong resistance to ionizing radiation. In this study, by constructing a radiation-resistant genetically engineered strain overexpressing the Cs gene, the tolerance of the bacterium to aluminum ions was enhanced, thereby achieving the goal of microbial sustainable remediation of uranium-contaminated environments. Methods: 1. Extraction of the recombinant plasmid pRADK-Cs, transformation into DR, and verification. 2. Investigation of factors such as time and initial uranium concentration on the efficiency of uranium accumulation by the recombinant strain, characterized by changes in functional groups and surface morphology before and after accumulation using techniques such as scanning electron microscope. Conclusions: The recombinant strain Deino-Cs can reduce the inhibitory effect of aluminum ions on uranium accumulation capability, and it exhibits a higher uranium accumulation rate compared to the wild-type strain.
作者机构：
[Wu, Min; Song, Zhiyin; He, H; Chen, Li; He, He; Liu, Bing; Meng, Qingtao; Ye, Fei; Dong, Jun; Lin, Jiacheng; Tang, Junhui; Zhou, Pang-Hu] Wuhan Univ, Renmin Hosp, Coll Life Sci, TaiKang Ctr Life & Med Sci,Frontier Sci Ctr Immuno, Wuhan, Hubei, Peoples R China.;[Song, Zhiyin; He, H; Chen, Li; He, He] Huazhong Univ Sci & Technol, Tongji Med Coll, Sch Basic Med, Dept Pathol, Wuhan, Hubei, Peoples R China.;[Song, Zhiyin; He, H; Chen, Li; He, He] Huazhong Univ Sci & Technol, State Key Lab Diag & Treatment Severe Zoonot Infec, Wuhan, Hubei, Peoples R China.;[Lu, Bin] Univ South China, Sch Basic Med Sci, Hengyang Med Sch, Dept Biochem & Mol Biol, Hengyang, Hunan, Peoples R China.;[Lu, Jia-Hong] Univ Macau, Inst Chinese Med Sci, State Key Lab Qual Res Chinese Med, Macau, Peoples R China.
通讯机构：
[Song, ZY; He, H ] W;Wuhan Univ, Renmin Hosp, Coll Life Sci, TaiKang Ctr Life & Med Sci,Frontier Sci Ctr Immuno, Wuhan, Hubei, Peoples R China.;Huazhong Univ Sci & Technol, Tongji Med Coll, Sch Basic Med, Dept Pathol, Wuhan, Hubei, Peoples R China.;Huazhong Univ Sci & Technol, State Key Lab Diag & Treatment Severe Zoonot Infec, Wuhan, Hubei, Peoples R China.
摘要：
Endoplasmic reticulum (ER)-mitochondria contacts are critical for the regulation of lipid transport, synthesis, and metabolism. However, the molecular mechanism and physiological function of endoplasmic reticulum-mitochondrial contacts remain unclear. Here, we show that Mic19, a key subunit of MICOS (mitochondrial contact site and cristae organizing system) complex, regulates ER-mitochondria contacts by the EMC2-SLC25A46-Mic19 axis. Mic19 liver specific knockout (LKO) leads to the reduction of ER-mitochondrial contacts, mitochondrial lipid metabolism disorder, disorganization of mitochondrial cristae and mitochondrial unfolded protein stress response in mouse hepatocytes, impairing liver mitochondrial fatty acid beta-oxidation and lipid metabolism, which may spontaneously trigger nonalcoholic steatohepatitis (NASH) and liver fibrosis in mice. Whereas, the re-expression of Mic19 in Mic19 LKO hepatocytes blocks the development of liver disease in mice. In addition, Mic19 overexpression suppresses MCD-induced fatty liver disease. Thus, our findings uncover the EMC2-SLC25A46-Mic19 axis as a pathway regulating ER-mitochondria contacts, and reveal that impairment of ER-mitochondria contacts may be a mechanism associated with the development of NASH and liver fibrosis. The molecular mechanism and physiological function of endoplasmic reticulum-mitochondrial contacts remain unclear. Here, authors uncover a role for the EMC2- SLC25A46-Mic19 axis in mitochondrial lipid metabolism and liver disease
期刊：
Computational and Structural Biotechnology Journal,2024年23:77-86 ISSN：2001-0370
通讯作者：
Zhang, Jian;Zhu, J;Li, CQ
作者机构：
[Zhang, Jian; Gao, Yu; Zhao, Jun; Zhu, Jiang; Zhang, J] Harbin Med Univ, Sch Med Informat, Daqing Campus, Daqing 163319, Peoples R China.;[Wang, Qiuyu; Li, Chunquan; Song, Chao] Univ South China, Affiliated Hosp 1, Hengyang Med Sch, Cardiovasc Lab Big Data & Imaging Artificial Intel, Hengyang 421001, Hunan, Peoples R China.;[Feng, Chenchen; Wang, Qiuyu; Song, Chao; Yin, Mingxue; Li, Chunquan] Univ South China, Sch Comp, Hengyang 421001, Hunan, Peoples R China.;[Wang, Qiuyu; Song, Chao; Yin, Mingxue; Li, Chunquan] Univ South China, Hunan Prov Key Lab Multiomics&Artificial Intellige, Hengyang 421001, Hunan, Peoples R China.;[Wang, Qiuyu; Yin, Mingxue; Li, Chunquan] Univ South China, Sch Basic Med Sci, Hengyang Med Sch, Dept Biochem & Mol Biol, Hengyang 421001, Hunan, Peoples R China.
通讯机构：
[Li, CQ ] U;[Zhang, J; Zhu, J ] H;Harbin Med Univ, Sch Med Informat, Daqing Campus, Daqing 163319, Peoples R China.;Univ South China, Affiliated Hosp 1, Hengyang Med Sch, Cardiovasc Lab Big Data & Imaging Artificial Intel, Hengyang 421001, Hunan, Peoples R China.
关键词：
Single cell integration database;Cell heterogeneity;Multi-method automatic cell-type annotation;Cell to cell communication
摘要：
Single-cell RNA sequencing (scRNA-seq), which profiles gene expression at the cellular level, has effectively explored cell heterogeneity and reconstructed developmental trajectories. With the increasing research on diseases and biological processes, scRNA-seq datasets are accumulating rapidly, highlighting the urgent need for collecting and processing these data to support comprehensive and effective annotation and analysis. Here, we have developed a comprehensive Single -Cell transcriptome integration database for human and mouse (SCInter, https://bio.liclab.net/SCInter/index.php), which aims to provide a manually curated database that supports the provision of gene expression profiles across various cell types at the sample level. The current version of SCInter includes 115 integrated datasets and 1016 samples, covering nearly 150 tissues/cell lines. It contains 8016,646 cell markers in 457 identified cell types. SCInter enabled comprehensive analysis of cataloged single-cell data encompassing quality control (QC), clustering, cell markers, multi-method cell type automatic annotation, predicting cell differentiation trajectories and so on. At the same time, SCInter provided a user-friendly interface to query, browse, analyze and visualize each integrated dataset and single cell sample, along with comprehensive QC reports and processing results. It will facilitate the identification of cell type in different cell subpopulations and explore developmental trajectories, enhancing the study of cell heterogeneity in the fields of immunology and oncology.
摘要：
Laccase-catalyzed oxidative reactions are increasingly examined as a reliable approach to environmental analysis and remediation, and it is urgent to widen metal category to compensate huge gap in the number of studies on copper- and non-copper laccase mimics. Herein, two-dimensional ultrathin MnO2 nanofilm (Mn-uNF) was designed via a chemical deposition and alkali etching process. Similar to Cu-laccase, Mn-uNF can oxidize phenols via a one-electron-transfer reaction of Mn(III) and accelerate the MnIII/MnIV state cycle through an unconventional oxygen reduction process. The excellent laccase-like performance of Mn-uNF can be ascribed to the abundant atomically dispersed Vo-assisted Mn(III) and surface -OH species, which was confirmed by characterizations and DFT calculation. Further, a facile dual-function colorimetric platform was designed for array sensing of o-, m-, and p-dihydroxybenzene isomers and one-step discrimination of tetracyclines containing phenol groups. These findings provide reasonable guidance for the design of a nanozyme with active Mn sites as a new family member of highly efficient copper-free laccase mimics.
通讯机构：
[Wang, PY; Liu, XL ] C;Chinese Acad Sci, Key Lab Design & Assembly Funct Nanostruct, Fujian Inst Res Struct Matter, Fuzhou 350002, Peoples R China.;Fujian Agr & Forestry Univ, Coll Life Sci, Fuzhou 350002, Peoples R China.;Hosp Fujian Med Univ, United Innovat Mengchao Hepatobiliary Technol Key, Mengchao Hepatobiliary, Fuzhou 350025, Peoples R China.
摘要：
Triggering the healing process of drug-resistant bacteria-infected wounds has attracted great attention due to global morbidity that may induce gangrene, amputation, and even death. Here, a chitin derivative, carboxymethyl chitosan (CMC), tannic acid (TA), and Cu(2+) were used for hydrogel engineering. Using sodium bicarbonate as the neutralizer and reductant, hydrogen bonds between CMC and TA and in situ Cu(OH)(2) generation via ion coordination force between Cu(2+) and TA facilitated the synthesis of CMC/TA/Cu hydrogel. Cu(2+) and TA release, cytotoxicity, in vitro cell migration, angiogenesis, and antidrug-resistant bacteria were measured. Besides, wound closure was evaluated in vivo using the methicillin-resistant Staphylococcus aureus (MRSA)-infected excisional dermal wound mouse model. Negligible toxicity was observed both in vitro and in vivo. Dermal cell migration and angiogenesis were significantly enhanced. In vivo, the CMC/TA/Cu hydrogel induced effective re-epithelialization, collagen deposition, inflammatory alleviation, and MRSA inhibition during wound repair in mice. All these results confirmed that the CMC/TA/Cu hydrogel is a promising novel dressing for chronic wound healing in clinic.
摘要：
An A2B2O7‐type high‐entropy oxide is applied for a photoelectrochemical photodetector for the first time. The experimental results demonstrated the tunable photodetection performance of the as‐prepared photodetector. Interestingly, the photodetector shows excellent long‐term stability and there is only ≈5.00 % attenuation in performance even after the photodetector is placed after 6 months in the ambient environment. Abstract Optoelectronics with excellent long‐term stability is meaningful for practical applications. Herein, for the first time, an A2B2O7 type high‐entropy oxide of (La0.2Ce0.2Nd0.2Gd0.2Bi0.2)2Ti2O7 (ATO) is synthesized and applied for photoelectrochemical photodetection. The lattice distortion, highly dispersed metal composition, and exposed active sites of ATO are beneficial for the fast separation and transmission of photogenerated electron/hole pairs, endowing ATO‐based devices with good photodetection performance. Both the density functional theory calculations and the nondegenerate transient absorption spectroscopy demonstrate the good optoelectronic properties of ATO. The systematic experimental studies reveal the tunable photodetection capability of ATO‐based photodetector (PD) in the visible region. A photocurrent of 772.00 nA cm−2 and a responsivity of 4.02 µA W−1 can be achieved as the PD in 1.0 m KOH with the bias potential of 0.6 V. Importantly, the robust and reproducible ON/OFF signals of the PD can be verified and there is only ≈5.00% attenuation in photocurrent even after 6 months, revealing the great potential of high‐ entropy oxides for practical applications.
期刊：
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY,2024年146(7):4363-4368 ISSN：0002-7863
通讯作者：
Yang, Z;Huang, J
作者机构：
[Yang, Zhen; Yang, Z; Wang, Zheyuan; Song, Zhilin] Peking Univ, Shenzhen Grad Sch, State Key Lab Chem Oncogen, Shenzhen 518055, Peoples R China.;[Yang, Zhen; Yang, Z; Wang, Zheyuan; Song, Zhilin] Peking Univ, Shenzhen Grad Sch, Key Lab Chem Genom, Shenzhen 518055, Peoples R China.;[Huang, Jun] Univ South China, Sch Chem & Chem Engn, Hengyang 421001, Peoples R China.;[Yang, Zhen; Yang, Z] Peking Univ, Key Lab Bioorgan Chem & Mol Engn, Beijing Natl Lab Mol Sci, Minist Educ, Beijing 100871, Peoples R China.;[Yang, Zhen; Yang, Z] Peking Univ, Peking Tsinghua Ctr Life Sci, Beijing, Peoples R China.
通讯机构：
[Yang, Z ] P;[Huang, J ] U;Peking Univ, Shenzhen Grad Sch, State Key Lab Chem Oncogen, Shenzhen 518055, Peoples R China.;Peking Univ, Shenzhen Grad Sch, Key Lab Chem Genom, Shenzhen 518055, Peoples R China.;Univ South China, Sch Chem & Chem Engn, Hengyang 421001, Peoples R China.
摘要：
The total syntheses of penicibilaenes A and B are described. The key step is the (t)BuOK/DMSO-mediated tandem 5-exo-dig Conia-ene type reaction and 6-exo-dig Conia-ene type reaction to install the tricyclic [6.3.1.0(1,5)] dodecane core of penicibilaenes from dibutynyl cyclohexanone in a single step, together with a sequence of copper-mediated conjugate addition and Crabtree's hydrogenation to forge the stereogenic centers at C5 and C2, respectively.
作者机构：
[Zhang, Yuexin; Mu, Xinxin; Zhang, Qinyi; Li, Chunquan; Song, Shuang; Zhang, Guorui; Song, Chao; Tang, Huifang; Yin, Mingxue; Zhang, Hang] Univ South China, Affiliated Hosp 1, Hengyang Med Sch, Hengyang 421001, Hunan, Peoples R China.;[Zhang, Yuexin; Mu, Xinxin; Zhang, Qinyi; Li, Chunquan; Song, Shuang; Zhang, Guorui; Song, Chao; Tang, Huifang; Yin, Mingxue; Zhang, Hang] Univ South China, Hengyang Med Sch, Hunan Prov Key Lab Multiom & Artificial Intelligen, Hengyang 421001, Hunan, Peoples R China.;[Zhang, Qinyi; Li, Chunquan; Song, Shuang; Zhang, Guorui; Yin, Mingxue] Univ South China, Sch Basic Med Sci, Dept Biochem & Mol Biol, Hengyang 421001, Hunan, Peoples R China.;[Zhang, Qinyi; Li, Chunquan; Song, Shuang; Zhang, Guorui; Yin, Mingxue] Univ South China, Hengyang Med Sch, MOE Key Lab Rare Pediat Dis, Hengyang 421001, Hunan, Peoples R China.;[Li, Chunquan] Univ South China, Hunan Prov Maternal & Child Hlth Care Hosp, Hengyang Med Sch, Key Lab Birth Defect Res & Prevent, Hengyang 421001, Hunan, Peoples R China.
通讯机构：
[Li, CQ ; Tang, HF ; Tang, HF] U;Univ South China, Affiliated Hosp 1, Hengyang Med Sch, Hengyang 421001, Hunan, Peoples R China.;Univ South China, Hengyang Med Sch, Hunan Prov Key Lab Multiom & Artificial Intelligen, Hengyang 421001, Hunan, Peoples R China.;Univ South China, Sch Basic Med Sci, Dept Biochem & Mol Biol, Hengyang 421001, Hunan, Peoples R China.;Univ South China, Hengyang Med Sch, MOE Key Lab Rare Pediat Dis, Hengyang 421001, Hunan, Peoples R China.
关键词：
gated blood-pool imaging;chromatin;genetics;mice;enhancer of transcription;candidate disease gene;single nucleotide polymorphism;crispr;genes;rna;genome;methylation
摘要：
Enhancer RNAs (eRNAs) transcribed from distal active enhancers serve as key regulators in gene transcriptional regulation. The accumulation of eRNAs from multiple sequencing assays has led to an urgent need to comprehensively collect and process these data to illustrate the regulatory landscape of eRNAs. To address this need, we developed the eRNAbase (http://bio.liclab.net/eRNAbase/index.php) to store the massive available resources of human and mouse eRNAs and provide comprehensive annotation and analyses for eRNAs. The current version of eRNAbase cataloged 10 399 928 eRNAs from 1012 samples, including 858 human samples and 154 mouse samples. These eRNAs were first identified and uniformly processed from 14 eRNA-related experiment types manually collected from GEO/SRA and ENCODE. Importantly, the eRNAbase provides detailed and abundant (epi)genetic annotations in eRNA regions, such as super enhancers, enhancers, common single nucleotide polymorphisms, expression quantitative trait loci, transcription factor binding sites, CRISPR/Cas9 target sites, DNase I hypersensitivity sites, chromatin accessibility regions, methylation sites, chromatin interactions regions, topologically associating domains and RNA spatial interactions. Furthermore, the eRNAbase provides users with three novel analyses including eRNA-mediated pathway regulatory analysis, eRNA-based variation interpretation analysis and eRNA-mediated TF-target gene analysis. Hence, eRNAbase is a powerful platform to query, browse and visualize regulatory cues associated with eRNAs. Graphical Abstract
作者：
Hu, Yu-wen;Sultana, Fozia;Balogun, M. -Sadeeq;Xiong, Tuzhi;Huang, Yongchao;...
期刊：
Nanoscale,2024年16(8):4325-4332 ISSN：2040-3364
通讯作者：
Xia, Y;Balogun, MS;Xiong, TZ
作者机构：
[Balogun, MS; Sultana, Fozia; Balogun, M. -Sadeeq; Hu, Yu-wen] Hunan Univ, Coll Mat Sci & Engn, Changsha 410082, Peoples R China.;[Xia, Yu] South China Univ Technol, Guangzhou Peoples Hosp 1, Sch Med, Dept Gastroenterol & Hepatol, Guangzhou 510180, Peoples R China.;[Xiong, TZ; Xiong, Tuzhi] Univ South China, Sch Chem & Chem Engn, Hengyang 421001, Peoples R China.;[Huang, Yongchao] Guangzhou Univ, Inst Environm Res Greater Bay, Key Lab Water Qual & Conservat Pearl River Delta, Minist Educ, Guangzhou 510006, Peoples R China.
通讯机构：
[Xiong, TZ ] U;[Xia, Y ] S;[Balogun, MS ] H;South China Univ Technol, Guangzhou Peoples Hosp 1, Sch Med, Dept Gastroenterol & Hepatol, Guangzhou 510180, Peoples R China.;Hunan Univ, Coll Mat Sci & Engn, Changsha 410082, Peoples R China.
摘要：
Nickel nitride (Ni(3)N) is a promising electrocatalyst for the hydrogen evolution reaction (HER) owing to its excellent metallic features and has been demonstrated to exhibit considerable activity for water oxidation. However, its undesirable characteristics as an HER electrocatalyst due to its poor unfavourable d-band energy level significantly limit its water dissociation kinetics. Herein, the HER electrocatalytic activity of Ni(3)N was prominently enhanced via the simultaneous incorporation of bi-cations (vanadium (V) and iron (Fe), denoted as V-Fe-Ni(3)N). The optimized V-Fe-Ni(3)N displays impressive performance with an overpotential of 69 mV at 10 mA cm(-2) and good stability in 1.0 M KOH, which is remarkably better than pristine Ni(3)N, V-doped Ni(3)N, and Fe-doped Ni(3)N and considerably closer to a commercial Pt/C catalyst. Based on density functional theory (DFT) studies, V and Fe atoms not only serve as active sites for promoting water dissociation kinetics but also tune the electronic structure of Ni(3)N to achieve optimized hydrogen adsorption capabilities. This work presents an inclusive understanding of the rational designing of high-performance transition metal nitride-based electrocatalysts for hydrogen production. Its electrocatalytic performance can be significantly enhanced by doping transition metal cations.
摘要：
Constructing desirable morphology has been demonstrated to be an effective strategy for enhancing the capabilities of the covalent organic frameworks (COFs) for the processing of uranium. Traditional 3D-COFs only possess a limited number of structural nodes, not being the ideal structure for uranium adsorption, but 2D-COFs with rich structural nodes also suffer from reduced exposure of adsorption sites due to stacking during uranium treatment, which is not beneficial for achieving sustained and efficient adsorption. To this end, by polymerizing COFs on the silica carrier, followed by etching the silica carrier, and utilizing the conversion of nitrile to amidoxime groups as chelation sites, we designed and synthesized a hollow 3D-like structure of 2D-COFs (COF-TD-H-AO, similar to three-dimensional COFs) as adsorbents to capture the radionuclide uranium. Systematic studies were carried out for the adsorption characteristics of this material at different pH values and in the presence of interfering ions, as well as its adsorption thermodynamics and kinetics. Compared with COF-TD-AO (pure 2D-COFs) and SiO2@COF-TD-AO (unetched), COF-TD-H-AO exhibited a higher adsorption capacity as well as selective adsorption of uranium. This work provides an innovative perspective on material design and preparation by providing more adsorption sites in an effort to improve the capacity of adsorption and the selectivity of adsorption.
