摘要：
[3]Radialene has a peculiar topology and cross‐conjugation system, representing a unique molecular scaffold in organic materials. Herein, we report a special class of stereoisomeric α‐cyano triaryl[3]radialenes (CTRs) that show concentration‐caused quenching in solution but emit red‐shifted and enhanced luminescence in the crystalline state. Clustering of multiple cyano groups and their through‐space interactions with the [3]radialene ring significantly extend π‐electron communication meanwhile rigidifying the propeller conformation multivalently, thus playing a key role behind the state‐dependent luminescence. These radialenes with a substantial electron affinity undergo a reversible electron transfer transition to anionic radicals with good stability, showing switching of photoabsorption, photoluminescence and electron spin resonance (ESR) signal. We also established proof‐of‐concept applications of CTRs for multimodal information encryption and chemical sensing.
摘要：
In this work, Fe, N co-doped hierarchical porous graphite-like carbon with carbon-encapsulated Fe/Fe3C@ Fe -N-C was synthesized by a facile solid-phase synthesis strategy, and was employed as an efficient catalyst to activate peroxymonosulfate (PMS) for oxidation of tetracycline (TC). The optimal Fe-N/C 800 outlined a highly catalytic performance in activating peroxymonosulfate (PMS) with TC decomposition rate reaching 89.2 % in 20 min at ultra-low catalyst dosage. Meanwhile, the effect of operating parameters was also investigated in order to evaluate the potential of using Fe-N/C 800 in practical applications. In addition, the characterization analysis and experiments results elucidated that graphitic N, pyridinic N, C--O, Fe3C, Fe0 and FeN4 were considered as the main reactive species promoting the PMS activation to generate reactive oxygen species (ROS) (including singlet oxygen (1O2), sulfate radical (SO4 & BULL;-) and hydroxyl radical (& BULL;OH)). The electron paramagnetic resonance (EPR) experiments and radicals quenching analyses further demonstrated that the non-radical species singlet oxygen (1O2) was the dominant reactive oxygen species. Moreover, the TC degradation pathways were presented by LC-MS. Ultimately, the toxicity of the intermediate products were also investigated by ECOSAR system.
摘要：
The main types of functional nucleic acids, signal amplification elements, and signal amplification technologies for detecting foodborne hazardous substances are described. Chen and coworkers have summarized the advantages and disadvantages of current detection methods based on functional nuclear acids biosensors, and put forward some suggestions for developing more effective detection methods of foodborne hazardous substances, which provide some significant references for the efficient detection of foodborne hazardous substances based on functional nucleic acids in the future. Abstract With the further improvement of food safety requirements, the development of fast, highly sensitive, and portable methods for the determination of foodborne hazardous substances has become a new trend in the food industry. In recent years, biosensors and platforms based on functional nucleic acids, along with a range of signal amplification devices and methods, have been established to enable rapid and sensitive determination of specific substances in samples, opening up a new avenue of analysis and detection. In this paper, functional nucleic acid types including aptamers, deoxyribozymes, and G‐quadruplexes which are commonly used in the detection of food source pollutants are introduced. Signal amplification elements include quantum dots, noble metal nanoparticles, magnetic nanoparticles, DNA walkers, and DNA logic gates. Signal amplification technologies including nucleic acid isothermal amplification, hybridization chain reaction, catalytic hairpin assembly, biological barcodes, and microfluidic system are combined with functional nucleic acids sensors and applied to the detection of many foodborne hazardous substances, such as foodborne pathogens, mycotoxins, residual antibiotics, residual pesticides, industrial pollutants, heavy metals, and allergens. Finally, the potential opportunities and broad prospects of functional nucleic acids biosensors in the field of food analysis are discussed.
期刊：
The Journal of Organic Chemistry,2023年88(17):12630-12640 ISSN：0022-3263
通讯作者：
Huang, JM
作者机构：
[Huang, JM; Zhong, Wei-Qiang; Huang, Jing-Mei; Chen, Shu-Jun] South China Univ, Sch Chem & Chem Engn, Key Lab Funct Mol Engn Guangdong Prov, Guangzhou 510640, Guangdong, Peoples R China.
通讯机构：
[Huang, JM ] S;South China Univ, Sch Chem & Chem Engn, Key Lab Funct Mol Engn Guangdong Prov, Guangzhou 510640, Guangdong, Peoples R China.
摘要：
We report a new method for the synthesis of trifluoromethylated and sulfonylated oxazolines by electrochemical radical cascade cyclizations of N-allylamides with sodium trifluoromethanesulfinate or sulfonylhydrazines. This protocol provides a green and useful strategy to synthesize trifluoromethylated and sulfonylated oxazolines with a broad substrate scope under ambient conditions.
摘要：
The new two‐dimensional (2D) polyoxometalate clusterphene (POMCene) with a similar hexagonal structure to graphene is synthesized and applied for photoelectrochemical (PEC)‐type photodetection for the first time. Such a 2D POMCene‐based photodetector shows good photodetection capability and excellent long‐term stability (over 3 months) in a harsh environment, indicating the great potential of 2D POMCene for practical applications. Abstract Exploration of novel two–dimensional (2D) nanomaterials with desired properties using a controlled approach remains one of the major challenges ahead. Clusterphene, the newly emerged 2D formation of self‐assembled clusters, exhibits a comparable structure to graphene with intriguing physicochemical features, which are applied in several scientific disciplines. Herein, it is demonstrated that polyoxometalate clusterphene (POMCene) is a promising 2D nanomaterial for photoelectrochemical (PEC) photodetection. The photodetection performance of POMCene can be subtly tuned by adjusting external conditions like bias voltage, electrolyte, and incident wavelength. A photocurrent of 1.88 µA cm‒2, a responsivity of 2.26 µA W‒1, a detectivity of 5.65 × 109 Jones, and a fast response speed of 0.02 s along with good long‐term stability can be achieved. It is believed that this research can pave a new direction for the future development of 2D POMCene in high‐performance optoelectronic devices.
期刊：
NEW JOURNAL OF CHEMISTRY,2023年47(2):660-665 ISSN：1144-0546
通讯作者：
Wei-Min He
作者机构：
[Hu, Chu-Qian; Li, Ning-Bo; Qiao, Jie; Wang, Yu-Xin; Zhou, Xue] Shanxi Med Univ, Sch Basic Med Sci, Taiyuan 030001, Peoples R China.;[Gu, Shuo] Shanxi Med Univ, Sch Pharmaceut Sci, Taiyuan 030001, Peoples R China.;[He, Wei-Min; Ji, Hong-Tao; Jiang, Jun] Univ South China, Sch Chem & Chem Engn, Hengyang 421001, Peoples R China.
通讯机构：
[Wei-Min He] S;School of Chemistry and Chemical Engineering, University of South China, Hengyang 421001, China
摘要：
A heterogeneous photocatalytic 3-trifluoromethylation and 3-perfluoroalkylation of 4-aminocoumarins was realized from 4-aminocoumarins and CnF2n+1SO2Na under mild conditions using mesoporous graphitic carbon nitride (mpg-C3N4) as an effective and recyclable photocatalyst without any other additives. This transition-metal-free procedure shows wide substrate scope with air as a green oxidant affording 3-trifluoromethylated/perfluoroalkylated 4-aminocoumarins in moderate to good yields.
期刊：
Journal of Cluster Science,2023年34(5):2373-2380 ISSN：1040-7278
通讯作者：
Yan-Ming Chen<&wdkj&>Xiao-Bo Nie
作者机构：
[Chen, Yan-Ming; Han, Jiao] Shenyang Univ Technol, Sch Petrochem Engn, Liaoyang 111003, Liaoning, Peoples R China.;[Nie, Xiao-Bo] Univ South China, Hengyang Med Coll, Sch Chem & Chem Engn, Postdoctoral Mobile Stn Basic Med Sci, Hengyang 421001, Hunan, Peoples R China.
通讯机构：
[Yan-Ming Chen] S;[Xiao-Bo Nie] P;School of Petrochemical Engineering, Shenyang University of Technology, Liaoyang, China<&wdkj&>Postdoctoral Mobile Station of Basic Medicine Sciences, Hengyang Medical College, School of Chemistry and Chemical Engineering, University of South China, Hengyang, China
关键词：
Chemical reduction;Morphological structure;Plasmon absorption;Sodium oleate;Solvothermal synthesis
摘要：
Silver (Ag) nanocrystals are appealing due to their excellent antimicrobial properties. Synthesis of harmless Ag nanocrystals by low toxic reagents remains significant. Herein, an environmentally benign solvothermal process was applied to synthesize Ag nanocrystals in ethylene glycol (EG) dissolving silver nitrate and sodium oleate. Silver ions were reduced by EG to zero-valent Ag atoms that underwent nucleation and growth to form oleate-stabilized Ag nanocrystals. Multiple experimental parameters including the reaction time, temperature, concentration of Ag precursor, and the molar ratio of sodium oleate and silver nitrate were investigated to probe their effects on morphological structures and surface plasmon resonance (SPR) properties of resulting Ag nanocrystals. Results from UV-Vis absorption spectra and TEM images show that structural and SPR features of Ag nanocrystals are extremely sensitive to the reaction temperature as well as the molar ratio of sodium oleate and silver nitrate. Especially, two absorption bands appeared. The short wavelength (similar to 450 nm) represents the characteristic SPR of Ag nanospheres. While, the plasmon absorption at long wavelength (500-700 nm depending on reaction conditions) indicates the anisotropic or heterogeneous structures of Ag nanocrystals that maybe pave their potential applications in asymmetric catalysis, selective growth of coating materials, nanomedicine and optoelectronics.
摘要：
As a widely used carbamate pesticide, carbaryl not only had neurotoxicity by inhibiting the activity of acetylcholinesterase, but also had environmental hormone effects, so it is important to establish a convenient and sensitive method for the detection of carbaryl. An original photoresponsive molecularly imprinted electrochemical sensor (MIP-MGCE) was fabricated from glassy carbon electrode (GCE) as the substrate, 5-[(4-(methacryloyloxy)phenyl)diazenyl]isophthalic acid (MAPDIA) as the functional monomer and carbaryl as the template, where a layer of molecular imprinting film was constructed and overattached on the surface of GCE modified by carboxylic multi-walled carbon nanotube-chitosan (MWCNT-CT) composite with the large specific surface area and good conductivity. The constructed sensors were characterized by FT-IR and cyclic voltammetry (CV). The ratio of template molecule to monomer, elution time, and incubation time were optimized to be 1:4, 2 min and 6 min, respectively. By the differential pulse voltammetry (DPV) method, the experimental amperometric curve of MIP-MGCE had favorable linear relationship. The linear equation was Delta I = 190.2933C + 1.9824 with R-2 = 0.9865 when in the carbaryl concentration range of 0.0035-0.1100 mu mol L-1, and the linear equation became Delta I = 2.8940C + 25.4230 with R-2 = 0.9917 when in the range of 0.1100-13.9600 mu mol L-1. The detection limit of the above method was 0.0011 mu mol L-1 (S/N = 3). The prepared sensor was also applied to the detection of carbaryl in tap water samples, and the results showed it had not only a better recovery rate of 97.00% with 3.43% of RSD but also excellent selectivity and repeatability.
摘要：
2D violet phosphorus (VP) nanosheets are utilized as self‐powered photoelectrochemical‐type photodetector. The results indicate that VP nanosheets achieve preferable photo‐response activities from ultraviolet to visible region along with good chemical and environmental stability. Abstract Violet phosphorus (VP) is a stable layered van der Waals phosphorus allotrope with unique electronic and optoelectronic properties. In this study, 2D VP nanosheets (NSs) are prepared by liquid phase exfoliation (LPE) method under ambient conditions. The prepared VP NSs are characterized and utilized for photoelectrochemical (PEC)‐type photodetector (PD). The systematic PEC measurements reveal that the as‐prepared VP‐based PD shows tunable photo‐response activities from ultraviolet to visible region. A current density of 0.52 µA cm−2, a photo‐responsivity of 31.70 µA W−1, and a detectivity of 7.92 × 1010 Jones can be obtained in 1.0 m KOH under 350 nm irradiation at 0 V, revealing the good self‐powered capability of VP‐based PD. Furthermore, the cycle and time stability tests exhibit the good chemical and environmental stability of the as‐prepared PD via processing 10 000 s on/off switching and placing after one month. It is expected that this work can offer an understanding of a PEC‐type VP NSs‐based PD, and highlight the further promising applications of 2D VP NSs for other optoelectronic devices.
作者机构：
[Song, Zhiyin; Yu, Jianglong; He, He; Zhao, Huabin; Guo, Hanze; He, H; Gong, Longlong; Hao, Tianshu; Wu, Zhida; Wang, Bingjun; Jiang, Jie] Wuhan Univ, Renmin Hosp, Taikang Ctr life & Med Sci, Coll Life Sci,Frontier Sci Ctr Immunol & Metab,Dep, Wuhan 430072, Hubei, Peoples R China.;[Lu, Bin] Univ South China, Sch Basic Med Sci, Hengyang Med Sch, Dept Biochem & Mol Biol, Hengyang 421001, Hunan, Peoples R China.;[Engelender, Simone] Technion Israel Inst Technol, Rappaport Fac Med, Dept Biochem, Haifa, Israel.
通讯机构：
[He, H; Song, ZY ] W;Wuhan Univ, Renmin Hosp, Taikang Ctr life & Med Sci, Coll Life Sci,Frontier Sci Ctr Immunol & Metab,Dep, Wuhan 430072, Hubei, Peoples R China.
摘要：
Mitochondria are the key organelles for sensing oxygen, which is consumed by oxidative phosphorylation to generate ATP. Lysosomes contain hydrolytic enzymes that degrade misfolded proteins and damaged organelles to maintain cellular homeostasis. Mitochondria physically and functionally interact with lysosomes to regulate cellular metabolism. However, the mode and biological functions of mitochondria-lysosome communication remain largely unknown. Here, we show that hypoxia remodels normal tubular mitochondria into megamitochondria by inducing broad inter-mitochondria contacts and subsequent fusion. Importantly, under hypoxia, mitochondria-lysosome contacts are promoted, and certain lysosomes are engulfed by megamitochondria, in a process we term megamitochondria engulfing lysosome (MMEL). Both megamitochondria and mature lysosomes are required for MMEL. Moreover, the STX17-SNAP29-VAMP7 complex contributes to mitochondria-lysosome contacts and MMEL under hypoxia. Intriguingly, MMEL mediates a mode of mitochondrial degradation, which we termed mitochondrial self-digestion (MSD). Moreover, MSD increases mitochondrial ROS production. Our results reveal a mode of crosstalk between mitochondria and lysosomes and uncover an additional pathway for mitochondrial degradation. Several organelle membranes make contact in the cell, with many contacts being spatially segregated sites dedicated to specific functions. Here, Hao et al. show that hypoxia increases mitochondria-lysosome contacts, leading to engulfment and degradation of the mitochondria.
摘要：
The separation and enrichment of uranium from uranium containing wastewater is important for the sustainable development of nuclear energy. Therefore, there is an urgent need to develop a low-cost, readily available, simple preparation process and environmentally friendly adsorbent. In this study, potassium manganese ferro-cyanide and carbon nanotube encapsulated calcium alginate beads (KMnFC/CNT@SA) for uranium adsorption was prepared by a simple method using the inexpensive natural polymer material sodium alginate and the ion exchange material potassium manganese ferricyanide as well as carbon nanotubes capable of enhancing the spatial structure. Static adsorption experiments show that the adsorption capacity of KMnFC/CNT@SA for uranium is significantly affected by pH, contact time, U(VI) concentration and temperature, but is not affected by sodium ion concentration in solution. Furthermore, desorption and cycling tests demonstrate that KMnFC/ CNT@SA has good reusability, with the adsorption capacity remaining above 89.83% of the maximum adsorption capacity after 10 adsorption-desorption cycles. It is worth noting that KMnFC/CNT@SA can adsorb uranium well under acidic conditions, and is easy to solid-liquid separation and recovery. This work provides an effective strategy for the development of high-quality, inexpensive, practical and durable adsorbents for uranium extraction from acidic uranium-containing wastewater.
期刊：
Chemical Engineering Journal,2023年452:139486 ISSN：1385-8947
通讯作者：
Yang, Pengfei(ypengfei2008@126.com)
作者机构：
[Ouyang, Yanquan; Yang, Pengfei; Peng, Guowen; Deng, Mingzhan; Zhao, Limei] Univ South China, Sch Chem & Chem Engn, Hengyang 421001, Peoples R China.;[Ouyang, Yanquan; Yang, Pengfei; Peng, Guowen; Deng, Mingzhan; Zhao, Limei] Univ South China, Joint Training Base Postgrad Students Univ South C, Hengyang 421001, Hunan, Peoples R China.
通讯机构：
[Pengfei Yang] S;School of Chemistry and Chemical Engineering, University of South China, Hengyang 421001, China<&wdkj&>Joint Training Base for Postgraduate Students of University of South China-230 Institute of Nuclear Industry, University of South China, Hengyang 421001, Hunan, China
摘要：
Cathode current is a key measure of the rated power of the diode and is closely related to the cathode structure. Compared with $\Pi $ cathode and helical cathode, the mesh cathode has been more widely used in high-power tetrode, because of its structural advantage. So far, the relationship between the space charge limited current (SCLC) and the cathode structure for thermionic emission mesh cathode diode has not been reported. In this article, we develop a calculation expression of the SCLC for the mesh cathode coaxial cylindrical diode, which is based on the calculation model of the helical cathode. The results show that the calculated values are in excellent agreement with the simulated values based on CST Particle Studio. In addition, we study the dependence of the SCLC of the mesh cathode diode with the change of the cathode height, radius of the cathode filament, anode voltage, and density of the mesh. It is helpful for the optimization of the cathode structure design of vacuum tubes and microwave tubes with the coaxial cylinder mesh cathode structure.
摘要：
The efficient removal of radionuclide uranium is crucial for sustainable nuclear energy and achieving a zero-carbon loop. In this study, we synthesized MXene/MnO2 nanocomposites and evaluated their ability to adsorb and reduce uranium. The results showed that the nanocomposites achieved a uranium removal rate of 99% and an adsorption capacity of 696 mg/g. Adsorption experiments were conducted under different conditions, including pH, cation, anion, and humic acid, and the uranium removal rate by the composite remained high at 91%, 70%, and 60% under the influence of pH = 4.97, 1.0 mM CaCl2, and 20 mg/L humic acid, respectively. The XRD and SEM analyses revealed that the uranium element was removed by the reduction and fixation of the composite material. These findings indicate that the MXene/MnO2 composite is an effective adsorption cleaning agent for the purification of radioactive nuclear wastewater, which has significant implications for pollution control.
期刊：
Progress in Solid State Chemistry,2023年71 ISSN：0079-6786
通讯作者：
Tareen, AK;Khan, K
作者机构：
[Long, Jianyu; Tareen, AK; Tareen, Ayesha Khan; Li, Chuan] Dongguan Univ Technol, Sch Mech Engn, Dongguan 523808, Peoples R China.;[Iqbal, Muhammad] Quaid i Azam Univ Islamabad, Dept Biochem, Islamabad 45320, Pakistan.;[Ahmad, Waqas] Univ Elect Sci & Technol China, Inst Fundamental & Frontier Sci, Chengdu 610054, Peoples R China.;[Khan, Muhammad Farooq] Sejong Univ, Dept Elect Engn, 209 Neungdong Ro, Seoul 05006, South Korea.;[Khan, Karim; Sun, Jinghua; Khan, K] Dongguan Univ Technol, Sch Elect Engn & Intelligentizat, Dongguan 523808, Peoples R China.
通讯机构：
[Khan, K ; Tareen, AK ] D;Dongguan Univ Technol, Sch Mech Engn, Dongguan 523808, Peoples R China.;Dongguan Univ Technol, Sch Elect Engn & Intelligentizat, Dongguan 523808, Peoples R China.
关键词：
Borophene synthesis/properties;Renewable energy storage;Batteries;Supercapacitors
摘要：
Due to ultralow defect formation energy, borophene differs significantly from other 2D (two-dimensional) materials in that it is difficult to distinguish between its crystal and boron (B) vacancy defect. In contrast to other 2D materials like graphene, borophene does not form layers when it is in its bulk state. In addition, borophene NM's atomic structure is different from graphene's in that it consists of connected triangles rather than hexagons. This atomic configuration has gaps where atoms are missing, resulting in a flaw called a "hollow hexagon" (HH). In borophene phases, these HHs can be found in a variety of ratios. The phase intermixing of borophene is a brandnew example of an 'ordered' defect discovered in 2D materials. The majority of 2D materials have flaws or disruptions to the atom arrangement at the boundaries between various domains or phases. Defects play a major influence in determining the properties of materials in a 2D system, because all atoms are virtually on the surface. For instance, the line defects along phase boundaries in borophene have no effect on the material's electrical characteristics at ambient temperature, in contrast to insulating flaws in metallic graphene. The atoms at the borders of borophene easily fit along line faults and adopt the configuration of their neighbors, causing no disruption. Additionally, the line flaws do not disrupt the seamless structure of borophene and maintain its stability and metallic properties. Experimentally, all four borophene phases have been synthesized, and they are all metallic. A list of borophene NM's special characteristics, including its negative Poisson's ratio and extremely anisotropic Young's modulus, is discussed. Here we also emphasized on B's conductive and superconductive qualities. An overview of borophene NM's uses in the energy sectors, including metal ion batteries, and supercapacitors (SCs), is covered in great length at the very end.
通讯机构：
[Huijun Liu] D;Department of Chemistry and Chemical Engineering, University of South China, Hengyang, Hunan 421001, China<&wdkj&>Hunan Key Laboratory for the Design and Application of Actinide Complexes, University of South China, Hengyang, Hunan 421001, China
关键词：
MXene;GSH;Redox-responsive;PEG;Drug delivery system
摘要：
MXene has a large surface area, which gives medicinal drug molecules enough anchor sites. This property can be utilized to design incredibly effective intracellular drug delivery systems. In this work, a non-toxic and safe Ti3C2Tx materials was chosen in MXene. Ti3C2Tx MXene was decorated with Methoxy Polyethylene Glycol (PEG) by a linker cystamine dihydrochloride disulfide bonds (-SS-). The DOX delivery system of Ti3C2Tx MXene modified by PEG was constructed. To further examine the system's potential as a cancer treatment, in vitro tests were conducted. The outcomes demonstrated the potential of PEG-modified MXene nanosheets as nanocarriers for the delivery of DOX to tumors because they had excellent biocompatibility and no discernible side effects. In contrast to the free DOX, the drug carrier MXene-SS-PEG@DOX was more toxic to human hepatoma cells (HepG2) and less toxic to healthy macrophages (RAW264.7). DOX is released at a rate of 84.4% in PBS solution with a pH of 4.50 and a GSH concentration of 10 mM, which is higher than that of normal cells' physiological environment. The redox response drug delivery system has been investigated in this work, and the findings indicate that the drug delivery system is a promising contender for both drug delivery and stimulus response release.
通讯机构：
[Lijun Hu] S;School of Chemistry and Chemical Engineering, University of South China, Hengyang, Hunan 421001, PR China<&wdkj&>Hunan Key Laboratory for the Design and Application of Actinide Complexes, University of South China, Hengyang, Hunan 421001, PR China
关键词：
Thermoelectric;Amphoteric Salts;PEDOT;PSS
摘要：
Continuous acid-base treatment can achieve high thermoelectric performance for PEDOT:PSS film, but multiple surface treatments damage samples easily, lowering yield rates as well as increasing preparation costs, pre-venting its commercialization. To this end, we present an amphoteric salt-based post-treatment strategy for optimizing the charge transport properties and doping levels of PEDOT:PSS films, thereby achieving high elec-trical conductivity (a) and Seebeck coefficient (S) simultaneously. As a result, the optimal PEDOT:PSS thermo-electric film delivers a a of 1462 S center dot cm- 1 and a S of 26.2 mu V center dot K-1, thus achieving a power factor (PF) of 100.4 mu W center dot m- 1 center dot K-2, which is significantly higher than pristine specimens with a PF lower than 0.1 mu W center dot m-1 center dot K-2.
摘要：
Emerging pollutants in the aquatic environment from pharmaceutical and personal care products (PPCPs) attract much attention due to their environmental risk and toxicological properties, posing a threat to human health and safety. In this study, we fulfilled the direct and efficient degradation of PPCPs (i.e. diclofenac sodium, 2-mercap-tobenzothiazole, paracetamol, and furosemide) using engineered H2O2-dependent heme enzymes based on myoglobin (Mb) with high peroxidase activity. Especially, the triple mutant F43Y/P88W/F138W Mb could efficiently degrade diclofenac sodium, 2-mercaptobenzothiazole, paracetamol, and furosemide with a degrada-tion rate of-98.5%,-99%,-98%, and-91%, respectively. These activities are much higher than other re-ported native enzymes, such as laccase and horseradial peroxidase. As further analyzed by ESI-MS, we identified multiple degradation products of those four contaminants and thus proposed possible degradation mechanisms. This study indicates that enzyme-based degradation of emerging pollutants is a promising environmental remediation approach.
摘要：
Cis-regulatory elements are important molecular switches in controlling gene expression and are regarded as determinant hubs in the transcriptional regulatory network. Collection and processing of large-scale cis-regulatory data are urgent to decipher the potential mechanisms of cardiovascular diseases from a cis-regulatory element aspect. Here, we developed a novel web server, Cis-Cardio, which aims to document a large number of available cardiovascular-related cis-regulatory data and to provide analysis for unveiling the comprehensive mechanisms at a cis-regulation level. The current version of Cis-Cardio catalogs a total of 45,382,361 genomic regions from 1,013 human and mouse epigenetic datasets, including ATAC-seq, DNase-seq, Histone ChIP-seq, TF/TcoF ChIP-seq, RNA polymerase ChIP-seq, and Cohesin ChIP-seq. Importantly, Cis-Cardio provides six analysis tools, including region overlap analysis,element upstream/downstream analysis, transcription regulator enrichment analysis, variant interpretation, andprotein-protein interaction-based co-regulatory analysis. Additionally, Cis-Cardio provides detailed and abundant (epi-) genetic annotations in cis-regulatory regions, such as super-enhancers, enhancers, transcription factor binding sites (TFBSs), methylation sites, common SNPs, risk SNPs, expression quantitative trait loci (eQTLs), motifs,DNase I hypersensitive sites (DHSs), and 3D chromatin interactions. In summary, Cis-Cardio is a valuable resourcefor elucidating and analyzing regulatory cues of cardiovascular-specific cis-regulatory elements. The platform is freely available at http://www.licpathway.net/Cis-Cardio/index.html.
