Regioselective aromatic O-demethylation with an artificial P450BM3/sugar alcohol oxidase peroxygenase system

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成果类型：

期刊论文

作者：

Zhao, Sijia;Lin, Yingwu;Wang, Jinghan;Li, Dong;Wang, Fang;...

通讯作者：

Xu, JK

作者机构：

[Zhao, Sijia; Li, Dong; Xu, Jiakun; Wang, Fang; Wang, Jinghan] Chinese Acad Fishery Sci, Yellow Sea Fisheries Res Inst, State Key Lab Mariculture Biobreeding & Sustainabl, Key Lab Sustainable Dev Polar Fisheries,Minist Agr, Qingdao 266071, Peoples R China.

[Zhao, Sijia; Wang, Jinghan] Ocean Univ China, Coll Food Sci & Engn, Qingdao Marine Sci & Technol Ctr, Lab Marine Drugs & Bioprod, Qingdao 266003, Peoples R China.

[Shoji, Osami] Nagoya Univ, Grad Sch Sci, Dept Chem, Furo Cho,Chikusa Ku, Nagoya 4648602, Japan.

[Lin, Yingwu] Univ South China, Sch Chem & Chem Engn, Hengyang 421001, Peoples R China.

通讯机构：

[Xu, JK ] C

Chinese Acad Fishery Sci, Yellow Sea Fisheries Res Inst, State Key Lab Mariculture Biobreeding & Sustainabl, Key Lab Sustainable Dev Polar Fisheries,Minist Agr, Qingdao 266071, Peoples R China.

语种：

英文

关键词：

Lignin;O-demethylation;P450BM3

期刊：

International Journal of Biological Macromolecules

ISSN：

0141-8130

年：

2025

卷：

309

期：

Pt 1

页码：

142768

DOI：

10.1016/j.ijbiomac.2025.142768

基金类别：

Acknowledgements We thank the National Natural Science Foundation of China (No. 32171263 ); the Central Public-interest Scientific Institution Basal Research Fund, Chinese Academy of Fishery Sciences , CAFS (No. 2023TD71 ) for funding this study.

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本校为其他机构

院系归属：

化学化工学院

摘要：

The enzymatic demethylation of aromatic compounds presents a major challenge in the valorization of lignin. The main goal was to develop an efficient artificial peroxygenase system combining engineered P450BM3 with AldO (sugar alcohol oxidase) and DFSM (dual function small molecule) for the regioselective O -demethylation of lignin-derived aromatic ethers. P450BM3 serves as a versatile biocatalyst, and its engineered variants demonstrate expanded substrate promiscuity toward non-native substrates. AldO, served as the H 2 O 2 in situ generation ...

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Regioselective aromatic O-demethylation with an artificial P450BM3/sugar alcohol oxidase peroxygenase system

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