期刊：
TRANSLATIONAL CANCER RESEARCH,2024年13(3):1382-1393 ISSN：2218-676X
作者机构：
[Mao, Yanmei; Xi, Lanyan; Zeng, Ying; Chen, Yanping; Chen, Jing] Department of Pharmacy, The Affiliated Changsha Central Hospital, Hengyang Medical School, University of South China, Changsha, China;[Zhang, Haibo] Department of Pharmacy, Hangzhou Women's Hospital, Hangzhou, China;[He, Xin] Department of Pharmacy, The Third Hospital of Changsha, Changsha, China
摘要：
BACKGROUND: Esophageal adenocarcinoma (EAC) is an aggressive cancer with poor prognosis. Thus, this study aimed to identify a prognostic molecular signature to predict the overall survival (OS) of patients with EAC. METHODS: The mRNA microarray data sets GSE13898 and GSE26886 were downloaded from the Gene Expression Omnibus (GEO) database. RNA sequencing profile and clinical data of EAC patients were downloaded from The Cancer Genome Atlas (TCGA) database. Differentially expressed genes (DEGs) between EAC tissues and adjacent non-cancerous tissues were obtained using R software. DEGs associated with prognosis of OS were assessed by univariate Cox analysis, and a prognostic signature was built using stepwise multivariate Cox analysis. Time-dependent receiver operating characteristic (ROC) analysis and stratification analysis were conducted to evaluate its predictive performance. Functional enrichment analysis was performed for genes co-expressed with the signature to explore its biological functions in EAC. RESULTS: A total of 336 genes were identified to be differentially expressed between EAC tissues and adjacent non-cancerous tissues. After univariate and multivariate Cox regression analysis, four genes (ALAD, ABLIM3, IL17RB and IFI6) were screened out to construct a prognostic signature. According to this signature, patients could be assigned into high-risk and low-risk group with significantly different OS (P=4.92e-05<0.0001). Multivariate Cox regression analysis suggested that the four-gene signature served as an independent factor in OS prediction. In the time-dependent ROC analysis, the areas under the curves (AUCs) were 0.804, 0.792 and 0.695 for 1-, 3- and 5-year survival prediction, respectively, suggesting a good performance. Functional enrichment analysis showed that the signature was mainly clustered in cell proliferation related biological processes or pathways. CONCLUSIONS: The four-gene signature identified in the current study may be a potential prognostic factor for predicting OS of EAC patients.
摘要：
Sleep deprivation (SD) is a global public health burden, and has a detrimental role in the nervous system. Retina is an important part of the central nervous system; however, whether SD affects retinal structures and functions remains largely unknown. Herein, chronic SD mouse model indicated that loss of sleep for 4 months could result in reductions in the visual functions, but without obvious morphologic changes of the retina. Ultrastructural analysis by transmission electron microscope revealed the deterioration of mitochondria, which was accompanied with the decrease of multiple mitochondrial proteins in the retina. Mechanistically, oxidative stress was provoked by chronic SD, which could be ameliorated after rest, and thus restore retinal homeostasis. Moreover, the supplementation of two antioxidants, α-lipoic acid and N-acetyl-l-cysteine, could reduce retinal reactive oxygen species, repair damaged mitochondria, and, as a result, improve the retinal functions. Overall, this work demonstrated the essential roles of sleep in maintaining the integrity and health of the retina. More importantly, it points towards supplementation of antioxidants as an effective intervention strategy for people experiencing sleep shortages.
作者机构：
[Wang, Haohua; Zhang, Jingwen; Peng, Jian] Hainan Univ, Sch Math & Stat, Haikou 570228, Hainan, Peoples R China.;[Wang, Yan] Univ South China, Affiliated Hosp 1, Dept Neurol, Hengyang 421001, Peoples R China.;[Zhang, Jingwen] Hainan Univ, Sch Cyberspace Secur, Haikou 570228, Hainan, Peoples R China.;[Wang, Haohua; Zhang, Jingwen] Hainan Univ, Key Lab Engn Modeling & Stat Computat Hainan Prov, Haikou 570228, Peoples R China.
通讯机构：
[Wang, HH ] H;Hainan Univ, Sch Math & Stat, Haikou 570228, Hainan, Peoples R China.
关键词：
HBV model;Information intervention;Stochastic analysis;Stationary distribution;Optimal control
摘要：
The stochastic fluctuation of information induces the dynamic behavior and disease control strategy to change in the HBV epidemic model, but how stochastic information dissemination affects them is vague. Here, we consider an HBV epidemic model with stochastic information intervention. Using the Lyapunov function, we demonstrate that the system has a unique global positive solution, in addition, we also derive the threshold dynamics to obtain sufficient conditions that can ensure the extinction and persistence, as well as stationarity of the system. Moreover, we qualify the impact of stochasticity of the information on the optimal control strategy of the HBV, indicating that while information intervention could effectively reduce the disease peak, the fluctuation will attenuate this effect, i.e., the stable information is better than the noisy one. Finally, various stochastic and optimal control simulations are performed to verify the theoretical results and verify that optimal control can accelerate the extinction of the disease.
通讯机构：
[Tang, HY ] C;Cent Hosp Shaoyang, Dept Neurol, Shaoyang, Hunan, Peoples R China.;Cent Hosp Shaoyang, Stroke Ctr, Shaoyang, Hunan, Peoples R China.
关键词：
Crohn's disease;stricture;surgery
摘要：
BACKGROUND: Stricture in patients with Crohn's disease (CD) carries a high risk of CD-related surgery in the course of the disease. The aim of this study was to assess the rate of occurrence of CD-related surgery and to determine baseline risk factors predicting subsequent surgery in this patient group. METHODS: Patients registered with stricturing CD were included. All baseline and follow-up data were collected retrospectively. Patients attended the clinic for follow-up at week 14 to assess their response to infliximab (IFX). CD-related surgery was the observational endpoint. Univariate and multivariate Cox regression analyses were used. RESULTS: A total of 123 patients with stricturing CD were included in this study. The cumulative risk of CD-related surgery for years 1-5 after diagnosis was 18.0%, 26.7%, 32.6%, 40.7%, and 46.4%, respectively. Prior gastrointestinal (GI) surgery, low body mass index (BMI), and high platelet count might be risk factors for future CD-related surgery. With 97 participants treated by IFX, prior GI surgery and primary non-response (PNR) to IFX correlated with future CD-related surgery. CONCLUSION: Prior GI surgery, BMI, and platelet counts were related to future CD-related surgery. Patients who were PNR to IFX had a higher risk of CD-related surgery in the future.
摘要：
Osteoarthritis (OA) is an age-related musculoskeletal disease that results in pain and functional disability. Stem cell therapy has been considered as a promising treatment for OA. In this study, the therapeutic action and potential mechanism of synovial mesenchymal stem cells (SMSCs)-derived exosomes (Exos) in OA cartilage damage were investigated. Cartilage cells were stimulated with IL-1β to establish an in vitro model of OA cartilage damage. Cartilage cell functions were detected by CCK-8, scratch assay, and flow cytometry, respectively. Inflammatory cytokine levels were assessed by ELISA. Target molecule levels were measured by qRT‒PCR and Western blotting. Exos-induced differential expression of miRNAs in cartilage cells were analyzed by microarray analysis. The interaction between miR-485-3p and neuropilin-1 (NRP1) was validated by dual luciferase reporter and RIP assays. We found that treatment with Exos promoted proliferation, migration, and ECM secretion, but restrained apoptosis and inflammation of IL-1β-exposed cartilage cells via up-regulation of miR-485-3p. Additionally, miR-485-3p directly targeted NRP1 to repress NRP1 expression, which subsequently caused inactivation of the PI3K/Akt pathway. The protective effect of Exos on cartilage damage was counteracted by NRP1 overexpression-mediated activation of the PI3K/Akt pathway. In conclusion, Exos delivered miR-485-3p to attenuate IL-1β-induced cartilage degradation by targeting NRP1 and succedent inactivation of the PI3K/Akt pathway. Our findings shed light on the novel protective mechanism of Exos in OA, which suggest that the restoration of miR-485-3p by Exos might be a novel approach for OA treatment.
期刊：
EUROPEAN JOURNAL OF MEDICAL RESEARCH,2024年29(1):1-21 ISSN：0949-2321
通讯作者：
Liu, T;Zhu, GH
作者机构：
[Liu, Tang; Wang, Lifan; Lin, Zhengjun; Wang, Mingrui; Ji, Yuqiao; Yang, Jing; Zhou, Ziting; Yang, Yaocheng] Cent South Univ, Xiangya Hosp 2, Dept Orthoped, Changsha 410011, Hunan, Peoples R China.;[Zhu, Guanghui] Hunan Childrens Hosp, Dept Pediat Orthoped, Hunan Prov Key Lab Pediat Orthoped, Changsha 410007, Hunan, Peoples R China.;[Zhu, Guanghui] Furong Lab, Changsha, Hunan, Peoples R China.;[Zhu, Guanghui] Univ South China, MOE Key Lab Rare Pediat Dis, Hengyang 421001, Hunan, Peoples R China.;[Wang, Mingrui] Cent South Univ, Sch Basic Med Sci, Changsha 410078, Hunan, Peoples R China.
通讯机构：
[Zhu, GH ] H;[Liu, T ] C;Cent South Univ, Xiangya Hosp 2, Dept Orthoped, Changsha 410011, Hunan, Peoples R China.;Hunan Childrens Hosp, Dept Pediat Orthoped, Hunan Prov Key Lab Pediat Orthoped, Changsha 410007, Hunan, Peoples R China.;Furong Lab, Changsha, Hunan, Peoples R China.
摘要：
BACKGROUND: The importance of protein tyrosine phosphatase non-receptor type 3 (PTPN3) in controlling multifaceted tumor cell behaviors throughout cancer development has received widespread attention. Nevertheless, little is known about the biological roles of PTPN3 in drug sensitivity, immunotherapeutic effectiveness, tumor immune microenvironment, and cancer prognosis. METHODS: The Cancer Genome Atlas (TCGA) database's RNAseq data were used to examine the expression of PTPN3 in 33 different cancer types. In addition, immunohistochemistry (IHC) was performed to validate the expression of PTPN3 across various cancer types within our clinical cohorts. The features of PTPN3 alterations were demonstrated throughout the cBioPortal database. This study focused on examining the prognostic and clinicopathological importance of PTPN3 through the acquisition of clinical data from the TCGA database. The investigation of PTPN3's probable role in the tumor immune microenvironment was demonstrated by theapplication of CIBERSORT, ESTIMATE algorithms, and the TISIDB database. Using Spearman's rank correlation coefficient, the relationships between PTPN3 expression and tumor mutation burden (TMB) and microsatellite instability (MSI) were evaluated. To further investigate the putative biological activities and downstream pathways of PTPN3 in various cancers in humans, Gene Set Enrichment Analysis (GSEA) was carried out. In addition, an examination was conducted to explore the associations between PTPN3 and the effectiveness of PD-1/PD-L1 inhibitors,utilizingdata extracted from the GEO database. RESULTS: PTPN3 was abnormally expressed in multiple cancer types and was also strictly associated with the prognosis of cancer patients. IHC was used to investigate and confirm the various expression levels of PTPN3 in various malignancies, including breast cancer, lung cancer, sarcoma, and kidney renal clear cell carcinoma in our clinical cohorts. There is a high correlation between the levels of PTPN3 expression in different cancers and infiltrating immune cells, including mast cells, B cells, regulatory T cells, CD8 + T cells, macrophages, and dendritic cells. Infiltrating immune cells, such as regulatory T cells, CD8 + T cells, macrophages, B cells, dendritic cells, and mast cells, are strongly correlated with PTPN3 expression levels in various tumors. The expression of PTPN3 exhibited a substantial correlation with many immune-related biomolecules and the expression of TMB and MSI in multiple types of cancer. In addition, PTPN3 has demonstrated promise in predicting the therapeutic benefits of PD-1/PD-L1 inhibitors and the susceptibility to anti-cancer medications in the treatment of clinical cancer. CONCLUSIONS: Our findings highlight the importance of PTPN3 as a prognostic biomarker and predictor of immunotherapy success in various forms of cancer. Furthermore, PTPN3 appears to have an important role in modifying the tumor immune microenvironment, highlighting its potential as a promising biomarker for prognosis prediction, immunotherapeutic efficacy evaluation, and identification of immune-related characteristics in diverse cancer types.
摘要：
BACKGROUND: The newly approved third-generation oral anti-HIV-1 drug, ainuovirine (ANV), was used in combination with nucleoside reverse transcriptase inhibitors (NRTIs) in our study, and its effects on the lipid profile of antiretroviral-experienced HIV/AIDS patients are unclear. OBJECTIVES: This study aimed to examine the effects of antiretroviral agents on the lipid profile in patients with HIV/AIDS. METHODS: We conducted a real-world prospective study involving treatment-naive and treatment-experienced adult participants living with HIV-1 infection provided with ANV- or efavirenz (EFV)-based regimens. The primary endpoint was the proportion of participants with an HIV-1 RNA level of <50 copies/mL at week 24 of treatment. Secondary endpoints included the change from baseline in CD4+ T-cell count and lipid profile. RESULTS: A total of 60 treatment-naive and 47 treatment-experienced participants received an ANV-based regimen, while 88 treatment-naive and 47 treatment-experienced participants receiving an EFV-based regimen were, respectively, matched as controls. At week 24 following treatment, the proportion of participants with an HIV-1 RNA level of <50 copies/mL and the mean changes of CD4+ T-cell counts from baseline were significantly higher in naive-ANV group than those in naive-EFV group (p < 0.01). Compared with the EFV group, both naive and experienced ANV groups exhibited a favorable lipid profile, including constant changes in total cholesterol and triglycerides, a significant decrease in LDL-cholesterol (p < 0.0001), and a dramatic increase in HDL-cholesterol (p < 0.001). CONCLUSION: The efficacy of ANV was non-inferior to EFV when combined with two NRTIs. Patients receiving ANV-based regimens had a decreased prevalence of dyslipidemia.
摘要：
Cancer immunotherapy, particularly with immune checkpoint inhibitors, has revolutionized the paradigm of cancer treatment. Nevertheless, the efficacy of cancer immunotherapy remains limited in most clinical settings due to the lack of a preexisting antitumor T-cell response in tumors. Therefore, the clinical outcomes of cancer immunotherapy must be improved crucially. With increased awareness of the importance of the innate immune response in the recruitment of T cells, as well as the onset and maintenance of the T cell response, great interest has been shown in activating the cGAS-STING signaling pathway to awaken the innate immune response, thereby orchestrating both innate and adaptive immune responses to induce tumor clearance. However, tumor cells have evolved to overexpress ectonucleotide pyrophosphate phosphodiesterase 1 (ENPP1), which degrades the immunotransmitter 2',3'-cGAMP and promotes the production of immune-suppressing adenosine, resulting in inhibition of the anticancer immune response in the tumor microenvironment. Clinically, ENPP1 overexpression is closely associated with poor prognosis in patients with cancer. Conversely, depleting or inhibiting ENPP1 has been verified to elevate extracellular 2',3'-cGAMP levels and inhibit the generation of adenosine, thereby reinvigorating the anticancer immune response for tumor elimination. A variety of ENPP1 inhibitors have recently been developed and have demonstrated significant promise for cancer immunotherapy. In this review, we provide an overview of ENPP1, dissect its immunosuppressive mechanisms, and discuss the development of ENPP1 inhibitors with the potential to further improve the efficacy of cancer immunotherapy.
期刊：
Journal of colloid and interface science,2024年665:188-203 ISSN：0021-9797
通讯作者：
Fu, Yan;Hee Lee, Jung;Yu Yang, Hong
作者机构：
[Liu, Changling; Tian Yan, Hao] College of Materials Science and Engineering, Jilin Institute of Chemical Technology, Jilin City 132022, Jilin Province, China;[Jang, Moon-Sun] Department of Radiology, Samsung Medical Center, Sungkyunkwan University School of Medicine and Center for Molecular and Cellular Imaging, Samsung Biomedical Research Institute, Seoul 06351, the Republic of Korea;[Fu, Qiang] Department of Rheumatology and Immunology, The First Affiliated Hospital of University of South China, Hengyang, China;[Wang, Bo] Jilin Provincial Key Laboratory of Straw-Based Functional Materials, Institute for Interdisciplinary Biomass Functional Materials Studies, Jilin Engineering Normal University, Changchun 130052, P. R. China;[Fu, Yan] College of Materials Science and Engineering, Jilin Institute of Chemical Technology, Jilin City 132022, Jilin Province, China. Electronic address: fuyanqd@163.com
通讯机构：
[Yu Yang, Hong; Fu, Yan] C;[Hee Lee, Jung] D;College of Materials Science and Engineering, Jilin Institute of Chemical Technology, Jilin City 132022, Jilin Province, China. Electronic address:;Department of Radiology, Samsung Medical Center, Sungkyunkwan University School of Medicine and Center for Molecular and Cellular Imaging, Samsung Biomedical Research Institute, Seoul 06351, the Republic of Korea. Electronic address:
摘要：
Anti-tumor therapies reliant on reactive oxygen species (ROS) as primary therapeutic agents face challenges due to a limited oxygen substrate. Photodynamic therapy (PDT) is particularly hindered by inherent hypoxia, while chemodynamic therapy (CDT) encounters obstacles from insufficient endogenous hydrogen peroxide (H(2)O(2)) levels. In this study, we engineered biodegradable tumor microenvironment (TME)-activated hollow mesoporous MnO(2)-based nanotheranostic agents, designated as HAMnO(2)A. This construct entails loading artemisinin (ART) into the cavity and surface modification with a mussel-inspired polymer ligand, namely hyaluronic acid-linked poly(ethylene glycol)-diethylenetriamine-conjugated (3,4-dihydroxyphenyl) acetic acid, and the photosensitizer Chlorin e6 (mPEG-HA-Dien-(Dhpa/Ce6)), facilitating dual-modal imaging-guided PDT/CDT synergistic therapy. In vitro experimentation revealed that HAMnO(2)A exhibited ideal physiological stability and enhanced cellular uptake capability via CD44-mediated endocytosis. Additionally, it was demonstrated that accelerated endo-lysosomal escape through the pH-dependent protonation of Dien. Within the acidic and highly glutathione (GSH)-rich TME, the active component of HAMnO(2)A, MnO(2), underwent decomposition, liberating oxygen and releasing both Mn(2+) and ART. This process alleviates hypoxia within the tumor region and initiates a Fenton-like reaction through the combination of ART and Mn(2+), thereby enhancing the effectiveness of PDT and CDT by generating increased singlet oxygen ((1)O(2)) and hydroxyl radicals (•OH). Moreover, the presence of Mn(2+) ions enabled the activation of T(1)-weighted magnetic resonance imaging. In vivo findings further validated that HAMnO(2)A displayed meaningful tumor-targeting capabilities, prolonged circulation time in the bloodstream, and outstanding efficacy in restraining tumor growth while inducing minimal damage to normal tissues. Hence, this nanoplatform serves as an efficient all-in-one solution by facilitating the integration of multiple functions, ultimately enhancing the effectiveness of tumor theranostics.
摘要：
An improved metallized polyethylene terephthalate (PET) substrate prepared by catechol (CA) and tetraethylenepentamine (TEPA) composites modification with electroless deposition (ELD) copper layer is presented. Through the polymerization of CA with TEPA, amino and imino groups were generated to adsorb the activated particles required for metallization. To achieve the practical application of this method, different catalytic approaches were validated. Under different catalytic conditions, the catalytic effect of UV light was most pronounced, reaching almost four times than that in darkness. The resulting solid copper layers exhibited highly reliable electrical properties, including a low resistivity of 2.73 mu omega cm, tightly spaced crystalline particles and excellent mechanical properties. The fabricated metallized PET substrates were verified for use in flexible circuit boards, demonstrating the compatibility of the proposed CA-TEPA composites modification method with the PET substrates. This method provides an effective approach to the metallization of the PET substrates, which has a widespread application in manufacturing of flexible electronics such as film capacitors.
作者机构：
China Nuclear Industry Key Laboratory of High-Performance Concrete, University of South China, Hengyang 421001, China;School of Civil Engineering, University of South China, Hengyang 421001, China;Hunan Provincial Key Laboratory of High-Performance Special Concrete, University of South China, Hengyang 421001, China;Author to whom correspondence should be addressed.;[Yan’e Yang] School of Civil Engineering, Lanzhou University of Technology, Lanzhou 730050, China
通讯机构：
[Zhenfu Chen] C;China Nuclear Industry Key Laboratory of High-Performance Concrete, University of South China, Hengyang 421001, China<&wdkj&>School of Civil Engineering, University of South China, Hengyang 421001, China<&wdkj&>Hunan Provincial Key Laboratory of High-Performance Special Concrete, University of South China, Hengyang 421001, China<&wdkj&>Author to whom correspondence should be addressed.
关键词：
high temperature;lead–zinc tailings;radiation shielding concrete;mechanical strength;gamma ray shielding;ultrasonic pulse velocity
摘要：
Due to the high prices, the popularity of radiation shielding concrete (RSC) has been greatly limited. To solve this, this research reused the lead–zinc tailings (LZT) as a fine aggregate replacement ranging from 0% to 60% for the RSC. The results revealed that the RSC containing 30% LZT presented better workability and achieved 95.84% of the compressive strength and 98.49% of the linear attenuation coefficient of the RSC, and reached the highest splitting tensile strength values, which increased by 4.43%. Meanwhile, after the heat treatments, there were favorable correlations between the relative velocity and relative strength, as well as between the damage index and the relative linear attenuation coefficient, which could accurately reflect the degradation of not only the mechanical but also the shielding properties. Considering the temperature and shielding thickness, the reuse of LZT can bring considerable economic and environmental benefits.
期刊：
Nuclear Engineering and Technology,2024年 ISSN：1738-5733
通讯作者：
Changjun Qiu
作者机构：
School of Resource Environment and Safety Engineering, University of South China, Hengyang, Hunan, 421001, China;School of Mechanical Engineering, University of South China, Hengyang, Hunan, 421001, China;Key Laboratory of Emergency Safety Technology and Equipment of Nuclear Facilities in Hunan Province, Hengyang, Hunan, 421001, China;[Wen Chen; Jianyong Dai; Meirong Zhang] School of Resource Environment and Safety Engineering, University of South China, Hengyang, Hunan, 421001, China<&wdkj&>Key Laboratory of Emergency Safety Technology and Equipment of Nuclear Facilities in Hunan Province, Hengyang, Hunan, 421001, China;[Shuliang Zou; Changjun Qiu] School of Mechanical Engineering, University of South China, Hengyang, Hunan, 421001, China<&wdkj&>Key Laboratory of Emergency Safety Technology and Equipment of Nuclear Facilities in Hunan Province, Hengyang, Hunan, 421001, China
通讯机构：
[Changjun Qiu] S;School of Mechanical Engineering, University of South China, Hengyang, Hunan, 421001, China<&wdkj&>Key Laboratory of Emergency Safety Technology and Equipment of Nuclear Facilities in Hunan Province, Hengyang, Hunan, 421001, China
摘要：
Modern risk management philosophy emphasizes the invulnerability of human beings to cope with all kinds of emergencies. The Nuclear Accidents Emergency Response Organization (NAERO) of Nuclear Power Plant (NPP) is the primary body responsible for nuclear accidents emergency response. The invulnerability of the organization to disturbance or attack from internal and external sources is crucial in the completion of its response missions, reduction of severity of accidents, and assurance of public and environmental safety. This paper focused on the NAERO of a certain NPP in China, and applied the complex network theory to construct the network model of the organization. The topological characteristics of the network were analyzed. Four importance evaluation indexes of network nodes including Degree Centrality (DC), Betweeness Centrality (BC), Closeness Centrality (CC) and Eigenvector Centrality (EC), along with Pearson coefficient correlation among the indexes were calculated and analyzed. Size of the Largest Connected Component (LCC) and Network Efficiency were used as measures regarding the invulnerability of the network. Simulation experiments were conducted to assess the invulnerability of network against various attack strategies. These experiments were conducted both in the absence of node protection measures and under protection measures with different node protection rates. This study evaluated the invulnerability of the NAERO network, and provided significant decision-making basis for the enhancement of the network's invulnerability.
摘要：
The fusion of low-resolution hyperspectral image (LR-HSI) and high-resolution multispectral image (HR-MSI) is a crucial technology for producing high-resolution hyperspectral images. Most existing image fusion algorithms based on deep learning do not fully utilize the ability of neural network to extract and process multi-scale features, which leads to the problem of difficulty in fully learning features and ambiguity of features. In order to overcome these issues, a residual selective kernel attention-based U-net named RSKAU-net is designed for LR-HSI and HR-MSI fusion. RSKAU-net is constructed by a residual selective kernel module with an attention mechanism and a channel attention block. The residual selective kernel attention-based (RSKA) module is designed to process images of different resolutions, which adaptively extracts multi-scale features and efficiently emphasizes significant features through the attention mechanism. The channel attention (CA) module retains important spectral information by assigning different weights to each channel of LR-HSI. The proposed network can enhance the spatial information of LR-HSI while preserving its spectral information. Meanwhile, it effectively fuses the features from the source image to obtain the HR-HSI with rich details. The experimental results demonstrate that the proposed network has advantages in terms of both visual effect and objective quantitative indices when compared to existing HSI-MSI fusion approaches.
