Identification and verification of PTPN3 as a novel biomarker in predicting cancer prognosis, immunity, and immunotherapeutic efficacy

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作者信息关键词期刊信息基础信息归属信息摘要

成果类型：

期刊论文

作者：

Zhou, Ziting;Lin, Zhengjun;Wang, Mingrui;Wang, Lifan;Ji, Yuqiao;...

通讯作者：

Liu, T;Zhu, GH

作者机构：

[Liu, Tang; Wang, Lifan; Lin, Zhengjun; Wang, Mingrui; Ji, Yuqiao; Yang, Jing; Zhou, Ziting; Yang, Yaocheng] Cent South Univ, Xiangya Hosp 2, Dept Orthoped, Changsha 410011, Hunan, Peoples R China.

[Zhu, Guanghui] Hunan Childrens Hosp, Dept Pediat Orthoped, Hunan Prov Key Lab Pediat Orthoped, Changsha 410007, Hunan, Peoples R China.

[Zhu, Guanghui] Furong Lab, Changsha, Hunan, Peoples R China.

[Zhu, Guanghui] Univ South China, MOE Key Lab Rare Pediat Dis, Hengyang 421001, Hunan, Peoples R China.

[Wang, Mingrui] Cent South Univ, Sch Basic Med Sci, Changsha 410078, Hunan, Peoples R China.

通讯机构：

[Zhu, GH ] H

[Liu, T ] C

Cent South Univ, Xiangya Hosp 2, Dept Orthoped, Changsha 410011, Hunan, Peoples R China.

Hunan Childrens Hosp, Dept Pediat Orthoped, Hunan Prov Key Lab Pediat Orthoped, Changsha 410007, Hunan, Peoples R China.

Furong Lab, Changsha, Hunan, Peoples R China.

语种：

英文

期刊：

EUROPEAN JOURNAL OF MEDICAL RESEARCH

ISSN：

0949-2321

年：

2024

卷：

期：

页码：

1-21

DOI：

10.1186/s40001-023-01587-5

基金类别：

This study was supported by grants from Natural Science Foundation of Xinjiang Uygur Autonomous Region (NO. 2022D01C565), Opening fundings of Hunan Provincial Key Laboratory of Pediatric Orthopedics Science (2023TP1019), and Technology Project of Furong Laboratory (2023SK2111).

机构署名：

本校为通讯机构

摘要：

BACKGROUND: The importance of protein tyrosine phosphatase non-receptor type 3 (PTPN3) in controlling multifaceted tumor cell behaviors throughout cancer development has received widespread attention. Nevertheless, little is known about the biological roles of PTPN3 in drug sensitivity, immunotherapeutic effectiveness, tumor immune microenvironment, and cancer prognosis. METHODS: The Cancer Genome Atlas (TCGA) database's RNAseq data were used to examine the expression of PTPN3 in 33 different cancer types. In addition, immunohistochemistry (IHC...

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Identification and verification of PTPN3 as a novel biomarker in predicting cancer prognosis, immunity, and immunotherapeutic efficacy

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