Synovial mesenchymal stem cell-derived exosomal miR-485-3p relieves cartilage damage in osteoarthritis by targeting the NRP1-mediated PI3K/Akt pathway Exosomal miR-485-3p relieves cartilage damage.

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作者信息关键词期刊信息基础信息归属信息摘要

成果类型：

期刊论文

作者：

Qiu, Mingjun;Xie, Yanhua;Tan, Guanghua;Wang, Xiaoxu;Huang, Peiguan;...

通讯作者：

Hong, L

作者机构：

[Hong, Liang; Qiu, Mingjun; Wang, Xiaoxu; Tan, Guanghua; Huang, Peiguan] Univ South China, Affiliated Hosp 2, Dept joint Surg, Hengyang, Peoples R China.

[Xie, Yanhua] Univ South China, Affiliated Hosp 2, Dept Orthoped, Hengyang, Peoples R China.

通讯机构：

[Hong, L ] U

Univ South China, Affiliated Hosp 2, Dept joint Surg, Hengyang, Peoples R China.

语种：

英文

关键词：

Cartilage damage;Exos;NRP1;Osteoarthritis;miR-485-3p

期刊：

Heliyon

ISSN：

2405-8440

年：

2024

卷：

期：

页码：

e24042

DOI：

10.1016/j.heliyon.2024.e24042

基金类别：

Hengyang Science and Technology Bureau [2019jh010986]

机构署名：

本校为第一且通讯机构

摘要：

Osteoarthritis (OA) is an age-related musculoskeletal disease that results in pain and functional disability. Stem cell therapy has been considered as a promising treatment for OA. In this study, the therapeutic action and potential mechanism of synovial mesenchymal stem cells (SMSCs)-derived exosomes (Exos) in OA cartilage damage were investigated. Cartilage cells were stimulated with IL-1β to establish an in vitro model of OA cartilage damage. Cartilage cell functions were detected by CCK-8, scratch assay, and flow cytometry, respectively. I...

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Synovial mesenchymal stem cell-derived exosomal miR-485-3p relieves cartilage damage in osteoarthritis by targeting the NRP1-mediated PI3K/Akt pathway Exosomal miR-485-3p relieves cartilage damage.

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