通讯机构：
[Li, T ] U;Univ South China, Sch Resource Environm & Safety Engn, Hengyang 421001, Peoples R China.
摘要：
Low-concentration electrolyte demonstrates significant advantages in terms of low cost, low viscosity, and high wettability. However, its high solvent ratio usually induces a fragile organic-rich solid electrolyte interphase (SEI), which is not compatible with high-voltage lithium metal batteries (LMBs). Herein, a screening rule for diluents has been established based on the electrostatic potential, which guides the rational design of diluted low-concentration electrolyte (DLCE) with a high anion-to-solvent ratio. Specifically, the anti-solvating power of a diluent is positively correlated with its value of the most positive surface potential (ESPmax), and thus diluents with a high ESPmax value easily cause salt precipitation when diluting concentrated electrolyte to low concentration (<1 M). In light of this observation, a diluent with a low ESPmax value is selected to ensure the preparation of a transparent DLCE, thus maintaining a high anion-to-solvent ratio in DLCE. As an exemplary study, a 0.5 M ether-based DLCE is developed for high-voltage LMBs. Due to the high anion-to-solvent ratio, a robust LiF-rich SEI is formed and enables the stable operation of LMBs under high voltage (4.5 V) and a wide temperature range (-20 to 55 C-degrees). This work offers a guideline for screening diluents to design high-performance LCEs for high-voltage batteries.
摘要：
BACKGROUND: Depression is a highly prevalent comorbidity arising in patients with Parkinson's disease (PD). However, depression in patients with PD is poorly treated. Hydrogen sulfide (H(2)S), a neuromodulator, has the potential to relieve depression. OBJECTIVE: To investigate whether H(2)S attenuates depression-like behaviours in a rat model of PD and examine the underlying mechanisms. METHODS: We utilised rotenone to develop a PD model with subcutaneous injections in the dorsal cervical region of Sprague-Dawley rats. The depression-like behaviours in the rotenone-induced PD model rats were assessed through forced swimming, tail suspension, open field, novelty-suppressed feeding, and elevated plus-maze tests. The expression of postsynaptic density protein-95 and synapsin-1, related to synaptic plasticity, was detected using Western blot in the hippocampus. The hippocampal ultrastructure, including the synaptic density, length of the synaptic active zone, postsynaptic density thickness, and synaptic gap width, was detected using transmission electron microscopy. RESULTS: We proved that sodium hydrosulfide (NaHS; a donor of H(2)S) significantly attenuated the depression-like behaviours and disorders of hippocampal synaptic plasticity in rotenone-induced PD rats. Furthermore, inhibition of the hippocampal Warburg effect by 2-deoxyglucose abolished NaHS-enhanced hippocampal synaptic plasticity and reversed NaHS-attenuated depression-like behaviours in the rotenone-induced PD rats. CONCLUSION: H(2)S attenuates PD-associated depression by improving the hippocampal synaptic plasticity in a hippocampal Warburg effect-dependent manner.
摘要：
In Particle-In-Cell simulation, macro-particles represent clusters of numerous physical particles. Rational merging or splitting of these macro-particle clusters can significantly improve the efficiency of simulation and reduce unnecessary computational requirements and memory consumption. Here, we propose a dynamical particle merging and splitting algorithm. For macro-particle in different density regions, regional macro-particle clusters are obtained by dividing them with the Minkowski metric function. Dynamic merging and splitting of macro-particles is achieved by dynamically changing the number of macro-particle clusters to reduce the number of macro-particles without substantially distorting the physical description of the system. To test the capability of the algorithm, we also compare its performance under three types of classical plasma cases: two-stream instability (1D), QED cascades (2D), and magnetic shower (3D). The results show a good agreement with expectations. (c) 2023 Elsevier B.V. All rights reserved.
关键词：
Germanium;Tartaric acid;Selective separation;Column separation;D201 x 7 resin
摘要：
Germanium (Ge) exhibits excellent optical and electrical properties. Due to the low reserves of Ge and lack of independent mineral resources, zinc refinery residues have become an important source of Ge. In this work, a D201 x 7 resin has been employed in the selective separation of Ge from a sulfuric solution using tartaric acid as a complexing agent. In the sulfuric acid system, Ge(OH)4 was converted to an anionic complex [GeO2(OH)2C4H4O4]2- at a 1:1 tartaric acid to Ge molar ratio. The anion exchange D201 x 7 resin adsorbed the Ge tartrate anionic complex. The adsorption process exhibited pseudo-second-order kinetic behavior and adhered to the Langmuir isothermal adsorption model. The maximum adsorption capacity of D201 x 7 resin for Ge was 214 mg g-1. Selective Ge uptake and purification could proceed by column separation The results showed that enrichment factor was 74.7, and the desorption concentration of Ge was increased from 500 mg L-1 to 36.6 g L-1. The D201 x 7 resin exhibited high selectivity, excellent adsorption performance and good stability, making it a viable candidate in industrial applications.
期刊：
European Journal of Pharmacology,2024年972:176558 ISSN：0014-2999
通讯作者：
Hu, Jinyue
作者机构：
[Wang, Yufei; Xiang, Wei; Jiang, Manli; Liu, Xueting] Medical Research Center, Affiliated Changsha Central Hospital of Hengyang Medical School, University of South China, Changsha, 410004, China;[Wang, Guihua] Department of Oncology, Affiliated Changsha Central Hospital of Hengyang Medical School, University of South China, Changsha, 410004, China;[Hu, Jinyue] Medical Research Center, Affiliated Changsha Central Hospital of Hengyang Medical School, University of South China, Changsha, 410004, China. Electronic address: 2018050703@usc.edu.cn
通讯机构：
[Hu, Jinyue] M;Medical Research Center, Affiliated Changsha Central Hospital of Hengyang Medical School, University of South China, Changsha, 410004, China. Electronic address:
摘要：
Inhibitors of polo-like kinase (PLK) are currently being evaluated as anticancer drugs. However, the molecular mechanism of PLK inhibitor-induced cell death is not fully understood. In this study, we found that GW843682X and BI2536, two inhibitors of PLK1, significantly induced cell death in multiple type cells. The induction of cell death was related to the preferring expression of PLK1. However, in human umbilical vascular endothelial cells (HUVEC) and human colorectal carcinoma cells, which expressed higher levels of both PLK1 and PLK2, PLK1 inhibitors induced very low levels of cell death. Clinical analysis reveals PLK1 presence in 26 of 30 NPC tumor tissues. In in vivo NPC lung metastasis nude mouse models, PLK1 inhibitors decreased NPC progress. Mechanistically, the PLK1 inhibitor did not activate p53, and the cell death was not reversed by p53 inhibition. Moreover, PLK1 inhibitor-induced cell death was PARP- and caspase-independent. Although PLK1 inhibitors induced down-regulation of calpain inhibitor calpastatin and calpain was activated by PLK1 inhibition, calpain blocking did not reverse cell death induced by PLK1 inhibitors, suggesting the non-involvement of calpain. Surprisingly, we found that PLK1 inhibitors induced the activation of proteasome, and the treatment of cells with PLK1 inhibitors reduced the levels of ubiquitinated proteins. And proteasome inhibitors reversed cell death induced by PLK1 inhibitors in various cell types in which PLK1 was preferentially expressed. Moreover, PLK1 inhibition reversed the degradation of proteins including p53, caspase 8, PARP and calpastatin. These results suggest that the activation of proteasome is critical for cell death induced by PLK1 inhibition.
摘要：
Metal halide perovskite (MHP) detectors are highly esteemed for their outstanding photoelectric properties and versatility in applications. However, they are unfortunately prone to degradation, which constitutes a significant barrier to their sustained performance. This review meticulously delves into the causes leading to their instability, predominantly attributable to factors such as humidity, temperature, and electric fields and, notably, to various radiation factors such as X-rays, gamma-rays, electron beams, and proton beams. Furthermore, it outlines recent advancements in strategies aimed at mitigating these detrimental effects, emphasizing breakthroughs in composition engineering, heterostructure construction, and encapsulation methodologies. At last, this review underscores the needs for future improvements in theoretical studies, material design, and standard testing protocols. In the pursuit of optimizing the chemical stability of MHP detectors, collaborative efforts are in an imperative need. In this way, broad industrial applications of MHP detectors could be achieved.
作者机构：
[Peiguan Huang; Xiaojun Tang] Second Affiliated Hospital, Department of Joint Surgery, Hengyang Medical School, University of South China, Hengyang, Hunan, China
通讯机构：
[Peiguan Huang] S;Second Affiliated Hospital, Department of Joint Surgery, Hengyang Medical School, University of South China, Hengyang, Hunan, China
摘要：
At present, the suture bridge is a widely used surgical pattern in the treatment of supraspinatus tendon tear, but the shortcomings of a suture bridge, including expensive lateral-row anchor and increased type 2 retear rate, is obvious. The double-pulley suture-bridge described in this Technical Note uses a double-loaded suture anchor (medial-row anchor) as lateral-row anchor instead of traditional lateral-row anchor, combined with double-pulley technology forming suture-bridge in treatment of supraspinatus tendon tears. The surgical technique is described in pearls, pitfalls, advantages, and disadvantages.
作者机构：
[Liu, Li; He, Jingzhe; Wang, Jiaren; Li, Ruining; Li, Qimei; Zeng, Lin; Xiao, Lushan; Li, Yan; Hong, Chang; Cui, Hao] Southern Med Univ, Nanfang Hosp, Hepatol Unit, Guangdong Prov Key Lab Viral Hepatitis Res, Guangzhou, Peoples R China.;[Liu, Li; He, Jingzhe; Wang, Jiaren; Li, Ruining; Li, Qimei; Zeng, Lin; Xiao, Lushan; Li, Yan; Hong, Chang; Cui, Hao] Southern Med Univ, Nanfang Hosp, Dept Infect Dis, Guangzhou, Peoples R China.;[Liu, Li; Wang, Jiaren; Xiao, Lushan] Southern Med Univ, Nanfang Hosp, Big Data Ctr, Guangzhou, Peoples R China.;[Wang, Weizhen] Southern Med Univ, Nanfang Hosp, Dept Ultrasound, Guangzhou, Peoples R China.;[Zhu, Hongbo] Univ South China, Affiliated Hosp 1, Hengyang Med Sch, Dept Med Oncol, Hengyang, Hunan, Peoples R China.
通讯机构：
[Xiao, LS ; Liu, L ; Zhu, H ] S;Southern Med Univ, Nanfang Hosp, Guangzhou 510515, Peoples R China.;Southern Med Univ, Nanfang Hosp, Big Data Ctr, Guangzhou 510515, Peoples R China.;Southern Med Univ, Nanfang Hosp, Hepatol Unit, Guangdong Prov Key Lab Viral Hepatitis Res, Guangzhou 510515, Peoples R China.;Southern Med Univ, Nanfang Hosp, Dept Infect Dis, Guangzhou 510515, Peoples R China.
关键词：
CCR;MSFLD;risk factor;UK Biobank
摘要：
OBJECTIVE: Metabolic dysfunction-associated steatotic liver disease (MASLD) affects many populations, and screening out the high-risk populations at an early stage is a challenge. As a sarcopenia index, the relationship between creatinine to cystatin C ratio (CCR) and MASLD remains unclear. This cross-sectional, prospective study aimed to explore the relationship between CCR and MASLD. Design Firstly, explored the correlation between CCR and MASLD in cross-sectional analyses. Then excluded the population with baseeline diagnosis of MASLD and analyzed the association with baseline CCR levels and the onset of MASLD in the population with available follow-up data. Univariate and multivariate logistic regression analyses were used to calculate odds ratios (ORs) to evaluate the association between CCR levels and MASLD. PATIENTS AND MEASUREMENTS: This study included 368,634 participants from the UK Biobank for cross-sectional and prospective analyses. The demographic characteristics and laboratory measurements of all participants were obtained from the UK Biobank. MASLD was diagnosed according to the multi-society consensus nomenclature. Hepatic steatosis was defined as FLI ≥60. RESULTS: We grouped the study participants according to CCR tertiles. In cross-sectional analyses, participants in CCR tertile 1 had the highest MASLD risk (OR: 1.070, 95%CI: 1.053-1.088, p < .001). And the similar association was observed in the prospective analyses (CCR tertile 1 OR: 1.340, 95%CI: 1.077-1.660, p = .009; CCR tertile 2 OR: 1.217, 95%CI: 1.021-1.450, p = .029, respectively). After stratification by gender, the significant association between CCR and the onset of MASLD was only observed in males (CCR tertile 1 OR: 1.639, 95%CI: 1.160-2.317, p = .005; CCR tertile 2 OR: 1.322, 95%CI: 1.073-1.628, p = .005, respectively). CONCLUSION: Our results indicated that lower CCR was significantly associated with higher risk of MASLD, based on which predictive models can be developed to screen populations at high risk of developing MASLD.
通讯机构：
[Chen, GD; Wu, DC ] U;Univ South China, Affiliated Hosp 1, Hengyang Med Sch, Dept Hepatopancreatobiliary Surg,Lab Struct Immuno, Hengyang 421001, Hunan, Peoples R China.
关键词：
Combination therapy;Therapeutic cancer vaccine;Tumor antigen
摘要：
Therapeutic cancer vaccines have shown promising efficacy in helping immunotherapy for cancer patients, but the systematic characterization of the clinical application and the method for improving efficacy is lacking. Here, we mainly summarize the classification of therapeutic cancer vaccines, including protein vaccines, nucleic acid vaccines, cellular vaccines and anti-idiotypic antibody vaccines, and subdivide the above vaccines according to different types and delivery forms. Additionally, we outline the clinical efficacy and safety of vaccines, as well as the combination strategies of therapeutic cancer vaccines with other therapies. This review will provide a detailed overview and rationale for the future clinical application and development of therapeutic cancer vaccines.
作者机构：
[Ya Guo] Southwest Jiaotong University, 111 Second Ring, North 1st Section, Chengdu, Sichuan, 610031, CHINA;[Hiroaki Nakajima; Wenbin Lin] University of South China, 28 Changsheng West Road, Hengyang, Hunan, 421001, CHINA
摘要：
We study the wave equations with various spins on the background of the general spherically symmetric spacetime. We obtain the unified expression of the Teukolsky-like master equations and the corresponding radial equations with the general spins. We also discuss the gauge dependence in the gravitational-wave equations, which have appeared in the previous studies.
关键词：
lung adenocarcinoma;Mendelian randomization;non-small cell lung cancer;serum metabolites;squamous lung cancer
摘要：
This study seeks to understand the causal association between serum metabolites and different lung cancer types, an area yet to be extensively studied. We Used a two-sample Mendelian randomization (TSMR) approach, utilizing 486 blood metabolites as exposures and 3 distinct lung cancer types genome-wide association studies datasets as outcomes. We employed inverse variance weighting, MR-Egger, weighted median, simple mode, and weighted mode to estimate causal effects. We performed sensitivity analyses using Cochran Q test, MR-Egger intercept test, and MR-pleiotropy residual sum and outlier (MR-PRESSO). Linkage disequilibrium score (LDSC) analysis was conducted on the selected metabolites, and common confounding single nucleotide polymorphisms were eliminated using the human genotype-phenotype association Database. Metabolic pathway analysis was performed with MetaboAnalyst 5.0 software. Subsequently, a multivariate Mendelian randomization analysis was conducted to ascertain independent risk exposures. Our findings suggest independent risk factors for specific types of lung cancer: 7-methylxanthine and isoleucine for lung adenocarcinoma, cysteine and 1-arachidonoylglycerophosphocholine are identified as independent protective and risk factors for squamous lung cancer. Undecanoate (11:0) with Linoleate (18:2n6) showed a protective effect for small cell lung cancer. Additionally, 11 metabolic pathways were associated with lung cancer. This novel perspective offers a multidimensional understanding of lung cancer phenotypes, providing valuable guidance for identifying and screening of diverse lung cancer phenotypes.
摘要：
The endometrium microvessel system, responsible for supplying oxygen and nutrients to the embryo, holds significant importance in evaluating endometrial receptivity (ER). Visualizing this system directly can significantly enhance ER evaluation. Currently, clinical methods like Narrow-band hysteroscopy and Color Doppler ultrasound are commonly used for uterine blood vessel examination, but they have limitations in depth or resolution. Endoscopic Photoacoustic Imaging (PAE) has proven effective in visualizing microvessels in the digestive tract, while its adaptation to uterine imaging faces challenges due to the uterus's unique physiological characteristics. This paper for the first time that uses high-resolution PAE in vivo to capture a comprehensive network of endometrial microvessels non-invasively. Followed by continuous observation and quantitative analysis in the endometrial injury model, we further corroborated that PAE detection of endometrial microvessels stands as a valuable indicator for evaluating ER. The PAE system showcases its promising potential for integration into reproductive health assessments.
摘要：
Halloysite nanotubes (HNTs) are nanomaterials (NMs) derived from natural clays and have been considered as biocompatible NMs for biomedical uses. However, the cardiovascular toxicity of HNTs has not been thoroughly investigated. In this study, we compared the cardiotoxicity of HNTs and multi-walled carbon nanotubes (MWCNTs), focusing on the changes in Kruppel-like factor (KLF)-mediated signaling pathways. Mice were intravenously injected with 50µg NMs, once a day, for 5 days, and then mouse hearts were removed for experiments. While HNTs or MWCNTs did not induce obvious pathological changes, RNA-sequencing data suggested the alterations of KLF gene expression. We further confirmed an increase of Klf15 positive cells, accompanied by changes in Klf15-related gene ontology (GO) terms. We noticed that most of the changed GO terms are related with the regulation of gene expression, and we confirmed that the NMs increased myoneurin (Mynn) but decreased snail family transcriptional repressor 1 (Snai1), two transcription factors (TFs) related with Klf15. Besides, the changed GO terms also include metal ion binding and positive regulation of glucose import, and we verified an increase of phosphoenolpyruvate carboxykinase 1 (Pck1) and insulin receptor (Insr). However, HNTs and MWCNTs only showed minimal impact on cell death signaling pathways, and no increase in apoptotic sites was observed after NM treatment. We concluded that intravenous administration of HNTs and MWCNTs activated a protective TF, namely Klf15 in mouse aortas, to alter gene expression and signaling pathways related with metal ion binding and glucose import.
作者机构：
[Xie, Chao; Wang, Hong; Yu, Tao] Univ South China, Sch Nucl Sci & Technol, Hengyang 421001, Peoples R China.;[Xie, Chao; Wang, Hong; Lu, Wenjun; Wang, Xiangshuai] Univ South China, Sch Resources Environm & Safety Engn, Hengyang 421001, Peoples R China.;[Xie, Chao; Yu, Tao] Univ South China, Key Lab Adv Nucl Energy Technol Design & Safety, Minist Educ, Hengyang 421001, Peoples R China.
通讯机构：
[Wang, H ] U;Univ South China, Sch Nucl Sci & Technol, Hengyang 421001, Peoples R China.;Univ South China, Sch Resources Environm & Safety Engn, Hengyang 421001, Peoples R China.
摘要：
To ensure the safety and stability of the beach surface of the decommissioned uranium mill tailings pond, this paper uses red clay-bentonite and red clay (1:1) to carry out covering layer radon reduction simulation experiments to study the temperature, humidity, and radon reduction effect of the covering layer under natural conditions. The results show that the radon exhalation rate of red clay-bentonite cover layer is only 0.32 times that of red clay, which has a better radon reduction effect. The red clay-bentonite cover layer has better water retention and comparable heat preservation effect than red clay cover layer. The red clay-bentonite and red clay temperature curves follow the same evolution trend and were close together in the same outdoor conditions, and the humidity curves showed a difference of 1% to 3%. Soil temperature is the dominant factor affecting the variation of radon exhalation of red clay-bentonite and red clay covering layer with unsaturated water content.
