摘要：
Uranium mining operations produce large volumes of acidic uranium mining wastewater, necessitating the development of environmentally friendly and recyclable materials for efficient uranium removal and recovery. The current study successfully produced hydroxyapatite (HAP-L) and magnetic phosphate composites (CaFeP-1, CaFeP-2, and FePO4) through a combination of mixing, ultrasonication, hydrothermal precipitation, and calcination methods. The research explores the influence of various parameters such as pH, solid-liquid ratio, contact time, initial uranium concentration, co-existing ions, and recyclability on the uranium removal efficiency of these materials. The findings indicate exceptional uranium adsorption capacities, with CaFeP-1 exhibiting the highest capacity among the materials, especially in acidic environments. Moreover, CaFeP-1 displays strong resistance to interference from other ions and can be recycled multiple times while maintaining high removal rates. Treatment of acidic uranium mining wastewater by CaFeP-1 results in pH adjustment and the reduction of uranium and other ion concentrations, making it a promising solution for comprehensive remediation of acidic uranium mining wastewater. The U(VI) removal mechanism by CaFeP-1 was validated through XRD, FT-IR, and XPS results. The U(VI) removal was attributed to processes such as dissolution-precipitation, surface complexation, and ion exchange. The formation of sodium uranyl phosphate hydrate was identified as a new product following U(VI) abatement by CaFeP-1. In summary, CaFeP-1 shows great potential for the effective treatment of acidic uranium mining wastewater.
摘要：
BACKGROUND: We previously revealed that hydrogen sulfide (H(2)S) attenuates chronic stress-induced cognitive impairment, but the underlying mechanism needs to be further clarified. Growth differentiation factor 11 (GDF11) plays an important regulatory role in cognitive function and that hippocampal NLRP3/caspase-1-mediated pyroptosis contributes to the pathogenesis of cognitive impairment. Hence, this research aimed to explore whether promoting GDF11 levels and suppressing hippocampal NLRP3/caspase-1-mediated pyroptosis mediate H(2)S to alleviate chronic stress-induced cognitive impairment. METHODS: Sprague-Dawley rats were subjected to unpredictable chronic mild stress lasting four weeks to establish an animal model of chronic stress-induced cognitive impairment. Behavioral performance was assessed by the Y-maze test and the novel object recognition test. The expression levels of proteins were analyzed by Western blot analysis. The levels of IL-1β and IL-18 in the hippocampus were measured by ELISA. RESULTS: NaHS upregulated the expression of GDF11 in the hippocampus of chronic unpredictable mild stress (CUMS)-exposed rats. Silencing GDF11 blocked NaHS-improved cognitive impairment in CUMS-exposed rats, according to the Y-maze test and the novel object recognition test. Furthermore, NaHS mitigated NLRP3/caspase-1-mediated pyroptosis in the hippocampus of CUMS-exposed rats and this effect was reversed by silencing GDF11. Moreover, overexpression of GDF11 alleviated CUMS-induced cognitive impairment and NLRP3/caspase-1-mediated hippocampal pyroptosis. CONCLUSIONS: GDF11 mediates H(2)S to attenuate chronic stress-induced cognitive impairment via inhibiting hippocampal NLRP3/caspase-1-mediated pyroptosis.
作者机构：
[Song, Wanying; Liu, Keli; Liu, Chunqiao; Lin, Haotian; Yang, Liu; Liang, Juanran; Zou, Bin; Li, Jing Jing; Peng, Peiyao; Wei, Lai; Peng, Shanzhen; Chen, Tingting; Zeng, Lei; Xue, Wei; Guo, Shixin; Liang, Qiaoxing; Li, Ye; Li, Wenxuan; Zhang, Zhihui] State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou 510060, China;[Wen, Xiaofeng] School of Pharmaceutical Sciences, Southern Medical University, Guangzhou 510000, China;[Shang, Haitao] Precision Medicine Institute, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou 510080, China;[Zhang, Zhihui] Tianjin Medical University Eye Hospital, Eye Institute & School of Optometry and Ophthalmology, Tianjin 300384, China;[Li, Wenxuan] Department of Biostatistics, Yale School of Public Health, New Haven, CT 06510, USA
摘要：
The Crumbs homolog 1 (CRB1) gene is associated with retinal degeneration, most commonly Leber congenital amaurosis (LCA) and retinitis pigmentosa (RP). Here, we demonstrate that murine retinas bearing the Rd8 mutation of Crb1 are characterized by the presence of intralesional bacteria. While normal CRB1 expression was enriched in the apical junctional complexes of retinal pigment epithelium and colonic enterocytes, Crb1 mutations dampened its expression at both sites. Consequent impairment of the outer blood retinal barrier and colonic intestinal epithelial barrier in Rd8 mice led to the translocation of intestinal bacteria from the lower gastrointestinal (GI) tract to the retina, resulting in secondary retinal degeneration. Either the depletion of bacteria systemically or the reintroduction of normal Crb1 expression colonically rescued Rd8-mutation-associated retinal degeneration without reversing the retinal barrier breach. Our data elucidate the pathogenesis of Crb1-mutation-associated retinal degenerations and suggest that antimicrobial agents have the potential to treat this devastating blinding disease.
期刊：
Journal of the European Academy of Dermatology and Venereology,2024年 ISSN：0926-9959
通讯作者：
Zhao, FJ;Liu, SQ
作者机构：
[Xiong, Shun; Zhao, Feijun; Liu, Shuangquan; Liu, Zhaoping; Ding, Xuan; Huang, Shaobin; Yao, Jiangchen; Zhang, Xiaohong; Xu, Man] Univ South China, Hengyang Med Coll, Inst Pathogen Biol, Hengyang, Peoples R China.;[Xiong, Shun; Zhao, Feijun; Liu, Shuangquan; Liu, Zhaoping; Ding, Xuan; Huang, Shaobin; Yao, Jiangchen; Zhang, Xiaohong; Xu, Man] Univ South China, Hengyang Med Coll, Key Lab Special Pathogen Prevent & Control Hunan P, Hengyang, Peoples R China.;[Xiong, Shun; Zhao, Feijun; Liu, Shuangquan; Liu, Zhaoping; Ding, Xuan; Huang, Shaobin; Yao, Jiangchen; Zhang, Xiaohong; Xu, Man] Univ South China, Affiliated Hosp 1, Hengyang Med Coll, Dept Clin Lab Med, Hengyang, Peoples R China.;[Zhao, Feijun; Zhao, FJ] Univ South China, Hengyang Med Coll, Inst Pathogen Biol, Hengyang 421001, Peoples R China.;[Zhao, Feijun; Zhao, FJ] Univ South China, Hengyang Med Coll, Key Lab Special Pathogen Prevent & Control Hunan P, Hengyang 421001, Peoples R China.
通讯机构：
[Zhao, FJ ; Liu, SQ ] U;Univ South China, Hengyang Med Coll, Inst Pathogen Biol, Hengyang 421001, Peoples R China.;Univ South China, Hengyang Med Coll, Key Lab Special Pathogen Prevent & Control Hunan P, Hengyang 421001, Peoples R China.;Univ South China, Affiliated Hosp 1, Hengyang Med Sch, Inst Microbiol & Infect Dis,Dept Clin Lab Med, Hengyang 421001, Peoples R China.
摘要：
Treponema pallidum is the causative factor of syphilis, a sexually transmitted disease (STD) characterized by perivascular infiltration of inflammatory cells, vascular leakage, swelling and proliferation of endothelial cells (ECs). The endothelium lining blood and lymphatic vessels is a key barrier separating body fluids from host tissues and is a major target of T. pallidum. In this review, we focus on how T. pallidum establish intimate interactions with ECs, triggering endothelial dysfunction such as endothelial inflammation, abnormal repairment and damage of ECs. In addition, we summarize that migration and invasion of T. pallidum across vascular ECs may occur through two pathways. These two mechanisms of transendothelial migration are paracellular and cholesterol-dependent, respectively. Herein, clarifying the relationship between T. pallidum and endothelial dysfunction is of great significance to provide novel strategies for diagnosis and prevention of syphilis, and has a great potential prospect of clinical application.
摘要：
Curcumin (CUR) exhibits a definite curative effect in the treatment of depression. To identify potential antidepressant targets and mechanisms of action of CUR. This study used network pharmacology to explore the signaling pathways and CUR-related targets in depression. C57BL/6J mice (male,12-14weeks old) were randomly divided into four groups (n = 8): saline-treated (control mice), lipopolysaccharide (LPS, 2mg/kg/day, intraperitoneally), LPS + CUR (50mg/kg/day, intragastrically), and LPS + CUR + LY294002 (7.5mg/kg/day, intraperitoneally). After 1week, behavioral tests were performed. Then, neuronal damage in the prefrontal cortex of mice was evaluated by hematoxylin-eosin (HE) staining. We uncovered the main active mechanism of CUR against depression using Western blotting and enzyme-linked immunosorbent assay (ELISA). Gene set enrichment analysis (GSEA) and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathways showed that the most significantly enriched pathway in CUR against depression was the PI3K-Akt pathway. Moreover, 52 targets were significantly correlated with the PI3K-Akt signaling pathway and CUR-related targets. In addition, among the top 50 targets ranked by degree in the protein-protein interaction (PPI) network, there were 23 targets involved in the 52 intersection targets. Administration of LPS alone extended immobility time in the open field test (OFT) and tail suspension test (TST) and decreased sucrose consumption in the sucrose preference test (SPT). Pretreatment with CUR relieved LPS-induced changes in the behavioral tests, activity of the PI3K-Akt signaling pathway, neuronal damage in the prefrontal cortex (PFC), and inflammatory response. Moreover, inhibition of the PI3K-Akt signaling pathway by LY294002 blocked the therapeutic effects of CUR. Our study indicates that CUR may be an effective antidepressant agent in an LPS-induced mouse model, partly because of its anti-inflammatory action through the PI3K-Akt signaling pathway.
期刊：
Indian Journal of Hematology and Blood Transfusion,2024年:1-8 ISSN：0971-4502
通讯作者：
Tan, C
作者机构：
[Tan, C; Tan, Chuang; Wu, Chuanfang; Yang, Donghua] Univ South China, Hengyang Med Sch, Affiliated Changsha Cent Hosp, Dept Nursing, Changsha 410004, Peoples R China.;[Dai, Fan] Hunan Univ Chinese Med, Sch Nursing, Changsha 410208, Peoples R China.;[You, Xin] Univ South China, Affiliated Changsha Cent Hosp, Hengyang Med Sch, Neurol Intens Care Unit, Changsha 410004, Peoples R China.
通讯机构：
[Tan, C ] U;Univ South China, Hengyang Med Sch, Affiliated Changsha Cent Hosp, Dept Nursing, Changsha 410004, Peoples R China.
关键词：
Central Venous Catheter;Bloodstream Infection;Multisectoral Cooperation;Intelligent Monitoring;Regulation
摘要：
Central line-associated bloodstream infections (CLABSIs) can result in worse outcomes and high hospitalization cost for patients. This study aimed to assess the effectiveness of multi-department cooperation, intelligent prevention, and supervision (MDCIPS) in reducing the incidence of CLABSIs and improving the clinical outcomes of the patients. Key issues were identified through a literature review and survey on the status quo. A MDCIPS model was thus built. A total of 440 patients with indwelling central venous catheters (CVCs) were enrolled in the study. The control group (n = 219) received conventional infection-control managements, while the intervention group (n = 221) received MDCIPS interventions in addition to conventional infection-control managements. The number of CLABSIs patients, incidence of CLABSIs, average length of hospital stay, average total hospitalization cost, and disease outcomes were compared between the two groups. The intervention group had a significant reduction in the number and incidence of CLABSIs (0[0%] vs. 4[1.33%], P < 0.05). Two of the four patients with CLABSIs in the control group died. The average length of hospital stay was significantly longer in the control group than the intervention group (17 days vs. 13 days, P < 0.001). The average hospitalization cost in the control group was much higher than that in the intervention group (92.8 thousand yuan vs. 65.2 thousand yuan, P < 0.001). Patient outcome was improved in the intervention group than the control group (P = 0.001). In summary, the MDCIPS model effectively reduces the incidence of CLABSIs, alleviates the patients' economic burden, and improves the clinical outcomes of the patients.
作者机构：
[Li, Kai; Tan, Fenghua; Chen, Liujie; Li, Jia; Hu, Zheng; Zeng, Jianling; Qu, Jiayao; Duan, Lili; Liang, Xinquan] Translational Medicine Institute, the First People's Hospital of Chenzhou, Hengyang Medical School, University of South China, Chenzhou 423000, China;[Tan, Fenghua; Chen, Liujie; Li, Jia; Hu, Zheng; Zeng, Jianling; Duan, Lili; Liang, Xinquan] The First Affiliated Hospital of Xiangnan University, Chenzhou 423000, China;[Li, Kai] National Engineering Research Center of Personalized Diagnostic and Therapeutic Technology, Hunan University of Chinese Medicine, Changsha 410208, China;[Luo, Dixian] Department of Laboratory Medicine, Huazhong University of Science and Technology Union Shenzhen Hospital (Nanshan Hospital), Shenzhen 518000, China;[Hu, Zheng] National & Local Joint Engineering Laboratory for High-through Molecular Diagnosis Technology, the First People's Hospital of Chenzhou, Chenzhou 423000, China
摘要：
The BCR-ABL fusion gene, formed by the fusion of the breakpoint cluster region protein ( BCR) and the Abl Oncogene 1, Receptor Tyrosine Kinase ( ABL) genes, encodes the BCR-ABL oncoprotein, which plays a crucial role in leukemogenesis. Current therapies have limited efficacy in patients with chronic myeloid leukemia (CML) because of drug resistance or disease relapse. Identification of novel strategies to treat CML is essential. This study aims to explore the efficiency of novel CRISPR-associated protein 9 (Cas9)/dual-single guide RNA (sgRNA)-mediated disruption of the BCR-ABL fusion gene by targeting BCR and c-ABL introns. A co-expression vector for Cas9 green fluorescent protein (GFP)/dual-BA-sgRNA targeting BCR and c-ABL introns is constructed to produce lentivirus to affect BCR-ABL expression in CML cells. The effects of dual-sgRNA virus-mediated disruption of BCR-ABL are analyzed via the use of a genomic sequence and at the protein expression level. Cell proliferation, cell clonogenic ability, and cell apoptosis are assessed after dual sgRNA virus infection, and phosphorylated BCR-ABL and its downstream signaling molecules are detected. These effects are further confirmed in a CML mouse model via tail vein injection of Cas9-GFP/dual-BA-sgRNA virus-infected cells and in primary cells isolated from patients with CML. Cas9-GFP/dual-BA-sgRNA efficiently disrupts BCR-ABL at the genomic sequence and gene expression levels in leukemia cells, leading to blockade of the BCR-ABL tyrosine kinase signaling pathway and disruption of its downstream molecules, followed by cell proliferation inhibition and cell apoptosis induction. This method prolongs the lifespan of CML model mice. Furthermore, the effect is confirmed in primary cells derived from patients with CML.
期刊：
Journal of Cleaner Production,2024年448:141538 ISSN：0959-6526
通讯作者：
Qingyi Zeng
作者机构：
[Shuaishuai Guo; Guowen Peng; Qingming Zeng; Lulin Guo; Chao Zhang; Qingyan Zhang; Xijun Fu; Junwen Lv; Qingyi Zeng] School of Resources & Environment and Safety Engineering, University of South China, Hengyang, Hunan, 421001, China
通讯机构：
[Qingyi Zeng] S;School of Resources & Environment and Safety Engineering, University of South China, Hengyang, Hunan, 421001, China
摘要：
Developing efficient, stable, and user-friendly adsorbents for removing uranium from radioactive wastewater is critical for ensuring the security of nuclear energy development. Here, a fixed adsorbent (nZVI@NC/CF), composed of in-situ derived N-doped carbon (NC) encapsulated nano zero-valent iron (nZVI) coated on carbon fiber (CF), was synthesized via carbonizing Prussian blue decorated CF, and used to synergistically adsorb and reduce UO22+ from contaminated water. The optimized nZVI@NC/CF exhibited an extremely high adsorption capacity of 2120.27 mg g−1 with a superior adsorption rate, and about 56.8 % fixed uranium was reduced into insoluble U(IV) species. This outstanding adsorption activity could be ascribed to the strong reducing property of nZVI and the package of NC that effectively prevented the agglomeration of nZVI and facilitated the adsorption and reduction of UO22+ due to the rich adsorption sites and good charge transport property. The nZVI@NC/CF also showed excellent anti-interference properties and regeneration performance that exhibited great potential in treating real uranium wastewater and extracting uranium from seawater. Mechanism study revealed that the fixation of UO22+ was mainly achieved through the synergistical adsorption by NC and reduction by nZVI, complexation by hydroxyl groups, and hydrolytic precipitation by local OH−. This study underscores the potential of nZVI@NC/CF as a highly effective adsorbent material, and provides valuable insights into developing efficient, stable, and easily manageable materials for uranium recovery.
期刊：
Separation and Purification Technology,2024年335:126214 ISSN：1383-5866
通讯作者：
Xie, D
作者机构：
[Li, Suzhe; Tang, Zengming; Yang, Xiaomin] Univ South China, Sch Resource & Environm & Safety Engn, Hengyang 421001, Peoples R China.;[Xie, D; Xie, Dong; Li, Suzhe; Tang, Zengming; Yang, Xiaomin] Natl & Local Joint Engn Res Ctr Airborne Pollutant, Hengyang 421001, Peoples R China.;[Xie, D; Xie, Dong] Univ South China, Sch Civil Engn, Hengyang 421001, Peoples R China.
通讯机构：
[Xie, D ] N;Natl & Local Joint Engn Res Ctr Airborne Pollutant, Hengyang 421001, Peoples R China.;Univ South China, Sch Civil Engn, Hengyang 421001, Peoples R China.
摘要：
Finding an inexpensive and efficient porous adsorbent to capture the gaseous radioiodine generated during spent fuel reprocessing has been challenging. Herein, we present a design philosophy for waste control to develop porous carbon for gaseous iodine capture from sewage sludge waste. Among them, the novel in situ etching of polytetrafluoroethylene was employed to improve pore accessibility. The hazards of the conventional preparation of sludge-derived carbon using highly corrosive NaOH and HF solutions were overcome. Polytetrafluoro-ethylene etched porous carbon with large specific surface area (1103 m2/g), interconnected hierarchical porous structure, and excellent hydrophobicity (water contact angle 126.52 degrees), providing efficient adsorption of gaseous iodine in hot (30-150 degrees C) and humid (50-96% relative humidity [RH]) environments. The iodine adsorption of hierarchical porous carbon was tested under static and dynamic conditions, and high records have been achieved. Notably, due to the structural advantage of hydrophobicity, a considerable dynamic adsorption capacity (1746.77 mg/g) was also maintained in a mixed iodine gas stream containing water vapor in a humid (50% RH) hot (75 degrees C) condition. This study is the first to use an in situ etching strategy for polytetrafluoroethylene, which opens a new avenue for converting sludge waste into low-cost porous carbon and provides an attractive option for capturing iodine in hot and humid environments.
作者：
Ji, Hong-Tao;Jiang, Jun;He, Wei-Bao;Lu, Yu-Han;Liu, Yuan-Yuan;...
期刊：
JOURNAL OF ORGANIC CHEMISTRY,2024年89(6):4113-4119 ISSN：0022-3263
通讯作者：
He, WM
作者机构：
[He, Wei-Bao; Lu, Yu-Han; He, Wei-Min; Li, Xiao; Ji, Hong-Tao; Liu, Yuan-Yuan; Jiang, Jun; He, WM] Univ South China, Sch Chem & Chem Engn, Hengyang 421001, Peoples R China.
通讯机构：
[He, WM ] U;Univ South China, Sch Chem & Chem Engn, Hengyang 421001, Peoples R China.
摘要：
The first example of an electrochemical multicomponent synthesis of selenium-containing compounds with inexpensive and abundant elemental selenium as the selenating reagent was developed. A variety of selenazol-2-amines were constructed in high yields with good functional group tolerance under metal-free and chemical oxidant-free conditions.
作者：
Ye, Shiying;Sun, Shaowei;Cai, Jiye;Jiang, Jinhuan
期刊：
MINI-REVIEWS IN MEDICINAL CHEMISTRY,2024年 ISSN：1389-5575
作者机构：
[Sun, Shaowei; Jiang, Jinhuan; Ye, Shiying] Institute of Pharmacy and Pharmacology, School of Pharmaceutical Science, Hengyang Medical School, University of South China. Hengyang, Hunan. China;[Sun, Shaowei; Jiang, Jinhuan] Hunan Provincial Key Laboratory of Tumor Microenvironment Responsive Drug Research, School of Pharmaceutical Science, Hengyang Medical School, University of South China, Hengyang, Hunan. China;[Cai, Jiye] Department of Chemistry, Jinan University, Guangzhou 510632, China
摘要：
Selenium, an essential trace element of the human body, is pivotal in human health and disease prevention. Nevertheless, the narrow therapeutic index of selenium, where the toxic and therapeutic doses are close, limits its clinical utility. Significantly, nanoscale selenium synthesized by different methods using polysaccharides as stabilizers has low toxicity properties and exhibits excellent bioactivity. Its biological activities, such as anti-tumor, anti-inflammatory, antioxidant, antibacterial, and immune function enhancement, are improved compared with traditional organic and inorganic selenium compounds, conferring greater potential for application in biomedicine. Therefore, this review evaluates the advancements in various synthesis methodologies for polysaccharide selenium nanoparticles (Se NPs) and their biological activities. It aims to provide a comprehensive theoretical basis and research directions for the future development of highly efficient, minimally toxic, and biocompatible polysaccharide-Se NPs and the application of polysaccharide-Se NPs in biomedicine.
通讯机构：
[Gu, YY ] U;Univ South China, Sch Resource Environm & Safety Engn, Hengyang 421001, Peoples R China.
关键词：
Composite cathode;Stability;BSCF;PCFCs
摘要：
Improving chemical stability and performance is desirable for protonic ceramic cathodes (PCFCs). In this study, the proton conductor SrSn0.8Sc0.2O3-delta (SSSc) is used to couple the classically unstable Ba0.5Sr0.5Co0.8Fe0.2O3-delta (BSCF) cathode to increase the chemical stability of the composite cathode. Compared to the conventional BSCF + BaCe0.7Zr0.1Y0.2O3-delta (BCZY) composite cathode, the new BSCF + SSSc cathode demonstrates enhanced chemical stability. This is a result of the superior chemical stability of SSSc, which protects BSCF. Moreover, the formation of oxygen vacancies is easier at the BSCF/SSSc interface than at the BSCF/BCZY interface, thereby enhancing the cathode oxygen reduction reaction (ORR) activity. The closer proximity of the O p-band center to the Fermi level in BSCF + SSSc compared to BSCF + BCZY further validates the higher ORR activity of the BSCF + SSSc cathode. The peak power density of the PCFC with BSCF + SSSc cathode, which reaches 1404 mW cm-2 at 700 degrees C, is significantly greater than that with BSCF + BCZY cathode. The protection of SSSc to BSCF is also reflected in the fuel cell's long-term operation, as the BSCF + SSSc cell operates without detectable degradations for more than 150 h, whereas the BSCF + BCZY cell exhibits observable degradation. These findings indicate that utilizing the SSSc proton conductor to couple the cathode material is a feasible and effective strategy for producing the composite cathode with high chemical stability and superior electrochemical performance for PCFCs.
通讯机构：
[Yang, SY ] U;Univ South China, Coll Publ Hlth, Hengyang Med Sch, Hengyang 421001, Hunan, Peoples R China.;Hunan Key Lab Typ Environm Pollut & Hlth Hazards, Hengyang 421001, Hunan, Peoples R China.
关键词：
Cobalt -nitrogen co -doped carbon dots;Colorimetric;Fluorometric;Dual -mode;Gallic acid
摘要：
Gallic acid (GA), widely used in food and medicine production industries. Herein, a kind of newly synthesized cobalt-nitrogen co-doped carbon dots (Co,N-CDs) with dual functional properties of oxidase-like activity and photoluminescence property could oxidize the 3,3 ',5,5 '-tetramethylbenzidine (TMB) to oxTMB with a new ab-sorption peak at 653 nm. In addition, it was found that oxTMB performed a fluorescence-quenching effect on Co, N-CDs at 440 nm attributed to FRET (Fluorescence resonance energy transfer). Reductive GA could reduce oxTMB to TMB, weaken the blue color, and restore the fluorescence of Co,N-CDs. Thus, a colorimetric and fluorometric method for dual-mode detection of GA was established. The synthesis of the dual-signal probe was completed with a single and environmental precursor in just one step. Simultaneously, the dual-mode detection reduced detection limits, broadened the linear range and improved anti-interference ability. This method exhibited a satisfactory application prospect in the actual detection of GA in tea beverages.
期刊：
FRONTIERS IN SURGERY,2024年11:1351511 ISSN：2296-875X
作者机构：
The First Affiliated Hospital, University of South China, Hengyang, 421001, Hunan Province, China
关键词：
Full-endoscopic lumbar discectomy;Microsurgery;Disc herniation;clinical efficacy;Posterior apophyseal ring fracture
摘要：
The objective of this study was to evaluate the mid-term efficacy of full-endoscopic lumbar discectomy for patients with posterior apophyseal ring fracture (PARF) combined with lumbar disc herniation (LDH). Methods: Data from patients with PARF combined with LDH who were admitted to our hospital from 2015 to 2020 were reviewed. A total of 42 patients (29 males and 13 females) met the inclusion criteria. Among them, 15 had type I PARF, 20 had type II PARF, and 7 had type III PARF. The mean age was 34.5±2.6 years, and the mean follow-up time was approximately 5.5 years. A total of 30 patients with type I/II PARF were treated with transforaminal approach endoscopy, 5 patients with type I/II PARF who could not be treated with transforaminal approach endoscopy and all patients with type III PARF were treated with interlaminar approach endoscopy. Results: All patients successfully underwent the operation without serious complications. Four patients had unstable vital signs during the operation, and 3 patients had dural rupture during the operation. Four patients had transient neurological symptoms after the operation; three of these patients reported postoperative low back and leg pain, and 1 patient reported postoperative numbness in the perineal area, all of which improved after conservative treatment. The patients' mean postoperative scores on the visual analog scale and the Oswestry Disability Index were significantly improved compared with the preoperative scores. According to the modified MacNab criteria, 27 patients had excellent surgical efficacy, 9 patients had good surgical efficacy, 3 patients had fair surgical efficacy, only 1 patient had poor surgical efficacy. The patients with fair or poor efficacy had more serious neurological dysfunction before surgery. Conclusion: As total spinal endoscopy technology has progressed, it has gradually become the treatment of choice for patients with PARF combined with LDH due to its advantages of safety and minimal invasiveness. However, the technique is difficult for young surgeons due to the small surgical field and operating channel as well as the ambiguous anatomical structure under the mirror. To achieve good surgical efficacy, a longer learning cycle is needed, and more care and patience are needed.
作者：
Nie, Mingxing;Zou, Liwei;Cui, Hao;Zhou, Xinhui;Wan, Yaping
期刊：
Electronics,2024年13(2):264- ISSN：2079-9292
通讯作者：
Wan, YP
作者机构：
[Wan, YP; Wan, Yaping; Cui, Hao; Zhou, Xinhui; Nie, Mingxing; Zou, Liwei] Univ South China, Sch Comp Sci, Hengyang 421001, Peoples R China.
通讯机构：
[Wan, YP ] U;Univ South China, Sch Comp Sci, Hengyang 421001, Peoples R China.
关键词：
human activity recognition;LoRa wireless RF signal preprocessing;deep learning;feature extraction;differential signal processing
摘要：
This paper introduces a novel approach for enhancing human activity recognition through the integration of LoRa wireless RF signal preprocessing and deep learning. We tackle the challenge of extracting features from intricate LoRa signals by scrutinizing the unique propagation process of linearly modulated LoRa signals—a critical aspect for effective feature extraction. Our preprocessing technique involves converting intricate data into real numbers, utilizing Short-Time Fourier Transform (STFT) to generate spectrograms, and incorporating differential signal processing (DSP) techniques to augment activity recognition accuracy. Additionally, we employ frequency-to-image conversion for the purpose of intuitive interpretation. In comprehensive experiments covering activity classification, identity recognition, room identification, and presence detection, our carefully selected deep learning models exhibit outstanding accuracy. Notably, ConvNext attains 96.7% accuracy in activity classification, 97.9% in identity recognition, and 97.3% in room identification. The Vision TF model excels with 98.5% accuracy in presence detection. Through leveraging LoRa signal characteristics and sophisticated preprocessing techniques, our transformative approach significantly enhances feature extraction, ensuring heightened accuracy and reliability in human activity recognition.
