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作者信息关键词期刊信息基础信息归属信息摘要

成果类型：

期刊论文

作者：

Wang, Bo;Chen, Si-Min;Yang, San-Qiao;Jiang, Jia-Mei;Zhang, Ping;...

通讯作者：

Tang, XQ;Zou, W

作者机构：

[Yang, San-Qiao; Wang, Bo; Tang, Xiao-Qing; Jiang, Jia-Mei; Chen, Si-Min; Tang, XQ] Univ South China, Affiliated Hosp 1, Inst Neurol, Hengyang Med Sch, Hengyang 421001, Hunan, Peoples R China.

[Wang, Bo] Univ South China, Affiliated Hosp 1, Inst Anesthesiol, Hengyang Med Sch, Hengyang 421001, Hunan, Peoples R China.

[Zou, Wei; Zhang, Ping] Univ South China, Affiliated Nanhua Hosp, Hengyang Med Sch, Dept Neurol, Hengyang 421001, Hunan, Peoples R China.

[Tang, Xiao-Qing] Univ South China, Inst Neurosci, Hengyang Med Sch, Hengyang Key Lab Neurodegenerat & Cognit Impairmen, Hengyang 421001, Hunan, Peoples R China.

[Tang, Xiao-Qing] Univ South China, Affiliated Hosp 2, Inst Cerebral Dis, Hengyang Med Sch, Hengyang 421001, Hunan, Peoples R China.

通讯机构：

[Zou, W ; Tang, XQ ] U

Univ South China, Affiliated Hosp 1, Inst Neurol, Hengyang Med Sch, Hengyang 421001, Hunan, Peoples R China.

Univ South China, Affiliated Nanhua Hosp, Hengyang Med Sch, Dept Neurol, Hengyang 421001, Hunan, Peoples R China.

语种：

英文

关键词：

Chronic unpredictable mild stress;Cognitive impairment;Growth differentiation factor 11;Hydrogen sulfide;NLRP3/caspase-1-mediated pyroptosis

期刊：

Journal of Affective Disorders

ISSN：

0165-0327

年：

2024

卷：

344

页码：

600-611

DOI：

10.1016/j.jad.2023.10.040

基金类别：

This work was supported by the National Natural Science Foundation of China (grant number 82271559), and the Scientific Research Foundation of Hunan Provincial Education Department (grant number 20B513).

机构署名：

本校为第一且通讯机构

院系归属：

医学院

摘要：

BACKGROUND: We previously revealed that hydrogen sulfide (H(2)S) attenuates chronic stress-induced cognitive impairment, but the underlying mechanism needs to be further clarified. Growth differentiation factor 11 (GDF11) plays an important regulatory role in cognitive function and that hippocampal NLRP3/caspase-1-mediated pyroptosis contributes to the pathogenesis of cognitive impairment. Hence, this research aimed to explore whether promoting GDF11 levels and suppressing hippocampal NLRP3/caspase-1-mediated pyroptosis mediate H(2)S to allevia...

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