摘要：
Abstract A copper‐catalyzed direct C(sp2)−H bond aminosulfonylation of maleimides is demonstrated. This protocol enables concurrent construction of C(sp2)−N and C(sp2)−SO2 bonds in one‐step and features high efficiency, broad substrate scopes, good functional‐group tolerance, and mild reaction conditions. Preliminary mechanistic studies indicate that the reaction probably involves a radical way. Significantly, this method is applicable to synthesize derivatives of pharmaceuticals such as Desloratadine, Fluoxetine, Atomoxetine, and Maprotiline.
摘要：
Sirtuins are a family of NAD+-dependent deacetylases that regulate some important biological processes, including lipid metabolism and autophagy, through their deacetylase function. Autophagy is a new discovery in the field of lipid metabolism, which may provide a new idea for the regulation of lipid metabolism. There are many tandem parts in the regulation process of lipid metabolism and autophagy of sirtuins protein family. This paper summarized these tandem parts and proposed the possibility of sirtuins regulating lipid autophagy, as well as the interaction and synergy between sirtuins protein family. Currently, some natural drugs have been reported to affect metabolism by regulating sirtuins, some of which regulate autophagy by targeting sirtuins.
Lipid metabolism disorders, such as diabetes and atherosclerosis, have seriously harmed human health and caused economic and social burden. The role of sirtuins protein family in aging has been widely concerned, but they also show value in the regulation of lipid metabolism. Autophagy is a new discovery in the field of lipid metabolism, which may provide a new idea for the regulation of lipid metabolism. There are many tandem parts in the regulation process of lipid metabolism and autophagy of sirtuins protein family. This paper summarized these tandem parts and proposed the possibility of sirtuins regulating lipid autophagy, as well as the interaction and synergy between sirtuins protein family.
摘要：
PIWI proteins have a strong correlation with PIWI-interacting RNAs (piRNAs), which are significant in development and reproduction of organisms. Recently, emerging evidences have indicated that apart from the reproductive function, PIWI/piRNAs with abnormal expression, also involve greatly in varieties of human cancers. Moreover, human PIWI proteins are usually expressed only in germ cells and hardly in somatic cells, so the abnormal expression of PIWI proteins in different types of cancer offer a promising opportunity for precision medicine. In this review, we discussed current researches about the biogenesis of piRNA, its epigenetic regulatory mechanisms in human cancers, such as N6-methyladenosine (m6A) methylation, histone modifications, DNA methylation and RNA interference, providing novel insights into the markers for clinical diagnosis, treatment and prognosis in human cancers.
摘要：
Here we report a strategy for the facile assembly of fused 3-trifluoromethyl-1,2,4-triazoles, which are difficult to synthesize using traditional strategies, in 50-96% yields through a triethylamine-promoted intermolecular [3 + 2] cycloaddition pathway. This protocol features high efficiency, good functional group tolerance, mild conditions, and easy operation. Furthermore, a gram-scale reaction and product derivatizations were carried out smoothly to illustrate the practicability of this method.
摘要：
This work describes the electrochemical selenylation of alkynyl aryl ketones, which shows high efficiency in the synthesis of 3‐selenylated chromones under transition‐metal‐free and chemical‐oxidant‐free conditions. This method features mild conditions, easy operation, and wide substrate scope. Abstract An electrochemical synthesis of various 3‐selenylated chromones via selenylation of alkynyl aryl ketones without the employment of catalyst and chemical‐oxidant is described here. This method features mild conditions, high efficiency, and wide substrate scope. Furthermore, the scale‐up reaction runs smoothly which indicates the practicability of this electrosynthesis strategy.
摘要：
中性粒细胞与淋巴细胞比率(Neutrophil to Lymphocyte Ratio,NLR)已成为生物医学研究的一个引人注目的领域。目前发现NLR具有判断疾病预后的预测价值,与脓毒症、肺炎、新型冠状病毒感染、癌症、心...展开更多 中性粒细胞与淋巴细胞比率(Neutrophil to Lymphocyte Ratio,NLR)已成为生物医学研究的一个引人注目的领域。目前发现NLR具有判断疾病预后的预测价值,与脓毒症、肺炎、新型冠状病毒感染、癌症、心血管疾病等炎症性疾病的死亡率独立相关。本综述旨在概述NLR在目前已知相关的炎症性疾病诊治中的作用。收起
作者机构：
[王紫涵; 何剑琴; 凌宏艳; 罗金定; 杨丝丝; 李梦伟] Hengyang Medical College, University of South China, Dept of Physiology,, Hunan, Hengyang, 421001, China;Physical Education Institute, Jishou University, Xiangxi, Hunan416000, China;[丁星星] Chuanshan College University of Sowth China, Hunan, 421001, China;[奉水东] Public Health College, University of South China.Hengyang, Dept of Social Medicine and Health Management,, Hunan, 421001, China;[Lyu H.-J.] Hengyang Medical College, University of South China, Dept of Physiology,, Hunan, Hengyang, 421001, China, Physical Education Institute, Jishou University, Xiangxi, Hunan416000, China
