The epigenetic regulatory mechanism of PIWI/piRNAs in human cancers

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作者信息关键词期刊信息基础信息归属信息摘要

成果类型：

期刊论文

作者：

Zhang, Qun;Zhu, Yazhi;Cao, Xinyu;Tan, Wenhui;Yu, Jianglong;...

通讯作者：

Ermao Li

作者机构：

[Zhu, Yazhi; Lu, Yaqiong; Zhang, Qun; Tan, Wenhui; Yu, Jianglong] Univ South China, Hengyang Med Sch, Hengyang 421001, Hunan, Peoples R China.

[Cao, Xinyu] Univ South China, Chuanshan Coll, Hengyang 421001, Hunan, Peoples R China.

[Kang, Ran] Univ South China, Affiliated Hosp 1, Hengyang Med Sch, Dept Urol, Hengyang 421001, Hunan, Peoples R China.

[Wang, Xiaolan] Univ South China, Affiliated Hosp 1, Hengyang Med Sch, Dept Reprod Med, Hengyang 421001, Hunan, Peoples R China.

[Li, Ermao] Univ South China, Hengyang Med Sch, Inst Translat Med, Hengyang 421001, Hunan, Peoples R China.

通讯机构：

[Ermao Li] I

Institute of Translational Medicine, Hengyang Medical School, University of South China, Hengyang, China

语种：

英文

关键词：

PIWI protein;piRNA;m6A methylation;DNA methylation;Histone modification

期刊：

Molecular Cancer

ISSN：

1476-4598

年：

2023

卷：

期：

页码：

1-14

DOI：

10.1186/s12943-023-01749-3

基金类别：

This work was supported by the Natural Science Foundation for Young Scientists of Hunan Province (No.2020JJ5501), Scientific research project for Outstanding Young Scientists of Hunan Education Department (No. 18B272), Hunan University students Innovation training program project (No. S201910555127).

机构署名：

本校为第一机构

院系归属：

医学院

船山学院

摘要：

PIWI proteins have a strong correlation with PIWI-interacting RNAs (piRNAs), which are significant in development and reproduction of organisms. Recently, emerging evidences have indicated that apart from the reproductive function, PIWI/piRNAs with abnormal expression, also involve greatly in varieties of human cancers. Moreover, human PIWI proteins are usually expressed only in germ cells and hardly in somatic cells, so the abnormal expression of PIWI proteins in different types of cancer offer a promising opportunity for precision medicine. In this review, we discussed current researches abo...

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The epigenetic regulatory mechanism of PIWI/piRNAs in human cancers

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