Transcription Factor 21: A Transcription Factor That Plays an Important Role in Cardiovascular Disease

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成果类型：

期刊论文

作者：

Luo, Yaqian;He, Fangzhou;Zhang, Yifang;Li, Shufan;Lu, Ruirui;...

通讯作者：

Huang, J

作者机构：

[Wei, Xing; Zhang, Yifang; Huang, Ji; Luo, Yaqian] Univ South China, Hengyang Med Sch, Inst Cardiovasc Dis, Dept Pathophysiol,Key Lab Arteriosclerol Hunan Pr, Hengyang, Peoples R China.

[He, Fangzhou] Univ South China, Chuanshan Coll, Dept Anaesthesia, Hengyang, Peoples R China.

[Li, Shufan] Univ South China, Hengyang Med Sch, Dept Clin Med, Hengyang, Peoples R China.

[Lu, Ruirui] Univ South China, Sch Pharmaceut Sci, Hengyang Med Sch, Hunan Prov Cooperat Innovat Ctr Mol Target New Dr, Hengyang, Peoples R China.

通讯机构：

[Huang, J ] U

Univ South China, Hengyang Med Sch, Inst Cardiovasc Dis, Dept Pathophysiol,Key Lab Arteriosclerol Hunan Pr, Hengyang, Peoples R China.

语种：

英文

关键词：

basic helix loop helix transcription factor;microRNA;transcription factor;atherogenesis;atherosclerosis;blood vessel injury;cardiovascular disease;cell differentiation;controlled study;diagnosis;drug therapy;gene expression;human;hyperplasia;inflammation;intimal hyperplasia;neointima;phenotype;review;smooth muscle cell;vascular smooth muscle cell

期刊：

PHARMACOLOGY

ISSN：

0031-7012

年：

2024

卷：

109

期：

页码：

183-193

DOI：

10.1159/000536585

基金类别：

This study was supported by the National Natural Science Foundation of China (82100789), the Natural Science Foundation of Hunan Province (2022JJ40378), the Scientific Research Foundation for Doctor of University of South China (200XQD060), the Natural Science Foundation of Hunan Province (2023JJ40563), and the College Students\u2019 Innovation and Entrepreneurship Training Program (S202112650009).

机构署名：

本校为第一且通讯机构

院系归属：

医学院

药学与生物科学学院

船山学院

摘要：

Background: According to the World Health Organisation's Health Report 2019, approximately 17.18 million people die from cardiovascular disease each year, accounting for more than 30% of all global deaths. Therefore, the occurrence of cardiovascular disease is still a global concern. The transcription factor 21 (TCF21) plays an important role in cardiovascular diseases. This article reviews the regulation mechanism of TCF21 expression and activity and focuses on its important role in atherosclerosis in order to contribute to the development of ...

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Transcription Factor 21: A Transcription Factor That Plays an Important Role in Cardiovascular Disease

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