期刊:
Public Health Nursing,2023年40(5):782-789 ISSN:0737-1209
通讯作者:
Zeng, Y
作者机构:
[Huang, Yu-ting; Yue, Qian-qian; Tang, Tian; Zeng, Ying; Hu, Li-feng; Sun, Ying-xue; Zou, Jin-yu] Univ South China, Hengyang Med Sch, Dept Int & Humanist Nursing, Sch Nursing,Hunan Sci Popularizat Educ Base, Hengyang, Peoples R China.;[Zeng, Ying; Zeng, Xi] Univ South China, Canc Res Inst, Hengyang Med Sch, Key Lab Tumor Cellular & Mol Pathol, Hengyang, Peoples R China.;[Zeng, Ying] Univ South China, Hengyang Med Sch, Sch Nursing, Dept Int & Humanist Nursing, Hengyang, Peoples R China.
通讯机构:
[Zeng, Y ] U;Univ South China, Canc Res Inst, Hengyang Med Sch, Key Lab Tumor Cellular & Mol Pathol, Hengyang, Peoples R China.;Univ South China, Hengyang Med Sch, Sch Nursing, Dept Int & Humanist Nursing, Hengyang, Peoples R China.
摘要:
INTRODUCTION: Colorectal cancer (CRC) is associated with a high incidence and mortality rate. Fecal occult blood test (FOBT) is effective in the prevention of CRC. OBJECTIVE: This study aimed to assess knowledge and beliefs regarding FOBT-based screening. METHODS: This study used PubMed, Cochrane Library, MEDLINE Complete, and Web of Science to search for articles. Original full-text studies in English language focusing on knowledge and beliefs of FOBT screening were included. RESULTS: A total of 32 articles were included. This study indicated that the population in most studies had inadequate knowledge and lacked beliefs toward FOBT-based screening. Most of the extracted studies showed that less than half of the participants had heard of FOBT-based screening. Six studies showed that less than 50% of participants had knowledge of FOBT age. Three studies found that less than 40% of participants were aware of the screening interval. Some participants perceived the benefits of FOBT-based screening, while others perceived many barriers to the test. CONCLUSION: Participants' knowledge and belief in FOBT-based screening were insufficient. This review highlights the importance of educational programs to increase knowledge and beliefs regarding FOBT-based screening. It is important to include FOBT-based screening in the health care system to promote the secondary prevention of CRC.
摘要:
Background: This study was performed to investigate the compliance and rehabilitation effects of Zheng's supine rehabilitation exercise (ZSRE) performed at home in patients with chronic obstructive pulmonary disease (COPD).Methods: We performed telephone interviews with 157 patients with COPD who were hospitalized on the 26th floor of the National Clinical Research Center for Respiratory Disease and who received COPD education and ZSRE training from 1 September 2015 to 31 August 2016. We retrospectively analyzed the patients' compliance with performing ZSRE at home after discharge and the frequency of hospitalization for treatment of acute exacerbation in both the previous and subsequent years.Results: Among the 157 patients, 66 failed to complete home ZSRE after discharge (non-rehabilitation group), 41 performed home ZSRE once a day after discharge (one-session rehabilitation group), and 50 performed home ZSRE at least twice a day after discharge (multiple-session rehabilitation group). The home ZSRE compliance rate was 57.96% (91/157). There were no significant differences in the mean number of hospitalizations in the year prior to receiving COPD education and ZSRE training among the non-rehabilitation group (1.06 +/- 0.75), one-sessi on rehabilitation group (1.27 +/- 0.78), and multiple-session rehabilitation group (1.16 +/- 0.91). However, there was a significant difference in the mean number of hospitalizations among the groups in the year following discharge (1.44 +/- 1.17, 0.78 +/- 0.82, and 0.66 +/- 0.75, respectively). The number of hospitalizations significantly increased in the non-rehabilitation group and significantly decreased in the one-and multiple-session rehabilitation groups.Conclusions: Home ZSRE can be performed with high compliance by elderly patients with severe or extremely severe COPD and can reduce the number of readmissions.
作者机构:
[Li, W.; Wu, Y.; Liu, F.] Univ South China, Affiliated Hosp 1, Cardiac Intervent Imaging Ctr, Hengyang Med Sch, Hengyang 421001, Hunan, Peoples R China.;[Liu, F.; You, Z.; Liao, L.] Univ South China, Sch Nursing, Hengyang, Hunan, Peoples R China.;[Raja, Z.; Suthakorn, W.; Liu, F.] Chiang Mai Univ, Fac Nursing, Chiang Mai, Thailand.;[Raja, Z.] Dr Ruth KM Pfau Civil Hosp, Dept Plast & Reconstruct Surg, Karachi, Pakistan.;[Wang, J.] Hengyang Tradit Chinese Med Hosp, Occupat Hlth Dept, Hengyang, Hunan, Peoples R China.
通讯机构:
[Liu, F ] U;Univ South China, Affiliated Hosp 1, Cardiac Intervent Imaging Ctr, Hengyang Med Sch, Hengyang 421001, Hunan, Peoples R China.;Univ South China, Sch Nursing, Hengyang, Hunan, Peoples R China.;Chiang Mai Univ, Fac Nursing, Chiang Mai, Thailand.
摘要:
<b>Background:<b/> The ionising radiation generated in percutaneous coronary intervention has the largest hazard to medical staff among all interventional procedures, and thus has gained the attention of various researchers. Radioprotective shielding equipment is an effective measure; however, it has poor applicability to diverse interventional procedures. The aim of this study was to develop a new radioprotective shielding equipment for percutaneous coronary intervention and determine its effectiveness and applicability. <b>Methods:<b/> This study developed a radioprotective cabin for percutaneous coronary intervention and used fluoroscopy and cine models of a digital subtraction angiography machine to compare the effectiveness of experimental (radioprotective cabin) and control (current radioprotection strategies) groups. Radiation equivalent dose rates were measured at 231 data points: 210 points were distributed on four vertical planes around the therapy bed and 21 points were evenly distributed around the thyroid, head, and gonad areas of a standardised patient. <b>Results:<b/> Based on the cine model, there were statistically significant differences in the radiation equivalent dose rates between the control and experimental groups in the left plane, right plane, foot plane, head area, and gonad area (<i>Z<i/> = −6.645, −5.615, −6.204, −2.647, −2.882, respectively; <i>P<i/> < 0.05). Based on the fluoroscopy model, there were statistically significant differences in the radiation equivalent dose rates between the two groups in the left plane, right plane, foot plane, and gonad area (<i>Z<i/> = −6.060, −5.083, −5.203, −2.887, respectively; <i>P<i/> < 0.05). <b>Conclusion:<b/> The radioprotective cabin developed in this study can effectively reduce the radiation equivalent dose rates in the standing area of medical staff and radiation-sensitive areas of patients without affecting the operation, which can be promoted and applied in percutaneous coronary intervention.
摘要:
BackgroundTraditional emulsion adjuvants are limited in clinical application because of their surfactant dependence. Graphene oxide (GO) has unique amphiphilic properties and therefore has potential to be used as a surfactant substitute to stabilize Pickering emulsions. MethodsIn this study, GO-stabilized Pickering emulsion (GPE) was prepared and used as an adjuvant to facilitate an enhanced immune response to the Chlamydia trachomatis (Ct) Pgp3 recombinant vaccine. Firstly, GPE was prepared by optimizing the sonication conditions, pH, salinity, GO concentration, and water/oil ratio. GPE with small-size droplets was characterized and chosen as the candidate. Subsequently, controlled-release antigen delivery by GPE was explored. Cellular uptake behaviors, M1 polarization, and cytokine stimulation by GPE + Pgp3 was considered in terms of the production of macrophages. Finally, GPE's adjuvant effect was evaluated by vaccination with Pgp3 recombinant in BALB/c mouse models. ResultsGPE with the smallest droplet sizes was prepared by sonication under 163 W for 2 min at 1 mg/mL GO in natural salinity with a pH of 2 when the water/oil ratio was 10:1 (w/w). The optimized average GPE droplet size was 1.8 mu m and the zeta potential was -25.0 +/- 1.3 mv. GPE delivered antigens by adsorption onto the droplet surface, demonstrating the controlled release of antigens both in vitro and in vivo. In addition, GPE promoted antigen uptake, which stimulated proinflammatory tumor necrosis factor alpha (TNF-alpha), enhancing the M1 polarization of macrophages in vitro. Macrophage recruitment was also significantly promoted by GPE at the injection site. In the GPE + Pgp3 treatment group, higher levels of immunoglobin (IgG), immunoglobin G1 (IgG1), immunoglobin G2a (IgG2a) sera, and immunoglobin A (IgA) were detected in vaginal fluid, and higher levels of IFN-gamma and IL-2 secretion were stimulated, than in the Pgp3 group, showing a significant type 1 T helper (Th1)-type cellular immune response. Chlamydia muridarum challenging showed that GPE enhanced Pgp3's immunoprotection through its advanced clearance of bacterial burden and alleviation of chronic pathological damage in the genital tract. ConclusionThis study enabled the rational design of small-size GPE, shedding light on antigen adsorption and control release, macrophage uptake, polarization and recruitment, which enhanced augmented humoral and cellular immunity and ameliorated chlamydial-induced tissue damage in the genital tract.
作者机构:
[He, Zhiqing; Huang, YJ; Huang, Yanjin; Wang, Qi; Xu, Chaoyue] Univ South China, Hengyang Med Sch, Sch Nursing, Hengyang, Peoples R China.;[Zou, Ping] Nipissing Univ, Toronto, ON, Canada.;[Yang, Jing] Univ South China, Affiliated Hosp 2, Hengyang, Peoples R China.
通讯机构:
[Huang, YJ ] U;Univ South China, Hengyang Med Sch, Sch Nursing, Hengyang, Peoples R China.
摘要:
BACKGROUND: Coronary Heart Disease (CHD) is one of the most prevalent chronic diseases worldwide. Currently, percutaneous coronary intervention (PCI) with stent implantation is the main clinical treatment for CHD, and patients can achieve better outcomes after stenting. However, adverse cardiovascular events continue to recur, ultimately failing to yield good results. Several symptoms exist after stenting and are associated with health outcomes. Little is known about the symptom patterns of patients during the different postoperative periods. Therefore, this study aims to explore the dynamics of symptoms and clarify the experiences of post-stenting in patients during different periods, which may help the delivery of more specific patient management and improve survival outcomes in the future. METHODS: A mixed method (quantitative/qualitative) design will be adopted. Longitudinal research, including surveys regarding three different periods, will be sued to describe the symptom patterns of patients undergoing PCI with stent implantation, clarifying their focused symptom problems during different time periods or in populations with different features. Qualitative individual interviews aim to understand the feelings, experiences, opinions, and health conditions of patients post-stenting, which can explain and supplement quantitative data. Quantitative data will be analyzed using descriptive statistics, latent class analysis (LCA), and latent translation analysis (LTA). Qualitative data will be analyzed using content analysis. DISCUSSION: This study is the first study to explore the symptom patterns and experiences of patients in various domains after stent implantation using a novel design including quantitative and qualitative methods, which will help the delivery of more specific patient management, reduce the recurrence of adverse cardiovascular events, and improve survival outcomes in the future. It is also meaningful to use PROMIS profile-57 to help patients to proactively focus on their health problems, promote health literacy, and incorporate active patient participation into health management, which is a successful transition from passive medical treatment to active management.
摘要:
Mammalian autophagy-related protein Atg8, including the LC3 subfamily and GABARAP subfamily. Atg8 proteins play a vital role in autophagy initiation, autophagosome formation and transport, and autophagy-lysosome fusion. GABARAP subfamily proteins (GABARAPs) share a high degree of homology with LC3 family proteins, and their unique roles are often overlooked. GABARAPs are as indispensable as LC3 in autophagy. Deletion of GABARAPs fails autophagy flux induction and autophagy lysosomal fusion, which leads to the failure of autophagy. GABARAPs are also involved in the transport of selective autophagy receptors. They are engaged in various particular autophagy processes, including mitochondrial autophagy, endoplasmic reticulum autophagy, Golgi autophagy, centrosome autophagy, and dorphagy. Furthermore, GABARAPs are closely related to the transport and delivery of the inhibitory neurotransmitter γ-GABA(A) and the angiotensin II AT1 receptor (AT1R), tumor growth, metastasis, and prognosis. GABARAPs also have been confirmed to be involved in various diseases, such as cancer, cardiovascular disease, and neurodegenerative diseases. In order to better understand the role and therapeutic potential of GABARAPs, this article comprehensively reviews the autophagic and non-autophagic functions of GABARAPs, as well as the research progress of the role and mechanism of GABARAPs in cancer, cardiovascular diseases and neurodegenerative diseases. It emphasizes the significance of GABARAPs in the clinical prevention and treatment of diseases, and may provide new therapeutic ideas and targets for human diseases. GABARAP and GABARAPL1 in the serum of cancer patients are positively correlated with the prognosis of patients, which can be used as a clinical biomarker, predictor and potential therapeutic target. GABARAP family proteins: autophagy and non-autophagy related functions in diseases. By Figdraw ( https://www.figdraw.com ).
期刊:
Western Journal of Nursing Research,2023年46(2):68-80 ISSN:0193-9459
通讯作者:
Ouyang, Xinping;He, PP
作者机构:
[Li, Junyi; Wen, Min; Chen, Yeshi; Wen, Xiaohui; He, Pingping] Univ South China, Sch Nursing, Hengyang Med Sch, Hengyang, Peoples R China.;[Wen, Min] Yueyang Vocat Tech Coll, Sch Nursing, Yueyang, Peoples R China.;[Yu, Juping] Univ South Wales, Fac Life Sci & Educ, Pontypridd, Wales.;[He, Pingping; Ouyang, Xinping] Hunan Normal Univ, Med Coll, Changsha, Peoples R China.;[Ouyang, Xinping; He, Pingping] Hunan Normal Univ, Med Coll, Changsha 410013, Hunan, Peoples R China.
通讯机构:
[Ouyang, XP; He, PP ] H;Hunan Normal Univ, Med Coll, Changsha 410013, Hunan, Peoples R China.
关键词:
fatigue;self-management;quality of life;coronary heart disease
摘要:
Western Journal of Nursing Research, Volume 46, Issue 2, Page 68-80, February 2024. <br/>Objective:This research aimed to determine how a 12-week PRECEDE-PROCEED model-based intervention affected fatigue in patients with coronary heart disease.Methods:This cluster randomized controlled trial recruited participants diagnosed with coronary heart disease at 2 community health centers in China. Participants in the control group (n = 36) received routine health education, whereas those in the intervention group (n = 38) were given a 12-week PRECEDE-PROCEED model-based intervention and routine health education. The intervention consisted of 6 training sessions on coronary heart disease, fatigue, fatigue management, self-management skills and social support. A primary outcome (fatigue) and 4 secondary outcomes (knowledge of fatigue, self-management, quality of life and body mass index) were assessed using the Fatigue Scale-14, Fatigue Cognitive Questionnaire for Patients with Coronary Heart Disease, Coronary Artery Disease Self-Management Scale, Chinese Cardiovascular Questionnaire of Quality of Life, and electronic weighing scale, respectively. Data were collected 3 times over 12 weeks.Results:Compared with the control group, the intervention group showed a statistically significant improvement in the level of fatigue (8.72 vs 7.06, P < .001), knowledge of fatigue (P < .001), self-management skills (P < .001), and quality of life (P < .001). However, there was no significant difference in body mass index between the 2 groups (P = .504).Conclusions:The findings suggest that a well-designed intervention based on the PRECEDE-PROCEED model could alleviate fatigue symptoms and increase knowledge of fatigue, self-management skills and quality of life in patients with coronary heart disease.
摘要:
Older stroke survivors usually experience various psychology disorders, such as post-stroke depression (PSD), which may be associated with high experiential avoidance (EA) and can seriously affect their quality of life. To date, the efficacy of group-based acceptance and commitment therapy (ACT) for older stroke survivors has not been established. The aim of this study is to investigate the effectiveness of group-based ACT on EA, PSD, psychological distress, and quality of life in older stroke survivors after group-based ACT. This study is a randomized, single-blind, wait-list controlled, parallel-arm trial. A total of 66 stroke survivors will be randomly assigned to wait-list control group or intervention group. Participants in wait-list control group will receive treatment as usual (TAU), while the intervention group will receive group-based ACT once a week for eight weeks. The primary outcome measure being EA, and the secondary outcome measures being PSD, psychological distress, and quality of life. Results of the two groups will be blindly assessed by professional evaluators at baseline (T0), post-treatment (T1), and one-month follow up (T2). The results of this study will provide the first evidence for the effectiveness of a group-based ACT intervention in reducing EA, PSD, psychological stress, and improving quality of life for post-stroke survivors. ChiCTR2200066361. No study has explored the EA in older stroke survivors and related factors at present. Group-based ACT has been shown to have a positive impact on anxiety and depressive symptoms in stroke survivors, but no studies have explored the effect of group-based ACT on the psychological status in older stroke survivors. Based on the previously published randomized controlled trials, this study used the group-based ACT to compare the effects of intervention on the psychological status of stroke survivors at different time points. This study met the gold standard for clinical trial delivery and provided additional evidence for group-based ACT, which also helped to lay the foundation for the feasibility and effectiveness of group-based ACT for older stroke survivors. The study had a short follow-up period. In addition, its clinical nature prevents blinding of the participants and therapists.
期刊:
International Journal of Nursing Practice,2023年29(6):e13141 ISSN:1322-7114
通讯作者:
Lingling Gao PhD
作者机构:
[Han, Rongrong; Xiang, Zhixuan; Chen, Lu; Gao, Lingling; Yang, Xiao] Sun Yat Sen Univ, Sch Nursing, Guangzhou, Peoples R China.;[Li, Hanbing] Univ South China, Sch Nursing, Hengyang, Peoples R China.;[Zhao, Qian] Gem Flower Xian Changqing Staff Hosp, Party Comm, Xian, Peoples R China.;[Gao, Lingling] Sun Yat sen Univ, Sch Nursing, 74 Zhongshan Rd 2, Guangzhou 510080, Peoples R China.
通讯机构:
[Lingling Gao PhD] P;Professor in Nursing<&wdkj&>School of Nursing, Sun Yat-Sen University, Guangzhou, China
关键词:
clinical practice guidelines;exercise;gestational diabetes mellitus;physical activity;pregnancy;systematic reviews
摘要:
This review aimed to appraise clinical guidelines about exercise for women with gestational diabetes mellitus and summarize consensus and inconsistent recommendations.
Exercise is an effective non-pharmacological therapeutic for gestational diabetes mellitus, but the variety of relevant clinical practice guidelines is confusing for healthcare professionals.
This is a systematic review of clinical practice guidelines.
Websites of guideline development institutions, eight literature databases and organizations of obstetricians, gynaecologists, midwives, and medical sports associations were searched for guidelines published from January 2011 to October 2021.
Two reviewers independently extracted recommendations. Four reviewers assessed guideline quality using the AGREE II instrument independently.
Fifteen guidelines were included. All women with diabetes are recommended to exercise during pregnancy. The consistent recommendations were for pre-exercise screening, for 30 min per exercise session on 5 days of the week or every day after meals, exercise at moderate intensity, using aerobic and resistance exercise, and walking. The main non-consistent recommendations included warning signs for women on insulin during exercise, minimum duration per session, intensity assessment, duration and frequency of sessions for strengthening and flexibility exercise and detailed physical activity giving birth.
Guidelines strongly support pregnant women with diabetes to exercise regularly. Research is needed to make non-consistent recommendations clear.
What is already known about this topic?
What this paper adds?
The implications of this paper:
摘要:
The active proliferation and migration of vascular smooth muscle cells supports the healing of vessel damage while their abnormal aggression or destitution contribute to the aberrant intima-medial structure and function in various cardiovascular diseases, so the understanding of the proliferation disorders of vascular smooth muscle cell and the related mechanism is the basis of effective intervention and control for cardiovascular diseases. Recently, long non-coding RNAs have stood out as upstream switchers for multiple proliferative signaling pathways and molecules, and many of them have been shown to conduce to the dysregulated proliferation and apoptosis of vascular smooth muscle cells under various pathogenic stimuli. This article discusses the long non-coding RNAs disclosed and linked to atherosclerosis, pulmonary hypertension, and aneurysms, and focuses upon their modulation of vascular smooth muscle cell population affecting three deadly cardiovascular diseases.
作者机构:
[Qin, Xiao; Bi, Guoshan; Chen, Jie] Guangxi Med Univ, Affiliated Hosp 1, Dept Vasc Surg, 6 Shuangyong Rd, Nanning 530000, Guangxi, Peoples R China.;[Bi, Guoshan; Chen, Jie] Univ South China, Hengyang Med Sch, Affiliated Hosp 2, Dept Vasc Surg, 35 Jiefang Rd, Hengyang 421001, Hunan, Peoples R China.;[Wu, Fei] Univ South China, Sch Nursing, 28 Changsheng Rd, Hengyang 421001, Hunan, Peoples R China.
通讯机构:
[Xiao Qin] D;Department of Vascular Surgery, The First Affiliated Hospital of Guangxi Medical University, Nanning, China
摘要:
Direct oral anticoagulants (DOACs) are widely used to treat venous thromboembolism (VTE) in adults. Little attention is given to pediatric VTE (PVTE). The objective of this study is to study the efficacy and safety of DOACs in published PVTE randomized control trials (RCTs). PubMed, Embase, China National Knowledge Infrastructure, the Cochrane Library, SinoMed, and ClinicalTrials.gov were searched until 2021, to identify RCTs that enrolled patients with VTE <18 years of age who received DOACs versus standard anticoagulation. Outcomes were evaluated using the Mantel-Haenszel method of random-effects model. Our study evaluated seven RCTs that included 1139 cases of PVTE, which had a low risk of publication and assessment bias. Compared with standard anticoagulation, patients receiving DOACs presented a lower rate of recurrent VTE (relative risk [RR], 0.42 [confidence interval {CI}, 0.20 to 0.89]), similar mortality rate (RR, 0.50 [CI, 0.07 to 3.57]), major bleeding (RR, 0.46 [CI, 0.14 to 1.57]), and higher clinically relevant nonmajor bleeding (RR, 2.71 [CI, 1.05 to 7.02]) with low heterogeneity. Limiting to subgroups, dabigatran and rivaroxaban yielded similar findings, except for a higher incidence of nonmajor bleeding during rivaroxaban use. DOACs could be an alternative to standard anticoagulation in PVTE. Dabigatran and rivaroxaban have similar effects. Impact In venous thromboembolism (VTE), direct oral anticoagulants (DOACs) are widely used as a substitution for standard anticoagulation in most situations for adults; however, little attention is paid to the pediatric population. For pediatric VTE, previous meta-analyses have emphasized the epidemiology, risk factors, and the use of traditional anticoagulants, and seldom reported the use of novel oral anticoagulants. This is the first meta-analysis of randomized controlled trials that focuses on the efficacy outcomes and safety endpoints of DOACs compared with standard anticoagulation in pediatric VTE.
作者机构:
[Wu, Lirong; Yin, Jinzhi; Zhou, Hui] Univ South China, Sch Nursing, Hengyang Med Sch, Hengyang 421001, Hunan, Peoples R China.;[Wu, Lirong; Yin, Jinzhi; Zhou, Hui] Univ South China, Affiliated Changsha Cent Hosp, Hengyang Med Sch, Changsha 410013, Hunan, Peoples R China.;[Liu, Minhui; Huang, Chongmei] Cent South Univ, Nursing Sch, Changsha 410013, Peoples R China.;[Hu, Hongjuan] Univ South China, Affiliated Hosp 1, Dept Publ Serv, Nursing Dept,Hengyang Med Sch, Hengyang 421001, Hunan, Peoples R China.
通讯机构:
[Hongjuan Hu] T;The First Affiliated Hospital, Department of Public Service/Nursing department, Hengyang Medical School, University of South China, Hengyang, China
摘要:
Using accurate assessment tools to assess patients in clinical practice is important to mining influencing factors and implementing interventions. However, most evaluation tools for the self-management of elderly patients with hypertension lack a theoretical basis and wide applicability, which makes the intervention effect insignificant. Based on the Capability, Opportunity, and Motivation-Behaviour (COM-B) model, combined with literature review and qualitative research, a questionnaire item pool was initially formulated; then the initial items were screened and adjusted through expert consultation and pre-testing to form an initial scale. A field survey of 450 elderly hypertensive patients was then performed using the initial scale to test the reliability and validity of the scale. Cronbach’s alpha, test–retest reliability and composite reliability were used to test the reliability of the scale, and the validity of the scale was evaluated from two aspects: content validity and construct validity. The evaluation results of the content validity of the scale by experts were used as the content validity index; the results of exploratory factor analysis and confirmatory factor analysis were used as the structural validity index to further verify the model structure of the scale and develop a formal scale. The final self-management scale included 4 dimensions and 33 items. The Scale-Content Validity Index was 0.920. Exploratory factor analysis extracted four factors that explained 71.3% of the total variance. Cronbach’s alpha of the formal scale was 0.867, test–retest reliability was 0.894, and composite reliability of the 4 dimensions were within 0.943 ~ 0.973. Confirmatory factor analysis showed the scale had good construct validity. The Self-management Capability, Support and Motivation-Behaviour scale for elderly hypertensive patients has good reliability and validity, providing a tool for medical staff to evaluate the self-management level of elderly hypertensive patients.
作者机构:
[Chen, Yuping; Wu, Meichun; Chen, YP] Univ South China, Hengyang Med Sch, Hengyang 410001, Hunan, Peoples R China.;[Wu, Meichun] Univ South China, Sch Nursing, Hengyang 410001, Hunan, Peoples R China.;[Chen, Yuping; Xun, Min; Chen, YP] Univ South China, Inst Pharm & Pharmacol, Sch Pharmaceut Sci, Hengyang 410001, Hunan, Peoples R China.
通讯机构:
[Chen, YP ] U;Univ South China, Hengyang Med Sch, Hengyang 410001, Hunan, Peoples R China.;Univ South China, Inst Pharm & Pharmacol, Sch Pharmaceut Sci, Hengyang 410001, Hunan, Peoples R China.
关键词:
biodegradable metal stents;vascular smooth muscle cell;stent implantation;vascular microenvironment;atherosclerosis;restenosis
摘要:
Iron-, magnesium-, or zinc-based metal vessel stents support vessel expansion at the period early after implantation and degrade away after vascular reconstruction, eliminating the side effects due to the long stay of stent implants in the body and the risks of restenosis and neoatherosclerosis. However, emerging evidence has indicated that their degradation alters the vascular microenvironment and induces adaptive responses of surrounding vessel cells, especially vascular smooth muscle cells (VSMCs). VSMCs are highly flexible cells that actively alter their phenotype in response to the stenting, similarly to what they do during all stages of atherosclerosis pathology, which significantly influences stent performance. This Review discusses how biodegradable metal stents modify vascular conditions and how VSMCs respond to various chemical, biological, and physical signals attributable to stent implantation. The focus is placed on the phenotypic adaptation of VSMCs and the clinical complications, which highlight the importance of VSMC transformation in future stent design.