Th-P15:10 Mast cells improve ox-LDL induced vascular smooth muscle cells foaming
作者：
Gan, L.;Yang, Y. Z.;Wang, S.;Tang, Y. L.;Dong, B. H.;...
期刊：
Atherosclerosis Supplements ,2006年7(3):494-494 ISSN：1567-5688
作者机构：
[Wang, Z.; Gan, L.; Dong, B. H.; Tang, C. K.; Jin, H. Y.; Tang, Y. L.; Yang, Y. Z.; Wang, S.] Nanhua Univ, Inst Cardiovasc Dis, Hengyang, Peoples R China.
语种：
英文
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Mo-P6:445 Polymorphism of-191C/G of ABCA1 gene in patients with coronary artery disease in hans population
作者：
Shi, W. Y.;Yang, Y. Z.;Quan, Z. H.;Tang, C. K.;Liu, C. H.;...
期刊：
Atherosclerosis Supplements ,2006年7(3):144-144 ISSN：1567-5688
作者机构：
[Ouyang, G.; Shi, W. Y.; Quan, Z. H.; Li, Y. Q.; Tang, C. K.; Li, H. B.; Liu, C. H.; Yang, Y. Z.; Yang, X.] Nanhua Univ, Inst Cardiovasc Dis, Hengyang, Peoples R China.
语种：
英文
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Vascular Basement Membrane-derived Multifunctional Peptide, a Novel Inhibitor of Angiogenesis and Tumor Growth
作者：
Cao, Jian-Guo;Peng, Shu-Ping;Sun, Li;Li, Hui;Wang, Li;...
期刊：
生物化学与生物物理学报 ,2006年38(7):514-521 ISSN：1672-9145
通讯作者：
Deng, Han-Wu
作者机构：
[Deng, Han-Wu] Cent S Univ, Sch Pharmaceut Sci, Dept Pharmacol, Changsha 410078, Peoples R China.;Nanhua Univ, Canc Res Inst, Hengyang 421001, Peoples R China.
通讯机构：
[Deng, Han-Wu] C;Cent S Univ, Sch Pharmaceut Sci, Dept Pharmacol, Changsha 410078, Peoples R China.
关键词：
recombinant vascular basement membrane-derived multifunctional peptide;angiogenesis inhibitor;therapeutic action
摘要：
Vascular basement membrane-derived multifunctional peptide (VBMDMP) gene (fusion gene of the human immunoglobulin G3 upper hinge region and two tumstatin-derived fragments) obtained by chemical synthesis was cloned into vector pUC19, and introduced into the expression vector pGEX-4T-1 to construct a prokaryotic expression vector pGEX-4T-1-VBMDMP. Recombinant VBMDMP produced in Escherichia coli has been shown to have significant activity of antitumor growth and antimetastasis in Lewis lung carcinoma transplanted into mouse C57Bl/6. In the present study, we have studied the ability of rVBMDMP to inhibit endothelial cell tube formation and proliferation, to induce apoptosis in vitro, and to suppress tumor growth in vivo. The experimental results showed that rVBMDMP potently inhibited proliferation of human endothelial (HUVEC-12) cells and human colon cancer (SW480) cells in vitro, with no inhibition of proliferation in Chinese hamster ovary (CHO-K1) cells. rVBMDMP also significantly inhibited human endothelial cell tube formation and suppressed tumor growth of SW480 cells in a mouse xenograft model. These results suggest that rVBMDMP is a powerful therapeutic agent for suppressing angiogenesis and tumor growth. ©Institute of Biochemistry and Cell Biology, SIBS, CAS.
语种：
英文
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The preventive and therapeutic effect of a liver X receptor agonist on atherosclerotic lesions in apolipoprotein e knockout mice
作者：
Dai, X. Y.;Tang, C. K.;On, X.;Yang, J. H.;Jiang, Z. S.;...
期刊：
Atherosclerosis Supplements ,2006年7(3):254-254 ISSN：1567-5688
作者机构：
[Wang, Z.; Hao, X. R.; Tang, C. K.; Can, D. L.; Dai, X. Y.; Liu, L. S.; Yang, J. H.; Jiang, Z. S.; On, X.; Yi, G. H.] Nanhua Univ, Inst Cardiovasc Dis, Hengyang, Peoples R China.
语种：
英文
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Synthesis and anticancer effect of gem-difluoromethylenated chrysin derivatives
作者：
Zheng, Xing* ;Cao, Jian Guo;Liao, Duan Fang;Zhu, Bing Yang;Liu, Hui Ting
期刊：
中国化学快报：英文版 ,2006年17(11):1439-1442 ISSN：1001-8417
通讯作者：
Zheng, Xing
作者机构：
[Zheng, Xing] Nanhua Univ, Inst Pharm & Pharmacol, Hengyang 421001, Peoples R China.;Nanhua Univ, Inst Canc Res, Hengyang 421001, Peoples R China.
通讯机构：
[Zheng, Xing] N;Nanhua Univ, Inst Pharm & Pharmacol, Hengyang 421001, Peoples R China.
关键词：
Anticancer activity;Chrysin;Gem-difluoromethylenated
摘要：
Ten gem-difluoromethylenated chrysin derivatives were prepared and their anticancer activities in vitro were evaluated by the standard MTT method. The results of biological test showed that some of gem-difluoromethylenated chrysin derivatives had higher anticancer activity than chrysin.
语种：
英文
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Inducible nitric oxide synthase and cyclooxgenase-2 mediate protection of hydrogen peroxide preconditioning against apoptosis induced by oxidative stress in PC12 cells
作者：
Tang, Xiao-qing;Yu, Hui-min;Zhi, Jun-li;Cui, Yu;Tang, Er-hu;...
期刊：
Life Sciences ,2006年79(9):870-876 ISSN：0024-3205
通讯作者：
Feng, Jian-qiang
作者机构：
[Feng, Jian-qiang] Sun Yat Sen Univ, Zhongshan Med Coll, Dept Physiol, Guangzhou 510080, Peoples R China.;Nahua Univ, Coll Med, Dept Physiol, Hengyang City 421001, Hunan, Peoples R China.
通讯机构：
[Feng, Jian-qiang] S;Sun Yat Sen Univ, Zhongshan Med Coll, Dept Physiol, Guangzhou 510080, Peoples R China.
关键词：
Inducible nitric oxide synthase;Cyclooxygenase;Hydrogen superoxide;Apoptosis;Preconditioning
摘要：
The induction of inducible nitric oxide synthase (iNOS) in response to different stress is associated with simultaneous induction of cyclooxygenase-2 (COX-2) in various cell types. Both iNOS and COX-2 have been reported to mediate the late phase of cardioprotection induced by different preconditioning. However, whether both iNOS and COX-2 are mediators in the neuroprotection induced by preconditioning with hydrogen peroxide (H(2)O(2)) at low concentration is unknown. In this study, using the neurosecretory cell line-PC12 cells to set up the model of neuroprotection of preconditioning with H(2)O(2) against apoptosis, we first investigate what changes in expression of iNOS and COX-2 appear during H(2)O(2) preconditioning, then determine if both iNOS inhibitor and COX-2 inhibitor interfere with the neuroprotection elicited by preconditioning with H(2)O(2). We found that preconditioning with H(2)O(2) at 10 microM significantly protected PC12 cells against apoptosis induced by lethal H(2)O(2) (50 microM) and increased the expression of iNOS and COX-2 and that selective iNOS inhibitor, aminoguanidine (AG) and COX-2 inhibitor, NS-398 obviously blocked the protective effects induced by preconditioning with 10 microM H(2)O(2). The results of this study suggest that both iNOS and COX-2 are mediators of the neuroprotection induced by preconditioning with oxidative stress (H(2)O(2) at low concentration) in PC12 cells.
语种：
英文
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Tu-P7:224 LDTI inhibits the specific activity of tryptase in mast cell granules and blocks its function in inhibiting cholesterol efflux
作者：
Zhao, Z. Z.;Yang, Y. Z.;Wang, Z.;Dong, B. H.;Wang, S.;...
期刊：
Atherosclerosis Supplements ,2006年7(3):234-234 ISSN：1567-5688
作者机构：
[Wei, D. H.; Wang, Z.; Sun, W. Q.; Dong, B. H.; Zhao, Z. Z.; Liu, L. S.; Yang, Y. Z.; Wang, S.] Nanhua Univ, Inst Cardiovasc Dis, Hengyang, Peoples R China.
语种：
英文
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Regulation of the CD36 expression and cholesterol influx in THP-1 macrophage by PPAR
作者：
Yi, G. H.;Mo, Z. C.;Chen, X.;Wang, Z.;Ren, Z.;...
期刊：
Atherosclerosis Supplements ,2006年7(3):516-516 ISSN：1567-5688
作者机构：
Nanhua Univ, Inst Cardiovasc Res, Hengyang, Hunan, Peoples R China.;Nanhua Univ, Dept Histol & Embryol, Hengyang, Hunan, Peoples R China.
语种：
英文
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Effects of NO-1886 on inflammation-associated cytokines in atherosclerosis associated diabetes mellitus miniature pigs
作者：
Cai, M. B.;Li, J. J.;Yin, W. D.;Liao, D. F.;Li, Q. K.;...
期刊：
Atherosclerosis Supplements ,2006年7(3):195-195 ISSN：1567-5688
作者机构：
Nanhua Univ, Sch Life Sci & Technol, Dept Biochem & Mol Biol, Hengyang, Hunan, Peoples R China.;Nanhua Univ, Affiliated Hosp 2, Dept Renal Transplantat, Hengyang, Hunan, Peoples R China.;Nanhua Univ, Inst Cardiovasc Res, Hengyang, Hunan, Peoples R China.;Nanhua Univ, Sch Life Sci & Technol, Dept Lab Anim Sci, Hengyang, Hunan, Peoples R China.
语种：
英文
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Tu-P7:219 Oxidized low density lipoprotein up-regulate PCSK9 expression in rat vascular smooth muscle cells in vitro
作者：
Liu, L. S.;Cheng, Y. L.;Xie, M.;Tang, C. K.;Wang, Z.;...
期刊：
Atherosclerosis Supplements ,2006年7(3):233-233 ISSN：1567-5688
作者机构：
Nanhua Univ, Inst Cardiovasc Dis, Heng Yang, Hunan, Peoples R China.;Chongqing Univ, Bioengn Coll, Chongqing 630044, Peoples R China.
语种：
英文
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NO-1886 upregulates ATP binding cassette transporter A1 and inhibits diet-induced atherosclerosis in Chinese Bama minipigs
作者：
Zhang, Chi;Yin, Weidong* ;Liao, Duanfang;Huang, Liang;Tang, Chaoke;...
期刊：
Journal of Lipid Research ,2006年47(9):2055-2063 ISSN：0022-2275
通讯作者：
Yin, Weidong
作者机构：
[Yin, Weidong] Nanhua Univ, Sch Med, Inst Cardiovasc Res, Hengyang 421001, Hunan, Peoples R China.;Nanhua Univ, Sch Life Sci & Technol, Dept Biochem & Mol Biol, Hengyang 421001, Hunan, Peoples R China.;Nanhua Univ, Sch Med, Funct Lab Ctr, Hengyang 421001, Hunan, Peoples R China.;Nanhua Univ, Inst Pharm & Pharmacol, Hengyang 421001, Hunan, Peoples R China.;Nanhua Univ, Sch Med, Dept Operat Surg, Hengyang 421001, Hunan, Peoples R China.
通讯机构：
[Yin, Weidong] N;Nanhua Univ, Sch Med, Inst Cardiovasc Res, Hengyang 421001, Hunan, Peoples R China.
关键词：
liver X receptor alpha;scavenger receptor class B type I;[4-(4-bromo-2-cyano-phenylcarbamoyl)-benzyl] phosphonic;acid diethyl ester
摘要：
It is widely believed that high density lipoprotein-cholesterol (HDL-C) functions to transport cholesterol from peripheral cells to the liver by reverse cholesterol transport (RCT), a pathway that may protect against atherosclerosis by clearing excess cholesterol from arterial cells. A cellular ATP binding cassette transporter called ABCA1 mediates the first step of RCT. NO-1886 has been proven to be highly effective at increasing HDL-C and reducing atherosclerosis. However, the mechanism of atherosclerosis inhibition for NO-1886 is not fully understood. In this study, the effects of NO-1886 on ABCA1 were investigated in high-fat/high-sucrose/high-cholesterol-fed Chinese Bama minipigs. Administration of NO-1886 (0.1 g/kg body weight/day) in the diet for 5 months significantly reduced atherosclerosis lesions and significantly increased plasma HDL-C and apolipoprotein A-I levels. The mRNA and protein levels of ABCA1 in the liver, retroperitoneal adipose tissue, and aorta were increased by NO-1886 as well. Multivariate linear regression analysis showed that the levels of LPL in plasma and the levels of ABCA1 in aorta were independently associated with the atherosclerotic lesion area. In addition, NO-1886 upregulated liver X receptor α and affected the expression of scavenger receptor class B type I in the liver. These results demonstrate that the mechanism of atherosclerosis inhibition for NO-1886 is associated with its effect on ABCA1. Copyright ©2006 by the American Society for Biochemistry and Molecular Biology, Inc.
语种：
英文
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Small interfering RNA targeting the Bcl-2 gene induced apoptosis of HL-60 cell
作者：
Yan, Chun-yan;Lei, Xiao-yong;Zhong, Miao;Feng, Lan-fang;Tu, Yu-lin;...
期刊：
中国药理学报 ,2006年27:411-411 ISSN：1671-4083
作者机构：
Nanhua Univ, Inst Pharm & Pharmacol, Hengyang 421001, Peoples R China.;Nanhua Univ, Inst Cardiovasc Dis, Hengyang 421001, Peoples R China.
关键词：
small interfering RNA;Bcl-2;apoptosis;HL-60
语种：
英文
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Effects of rosiglitazone on collagen I/III and secretion of TGF beta 1 of vascular smooth muscle cell induced by high glucose
作者：
Wang, Bing-Xiang;Ling, Hong-Yan;Zhang, Yu-Chang;Feng, Shui-Dong;Hu, Bi
期刊：
中国药理学报 ,2006年27:162-162 ISSN：1671-4083
作者机构：
Nanhua Univ, Dept Physiol, Hengyang 421001, Peoples R China.;Nanhua Univ, Dept Epidemiol, Hengyang 421001, Peoples R China.
关键词：
rosiglitazone;high glucose;VSMC;collagen I / III;TGF beta 1
语种：
英文
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Diallyl disulfide suppresses growth of HL-60 cell through increasing histone acetylation and p21WAF1 expression in vivo and in vitro
作者：
Zhao, Jie;Huang, Wei-guo;He, Jie;Tan, Hui;Liao, Qian-jin;...
期刊：
中国药理学报 ,2006年27(11):1459-1466 ISSN：1671-4083
通讯作者：
Su, Qi
作者机构：
[Su, Qi] Nanhua Univ, Inst Canc Res, Hengyang 421001, Peoples R China.;Mawangdui Hosp, Dept Pathol, Changsha 410016, Peoples R China.
通讯机构：
[Su, Qi] N;Nanhua Univ, Inst Canc Res, Hengyang 421001, Peoples R China.
关键词：
diallyl disulfide;leukemia;growth inhibition;histone acetylation;p21WAF1
摘要：
Aim: To examine the differentiation induction and growth inhibition of HL-60 cells by diallyl disulfide (DADS), and its relationship with the alterations of histone acetylation and p21WAF1 expression in vitro and in vivo. Methods: Differentiation was studied by nitroblue tetrazolium (NBT) reduction of HL-60 cell in vitro. HL-60 cells 5×106 were injected into the right side of the peritoneal cavity of severe combined immunodeficiency (SCID) mice. When the peritoneal neoplasms were detected, the SCID mice were randomly divided into 3 groups and received an ip injection of vehicle alone (NS), DADS or sodium butyrate (SB). The growth inhibition of peritoneal neoplasms induced by DADS was observed by a growth curve. The cycle distribution of HL-60 cells in SCID mice was monitored by flow cytometry. The expression of acetylated histone H3, H4 and p21WAF1 were measured by Western blot. Results: After treatment with DADS for 0-72 h, the NBT reduction ability of HL-60 cells increased in a time-dependent manner, compared with no treatment of HL-60 cells. In the HL-60 cells treated with DADS for 24 h, the expression of acetylated histone H3, H4, and p21WAF1 increased obviously. After treatment with DADS, tumor growth was markedly suppressed. HL-60 cells from mice treated with DADS were blocked in the G1 phase, from 25.4% to 63.4%. The tumors from the mice treated with DADS showed an increase of acetylated histone H3, H4, and p21WAF1. Conclusion: DADS could induce differentiation and inhibit the growth of HL-60 cells through increasing the expression of acetylated histone H3, H4, and p21WAF1 in vitro and in vivo. © 2006 CPS and SIMM.
语种：
英文
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The centrally cardiovascular regulative effect of adrenomedullin in the medulla oblongata on stress-induced hypertensive rats
作者：
Xia, Li;Liang, Li;Yi, Wang;Jin, Wang;Lin, Shen Lin;...
期刊：
JOURNAL OF HYPERTENSION ,2006年24:308-308 ISSN：0263-6352
作者机构：
ESPCI, CNRS, UMR 7637, Lad Neurobiol, F-75005 Paris, France.;Fudan Univ, Shanghai Med Coll, Dept Physiol & Phatholphysiol, Shanghai 200433, Peoples R China.;Nanhua Univ, Nanhua Med Coll, Dept Physiol, Hunan, Peoples R China.;Fudan Univ, Shanghai Med Coll, Dept Phatholphysiol, Shanghai 200433, Peoples R China.
语种：
英文
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Th-P15:11 The role of PPARs in cellular cholesterol efflux mediated by high density lipoprotein. A possible involvement of ABCA1, LXRALPHA, and ERK1/2
作者：
Yi, G. -H.;Yin, X. -B.;Tan, Y. L.;Zeng, Y.;Feng, J. -T.;...
期刊：
Atherosclerosis Supplements ,2006年7(3):494-494 ISSN：1567-5688
作者机构：
[Wang, J.; Ren, Z.; Yin, X. -B.; Zeng, Y.; Zeng, D. -X.; Sun, L.; Feng, J. -T.; Tan, Y. L.; Yi, G. -H.; Xia, J. -H.] Nanhua Univ, Inst Cardiovasc Dis, Hengyang, Peoples R China.
语种：
英文
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Tu-P7:199 NO-1886 (IBROLIPIM) reduced plasma triglycerides and free fatty acids in fat-loaded Bama minipigs
作者：
Hou, H. J.;Yin, W. D.;Li, Q. K.;Cai, M. B.;Zhang, C.;...
期刊：
Atherosclerosis Supplements ,2006年7(3):228-228 ISSN：1567-5688
作者机构：
Nanhua Univ, Sch Life Sci & Technol, Hengyang, Hunan, Peoples R China.;Nanhua Univ, Inst Cardiovasc Dis, Hengyang, Hunan, Peoples R China.;Nanhua Univ, Inst Tumor Researcher, Hengyang, Hunan, Peoples R China.
语种：
英文
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Apolipoprotein A-1 activates ABCA1 gene transcription and protein synthesis
作者：
Yang, J. H.;Tang, C. K.;Dai, X. Y.;Ou, X.;Wang, Z. Q.;...
期刊：
Atherosclerosis Supplements ,2006年7(3):543-543 ISSN：1567-5688
作者机构：
[Ou, X.; Wang, Z.; Hao, X. R.; Cao, D. L.; Tang, C. K.; Dai, X. Y.; Yang, J. H.; Wang, Z. Q.; Jiang, Z. S.; Yi, G. H.] Nanhua Univ, Inst Cardiovasc Dis, Hengyang, Peoples R China.
语种：
英文
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Effects of NO-1886 on inflammation-associated cytokines in high-fat/high-sucrose/high-cholesterol diet-fed miniature pigs
作者：
Cai, Manbo;Yin, Weidong* ;Li, Qinkai;Liao, Duanfang;Tsutsumi, Kazuhiko;...
期刊：
European Journal of Pharmacology ,2006年540(1-3):139-146 ISSN：0014-2999
通讯作者：
Yin, Weidong
作者机构：
[Yin, Weidong] Nanhua Univ, Inst Cardiovasc Res, Hengyang 421001, Hunan, Peoples R China.;Nanhua Univ, Dept Biochem & Mol Biol, Sch Life Sci & Technol, Hengyang 421001, Hunan, Peoples R China.;Nanhua Univ, Inst Pharm & Pharmacol, Hunan, Peoples R China.;Otsuka Pharmaceut Factory Inc, Res & Dev, Tokushima 7728601, Japan.;Nanhua Univ, Affiliated Hosp 2, Dept Renal Transplantat, Hunan, Peoples R China.
通讯机构：
[Yin, Weidong] N;Nanhua Univ, Inst Cardiovasc Res, Hengyang 421001, Hunan, Peoples R China.
关键词：
Atherosclerosis;Diabetes mellitus;Inflammatory cytokine;NO-1886
摘要：
Inflammation, closely associated with obesity, is emerging as an important risk factor for the pathophysiological development of atherosclerosis and diabetes mellitus. Fat balance is critical in the aetiology of obesity. Lipoprotein lipase is an important enzyme in lipid metabolism. The aim of this study was to investigate the long-term effect of the lipoprotein lipase activator, NO-1886, on inflammation cytokines, adiposity and related diseases in miniature pigs fed a high-fat/high-sucrose/high-cholesterol diet (HFSC diet). Chinese Bama-miniature pigs were fed a control diet or HFSC diet with or without NO-1886 for 5 months. The levels of inflammation-associated cytokines were determined using the antibody arrays. Feeding of the HFSC diet to miniature pigs markedly increased the expression of inflammatory cytokines. On the other hand, supplementation of NO-1886 to HFSC diet decreased the expression of inflammatory cytokines significantly, protecting against the development of atherosclerosis and diabetes mellitus. NO-1886 may have a beneficial effect on the most inflammation-associated cytokines, and this effect may contribute to improving atherosclerosis and diabetes mellitus.
语种：
英文
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Inducing apoptosis of the human HL-60 myeloid cell lines by targeting Bcl-2 mRNA with small interfering RNA
作者：
Lei, XY;Yan, CY;Zhong, M;Feng, LF;Tu, YL;...
期刊：
ONCOLOGY RESEARCH ,2006年15(10-12):498-499 ISSN：0965-0407
作者机构：
Nanhua Univ, Inst Pharm & Pharmacol, Hengyang 421001, Peoples R China.;Nanhua Univ, Inst Cardiovasc Dis, Hengyang 421001, Peoples R China.
关键词：
small interfering RNA;Bcl-2;apoptosis;HL-60 cell
语种：
英文
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