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Effects of NO-1886 on inflammation-associated cytokines in high-fat/high-sucrose/high-cholesterol diet-fed miniature pigs

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成果类型:
期刊论文
作者:
Cai, Manbo;Yin, Weidong*;Li, Qinkai;Liao, Duanfang;Tsutsumi, Kazuhiko;...
通讯作者:
Yin, Weidong
作者机构:
[Yin, Weidong] Nanhua Univ, Inst Cardiovasc Res, Hengyang 421001, Hunan, Peoples R China.
Nanhua Univ, Dept Biochem & Mol Biol, Sch Life Sci & Technol, Hengyang 421001, Hunan, Peoples R China.
Nanhua Univ, Inst Pharm & Pharmacol, Hunan, Peoples R China.
Otsuka Pharmaceut Factory Inc, Res & Dev, Tokushima 7728601, Japan.
Nanhua Univ, Affiliated Hosp 2, Dept Renal Transplantat, Hunan, Peoples R China.
通讯机构:
[Yin, Weidong] N
Nanhua Univ, Inst Cardiovasc Res, Hengyang 421001, Hunan, Peoples R China.
语种:
英文
关键词:
Atherosclerosis;Diabetes mellitus;Inflammatory cytokine;NO-1886
期刊:
European Journal of Pharmacology
ISSN:
0014-2999
年:
2006
卷:
540
期:
1-3
页码:
139-146
基金类别:
The authors gratefully acknowledge the financial support from Project 973 of China G2000056905 and the National Natural Sciences Foundation of China (project 30370675).
机构署名:
本校为第一且通讯机构
院系归属:
化学化工学院
医学院
药学与生物科学学院
摘要:
Inflammation, closely associated with obesity, is emerging as an important risk factor for the pathophysiological development of atherosclerosis and diabetes mellitus. Fat balance is critical in the aetiology of obesity. Lipoprotein lipase is an important enzyme in lipid metabolism. The aim of this study was to investigate the long-term effect of the lipoprotein lipase activator, NO-1886, on inflammation cytokines, adiposity and related diseases in miniature pigs fed a high-fat/high-sucrose/high-cholesterol diet (HFSC diet). Chinese Bama-miniature pigs were fed a control diet or HFSC diet with...

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