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Diallyl disulfide suppresses growth of HL-60 cell through increasing histone acetylation and p21WAF1 expression in vivo and in vitro

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成果类型:
期刊论文
作者:
Zhao, Jie;Huang, Wei-guo;He, Jie;Tan, Hui;Liao, Qian-jin;...
通讯作者:
Su, Qi
作者机构:
[Su, Qi] Nanhua Univ, Inst Canc Res, Hengyang 421001, Peoples R China.
Mawangdui Hosp, Dept Pathol, Changsha 410016, Peoples R China.
通讯机构:
[Su, Qi] N
Nanhua Univ, Inst Canc Res, Hengyang 421001, Peoples R China.
语种:
英文
关键词:
diallyl disulfide;leukemia;growth inhibition;histone acetylation;p21WAF1
关键词(中文):
己二烯;二硫化物;乙酰化作用;组蛋白
期刊:
中国药理学报
ISSN:
1671-4083
年:
2006
卷:
27
期:
11
页码:
1459-1466
基金类别:
Project supported by Scientific Research Foundation of Hunan Province Education Department (No 02C394, 03C415, and 04B057).
机构署名:
本校为第一且通讯机构
院系归属:
医学院
摘要:
Aim: To examine the differentiation induction and growth inhibition of HL-60 cells by diallyl disulfide (DADS), and its relationship with the alterations of histone acetylation and p21WAF1 expression in vitro and in vivo. Methods: Differentiation was studied by nitroblue tetrazolium (NBT) reduction of HL-60 cell in vitro. HL-60 cells 5×106 were injected into the right side of the peritoneal cavity of severe combined immunodeficiency (SCID) mice. When the peritoneal neoplasms were detected, the SCID mice were randomly divided into 3 groups and ...
摘要(中文):
Aim:To examine the differentiation induction and growth inhibition of HL-60 cellsby diallyl disulfide(DADS),and its relationship with the alterations of histoneacetylation and p21WAF1expression in vitro and in vivo.Methods:Differentiationwas studied by nitroblue tetrazolium(NBT)reduction of HL-60 cell in vitro.HL-60cells 5×106 were injected into the right side of the peritoneal cavity of severecombined immunodeficiency(SCID)mice.When the peritoneal neoplasms weredetected,the SCID mice were randomly divided into 3 groups and received an ...

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