作者机构：
[Wang, Hong-Qing; He, Fang-Fang; Wang, Xiao-Feng] School of Chemistry and Chemical Engneering, University of South China, Hengyang 421001, China;[Zhou, Wei-Ping] College of Mathematics and Physical, University of South China, Hunan 421001, China;[Liu, Zhao-Jie] Institute of Organic Synthesis, Central China Normal University, Wuhan 430079, China
通讯机构：
[Wang, H.-Q.] S;School of Chemistry and Chemical Engneering, University of South China, China
摘要：
In the title compound, C30H23ClN6OS, the benzyl, the 3-chloroanilino, the phenyl and the anilino groups form dihedral angles of 85.95 (6), 29.63 (7), 28.55 (1) and 87.48 (6)°, respectively, with the pyrazolo[3,4-d]pyrimidine unit [maximum deviation = 0.052 (2) A]. An intramolecular N - H···N hydrogen bond occurs. The crystal structure features N - H···O hydrogen bonds.
通讯机构：
[He, Shuya] U;Univ S China, Dept Biochem & Mol Biol, Hengyang 421001, Peoples R China.
关键词：
small interfering RNA;hypoxia-inducible factor-1 alpha;multidrug resistance-1;multidrug resistance-associated protein
摘要：
This study aimed to investigate the effects of knocking down hypoxia-inducible factor-1α (HIF-1α) through RNA interference on hypoxia-induced increases in drug resistance in A549/CDDP cells, and to study the underlying mechanisms. A small interfering RNA (siRNA) eukaryotic expression vector targeting HIF-1α was constructed and transfected into A549/CDDP cells treated with hypoxia. The mRNA and protein levels of HIF-1α, multidrug resistance-1 (MDR1), and multidrug resistance-associated protein (MRP) were determined by reverse transcription polymerase chain reaction (RT-PCR) and immunocytochemistry. Cell viability following treatment with cisplatin was determined by MTT assay. Hypoxia increased the resistance of A549/CDDP cells to cisplatin and this effect was reversed by the siRNA inhibition of HIF-1α expression. Expression of HIF-1α siRNA also downregulated HIF-1α, MDR1 and MRP mRNA, and protein expression in A549/CDDP cells treated with hypoxia (p<0.05). Hypoxia-induced resistance of A549/CDDP cells to cisplatin is reversed by the siRNA inhibition of HIF-1α expression. This effect may be mediated by a decreased expression of MDR1 and MRP.
通讯机构：
[Wang, Hong-Qing] U;Univ South China, Sch Chem & Chem Engn, Hengyang 421001, Hunan, Peoples R China.
摘要：
C52H44N4O4Th, triclinic, P (1) over bar (no. 2), a = 16.3338(3) angstrom, b = 17.1662(3) angstrom, c = 18.5769(6) angstrom, alpha = 101.145(1)degrees, beta = 95.195(1)degrees, gamma = 117.054(1)degrees, V = 4455.6 angstrom(3), Z = 4, R-gt(F) = 0.0314, wR(ref)(F-2) = 0.0914, T = 296 K.
摘要：
As a novel kind of nanomaterial with wide potential applications, the adverse effects of carbon nanotubes (CNTs) have recently received significant attention after respiratory exposure. In this study, single-wall carbon nanotubes (SWCNTs) containing different metal contents were intratracheally instilled into lungs of spontaneously hypertensive rats. Pulmonary and cardiovascular system alterations were evaluated at 24 and 72 h post-instillation. Biomarkers of inflammation, oxidative stress and cell damage in the bronchoalveolar lavage fluid (BALF) were increased significantly 24 h post-exposure of SWCNTs. The increased endothelin-1 levels in BALF and plasma and angiotensin I-converting enzyme in plasma suggested endothelial dysfunction in the pulmonary circulation and peripheral vascular thrombosis. These findings suggest that respiratory exposure to SWCNTs can induce acute pulmonary and cardiovascular responses and individuals with existing cardiovascular diseases are very susceptible to SWCNTs exposure. The co-existence of metal residues in SWCNTs can aggravate the adverse effects.
摘要：
A wireless sensing method for the measurement of gamma radiation dose has been developed based on the fact that gamma rays can initiate the polymerization of acrylamide, which causes an increase in solution viscosity that can be detected with a wireless magnetoelastic sensor. The magnetoelastic sensor is able to wirelessly detect the resonance frequency shifts of a magnetoelastic foil in response to changes in solution viscosity. There is a linear relationship between the resonance frequency shift and gamma radiation dose in the range of 0–50 Gy (under optimal conditions) with a detection limit of 0.25 Gy. This method has the advantage of providing real-time, continuous measurement in situ. The method has been used successfully to determine the gamma radiation dose in real exposure scenarios, with satisfactory results.
作者：
Wang, X. -F.*;Chen, Z. -Q.;Yang, P. -F.;Wang, Y. -F.
期刊：
Russian Journal of Coordination Chemistry,2012年38(12):733-737 ISSN：1070-3284
通讯作者：
Wang, X. -F.
作者机构：
[Wang, Y. -F.; Wang, X. -F.; Chen, Z. -Q.; Yang, P. -F.] Univ S China, Sch Chem & Chem Engn, Hengyang 421001, Peoples R China.
通讯机构：
[Wang, X. -F.] U;Univ S China, Sch Chem & Chem Engn, Hengyang 421001, Peoples R China.
关键词：
Pyridyl;Nitroxide;Oxyl;Cobalt Atom;Nitronyl
摘要：
A new cobalt coordination compound with nitronyl nitroxide and benzonate, Co(PyNIT)2(PhCOO)2(H2O)2, where PyNIT = 2-(p-pyridyl)-4,4′,5,5′-tetramethylimidazoline-1-oxyl-3-oxide, was synthesized and its X-ray diffraction analysis was carried out. The crystals were triclinic: a = 6.7749(4), b = 11.3472(7), c = 12.9066(8) Å, α = 87.906(1)°, β = 88.631(1)°, γ = 79.080(1)°, V = 973.45(10) Å3, space group P
$$
\bar 1
$$
, Z = 1, ρcalcd = 1.375 mg/m3, R = 0.0316. The environment of the cobalt atom is distorted octahedral formed by two oxygen atoms of two carboxylate groups of benzoate, two oxygen atoms of waters and two nitrogen atoms from two pyridyl nitronyl nitroxide molecules.
摘要：
A two dimensional coordination polymer with pseudo-Kagomé net [Cu3(btc)2(NH3)8(H2O)] was prepared from Cu(NO3)2·3H2O and 1, 3, 5-benzenetricarboxylic acid (btc) in ammonia aqua solution and was structurally characterized by X-ray diffraction. The magnetic susceptibility measurements, measured from 2 to 300 K, revealed a weak anti-ferromagnetic interaction between the CuII ions via the btc ligands.
