Acute pulmonary and moderate cardiovascular responses of spontaneously hypertensive rats after exposure to single-wall carbon nanotubes

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成果类型：

期刊论文

作者：

Ge, Cuicui;Meng, Li;Xu, Ligeng;Bai, Ru;Du, Jiangfeng;...

通讯作者：

Chen, Chunying

作者机构：

[Zhang, Lili; Meng, Li; Zhao, Yuliang; Chen, Chunying; Xu, Ligeng; Bai, Ru; Ge, Cuicui] Chinese Acad Sci, Natl Ctr Nanosci & Technol China, Beijing 100190, Peoples R China.

[Zhang, Lili; Meng, Li; Zhao, Yuliang; Chen, Chunying; Xu, Ligeng; Bai, Ru; Ge, Cuicui] Chinese Acad Sci, Inst High Energy Phys, CAS Key Lab Biomed Effects Nanomat & Nanosafety, Beijing 100190, Peoples R China.

[Du, Jiangfeng] Univ S China, Sch Chem & Chem Engn, Hengyang, Peoples R China.

[Chang, Yanzhong; Li, Yang] Hebei Normal Univ, Coll Life Sci, Lab Mol Iron Metab, Shijiazhuang, Peoples R China.

[Chen, Chunying] Chinese Acad Sci, Natl Ctr Nanosci & Technol China, 11 Beiyitiao, Beijing 100190, Peoples R China.

通讯机构：

[Chen, Chunying] C

Chinese Acad Sci, Natl Ctr Nanosci & Technol China, 11 Beiyitiao, Beijing 100190, Peoples R China.

语种：

英文

关键词：

Intratracheal instillation;single-wall carbon nanotube;metal residues;cardiovascular effect;pulmonary toxicity

期刊：

Nanotoxicology

ISSN：

1743-5390

年：

2012

卷：

期：

页码：

526-542

DOI：

10.3109/17435390.2011.587905

基金类别：

Ministry of Science and Technology of ChinaMinistry of Science and Technology, China [2011CB933401, 2009AA3Z335, 2010CB934004]; National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [10975040]; CAS Knowledge Innovation ProgramKnowledge Innovation Program of the Chinese Academy of Sciences

机构署名：

本校为其他机构

院系归属：

化学化工学院

摘要：

As a novel kind of nanomaterial with wide potential applications, the adverse effects of carbon nanotubes (CNTs) have recently received significant attention after respiratory exposure. In this study, single-wall carbon nanotubes (SWCNTs) containing different metal contents were intratracheally instilled into lungs of spontaneously hypertensive rats. Pulmonary and cardiovascular system alterations were evaluated at 24 and 72 h post-instillation. Biomarkers of inflammation, oxidative stress and cell damage in the bronchoalveolar lavage fluid (BALF) were increased significantly 24 h post-exposur...

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Acute pulmonary and moderate cardiovascular responses of spontaneously hypertensive rats after exposure to single-wall carbon nanotubes

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