作者机构：
School of Resources Environment and Safety Engineering, University of South China, Hengyang 421001, China;National & Local Joint Engineering Research Center for Airborne Pollutants Control and Radioactivity Protection in Buildings, Hengyang 421001, China;Key Laboratory of Prefabricated Building Energy Saving Technology of Hunan Province, Hengyang 421001, China;[Caiting Li] College of Environmental Science and Engineering, Hunan University, Changsha 410082, China;[Jiajie Wang; Jie Liu; Huiyu Xiong; Jiaqi Xie; Yueguo Pan] School of Resources Environment and Safety Engineering, University of South China, Hengyang 421001, China<&wdkj&>National & Local Joint Engineering Research Center for Airborne Pollutants Control and Radioactivity Protection in Buildings, Hengyang 421001, China<&wdkj&>Key Laboratory of Prefabricated Building Energy Saving Technology of Hunan Province, Hengyang 421001, China
通讯机构：
[Lei Gao] S;School of Resources Environment and Safety Engineering, University of South China, Hengyang 421001, China<&wdkj&>National & Local Joint Engineering Research Center for Airborne Pollutants Control and Radioactivity Protection in Buildings, Hengyang 421001, China<&wdkj&>Key Laboratory of Prefabricated Building Energy Saving Technology of Hunan Province, Hengyang 421001, China<&wdkj&>College of Environmental Science and Engineering, Hunan University, Changsha 410082, China
摘要：
In this study, a string of Cr-Mn co-modified activated coke catalysts (XCryMn1-y/AC) were prepared to investigate toluene and Hg0 removal performance. Multifarious characterizations including XRD, TEM, SEM, in situ DRIFTS, BET, XPS and H2-TPR showed that 4%Cr0.5Mn0.5/AC had excellent physicochemical properties and exhibited the best toluene and Hg0 removal efficiency at 200℃. By varying the experimental gas components and conditions, it was found that too large weight hourly space velocity would reduce the removal efficiency of toluene and Hg0. Although O2 promoted the abatement of toluene and Hg0, the inhibitory role of H2O and SO2 offset the promoting effect of O2 to some extent. Toluene significantly inhibited Hg0 removal, resulting from that toluene was present at concentrations orders of magnitude greater than mercury's or the catalyst was more prone to adsorb toluene, while Hg0 almost exerted non-existent influence on toluene elimination. The mechanistic analysis showed that the forms of toluene and Hg0 removal included both adsorption and oxidation, where the high-valent metal cations and oxygen vacancy clusters promoted the redox cycle of Cr3+ + Mn3+/Mn4+ ↔ Cr6+ + Mn2+, which facilitated the conversion and replenishment of reactive oxygen species in the oxidation process, and even the CrMn1.5O4 spinel structure could provide a larger catalytic interface, thus enhancing the adsorption/oxidation of toluene and Hg0. Therefore, its excellent physicochemical properties make it a cost-effective potential industrial catalyst with outstanding synergistic toluene and Hg0 removal performance and preeminent resistance to H2O and SO2.
作者机构：
[Min Hu; Siying He; Yuhang Ye; Yinping Xiang; Haihao Peng; Honglin Zhang; Weixiang Li; Shudian Peng] College of Environmental Science and Engineering, Hunan University and Key Laboratory of Environmental Biology and Pollution Control (Hunan University), Ministry of Education, Changsha 410082, China;Hunan Boke Environmental Engineering Co. Ltd., Hengyang 421099, China;College of Environmental Protection and Safety Engineering, University of South China, Hengyang 421001, China;[Zhengyong Xu] Hunan Modern Environmental Technology Co. Ltd., Changsha 410004, China;[Weiping Xiong] College of Environmental Science and Engineering, Hunan University and Key Laboratory of Environmental Biology and Pollution Control (Hunan University), Ministry of Education, Changsha 410082, China<&wdkj&>Hunan Boke Environmental Engineering Co. Ltd., Hengyang 421099, China
通讯机构：
[Weiping Xiong] C;College of Environmental Science and Engineering, Hunan University and Key Laboratory of Environmental Biology and Pollution Control (Hunan University), Ministry of Education, Changsha 410082, China<&wdkj&>Hunan Boke Environmental Engineering Co. Ltd., Hengyang 421099, China
摘要：
Microplastics (MPs) are of particular concern due to their ubiquitous occurrence and propensity to interact and concentrate various waterborne contaminants from aqueous surroundings. Studies on the interaction and joint toxicity of MPs on engineered nanoparticles (ENPs) are exhaustive, but limited research on the effect of MPs on the properties of ENPs in multi-solute systems. Here, the effect of MPs on adsorption ability of ENPs to antibiotics was investigated for the first time. The results demonstrated that MPs enhanced the adsorption affinity of ENPs to antibiotics and MPs before and after aging showed different effects on ENPs. Aged polyamide prevented aggregation of ZnONPs by introducing negative charges, whereas virgin polyamide affected ZnONPs with the help of electrostatic attraction. FT-IR and XPS analyses were used to probe the physicochemical interactions between ENPs and MPs. The results showed no chemical interaction and electrostatic interaction was the dominant force between them. Furthermore, the adsorption rate of antibiotics positively correlated with pH and humic acid but exhibited a negative correlation with ionic strength. Our study highlights that ENPs are highly capable of accumulating and transporting antibiotics in the presence of MPs, which could result in a widespread distribution of antibiotics and an expansion of their environmental risks and toxic effects on biota. It also improves our understanding of the mutual interaction of various co-existing contaminants in aqueous environments.
期刊：
Chemical Engineering Journal,2024年485:149856 ISSN：1385-8947
通讯作者：
Yi-Lin Liu<&wdkj&>Qingyi Zeng
作者机构：
[Chao Zhang; Yi-Lin Liu; Qingming Zeng; Yanjun Wen; Lulin Guo; Haodong Chen; Xinyi Xie; Qingyi Zeng] School of Mechanical Engineering, & School of Resources & Environment and Safety Engineering, University of South China, Hengyang 421001, PR China;[Yi Wang] Laboratory of Environmental Technology, INET, Tsinghua University, Beijing 100084, China
通讯机构：
[Yi-Lin Liu; Qingyi Zeng] S;School of Mechanical Engineering, & School of Resources & Environment and Safety Engineering, University of South China, Hengyang 421001, PR China
摘要：
An innovative MnO/Ti3C2 MXene heterostructure, consisting of three-dimensional (3D) MnO nanosheet array directly assembled on two-dimensional (2D) Ti3C2 MXene nanosheets, was synthesized via a simple hydrothermal-annealing strategy for uranium elimination. This unique 3D/2D heterostructure derived substantially high specific surface area (311.9 m2/g) and exposed considerable amount of surface oxygen groups, including surface lattice M–O and adsorbed –OH. Through a comprehensive exploration encompassing adsorbent dosage, pH, ionic strength, initial U(VI) concentration, and environmental conditions, the MnO/Ti3C2 MXene heterostructure demonstrated an extraordinary proficiency and specificity in the removal of U(VI). This composite exhibited an outstanding adsorption capacity of 862.1 mg/g, with a removal efficiency of 99.7 % and rapid kinetics (above 90 % within 20 s). The kinetic study indicated the adsorption process followed chemisorption dynamics and single-layer adsorption behavior. Comprehensive analyses validated the structural integrity and confirmed the successful uranium adsorption via strong interaction between UO22+ and surface unsaturated oxygen groups. Notably, the MnO/Ti3C2 MXene maintained excellent recyclability, highlighting its potential for large-scale applications. It emerges as a promising candidate for uranium removal, offering insights for optimizing composite materials in diverse environmental conditions and fostering advancements in water purification technologies.
摘要：
Capsaicin is the main active ingredient of chili peppers and the most pungent alkaloid. It is reported that capsaicin has many pharmacological effects such as analgesia, anticancer, anti-inflammatory, antibacterial, and anti-obesity. However, the application of capsaicin is limited by its adverse side effects, such as stomach irritation, stomach cramps, and burning sensation. In recent years, many capsaicin derivatives have been synthesized and their biological activities have been evaluated. Some capsaicin derivatives have shown promising activities in cells and animal models. Herein, we described the synthesis and biological activity of capsaicin and its derivatives. It is hoped that the insights obtained in this perspective will facilitate the synthesis of a second generation of capsaicin analogs with improved biological activities.
作者机构：
[Fang, Hongyi; Ke, Weijun; Pu, Dexin; Guan, Hongling; Zhou, Shun; Chen, Guoyi; Fang, Guojia; Fu, Shiqiang; Ke, WJ; Jia, Peng; Wang, Chen] Wuhan Univ, Sch Phys & Technol, Key Lab Artificial Micro & Nanostruct, Minist Educ, Wuhan 430072, Peoples R China.;[Jumabaev, Abduvakhid; Hushvaktov, Hakim] Samarkand State Univ, 15 Univ Blvd, Samarkand 140104, Uzbekistan.;[Meng, Weiwei] South China Normal Univ, South China Acad Adv Optoelect, Guangzhou 510006, Peoples R China.;[Wang, Xingzhu; Wang, XZ] Southern Univ Sci & Technol, Dept Mat Sci & Engn, Shenzhen 518055, Peoples R China.;[Wang, Xingzhu; Wang, XZ] Univ South China, Sch Elect Engn, Hengyang 421001, Peoples R China.
通讯机构：
[Meng, WW ; Wang, XZ ; Jumabaev, A ] S;[Ke, WJ ] W;Wuhan Univ, Sch Phys & Technol, Key Lab Artificial Micro & Nanostruct, Minist Educ, Wuhan 430072, Peoples R China.;Samarkand State Univ, 15 Univ Blvd, Samarkand 140104, Uzbekistan.;South China Normal Univ, South China Acad Adv Optoelect, Guangzhou 510006, Peoples R China.
关键词：
blade coating;large area;strain;tandem solar cells;wide-bandgap perovskites
摘要：
Blade‐coated wide‐bandgap perovskites encounter top–down inhomogeneity strains. Utilizing mixed‐cation post‐treatment for strain relief, large‐area wide‐bandgap solar cells demonstrate enhanced efficiency and stability. Specifically, 1 cm2‐area 1.77 eV‐bandgap cells achieve an 18.71% efficiency (stabilized at 18.50%), while 4‐terminal all‐perovskite tandems reach an exceptional 27.64% efficiency, coupled with enhanced stability. Abstract The realization of efficient large‐area perovskite solar cells stands as a pivotal milestone for propelling their future commercial viability. However, the upscaling fabrication of perovskite solar cells is hampered by efficiency losses, and the underlying growth mechanism remains enigmatic. Here, it is unveiled that a prevalent upscaling technology, namely blade‐coating, inherently triggers top‐down inhomogeneity strains, predominantly concentrated on the surface of wide‐bandgap perovskite films. Through strain mitigation strategies, the perovskite films exhibit reduced halide vacancies, leading to enhanced stability and improved optoelectronic characteristics. Consequently, the blade‐coated perovskite solar cells achieve minimal efficiency loss when transitioning from small‐area to large‐area devices, enabling the realization of 1 cm2‐area 1.77 eV‐bandgap cells with a remarkable efficiency of 18.71%. Additionally, the strain‐relieved device exhibits an exceptional 109% retention of its initial efficiency even after 400 h of continuous operation, in stark contrast to the control device which experiences a decline to 91%. Furthermore, the resulting 4‐terminal all‐perovskite tandem solar cells crafted utilizing blade‐coated 1.77 eV‐bandgap subcells achieve a maximum efficiency of 27.64% (stabilized at 27.28%). This study not only sheds light on the intricacies of upscaling preparation techniques but also overcomes potential obstacles that can impede the trajectory toward achieving large‐scale perovskite solar cells.
摘要：
In order to improve the utilization of spent fuel, molten salt electrolysis is used to separate lanthanides from spent fuel. The electrochemical reduction mechanism of Ce(III) ions and dynamic properties of Ce(III)/Ce(0) were provided in the LiCl-KCl molten salt by diversified electrochemical techniques. The diffusion coefficient of Ce(III) and the exchange current densities of Ce(III)/Ce(0) on the W electrode were calculated by cyclic vol-tammetry and linear polarization, and the reaction activation energy was calculated to be 30.8 kJ center dot mol-1. The electrochemical behaviors were measured in the LiCl-KCl-CeCl3-K2ZrF6 molten salt on the W electrode and LiCl-KCl-CeCl3 molten salt on the Zr electrode at 753 K. The redox mechanism of Ce(III) ions was studied on the Zr electrode. Compared the reaction at different electrodes, the reduction potential of cerium on the Zr electrode is more correct than that on the W electrode, the underpotential displacement of cerium and zirconium due to the formation of alloy is 0.26 V, which was detecteted using cyclic voltammetry, square wave voltammetry and chronopotentiometry. In addition, the feasibility of extracting Ce on the Zr electrode by potentiostatic elec-trolysis at-1.9 V and-2.2 V in the LiCl-KCl molten salt. The cathodic deposition output was characterized by XRD and SEM-EDS, Ce-Zr solid solution was derived under the different conditions. Simultaneously, the Ce metal was discovered when the deposition potential at-2.2 V. The ICP-OES results showed that the extraction ratio of was about 94.02 % for Ce(III) after potentiostatic electrolysis at-2.2 V for 5 h.
作者：
Ablikim, M.;Achasov, M. N.;Adlarson, P.;Ai, X. C.;Aliberti, R.;...
期刊：
Journal of High Energy Physics,2024年(1) ISSN：1029-8479
通讯作者：
Ablikim, M
作者机构：
[Li, Xiaoyu; Hu, T.; Chen, T.; Hou, X. T.; Heng, Y. K.; Ji, Q.; Guan, C. Y.; Liao, Y. P.; Ji, X. B.; Dong, M. Y.; Fang, S. S.; Chang, J. F.; Ding, B.; Fu, C. D.; Lin, T.; Cao, G. F.; Fu, Y. W.; Jiang, X. S.; Kiuchi, R.; Gu, M. H.; Dong, L. Y.; Li, L. J.; Fang, Y.; Ji, X. L.; Li, L. K.; Li, H. B.; Liang, H.; Huang, Y. P.; Batozskaya, V.; Chen, X. T.; He, K. L.; Chen, G.; Ablikim, M.; Chang, W. L.; Jing, M. Q.; Chen, Y. B.; Du, M. C.; Ablikim, M; Dong, J.; Chen, M. L.; Hou, G. Y.; Hou, Z. L.; Liu, B. J.; Li, Ke; Chen, H. S.; Cao, N.; Deng, Z. Y.; Cai, X.; Kui, X.; Li, W. G.; Fang, J.; Hu, H. M.; Gong, W. X.; Hu, Y.; Li, F.; Li, G.; Dai, H. L.; Li, W. D.; Fang, W. X.] Inst High Energy Phys, Beijing 100049, Peoples R China.;[Yuan, L.] Beihang Univ, Beijing 100191, Peoples R China.;[Li, Lei] Beijing Inst Petrochem Technol, Beijing 102617, Peoples R China.;[Jaeger, S.; Fritsch, M.; Kuessner, M.; Pelizaeus, M.; Kopf, B.; Wollenberg, L.; Holtmann, T.; de Boer, R. E.; Feldbauer, F.; Wiedner, U.; Heinsius, F. H. H.; Coen, S. C.; Wenzel, C. W.] Bochum Ruhr Univ, D-44780 Bochum, Germany.;[Achasov, M. N.; Nikolaev, I. B.; Muchnoi, N. Yu.] Budker Inst Nucl Phys SB RAS BINP, Novosibirsk 630090, Russia.
通讯机构：
[Ablikim, M ] I;Inst High Energy Phys, Beijing 100049, Peoples R China.
关键词：
e(+)-e(-) Experiments;Particle and Resonance Production;Spectroscopy
摘要：
Based on e(+)e(-) collision data collected at center-of-mass energies from 2.000 to 3.080 GeV by the BESIII detector at the BEPCII collider, a partial wave analysis is performed for the process e(+)e(-) -> (KSKL0)-K-0 pi(0). The results allow the Born cross sections of the process e(+)e(-) -> (KSKL0)-K-0 pi(0), as well as its subprocesses e(+)e(-) -> K*(892)K-0(0) over bar and K-2*(1430)K-0(0) to be measured. The Born cross sections for e(+)e(-) -> (KSKL0)-K-0 pi(0) are consistent with previous measurements by BaBar, but with substantially improved precision. The Born cross section lineshape of the process e(+)e(- )-> K*(892)K-0(0) is consistent with a vector meson state around 2.2 GeV with a significance of 3.2 sigma. A Breit-Wigner fit determines its mass as M-Y = (2164.7 +/- 9.1 +/- 3.1) MeV/c(2) and its width as Gamma(Y) = (32.4 +/- 21.0 +/- 1.8) MeV.
摘要：
Diabetic nephropathy (DN) is one of the most serious and general complications of diabetes, while schedules for prevention and treatment are unsatisfactory. Leucine aminopeptidase (LAP) as one of the biomarkers of DN is associated with glomerular and/or tubular injury. Imaging of LAP activity in DN disease model in vivo is thus beneficial for early diagnosis and prevention of DN, but such a strategy is still lacking. Herein, an enzyme-activated probe HD-LAP with a NIR fluorescence emission for specific detection of LAP activity in the DN model is designed and synthesized. HD-LAP has a significant fluorescence enhancement after reacted with LAP and shows a NIR fluorescence emission at 704 nm based on intramolecular charge transfer mechanism. Moreover, HD-LAP can be employed to image LAP activity in HK-2 and HepG2 cells. More importantly, HD-LAP is the first example to real-time image LAP in DN mice and clinical serum samples. These results demonstrated that HD-LAP is promising as a powerful tool for the research on LAP associated diabetic diseases in future.
作者：
Ye, Xu;Wang, Tao;Zhong, Liyuan;Farrés, Jaume;Xia, Jiliang;...
期刊：
JOURNAL OF CANCER,2024年15(6):1657-1667 ISSN：1837-9664
作者机构：
[Ye, Xu] Hunan Cancer Hospital and the Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University, Hunan 410031, China;[Wang, Tao; Zhong, Liyuan; Cao, Deliang; Xia, Jiliang; Zeng, Xi] Hunan Province Key Laboratory of Cancer Cellular and Molecular Pathology, Cancer Research Institute, University of South China Hengyang Medical College. 28 W Changsheng Road, Hengyang, Hunan 421009, China;[Farrés, Jaume] Department of Biochemistry and Molecular Biology, Universitat Autònoma de Barcelona, E-08193, Bellaterra, Barcelona, Spain
关键词：
AKR1B10;Biomarker;Colorectal cancer;Tissue microarrays;and DNA damage
摘要：
Colorectal cancer (CRC) is the leading cause of cancer death, but little is known about its etiopathology. Aldo-keto reductase 1B10 (AKR1B10) protein is primarily expressed in intestinal epithelial cells, but lost in colorectal cancer tissues. This study revealed that AKR1B10 may not be a prognostic but an etiological factor in colorectal tumorigenesis. Using a tissue microarray, we investigated the expression of AKR1B10 in tumor tissues of 592 colorectal cancer patients with a mean follow-up of 25 years. Results exhibited that AKR1B10 protein was undetectable in 374 (63.13%), weakly positive in 146 (24.66%), and positive 72 (12.16%) of 592 tumor tissues. Kaplan-Meier analysis showed that AKR1B10 expression was not correlated with overall survival or disease-free survival. Similar results were obtained in various survival analyses stratified by clinicopathological parameters. AKR1B10 was not correlated with tumor T-pathology, N-pathology, TNM stages, cell differentiation and lymph node/regional/distant metastasis either. However, AKR1B10 silencing in culture cells enhanced carbonyl induced protein and DNA damage; and in ulcerative colitis tissues, AKR1B10 deficiency was associated acrolein-protein lesions. Together this study suggests that AKR1B10 downregulation may not be a prognostic but a carcinogenic factor of colorectal cancer.
期刊：
JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY,2024年38(1):e23608- ISSN：1095-6670
通讯作者：
Zhenjie Wang<&wdkj&>Zhenjie Wang Zhenjie Wang Zhenjie Wang
作者机构：
Department of Emergency Medicine, The First Affiliated Hospital of Bengbu Medical College, Bengbu, Anhui, China;Institute of Emergency and Critical Care Medicine, The First Affiliated Hospital of Bengbu Medical College, Bengbu, Anhui, China;[Shugen Xu; Shugen Xu Shugen Xu Shugen Xu] Department of Emergency Medicine, The Affiliated Changsha Central Hospital, Hengyang Medical School, University of South China, Changsha, Hunan, China;[Zhenjie Wang; Zhaolei Qiu; Chuanming Zheng; Feng Cheng; Lei Li; Zhipeng Xu; Qi Song; Fulong Zhang; Zhenjie Wang Zhenjie Wang Zhenjie Wang; Zhaolei Qiu Zhaolei Qiu Zhaolei Qiu; Chuanming Zheng Chuanming Zheng Chuanming Zheng; Feng Cheng Feng Cheng Feng Cheng; Lei Li Lei Li Lei Li; Zhipeng Xu Zhipeng Xu Zhipeng Xu; Qi Song Qi Song Qi Song; Fulong Zhang Fulong Zhang Fulong Zhang] Department of Emergency Medicine, The First Affiliated Hospital of Bengbu Medical College, Bengbu, Anhui, China<&wdkj&>Institute of Emergency and Critical Care Medicine, The First Affiliated Hospital of Bengbu Medical College, Bengbu, Anhui, China
通讯机构：
[Zhenjie Wang; Zhenjie Wang Zhenjie Wang Zhenjie Wang] D;Department of Emergency Medicine, The First Affiliated Hospital of Bengbu Medical College, Bengbu, Anhui, China<&wdkj&>Institute of Emergency and Critical Care Medicine, The First Affiliated Hospital of Bengbu Medical College, Bengbu, Anhui, China
摘要：
This study aimed to explore the impact of different pH values of resuscitation fluid on traumatic hemorrhagic shock (THS),focusing on their effects on glycocalyx and inflammation. A rat model of THS was induced by hemorrhage from a left femur fracture, while an oxygen-glucose deprivation/reoxygenation (OGD/R)-induced HULEC-5acell model was considered as an in vitro THSmodel. The lung tissue pathology and glycocalyx structure were assessed through hematoxylin-eosin (H&E) staining and transmission electron microscope examination. The levels of glycocalyx-related factors and inflammation-related factors were determined by enzyme-linked immunosorbent assay (ELISA).The expression of glycocalyx-related proteins, cell junction-related proteins, and proteins involved in the PI3K/Akt/NF-κB signaling pathway was analyzed by western blot. The results showed that both sodium bicarbonate Ringer's solution (BRS)and lactate Ringer's solution (LRS)were effective in restoring mean arterial pressure and heart rate in THS rats. However, LRS has a stronger impact on promoting inflammation and damaging the glycocalyx compared withBRS. In OGD/R-induced HULEC-5a cells, a pH of 7.4 and 6.5 increased inflammation and disrupted the glycocalyx, while a pH of 8.1 had no significant effect on inflammation or glycocalyx. Furthermore, the PI3K/Akt/NF-κBsignaling pathway was activated by fluid resuscitation and different pH values. However, the activating effect of BRS and pH 8.1 on the PI3K/Akt/NF-κBsignaling pathway was milder compared withLRS and pH6.5. In conclusion, an alkaline recovery environment was more beneficial for the treatment of THS.
期刊：
Chinese Journal of Physics,2024年 ISSN：0577-9073
通讯作者：
Wenbin Lin
作者机构：
[Jie Li] School of Nuclear Science and Technology, University of South China, Hengyang 421001, China;[Bo Yang; Wenbin Lin] School of Mathematics and Physics, University of South China, Hengyang, 421001, China
通讯机构：
[Wenbin Lin] S;School of Mathematics and Physics, University of South China, Hengyang, 421001, China
摘要：
We investigate the hydrostatic equilibrium configurations of strange stars within the framework of Rastall-Rainbow theory of gravity. These stars are primarily composed of strange quark matter, with its distribution governed by the color-flavor-locked phase of quark matter equation of state (EoS). Using this EoS, we numerically solve the modified Tolman–Oppenheimer–Volkoff equation to obtain different quark star models. We find that the parameters from this modified gravity have specific contributions to the structure of quark stars and introduce new descriptions for massive celestial bodies. Aslo, the mass–radius relation strongly depends on the parameters from the considered EoS. Furthermore, we analyze the impact of these parameters on the gravitational redshift and compactness of quark stars.
期刊：
BMC Medical Education,2024年24(1):1-6 ISSN：1472-6920
通讯作者：
Ke Cao<&wdkj&>Xiangyang Zeng
作者机构：
[Songshu Xiao; Jing Yuan; Qiaofen Li; Xiangyang Zeng] Department of Obstetrics and Gynecology, the Third Xiangya Hospital of Central South University, Changsha, People’s Republic of China;Department of Obstetrics and Gynecology, Changsha Central Hospital of University of South China, Changsha, China;[Yan Cheng] Department of Pharmacy, The Second Xiangya Hospital, Central South University, Changsha, China;[Ke Cao] Department of Oncology, the Third Xiangya Hospital of Central South University, Changsha, People’s Republic of China;[Hua Lan] Department of Obstetrics and Gynecology, the Third Xiangya Hospital of Central South University, Changsha, People’s Republic of China<&wdkj&>Department of Obstetrics and Gynecology, Changsha Central Hospital of University of South China, Changsha, China
通讯机构：
[Ke Cao; Xiangyang Zeng] D;Department of Oncology, the Third Xiangya Hospital of Central South University, Changsha, People’s Republic of China<&wdkj&>Department of Obstetrics and Gynecology, the Third Xiangya Hospital of Central South University, Changsha, People’s Republic of China
摘要：
Narrative Medicine (NM), a contemporary medical concept proposed in the 21st century, emphasizes the use of narrative as a literary form in medicine. This study aims to explore the understanding about NM and willingness to learn NM among medical students in our hospital. A questionnaire survey was conducted among 130 students at Xiangya Medical College of Central South University. The findings revealed that a small percentage of students (3.1%) were familiar with narrative medicine and its training methods. Knowledge about the treatment skills (77.7%) and core content (55.4%) of narrative medicine was limited among the students. Despite this, a majority (63.1%) expressed a lack of interest in further understanding and learning about narrative medicine. Surprisingly, the survey indicated that students possessed a high level of narrative literacy, even without formal training in narrative medicine. Additionally, over half of the surveyed students (61.5%) believed that narrative medicine could benefit their clinical practice. This study serves as a preliminary basis for the future development of narrative medicine education in China. It highlights the need to prioritize medical humanities education and provide medical students with more opportunities to access information on narrative medicine. By doing so, we can strive to enhance the visibility and promote the integration of narrative medicine into medical humanities education in China.
摘要：
Neutralizing antibodies are a key component in protective humoral immunity against SARS-CoV-2. Currently, available technologies cannot track epitope-specific antibodies in global antibody repertoires. Thus, the comprehensive repertoire of spike-specific neutralizing antibodies elicited by SARS-CoV-2 infection is not fully understood. We therefore combined high-throughput immunoglobulin heavy chain (IgH) repertoire sequencing, and structural and bioinformatics analysis to establish an antibodyomics pipeline, which enables tracking spike-specific antibody lineages that target certain neutralizing epitopes. We mapped the neutralizing epitopes on the spike and determined the epitope-preferential antibody lineages. This analysis also revealed numerous overlaps between immunodominant neutralizing antibody-binding sites and mutation hotspots on spikes as observed so far in SARS-CoV-2 variants. By clustering 2677 spike-specific antibodies with 360 million IgH sequences that we sequenced, a total of 329 shared spike-specific antibody clonotypes were identified from 33 COVID-19 convalescents and 24 SARS-CoV-2-naïve individuals. Epitope mapping showed that the shared antibody responses target not only neutralizing epitopes on RBD and NTD but also non-neutralizing epitopes on S2. The immunodominance of neutralizing antibody response is determined by the occurrence of specific precursors in human naïve B-cell repertoires. We identified that only 28 out of the 329 shared spike-specific antibody clonotypes persisted for at least 12 months. Among them, long-lived IGHV3-53 antibodies are likely to evolve cross-reactivity to Omicron variants through accumulating somatic hypermutations. Altogether, we created a comprehensive atlas of spike-targeting antibody lineages in COVID-19 convalescents and antibody precursors in human naïve B cell repertoires, providing a valuable reference for future vaccine design and evaluation.
期刊：
FRONTIERS IN ENDOCRINOLOGY,2024年15:1330206 ISSN：1664-2392
作者机构：
Wuxi Medical College, Jiangnan University, Wuxi, China;Wuxi Maternity and Child Health Care Hospital, Wuxi, Jiangsu Province, China;University of South China, Hengyang, Hunan Province, China
关键词：
Secondary infertility;weight-adjusted-waist index (WWI);Depression;NHANES;ROC;Mediating effect
摘要：
Background Obesity and psychological factors were identified as risk factors for female infertility. The study investigated the correlation between WWI, depression, and secondary infertility, focusing on the potential mediating role of depression. Methods According to the data from NHANES, this cross-sectional study used multiple regression analysis, subgroup analysis, and smooth curve fitting to explore the relationship between WWI, depression, and secondary infertility. The diagnostic ability of WWI was evaluated and compared to other obesity indicators using the ROC curve. The mediating effect test adopted the distribution of the product. Results This study involved 2778 participants, including 381 (13.7%) women with secondary infertility. Results showed that higher WWI (OR = 1.31; 95% CI, 1.11-1.56) and depression scores (OR = 1.03; 95% CI, 1.01-1.06) were associated with secondary infertility. There was a positive correlation between WWI and secondary infertility (nonlinear p = 0.8272) and this association was still consistent in subgroups (all P for interaction> 0.05). Compared with other obesity indicators, WWI (AUC = 0.588) also shows good predictive performance for secondary infertility. Mediation analysis showed that depression mediated the relationship between 3.94% of WWI and secondary infertility, with a confidence interval of Za * Zb excluding 0. Conclusion WWI exhibited a relatively good correlation in predicting secondary infertility than other obesity indicators, and depression may be a mediator between WWI and secondary infertility. Focusing on the potential mediating role of depression, the risk of secondary infertility due to obesity may be beneficially reduced in women. Keywords Secondary infertility, Weight-adjusted-waist index (WWI), Body mass index (BMI), A body shape index (ABSI), Depression, National Health and Nutrition Examination Survey (NHANES), Receiver operator characteristic (ROC), Mediating effect.
期刊：
NEW JOURNAL OF CHEMISTRY,2024年48(6):2855-2865 ISSN：1144-0546
通讯作者：
Sun, YK;Sun, Yunkai;Yang, PF
作者机构：
[Ding, Yi; Sun, Yunkai] Changzhou Inst Technol, Sch Chem Engn & Mat, Changzhou 213032, Peoples R China.;[Yang, Pengfei; Liu, Cheng; Sun, Yunkai; Yin, Na] Univ South China, Sch Chem & Chem Engn, Hengyang 421001, Peoples R China.;[Ding, Yi; Sun, Yunkai] Changzhou Inst Technol, Ind Coll Carbon Fiber & New Mat, Changzhou 213032, Peoples R China.
通讯机构：
[Sun, YK ] C;[Sun, YK; Yang, PF ] U;Changzhou Inst Technol, Sch Chem Engn & Mat, Changzhou 213032, Peoples R China.;Univ South China, Sch Chem & Chem Engn, Hengyang 421001, Peoples R China.;Changzhou Inst Technol, Ind Coll Carbon Fiber & New Mat, Changzhou 213032, Peoples R China.
摘要：
Nanoscale zero-valent iron (nZVI) was cured by vulcanization and biochar functionalization to overcome the tendency of oxidation and aggregation, and the sulfurized nano-zero-valent iron functional material supported by amino biochar (SnZVI-BC-NH2) was obtained, which was used to remove U(VI) from wastewater in this study. A variety of measurements (SEM, TEM, XRD, BET, VSM, FT-IR, and XPS) were used to characterize the morphology, structure, magnetic properties, characteristic functional groups and chemical bonds of SnZVI-BC-NH2. Analysis results confirm that the aminated biochar can support sulfurized nZVI well. The good kinetics, thermodynamics, and large removal capacity data (at pH 6, T = 298 K, Q(m) = 158.1 mg g(-1)) indicate that SnZVI-BC-NH2 has excellent removal performance for U(VI), and the experimental data are in good agreement with the pseudo-second-order kinetic model. Cycling and anti-oxidation tests demonstrate that the FeSx shell plays a crucial role in enhancing the removal of SnZVI-BC-NH2 on U(VI). XPS and FT-IR analysis results show that SnZVI-BC-NH2 removes U(VI) through the synergistic effect of adsorption and reduction.
作者机构：
[Luo, Jiayou; Pan, Xiongfeng] Pediatrics Research Institute of Hunan Province, Hunan Children's Hospital, Changsha, China;[Luo, Jiayou; Yao, Zhenzhen; Pan, Xiongfeng; Luo, Miyang; Dai, Wen; Xiao, Xiang; Wei, Jia; Duan, Yamei; Ouyang, SiSi; Liu, Yixu] Department of Maternal and Child Health, Xiangya School of Public Health, Central South University, Changsha, China;[Luo, Miyang] Department of Epidemiology and Health Statistics, Xiangya School of Public Health, Central South University, Changsha, China;[Luo, Miyang] Saw Swee Hock School of Public Health, National University of Singapore, Singapore, Singapore;[Kaminga, Atipatsa C] Department of Mathematics and Statistics, Mzuzu University, Mzuzu, Malawi
摘要：
Altered gut microbiota and metabolites are important for non-alcoholic fatty liver disease (NAFLD) in children. We aimed to comprehensively examine the effects of gut metabolites on NAFLD progression. We performed integrative metabolomics (untargeted discovery and targeted validation) analysis of non-alcoholic fatty liver (NAFL), non-alcoholic steatohepatitis (NASH), and obesity in children. Fecal samples were collected from 75 subjects in the discovery cohort (25 NAFL, 25 NASH, and 25 obese control children) and 145 subjects in an independent validation cohort (53 NAFL, 39 NASH, and 53 obese control children). Among 2,491 metabolites, untargeted metabolomics revealed a complete NAFLD metabolic map containing 318 increased and 123 decreased metabolites. Then, machine learning selected 65 important metabolites that can distinguish the severity of the NAFLD. Furthermore, precision-targeted metabolomics selected 5 novel gut metabolites from 20 typical metabolites. The functionality of candidate metabolites was validated in hepatocyte cell lines. In the end, this study annotated two novel elevated pathogenic metabolites (dodecanoic acid and creatinine) and a relationship between depleted protective gut microbiota (Butyricicoccus and Alistipes), increased inflammation (IL-1β), lipid metabolism (TG), and liver function (ALT and AST). This study demonstrates the role of novel gut metabolites (dodecanoic acid and creatinine), as the fatty acid metabolism regulator contributing to NAFLD development through its influence on inflammation and liver function. IMPORTANCE: Altered gut microbiota and metabolites are a major cause of non-alcoholic fatty liver disease (NAFLD) in children. This study demonstrated a complete gut metabolic map of children with NAFLD, containing 318 increased and 123 decreased metabolites by untargeted metabolomic. Multiple validation approaches (machine learning and targeted metabolomic) selected five novel gut metabolites for targeted metabolomics, which can distinguish NAFLD status and severity. The gut microbiota (Butyricicoccus and Alistipes) and metabolites (creatinine and dodecanoic acid) were novel biomarkers associated with impaired liver function and inflammation and validated by experiments of hepatocyte cell lines. The data provide a better understanding of the importance of gut microbiota and metabolite alterations in NAFLD, which implies that the altered gut microbiota and metabolites may represent a potential target to prevent NAFLD development.
期刊：
FRONTIERS IN NEUROLOGY,2024年15:1322228 ISSN：1664-2295
通讯作者：
Zhu, Shuzhen;Wang, Q
作者机构：
[Zhu, Shuzhen; Li, Fangyi; Zhang, Wenjie; Deng, Bin; Zhu, SZ; Wang, Qing; Zhou, Hang; Wang, Q; Weng, Guomei; Luo, Yuqi] Southern Med Univ, Dept Neurol, Zhujiang Hosp, Guangzhou, Peoples R China.;[Li, Fangyi] Univ South China, Affiliated Changsha Cent Hosp, Hengyang Med Sch, Dept Neurol, Changsha, Peoples R China.;[Weng, Guomei] First Peoples Hosp Zhaoqing, Dept Neurol, Zhaoqing, Peoples R China.;[Tao, Xi] Hunan Normal Univ, Hunan Prov Peoples Hosp, Dept Neurol Rehabil, Affiliated Hosp 1, Changsha, Peoples R China.;[Deng, Mingzhu] Brain Hosp Hunan Prov, Peoples Hosp Hunan Prov 2, Dept Neurol, Changsha, Peoples R China.
通讯机构：
[Wang, Q ; Zhu, SZ] S;Southern Med Univ, Dept Neurol, Zhujiang Hosp, Guangzhou, Peoples R China.
关键词：
Parkinson’s disease;inflammation;lymphocyte-to-monocyte ratio;neutrophil-to-high-density lipoprotein ratio;neutrophil-to-lymphocyte ratio
摘要：
BACKGROUND: Inflammation plays a pivotal role in the pathogenesis of Parkinson's disease (PD). However, the correlation between peripheral inflammatory markers and the severity of PD remains unclear. METHODS: The following items in plasma were collected for assessment among patients with PD (n = 303) and healthy controls (HCs; n = 303) were assessed for the neutrophil-to-lymphocyte ratio (NLR), lymphocyte-to-monocyte ratio (LMR) and neutrophil-to-high-density-lipoprotein ratio (NHR) in plasma, and neuropsychological assessments were performed for all patients with PD. Spearman rank or Pearson correlation was used to evaluate the correlation between the NLR, the LMR and the NHR and the severity of PD. Receiver operating characteristic (ROC) curves were used to evaluate the diagnostic performance of the NLR, LMR and NHR for PD. RESULTS: The plasma NLR and NHR were substantially higher in patients with PD than in HCs, while the plasma LMR was substantially lower. The plasma NLR was positively correlated with Hoehn and Yahr staging scale (H&Y), Unified Parkinson's Disease Rating Scale (UPDRS), UPDRS-I, UPDRS-II, and UPDRS-III scores. Conversely, it exhibited a negative relationship with Mini-Mental State Examination (MMSE) and Montreal Cognitive Assessment (MoCA) scores. Furthermore, the plasma NHR was positively correlated with H&Y, UPDRS, UPDRS-I, UPDRS-II and UPDRS-III scores. Moreover, negative associations were established between the plasma LMR and H&Y, UPDRS, UPDRS-I, UPDRS-II, and UPDRS-III scores. Finally, based on the ROC curve analysis, the NLR, LMR and NHR exhibited respectable PD discriminating power. CONCLUSION: Our research indicates that a higher NLR and NHR and a lower LMR may be relevant for assessing the severity of PD and appear to be promising disease-state biomarker candidates.
摘要：
BACKGROUND: Depression is a highly prevalent comorbidity arising in patients with Parkinson's disease (PD). However, depression in patients with PD is poorly treated. Hydrogen sulfide (H(2)S), a neuromodulator, has the potential to relieve depression. OBJECTIVE: To investigate whether H(2)S attenuates depression-like behaviours in a rat model of PD and examine the underlying mechanisms. METHODS: We utilised rotenone to develop a PD model with subcutaneous injections in the dorsal cervical region of Sprague-Dawley rats. The depression-like behaviours in the rotenone-induced PD model rats were assessed through forced swimming, tail suspension, open field, novelty-suppressed feeding, and elevated plus-maze tests. The expression of postsynaptic density protein-95 and synapsin-1, related to synaptic plasticity, was detected using Western blot in the hippocampus. The hippocampal ultrastructure, including the synaptic density, length of the synaptic active zone, postsynaptic density thickness, and synaptic gap width, was detected using transmission electron microscopy. RESULTS: We proved that sodium hydrosulfide (NaHS; a donor of H(2)S) significantly attenuated the depression-like behaviours and disorders of hippocampal synaptic plasticity in rotenone-induced PD rats. Furthermore, inhibition of the hippocampal Warburg effect by 2-deoxyglucose abolished NaHS-enhanced hippocampal synaptic plasticity and reversed NaHS-attenuated depression-like behaviours in the rotenone-induced PD rats. CONCLUSION: H(2)S attenuates PD-associated depression by improving the hippocampal synaptic plasticity in a hippocampal Warburg effect-dependent manner.
摘要：
Electrochemical conversion of nitrate offers an efficient solution to nitrate pollution and a sustainable strategy for ammonia generation. Cu and Fe bimetallic electrocatalysts exhibit excellent electrochemical reduction of nitrate (NO3RR) reactivity but the conventional preparation strategy is complex and time-consuming and this reaction is still suffers from unsatisfied kinetic and unidentified mechanisms. Herein, in situ electrodeposition strategy is employed to induce Cu to modify the Fe active sites of iron-based N-doping carbon nanofiber electrode (Fe/Fe3C@NCNFs) during NO3RR in Cu-contained nitrate solution. Benefiting from the synergistic effect between Cu and Fe sites of CuFe/Fe3C@NCNFs electrode, superior activity of rate-determining reaction (*NO(3 )to *NO2) and reduced energy barriers of the following deoxidation and hydrogenation steps are achieved. Compared with Fe/Fe3C@NCNFs-500, the pseudo-first-order (PFO) rate constant for NO3RR by CuFe/Fe3C@NCNFs demonstrates nearly two-fold improvement with high current efficiencies over wide pH and voltage range. Furthermore, the maximum NO3N removal capacity and N-2 selectivity of CuFe/Fe3C@NCNFs reach 15593.8 mg N g(-1) Fe and ca. 92% after twenty cycles. This work offers an avenue for highly active bimetallic electrode design, paving more insights into the interactions between active site construction and NO3RR performance.
