摘要：
Uranium mining operations produce large volumes of acidic uranium mining wastewater, necessitating the development of environmentally friendly and recyclable materials for efficient uranium removal and recovery. The current study successfully produced hydroxyapatite (HAP-L) and magnetic phosphate composites (CaFeP-1, CaFeP-2, and FePO4) through a combination of mixing, ultrasonication, hydrothermal precipitation, and calcination methods. The research explores the influence of various parameters such as pH, solid-liquid ratio, contact time, initial uranium concentration, co-existing ions, and recyclability on the uranium removal efficiency of these materials. The findings indicate exceptional uranium adsorption capacities, with CaFeP-1 exhibiting the highest capacity among the materials, especially in acidic environments. Moreover, CaFeP-1 displays strong resistance to interference from other ions and can be recycled multiple times while maintaining high removal rates. Treatment of acidic uranium mining wastewater by CaFeP-1 results in pH adjustment and the reduction of uranium and other ion concentrations, making it a promising solution for comprehensive remediation of acidic uranium mining wastewater. The U(VI) removal mechanism by CaFeP-1 was validated through XRD, FT-IR, and XPS results. The U(VI) removal was attributed to processes such as dissolution-precipitation, surface complexation, and ion exchange. The formation of sodium uranyl phosphate hydrate was identified as a new product following U(VI) abatement by CaFeP-1. In summary, CaFeP-1 shows great potential for the effective treatment of acidic uranium mining wastewater.
作者机构：
[Meng-qi Jin; Kai Weng; Zhou-ping Guo; Deng-hui Chen; Xiao-jian Zhao] Xi'an Center,China Geological Survey,Ministry of Natural Resources,Xi'an 710054,China;[Xiao-jian Zhao] Xinjiang Research Center for Mineral Resources,Xinjiang Institute of Ecology and Geography,Chinese Academy of Sciences,Urumqi 830011,China;[Xiao-jian Zhao] College of Geography and Remote Sensing Sciences,Xinjiang University,Urumqi 830046,China;[Xiao-jian Zhao] University of Chinese Academy of Sciences,Beijing 100029,China;[Ming Wang] No.8 Geological Party,Xinjiang Bureau of Geology and Mineral Exploration and Development,Aksu 843000,China
关键词：
strata;Triassic;Xinjiang
摘要：
1. Objective
In the past decade, a group of medium to giant lead-zinc deposits, represented by Huoshaoyun, Sachakou, and Yuanbaoling, have been discovered in the Aksai Chin region of Karakoram, Xinjiang. They are all located in the Mesozoic carbonate and clastic rock formations. The Sachakou lead-zinc mining area is adjacent to the northwest of the Huoshaoyun lead-zinc mining area and is in the same stratigraphic layer as Huoshaoyun. Although many scholars have been arguing about the type and age of Huoshaoyun lead-zinc mineralization, few scholars have paid attention to the classification of the ore-bearing strata in the area. The stratigraphy of the Lower Permian Shenxianwan Group to the Upper Cretaceous Tielongtan Group is exposed in the Sachakou area of Karakorum, Xinjiang, however, the Late Permian-Early Triassic stratigraphy is missing (Fig. 1a). Due to the harsh natural conditions in the area and the low level of work, the stratigraphic delineation is not exhaustive, and the regional lithology is dominated by carbonates and clastic rocks, which makes it difficult to identify the age of the regional lithology and causes problems for the exploration and research of lead-zinc in the area.
作者机构：
[Jian Peng] School of Mathematics and Statistics, Hainan University, Haikou 570228, Hainan, People’s Republic of China;[Yan Wang] Department of Neurology, The First Affiliated Hospital, University of South China, Hengyang 421001, People’s Republic of China;School of Cyberspace Security, Hainan University, Haikou 570228, Hainan, People’s Republic of China;Hainan University, Key Laboratory of Engineering Modeling and Statistical Computation of Hainan Province, Haikou 570228, China;[Jingwen Zhang] School of Mathematics and Statistics, Hainan University, Haikou 570228, Hainan, People’s Republic of China<&wdkj&>School of Cyberspace Security, Hainan University, Haikou 570228, Hainan, People’s Republic of China<&wdkj&>Hainan University, Key Laboratory of Engineering Modeling and Statistical Computation of Hainan Province, Haikou 570228, China
通讯机构：
[Haohua Wang] S;School of Mathematics and Statistics, Hainan University, Haikou 570228, Hainan, People’s Republic of China<&wdkj&>Hainan University, Key Laboratory of Engineering Modeling and Statistical Computation of Hainan Province, Haikou 570228, China
关键词：
HBV model;Information intervention;Stochastic analysis;Stationary distribution;Optimal control
摘要：
The stochastic fluctuation of information induces the dynamic behavior and disease control strategy to change in the HBV epidemic model, but how stochastic information dissemination affects them is vague. Here, we consider an HBV epidemic model with stochastic information intervention. Using the Lyapunov function, we demonstrate that the system has a unique global positive solution, in addition, we also derive the threshold dynamics to obtain sufficient conditions that can ensure the extinction and persistence, as well as stationarity of the system. Moreover, we qualify the impact of stochasticity of the information on the optimal control strategy of the HBV, indicating that while information intervention could effectively reduce the disease peak, the fluctuation will attenuate this effect, i.e., the stable information is better than the noisy one. Finally, various stochastic and optimal control simulations are performed to verify the theoretical results and verify that optimal control can accelerate the extinction of the disease.
作者机构：
[Fu, Lichun; Zhen, Deshuai; Yang, Jing; Xiong, Lihao; Luo, Chunhua] Hengyang Market Supervis Inspect & Testing Ctr, Hengyang 421001, Peoples R China.;[Zhen, Deshuai; Xiong, Lihao; Yang, Fei] Univ South China, Sch Publ Hlth, Hengyang 421001, Peoples R China.;[Gao, Linxiao; Zhen, Deshuai; Luo, Xiaohu] Qiannan Normal Univ Nationalities, Engn Res Ctr Loss Efficacy & Anticorros Mat Guizho, Sch Chem & Chem Engn, Duyun 558000, Peoples R China.;[Zhou, Huang] Huaihua Univ, Coll Chem & Mat Engn, Huaihua 418000, Peoples R China.;[Yang, Lixia] Nanchang Hangkong Univ, Key Lab Jiangxi Prov Persistent Pollutants Control, Nanchang 330063, Peoples R China.
通讯机构：
[Gao, LX] Q;[Zhen, DS ] H;Hengyang Market Supervis Inspect & Testing Ctr, Hengyang 421001, Peoples R China.;Univ South China, Sch Publ Hlth, Hengyang 421001, Peoples R China.;Qiannan Normal Univ Nationalities, Engn Res Ctr Loss Efficacy & Anticorros Mat Guizho, Sch Chem & Chem Engn, Duyun 558000, Peoples R China.
关键词：
Yb@TiO2;Perfluorooctane Sulfonate;Tetrabromobisphenol A;Contaminants;SELDI-TOF MS
摘要：
Ytterbium modified TiO2 nanoparticles (Yb@TiO2), synthesized by a sol-gel process, were employed as an efficient adsorbent and matrix for the analysis of Perfluorooctane sulfonate (PFOS) and Tetrabromobisphenol A (TBBPA) via surface-enhanced laser desorption/ionization time-of-flight mass spectrometry (SELDI-TOF MS). The detection limits for PFOS and TBBPA are achievement with 0.01 pg center dot mL-1. The results of the analysis of camellia oil samples show good recovery (80.3%-86.8%) with a low detection limit for TBBPA.
期刊：
SAUDI JOURNAL OF GASTROENTEROLOGY,2024年30(2):108-113 ISSN：1319-3767
作者机构：
[Yin, Bolong; Wen, Xue; Zeng, Wen] Department of Scientific Research and Teaching, Central Hospital of Shaoyang, Shaoyan, China;[Chen, Yong; Luo, Lian] Department of Oncology, Central Hospital of Shaoyang, Shaoyan, China;[Wen, Xue; Luo, Lian; Xiao, Jian] Graduate School, University of South China, China;[Zheng, He; Xiao, Jian] Department of Hepatobiliary Surgery, Central Hospital of Shaoyang, Shaoyan, China;[Tang, Haiyuan] Department of Neurology and Stroke Center, Central Hospital of Shaoyang, Shaoyan, China
摘要：
BACKGROUND: Stricture in patients with Crohn's disease (CD) carries a high risk of CD-related surgery in the course of the disease. The aim of this study was to assess the rate of occurrence of CD-related surgery and to determine baseline risk factors predicting subsequent surgery in this patient group. METHODS: Patients registered with stricturing CD were included. All baseline and follow-up data were collected retrospectively. Patients attended the clinic for follow-up at week 14 to assess their response to infliximab (IFX). CD-related surgery was the observational endpoint. Univariate and multivariate Cox regression analyses were used. RESULTS: A total of 123 patients with stricturing CD were included in this study. The cumulative risk of CD-related surgery for years 1-5 after diagnosis was 18.0%, 26.7%, 32.6%, 40.7%, and 46.4%, respectively. Prior gastrointestinal (GI) surgery, low body mass index (BMI), and high platelet count might be risk factors for future CD-related surgery. With 97 participants treated by IFX, prior GI surgery and primary non-response (PNR) to IFX correlated with future CD-related surgery. CONCLUSION: Prior GI surgery, BMI, and platelet counts were related to future CD-related surgery. Patients who were PNR to IFX had a higher risk of CD-related surgery in the future.
作者机构：
[Ya Guo] Southwest Jiaotong University, 111 Second Ring, North 1st Section, Chengdu, Sichuan, 610031, CHINA;[Hiroaki Nakajima; Wenbin Lin] University of South China, 28 Changsheng West Road, Hengyang, Hunan, 421001, CHINA
摘要：
We study the wave equations with various spins on the background of the general spherically symmetric spacetime. We obtain the unified expression of the Teukolsky-like master equations and the corresponding radial equations with the general spins. We also discuss the gauge dependence in the gravitational-wave equations, which have appeared in the previous studies.
作者机构：
[Yan, Hui; Sun, Tao] Department of Hematology and Oncology Laboratory, The Affiliated Shaoyang Hospital, Hengyang Medical School, University of South China;[Chen, Xiaoyang] Department of Scientific Research and Teaching, The Affiliated Shaoyang Hospital, Hengyang Medical School, University of South China;[Liu, Jun] Department of Scientific Research, The First Affiliated Hospital of Shaoyang University, Shaoyang, Hunan Province, China
摘要：
This study seeks to understand the causal association between serum metabolites and different lung cancer types, an area yet to be extensively studied. We Used a two-sample Mendelian randomization (TSMR) approach, utilizing 486 blood metabolites as exposures and 3 distinct lung cancer types genome-wide association studies datasets as outcomes. We employed inverse variance weighting, MR-Egger, weighted median, simple mode, and weighted mode to estimate causal effects. We performed sensitivity analyses using Cochran Q test, MR-Egger intercept test, and MR-pleiotropy residual sum and outlier (MR-PRESSO). Linkage disequilibrium score (LDSC) analysis was conducted on the selected metabolites, and common confounding single nucleotide polymorphisms were eliminated using the human genotype-phenotype association Database. Metabolic pathway analysis was performed with MetaboAnalyst 5.0 software. Subsequently, a multivariate Mendelian randomization analysis was conducted to ascertain independent risk exposures. Our findings suggest independent risk factors for specific types of lung cancer: 7-methylxanthine and isoleucine for lung adenocarcinoma, cysteine and 1-arachidonoylglycerophosphocholine are identified as independent protective and risk factors for squamous lung cancer. Undecanoate (11:0) with Linoleate (18:2n6) showed a protective effect for small cell lung cancer. Additionally, 11 metabolic pathways were associated with lung cancer. This novel perspective offers a multidimensional understanding of lung cancer phenotypes, providing valuable guidance for identifying and screening of diverse lung cancer phenotypes.
通讯机构：
[Chen, GD; Wu, DC ] U;Univ South China, Affiliated Hosp 1, Hengyang Med Sch, Dept Hepatopancreatobiliary Surg,Lab Struct Immuno, Hengyang 421001, Hunan, Peoples R China.
关键词：
Combination therapy;Therapeutic cancer vaccine;Tumor antigen
摘要：
Therapeutic cancer vaccines have shown promising efficacy in helping immunotherapy for cancer patients, but the systematic characterization of the clinical application and the method for improving efficacy is lacking. Here, we mainly summarize the classification of therapeutic cancer vaccines, including protein vaccines, nucleic acid vaccines, cellular vaccines and anti-idiotypic antibody vaccines, and subdivide the above vaccines according to different types and delivery forms. Additionally, we outline the clinical efficacy and safety of vaccines, as well as the combination strategies of therapeutic cancer vaccines with other therapies. This review will provide a detailed overview and rationale for the future clinical application and development of therapeutic cancer vaccines.
摘要：
The formation of the BCR-ABL fusion gene drives human chronic myeloid leukemia (CML). The last 2 decades have witnessed that specific tyrosine kinase inhibitors (TKIs, e.g., imatinib mesylate, IM) against ABL1 improve disease treatment, although some patients still suffer from relapse and TKI resistance. Therefore, a better understanding of the molecular pathology of CML is still urgently needed. miR-181a-5p (miR-181a) acts as a tumor suppressor in CML; however, the molecular mechanism of miR-181a in CML stem/progenitor cells remains elusive. Herein, we showed that miR-181a inhibited the growth of CML CD34(+) cells, including the quiescent subset, and sensitized them to IM treatment, while miR-181a inhibition by a sponge sequence collaborated with BCR-ABL to enhance the growth of normal CD34(+) cells. Transcriptome data and biochemical analysis revealed that SERPINE1 was a bona fide and critical target of miR-181a, which deepened the understanding of the regulatory mechanism of SERPINE1. Genetic and pharmacological inhibition of SERPINE1 led to apoptosis mainly mediated by caspase-9 activation. The dual inhibition of SERPINE1 and BCR-ABL exhibited a significantly stronger inhibitory effect than a single agent. Taken together, this study demonstrates that a novel miR-181a/SERPINE1 axis modulates CML stem/progenitor cells, which likely provides an important approach to override TKI resistance.
期刊：
Journal of Cleaner Production,2024年448:141538 ISSN：0959-6526
通讯作者：
Qingyi Zeng
作者机构：
[Shuaishuai Guo; Guowen Peng; Qingming Zeng; Lulin Guo; Chao Zhang; Qingyan Zhang; Xijun Fu; Junwen Lv; Qingyi Zeng] School of Resources & Environment and Safety Engineering, University of South China, Hengyang, Hunan, 421001, China
通讯机构：
[Qingyi Zeng] S;School of Resources & Environment and Safety Engineering, University of South China, Hengyang, Hunan, 421001, China
摘要：
Developing efficient, stable, and user-friendly adsorbents for removing uranium from radioactive wastewater is critical for ensuring the security of nuclear energy development. Here, a fixed adsorbent (nZVI@NC/CF), composed of in-situ derived N-doped carbon (NC) encapsulated nano zero-valent iron (nZVI) coated on carbon fiber (CF), was synthesized via carbonizing Prussian blue decorated CF, and used to synergistically adsorb and reduce UO22+ from contaminated water. The optimized nZVI@NC/CF exhibited an extremely high adsorption capacity of 2120.27 mg g−1 with a superior adsorption rate, and about 56.8 % fixed uranium was reduced into insoluble U(IV) species. This outstanding adsorption activity could be ascribed to the strong reducing property of nZVI and the package of NC that effectively prevented the agglomeration of nZVI and facilitated the adsorption and reduction of UO22+ due to the rich adsorption sites and good charge transport property. The nZVI@NC/CF also showed excellent anti-interference properties and regeneration performance that exhibited great potential in treating real uranium wastewater and extracting uranium from seawater. Mechanism study revealed that the fixation of UO22+ was mainly achieved through the synergistical adsorption by NC and reduction by nZVI, complexation by hydroxyl groups, and hydrolytic precipitation by local OH−. This study underscores the potential of nZVI@NC/CF as a highly effective adsorbent material, and provides valuable insights into developing efficient, stable, and easily manageable materials for uranium recovery.
期刊：
Cancer Cell International,2024年24(1):1-21 ISSN：1475-2867
通讯作者：
Tan, Yeru;Li, YH
作者机构：
[Jiang, Baohong] Univ South China, Affiliated Hosp 1, Hengyang Med Sch, Dept Pharm, Hengyang, Hunan, Peoples R China.;[Zeng, Lijun; Tan, Yeru; Li, YH; Li, Yuehua; Tang, Yuanbin; Luo, Lunqi; Ouyang, Lianjie; Feng, Wenjie; Tan, YR; Wu, Sixuan] Univ South China, Affiliated Hosp 1, Hengyang Med Sch, Dept Oncol, Hengyang, Hunan, Peoples R China.;[Wu, Sixuan] Fujian Med Univ, Fujian Canc Hosp, Clin Oncol Sch, Fuzhou, Fujian, Peoples R China.
通讯机构：
[Li, YH ; Tan, YR] U;Univ South China, Affiliated Hosp 1, Hengyang Med Sch, Dept Oncol, Hengyang, Hunan, Peoples R China.
关键词：
Breast cancer;NDUFAF6;NRF2;PD-L1;Immune infiltration;Prognosis
摘要：
Breast cancer is a major global health concern, and there is a continuous search for novel biomarkers to predict its prognosis. The mitochondrial protein NDUFAF6, previously studied in liver cancer, is now being investigated for its role in breast cancer. This study aims to explore the expression and functional significance of NDUFAF6 in breast cancer using various databases and experimental models. We analyzed breast cancer samples from The Cancer Genome Atlas (TCGA), Gene Expression Omnibus (GEO), and Human Protein Atlas (HPA) databases, supplemented with immunohistochemistry (IHC) staining to assess NDUFAF6 expression. A breast cancer cell xenograft mouse model was used to evaluate tumor growth, apoptosis, and NDUFAF6 expression. Survival probabilities were estimated through Kaplan–Meier plots and Cox regression analysis. A Protein–Protein Interaction (PPI) network was constructed, and differentially expressed genes related to NDUFAF6 were analyzed using GO, KEGG, and GSEA. The relationship between NDUFAF6 expression, immune checkpoints, and immune infiltration was also evaluated. NDUFAF6 was found to be overexpressed in breast cancer patients and in the xenograft mouse model. Its expression correlated with worse clinical features and prognosis. NDUFAF6 expression was an independent predictor of breast cancer outcomes in both univariate and multivariate analyses. Functionally, NDUFAF6 is implicated in several immune-related pathways. Crucially, NDUFAF6 expression correlated with various immune infiltrating cells and checkpoints, particularly promoting PD-L1 expression by inhibiting the NRF2 signaling pathway. The study establishes NDUFAF6 as a potential prognostic biomarker in breast cancer. Its mechanism of action, involving the inhibition of NRF2 to upregulate PD-L1, highlights its significance in the disease's progression and potential as a target for immunotherapy.
摘要：
Halloysite nanotubes (HNTs) are nanomaterials (NMs) derived from natural clays and have been considered as biocompatible NMs for biomedical uses. However, the cardiovascular toxicity of HNTs has not been thoroughly investigated. In this study, we compared the cardiotoxicity of HNTs and multi-walled carbon nanotubes (MWCNTs), focusing on the changes in Kruppel-like factor (KLF)-mediated signaling pathways. Mice were intravenously injected with 50µg NMs, once a day, for 5 days, and then mouse hearts were removed for experiments. While HNTs or MWCNTs did not induce obvious pathological changes, RNA-sequencing data suggested the alterations of KLF gene expression. We further confirmed an increase of Klf15 positive cells, accompanied by changes in Klf15-related gene ontology (GO) terms. We noticed that most of the changed GO terms are related with the regulation of gene expression, and we confirmed that the NMs increased myoneurin (Mynn) but decreased snail family transcriptional repressor 1 (Snai1), two transcription factors (TFs) related with Klf15. Besides, the changed GO terms also include metal ion binding and positive regulation of glucose import, and we verified an increase of phosphoenolpyruvate carboxykinase 1 (Pck1) and insulin receptor (Insr). However, HNTs and MWCNTs only showed minimal impact on cell death signaling pathways, and no increase in apoptotic sites was observed after NM treatment. We concluded that intravenous administration of HNTs and MWCNTs activated a protective TF, namely Klf15 in mouse aortas, to alter gene expression and signaling pathways related with metal ion binding and glucose import.
