作者机构：
[李洁; 王小宜] Department of Radiology, Xiangya Hospital of Central South University, Changsha 410008, China;[倪军] Institute of Cancer Research, Nanhua University, Hengyang 421001, China
通讯机构：
[Wang, X.-Y.] D;Department of Radiology, Xiangya Hospital of Central South University, China
作者机构：
[LI Jianwei; CHEN Jionghao; ZHANG Yuanzhi; JIN Dan; PEI Guoxian] Department of Orthopaedics and Traumatology, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China;[LI Yanbing] Department of Anatomy, University of South China, Hengyang 421001, China;[ZHONG Shizhen] Institute of Anatomy, Southern Medical University, Guangzhou 510515, China
通讯机构：
[Guoxian Pei] D;Department of Orthopaedics and Traumatology, Nanfang Hospital, Southern Medical University, Guangzhou, China
关键词：
Digital technique;Imaging;Latissimus dorsi myocutaneous;Three-dimensional;Virtual Chinese Human
摘要：
Developments of digital technology and three-dimensional (3D) reconstruction allowed a precise description of anatomic structures. With the introduction of Visible Human Project and Virtual Chinese Human (VCH) techniques, more detailed anatomic images could be obtained. Digitized visible models of these structures can be applied as a useful tool in clinical training. The aim of this study was to reconstruct the normal structures of thoracodorsal artery in 3D images and to establish the digitized visible models of latissimus dorsi myocutaneous (LDM) flap. The cross-sectional images from the four VCH datasets were reviewed to study LDM and thoracodorsal artery structures on a section-by-section basis. Next, two adult fresh cadaver specimens were perfused with lead oxide-gelatine mixture and subject to radiographic CT scanning on their torsos. The cross-sectional images from the CT images were reviewed to study thoracodorsal artery structures. Three-dimensional computerized reconstructions of LDM flap structures were conducted from these datasets by using Amira 3.1 (TGS) software respectively. The 3D reconstructed visible models established from these datasets perfectly displayed the anatomic characteristics of LDM flap.
摘要：
Inflammation, closely associated with obesity, is emerging as an important risk factor for the pathophysiological development of atherosclerosis and diabetes mellitus. Fat balance is critical in the aetiology of obesity. Lipoprotein lipase is an important enzyme in lipid metabolism. The aim of this study was to investigate the long-term effect of the lipoprotein lipase activator, NO-1886, on inflammation cytokines, adiposity and related diseases in miniature pigs fed a high-fat/high-sucrose/high-cholesterol diet (HFSC diet). Chinese Bama-miniature pigs were fed a control diet or HFSC diet with or without NO-1886 for 5 months. The levels of inflammation-associated cytokines were determined using the antibody arrays. Feeding of the HFSC diet to miniature pigs markedly increased the expression of inflammatory cytokines. On the other hand, supplementation of NO-1886 to HFSC diet decreased the expression of inflammatory cytokines significantly, protecting against the development of atherosclerosis and diabetes mellitus. NO-1886 may have a beneficial effect on the most inflammation-associated cytokines, and this effect may contribute to improving atherosclerosis and diabetes mellitus.
