期刊论文

中文

中国生化药物杂志

1005-1678

2008

29

5

299-301

湖南省科技厅基金项目（2007KJ022）

本校为第一机构

目的观察甲壳低聚糖-硒（COS—Se）对2型糖尿病大鼠的降糖降脂作用及胰岛素含量的影响。方法制备2型糖尿病大鼠模型，分别给予COS—Se、Se、COS对其进行干预，观察20W，期间检测血糖、总胆固醇及胰岛素的含量。结果COS—Se、Se、COS均能降低模型鼠的血糖，但COS—Se效果显著（P〈0．05或P〈0．01）；COS—Se、COS对降低模型鼠血清总胆固醇水平部具有较好的效果（P〈0．05或P〈0．01），但两者没有显著差异（P〉0．05），而se未见明显作用；COS—Se、Se、COS对糖尿病模型的高胰岛素血症都有一定改善作用，随着时间的延长，COS—Se的改善作用更明显。结论COS—Se可降低2型糖尿病大鼠的血糖和血脂含...

Purpose To investigate the effect of COS-Se on plasma glucose, lipid levels and insulin levels in rats with type 2 diabetes. Methods After the rat model of type 2 diabetes was established by a single injection of low dose streptozotocin after high fatty diet, the animals were divided into control group, COS-Se group, Se group and COS group. Other 10 rats were employed as normal control group. The levels of blood glucose, total cholesterol and insulin in the serum were determined. Results COS-Se group was compared with the Se group and COS group...