期刊论文

中文

中国比较医学杂志

1671-7856

2009

19

2

1-3,封2

10.3969/j.issn.1671-7856.2009.02.001

湖南省自然科学基金（06JJ30016） 衡阳市科技局研究项目（2007KJ022）.

本校为第一机构

目的 观察甲壳低聚糖-硒 (COS-Se) 对高血糖大鼠血清抗氧化酶活力及大鼠胰岛细胞的保护作用.方法 制备高血糖大鼠模型,分别给予甲壳低聚糖-硒、硒、甲壳低聚糖对其进行干预,定期检测超氧化物歧化酶、谷胱甘肽过氧化物酶的活力;第20周末取胰腺组织进行切片形态学观察.结果 在提高糖尿病模型大鼠SOD活力方面, COS-Se与对照组比较,具有较明显的作用(P0.05);在改善糖尿病模型大鼠GSH-Px活力方面,COS-Se与对照组比较,差异有显著性(P0.05). 结论 COS-Se 对2型糖尿病大鼠的胰岛细胞具有保护作用,同时还能够改善血清抗氧化酶的活力.

Objective To investigate the effect of chitooligosaccharide-selenium （COS-Se） treatment on serum antioxidase activity and pancreatic islets in hyperglycemic rats. Methods Ten normal Wistar rats were included in the normal control group. Hyperglycemic rat model was established by both high-fat diet and following a single injection of low-dose streptozotocin. 80 hyperglycemic rats were randomized into four groups covering control, COS-Se, Se and COS groups. The serum antioxidase activity was determined at different time intervals. After 20 week...