期刊：
JOURNAL OF CLINICAL INVESTIGATION,2021年131(10) ISSN：0021-9738
通讯作者：
Liang, W.;He, J.;Fan, J.-B.
作者机构：
[Chen, Hanzhang; Wang, Jiaxuan; Yin, Weiqiang; Mo, Lili; Liu, Jun; Li, Caichen; He, Jianxing; Liang, Wenhua] Guangzhou Med Univ, Affiliated Hosp 1, China Natl Ctr Resp Med, China State Key Lab Resp Dis,Dept Thorac Surg & O, Guangzhou, Peoples R China.;[Chen, Hanzhang; Wang, Jiaxuan; Yin, Weiqiang; Mo, Lili; Liu, Jun; Li, Caichen; He, Jianxing; Liang, Wenhua] Natl Clin Res Ctr Resp Dis, Guangzhou, Peoples R China.;[Chen, Zhiwei; Tu, Xixiang; Zhao, Dezhi; Li, Hui; Fan, Jian-Bing; Tao, Jinsheng; Jiang, Zeyu] AnchorDx Med Co, Guangzhou, Peoples R China.;[Chen, Zhiwei; Liu, Xin] AnchorDx Inc, Fremont, CA USA.;[Cheng, Chao] Sun Yat Sen Univ, Affiliated Hosp 1, Dept Thorac Surg, Guangzhou, Peoples R China.
通讯机构：
[Fan, J.-B.; Liang, W.; He, J.] D;Department of Pathology, 1838 ShaTai Road, China;Department of Thoracic Surgery and Oncology, 151 Yanjiang Road, China
摘要：
PURPOSE: This study was undertaken to elucidate the clinical significance of widening of the popliteal hiatus on magnetic resonance imaging (MRI), and to document the clinical results and technical aspects of arthroscopic repair of this finding. METHODS: Included are 82 knees after arthroscopic surgery, divided according to arthroscopic diagnosis into group A, hypermobility of lateral meniscus, 8 knees; group B, tear of the anterior horn of the lateral meniscus, 32 knees; and group C, no abnormality of the lateral meniscus, 36 knees with medial meniscal tears and 6 with other conditions. Popliteal hiatus diameter was measured and the popliteal hiatus/lateral tibial plateau (LTP) ratio was calculated on preoperative sagittal and coronal MRI. At arthroscopy, the widened popliteal hiatus in group A was tightened anteriorly by outside-in or all-inside suture and posteriorly with all-inside suture. Outcomes were evaluated with MRI, Lysholm, Tegner and VAS scores. RESULTS: The preoperative diameter of the popliteal hiatus and the popliteal hiatus/LTP ratio were significantly larger in group A than in groups B and C (p < 0.05) on both views. Threshold popliteal hiatus/LTP values of 0.16 and 0.18 on the sagittal and coronal views demonstrated diagnostic discrimination, and these values were significantly reduced after arthroscopy in Group A. Lysholm and Tegner scores were improved after tightening of the popliteal hiatus, while VAS scores reduced (all p < 0.05). CONCLUSION: Widening of the popliteal hiatus on MRI may lead to recurrent subluxation of the lateral meniscus. Arthroscopic anterior and posterior tightening of the popliteal hiatus was a safe and effective treatment. LEVEL OF EVIDENCE: II.
摘要：
Rheumatoid arthritis (RA) is an autoimmune inflammatory disease comparing the inflammation of synovium. Macrophage-like synoviocytes and fibroblast-like synoviocytes (synoviocytes) are crucial ingredients of synovium. Therein, a lot of research has focused on synoviocytes. Researches demonstrated that TLR1, TLR2, TLR3, TLR4, TLR5, TLR6 TLR7 and TLR9 are expressed in synoviocyte. Additionally, the expression of TLR2, TLR3, TLR4 and TLR5 is increased in RA synoviocyte. In this paper, we review the exact role of TLR2, TLR3, TLR4 and TLR5 participate in regulating the production of inflammatory factors in RA synoviocyte. Furthermore, we discuss the role of vasoactive intestinal peptide (VIP), MicroRNA, Monome of Chinese herb and other cells (Monocyte and T cell) influence the function of synoviocyte by regulating TLRs. The activation of toll-like receptors (TLRs) in synoviocyte leads to the aggravation of arthritis, comparing with angiogenesis and bone destruction. Above all, TLRs are promising targets for managing RA.
作者：
Cui, Juncheng;Dean, Dylan;Hornicek, Francis J.;Chen, Zhiwei*;Duan, Zhenfeng*
期刊：
JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH,2020年39(1):1-11 ISSN：1756-9966
通讯作者：
Chen, Zhiwei;Duan, Zhenfeng
作者机构：
[Chen, Zhiwei; Cui, Juncheng] Univ South China, Affiliated Hosp 1, Dept Orthoped Surg, 69 Chuanshan Rd, Hengyang 421001, Hunan, Peoples R China.;[Hornicek, Francis J.; Duan, Zhenfeng; Dean, Dylan; Cui, Juncheng] Univ Calif Los Angeles, David Geffen Sch Med, Dept Orthoped Surg, Sarcoma Biol Lab, 615 Charles E Young Dr South, Los Angeles, CA 90095 USA.
通讯机构：
[Chen, Zhiwei; Duan, Zhenfeng] U;Univ South China, Affiliated Hosp 1, Dept Orthoped Surg, 69 Chuanshan Rd, Hengyang 421001, Hunan, Peoples R China.;Univ Calif Los Angeles, David Geffen Sch Med, Dept Orthoped Surg, Sarcoma Biol Lab, 615 Charles E Young Dr South, Los Angeles, CA 90095 USA.
摘要：
Osteosarcoma (OS) is the most common primary bone malignancy and responsible for considerable morbidity and mortality due to its high rates of pulmonary metastasis. Although neoadjuvant chemotherapy has improved 5-year survival rates for patients with localized OS from 20% to over 65%, outcomes for those with metastasis remain dismal. In addition, therapeutic regimens have not significantly improved patient outcomes over the past four decades, and metastases remains a primary cause of death and obstacle in curative therapy. These limitations in care have given rise to numerous works focused on mechanisms and novel targets of OS pathogenesis, including tumor niche factors. OS is notable for its hallmark production of rich extracellular matrix (ECM) of osteoid that goes beyond simple physiological growth support. The aberrant signaling and structural components of the ECM are rich promoters of OS development, and very recent works have shown the specific pathogenic phenotypes induced by these macromolecules. Here we summarize the current developments outlining how the ECM contributes to OS progression and metastasis with supporting mechanisms. We also illustrate the potential of tumorigenic ECM elements as prognostic biomarkers and therapeutic targets in the evolving clinical management of OS.
作者机构：
[李春; 黎宇; 陈志伟; 黄煊怀] Department of Bone Joint Surgery, the First Affiliated Hospital of University of South China, Hengyang 421001, Hunan, China;[黄煊怀] 5007843@qq.com
摘要：
Expression of transforming growth factor-beta 1 (TGF-beta 1) and vascular endothelial growth factor (VEGF) in patients with Achilles tendon rupture, and the predictive values and significance in clinical efficacy were explored. Forty-two patients with Achilles tendon rupture, surgically treated in the First Affiliated Hospital of University of South China, were selected and the clinical efficacy was evaluated based on the American Orthopaedic Foot and Ankle Society (AOFAS) scoring system. RT-qPCR was adopted to detect the expression of serum TGF-beta 1 and VEGF in the patients before and after treatment, and Spearman's correlation was used to analyze the correlation of TGF-beta 1 and VEGF with the clinical efficacy after treatment. Patients were divided into an excellent efficacy group and a good/general efficacy group according to the predictive efficacy. In the two groups, the expression levels of TGF-beta 1 and VEGF before treatment were observed, and the predictive values of TGF-beta 1 and VEGF in clinical efficacy using the receiver operating characteristic (ROC) curves were obtained. The 42 patients showed significantly higher expression of TGF-beta 1 and VEGF at 3 months after treatment, and significantly decreased expression at 6 months after treatment, compared to the results before treatment (both P<0.001). After treatment, the efficacy was excellent in 11 patients, good in 25 and general in 6. Spearman's correlation analysis revealed that the expression of TGF-beta 1 and VEGF decreased with the improvement of efficacy after treatment (P<0.001), and the excellent efficacy group showed significantly lower expression of TGF-beta 1 and VEGF than that in the good/general efficacy group (P<0.01). Moreover, according to ROC curves, the areas under the curves (AUCs) of TGF-beta 1 and VEGF were 0.651 and 0.645, respectively. In conclusion, TGF-beta 1 and VEGF can be considered as observational indexes and predictors for clinical efficacy in patients with Achilles tendon rupture, before and after treatment.
作者机构：
[戴祝] Department of Orthopaedics, the First Affiliated Hospital of University of South China, Hengyang Hunan, 421001, P.R.China.oliverdai@hotmail.com;[陈志伟; 符得红; 雷运亮; 廖瑛; 黎洲] Department of Orthopaedics, the First Affiliated Hospital of University of South China, Hengyang Hunan, 421001, P.R.China
作者机构：
[Liu, Hai] Third Department of Cardiac Surgery, First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, Henan, China;[Fu, Li] Institute of Clinical Medicine, Department of Endocrinology, The Central Hospital of Loudi Affiliated to the University of South China, Loudi 417000, China;[Chen, Zhiwei; Sun, Xiangke; Peng, Wei] Department of Cardiology, The Central Hospital of Loudi Affiliated to the University of South China, Loudi 417000, China;[Li, Yiliang] Department of Neurology, The Third Xiangya Hospital, Central South University, Changsha, Hunan 410013, China;[Li, Yiliang] Postdoctoral Research Workstation of Neurology, Clinical Medicine, The Third Xiangya Hospital, Central South University, Changsha 410013, China
通讯机构：
Third Department of Cardiac Surgery, First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, China
通讯机构：
[Chen, Zhiwei] U;Univ South China, Dept Orthopaed, Affiliated Hosp 1, 69 Chuanshan Rd, Hengyang 421001, Hunan, Peoples R China.
关键词：
Arthroscopy;External snapping hip;Gluteal muscle contracture;Open surgery
摘要：
PURPOSE: To compare the outcomes of contracture release by arthroscopic versus open surgical approach in patients with external snapping hip (ESH) caused by gluteal muscle contracture (GMC). METHODS: Medical records of patients with ESH due to GMC who underwent open surgery (n = 44) or arthroscopic surgery (n = 48) between October 2008 and October 2014 were reviewed. Patients were followed up at 1, 3, 12, and 24 months postoperatively. Operation time, incision length, postoperative pain, postoperative complication rate, and recurrence rate were compared between the 2 groups. Hip adduction, and Harris Hip Scores (HHS) at 1 and 2 years postoperatively were compared between the groups and with preoperative data. RESULTS: Mean operation time did not differ between the 2 groups (p>0.05). The arthroscopic surgery group had smaller incisions (p<0.05), less postoperative pain (p<0.05), lower complication rates (p<0.05) than did the open surgery group. The recurrence rates were similar for the 2 groups (p>0.05). Hip adduction, and HHS 1 year and 2 years postoperatively were significantly better postoperatively than they had been preoperatively for both groups (all p<0.01), and were similar for the 2 groups (all p>0.05). CONCLUSIONS: Arthroscopic release of contracture tissue is a safe and effective approach for the treatment of ESH caused by GMC, with the advantages of small scars, less postoperative pain, fewer complications compared with open surgery.
