作者机构：
[Dr. Yi Yuan; Dr. Yi Yuan Dr. Yi Yuan Dr. Yi Yuan] School of Chemistry and Chemical Engineering, University of South China, Hengyang, 421001 P. R. China;[Jiu-Dong Lin; Jiu-Dong Lin Jiu-Dong Lin Jiu-Dong Lin] WISPO Advanced Materials (Suzhou) Co., Ltd., No. Building 12, 200 Xingpu Rd, SIP, Suzhou, P. R. China;[Chen Cao; Ji-Hua Tan; Dr. Ze-Lin Zhu; Hong-Ji Tan; Huan Chen; Dr. Man-Kit Tse; Dr. Wen-Cheng Chen; Prof. Chun-Sing Lee; Chen Cao Chen Cao Chen Cao; Ji-Hua Tan Ji-Hua Tan Ji-Hua Tan; Dr. Ze-Lin Zhu Dr. Ze-Lin Zhu Dr. Ze-Lin Zhu; Hong-Ji Tan Hong-Ji Tan Hong-Ji Tan; Huan Chen Huan Chen Huan Chen; Dr. Man-Kit Tse Dr. Man-Kit Tse Dr. Man-Kit Tse; Dr. Wen-Cheng Chen Dr. Wen-Cheng Chen Dr. Wen-Cheng Chen; Prof. Chun-Sing Lee Prof. Chun-Sing Lee Prof. Chun-Sing Lee] Center of Super-Diamond and Advanced Films (COSDAF) and Department of Chemistry, City University of Hong Kong, Hong Kong SAR, 999077 P. R. China
通讯机构：
[Dr. Yi Yuan; Dr. Yi Yuan Dr. Yi Yuan Dr. Yi Yuan] S;[Prof. Chun-Sing Lee; Prof. Chun-Sing Lee Prof. Chun-Sing Lee Prof. Chun-Sing Lee] C;School of Chemistry and Chemical Engineering, University of South China, Hengyang, 421001 P. R. China<&wdkj&>Center of Super-Diamond and Advanced Films (COSDAF) and Department of Chemistry, City University of Hong Kong, Hong Kong SAR, 999077 P. R. China
摘要：
Glue! A green and practical one‐pot method for the electrochemical three‐component synthesis of tetrahydroimidazo[1,5‐a]quinoxalin‐4(5H)‐ones using cheap and environmentally benign paraformaldehyde as a C1 synthon, was developed. In this strategy, EtOH played dual roles (eco‐friendly solvent and waste‐free pre‐catalyst) and the in situ generated ethoxide promoted triple sequential deprotonations. Abstract A green and practical method for the electrochemical synthesis of tetrahydroimidazo[1,5‐a]quinoxalin‐4(5H)‐ones through the three‐component reaction of quinoxalin‐2(1H)‐ones, N‐arylglycines and paraformaldehyde was reported. In this strategy, EtOH played dual roles (eco‐friendly solvent and waste‐free pre‐catalyst) and the in situ generated ethoxide promoted triple sequential deprotonations.
通讯机构：
[Xie, ZJ ] S;[Tareen, AK ] D;Dongguan Univ Technol, Sch Mech Engn, Dongguan 523808, Peoples R China.;Southern Univ Sci & Technol, Shenzhen Childrens Hosp, Clin Med Coll, Shenzhen 518038, Guangdong, Peoples R China.
摘要：
Sensors are regarded as a fundamental vector for sustainable development of future advanced civilization. To satisfy the demands of future generations, fabrication of advanced sensor systems integrated with artificial intelligence (AI), fifth generation (5G) connectivity, machine learning (ML), and internet of things (IoTs) is growing very fast. Incorporation of two-dimensional (2D) nanomaterials (NMs) with IoTs/5G/AI/ML technologies has transformed wide range of sensor applications in healthcare, wearable electronics for, safety, environment, military, space, and agriculture sectors. Finally, to operate those sensors we need powerful energy storage devices (ESDs) and hence advance 2D NMs. Since the discovery of MXenes NMs in 2011, and 2D boron nanosheets (NSs) (borophene) on Ag substrates (2015) their research has been accelerated in the domains of advanced nanotechnological world. Borophene and MXenes NMs have came out as an outstanding 2D NMs to construct next generation novel sensors and ESDs due to their novel physicochemical properties and surface functions. By lowering costs, requiring fewer resources (including labor), and minimizing contamination, ML/AI based theoretical simulation has effectively directed the study and manufacturing of improved 2D NMs based sensors/ESDs applications on large scale industrial level. Modern 2D NMs based flexible sensors and ESDs can fundamentally alter the traditional sensing/ESDs technologies since they are adaptable, wearable, intelligent, portable, biocompatible, energy-efficient, self-sustaining, point-of-care, affordable etc. this review summarized the MXenes and borophene NMs synthesis with corresponding achievements, and there advancement, limitations, and challenges in sensors/ESDs technological applications.
作者机构：
[Hu, Xiaobo; Luo, Yongjia] Department of Biochemistry and Molecular Biology, School of Basic Medicine, Hengyang Medical School, University of South China, Hengyang 421001, China;[Zhao, Zhenwang] Department of Pathology and Pathophysiology, School of Basic Medicine, Health Science Center, Hubei University of Arts and Science, Xiangyang 441053, China
期刊：
NEW JOURNAL OF CHEMISTRY,2023年47(30):14242-14248 ISSN：1144-0546
通讯作者：
Sen Liao<&wdkj&>Guoping Wang
作者机构：
[Liao, Sen; Zhang, Lilei; Li, Shiyu; Yue, Siyao; Wang, Guoping] School of Chemistry and Chemical Engineering, University of South China, Hengyang Hunan Province 421001, P. R. China
通讯机构：
[Sen Liao; Guoping Wang] S;School of Chemistry and Chemical Engineering, University of South China, Hengyang Hunan Province 421001, P. R. China
摘要：
Si-CQDs with uniform particle size and good water solubility were synthesised using low-cost citric acid (CA) and aminopropyltriethoxysilane (APTEOS) as precursors. Si-CQDs were used as a novel fluorescent probe for sensitive and selective detection of mercury ions (Hg2+) by fluorescence quenching. Following the optimisation of the experimental conditions, the fluorescence intensity of Si-CQDs was found to be linearly dependent on the Hg2+ concentration ranging from 0.02 to 5.0 μM with the limit of detection as low as 0.015 μM. A fluorescence resonance energy transfer (FRET) effect between Si-CQDs and Rhodamine B (RhB) was also observed, and it was found that Si-CQDs can be used as fluorescence donors and RhB as fluorescence receptors. On this basis, a ratiometric fluorescent probe (Si-CQDs/RhB) was constructed for Hg2+ detection. When the Hg2+ concentration was 1.0–80.0 μM, the fluorescence intensity ratio (I540nm/I440nm) of Si-CQDs/RhB exhibited a good linear relationship with Hg2+ concentration and the detection limit was 0.6 μM. A wide range of Hg2+ detection was ultimately achieved in real samples.
摘要：
The conversion of superoxide radical (& BULL;O2 ) to hydrogen peroxide (H2O2) is critical in the photocatalytic for-mation of H2O2 via the sequential two-step single-electron oxygen reduction mechanism. Providing a high concentration of & BULL;O2  is an effective approach to promoting this process in terms of chemical kinetics. It is, however, extremely challenging to implement this idea in the photocatalytic solution due to the limited lifespan of & BULL;O2 . To this end, a concept about local & BULL;O2  enrichment catalyst surface was proposed in this study and achieved in an innovative PSI/C3N4 photocatalyst. The results of theoretical calculations and temperature-dependent photocatalytic studies indicate that PSI on the C3N4 surface can serve as a diffusion buffer for & BULL;O2 , capturing them through Van der Waals interactions and separating them by energy perturbations. As a result, a local enrichment of & BULL;O2  was established on the PSI/C3N4 surface during photocatalysis, strengthening the photocatalytic conversion of & BULL;O2  to H2O2, thus allowing the PSI/C3N4-4 photocatalyst to produce H2O2 at a rate of approximately 2.4 and 2.65 times greater than pure C3N4 under visible light and LED irradiation, respectively. This study presents a promising strategy for enhancing photocatalytic H2O2 production efficiency by selectively enriching & BULL;O2  on the catalyst surface.
期刊：
Chemical Communications,2023年59(19):2743-2746 ISSN：1359-7345
通讯作者：
Hu, Rong(hurong@usc.edu.cn);Qin, Anjun(msqinaj@scut.edu.cn);Tang, Ben Zhong(tangbenz@cuhk.edu.cn)
作者机构：
[Zhang, Guiquan; Qin, Anjun; Han, Pengbo; Hu, Rong; Yang, Xinzhe; Wang, Zhiming] South China Univ Technol, Guangdong Prov Key Lab Luminescence Mol Aggregates, State Key Lab Luminescent Mat & Devices, Guangzhou 510640, Peoples R China.;[Zhang, Guiquan; Qin, Anjun; Han, Pengbo; Hu, Rong; Yang, Xinzhe; Wang, Zhiming; Tang, Ben Zhong] South China Univ Technol, AIE Inst, Ctr Aggregat Induced Emiss, Guangzhou 510640, Peoples R China.;[Tang, Ben Zhong] Chinese Univ Hong Kong, Shenzhen Inst Aggregate Sci & Technol, Sch Sci & Engn, Shenzhen 518172, Guangdong, Peoples R China.;[Tang, Ben Zhong] Hong Kong Univ Sci & Technol, Chinese Natl Engn Res Ctr Tissue Restorat & Recons, Hong Kong Branch, Clear Water Bay, Hong Kong, Peoples R China.;[Hu, Rong] Univ South China, Sch Chem & Chem Engn, Hengyang 421001, Peoples R China.
通讯机构：
[Rong Hu; Anjun Qin] S;[Ben Zhong Tang] C;State Key Laboratory of Luminescent Materials and Devices, Guangdong Provincial Key Laboratory of Luminescence from Molecular Aggregates, South China University of Technology, Guangzhou, China<&wdkj&>Center for Aggregation-Induced Emission, AIE Institute, South China University of Technology, Guangzhou, China<&wdkj&>Center for Aggregation-Induced Emission, AIE Institute, South China University of Technology, Guangzhou, China<&wdkj&>School of Science and Engineering, Shenzhen Institute of Aggregate Science and Technology, The Chinese University of Hong Kong, Shenzhen, Guangdong, China<&wdkj&>Hong Kong Branch of Chinese National Engineering Research Centre for Tissue Restoration and Reconstruction, The Hong Kong University of Science & Technology, Clear Water Bay, Kowloon, Hong Kong, China<&wdkj&>State Key Laboratory of Luminescent Materials and Devices, Guangdong Provincial Key Laboratory of Luminescence from Molecular Aggregates, South China University of Technology, Guangzhou, China<&wdkj&>Center for Aggregation-Induced Emission, AIE Institute, South China University of Technology, Guangzhou, China<&wdkj&>School of Chemistry and Chemical Engineering, University of South China, Hengyang, China
摘要：
A near-infrared (NIR) luminogen TST was designed and used to efficiently trigger HSP90α protein knockdown through photo-thermal conversion based on a gene interference strategy, by which in vitro and in vivo tumor ablation were significantly acquired at low-temperature.
通讯机构：
[Xilin Xiao] S;School of Chemistry and Chemical Engineering, School of Resource & Environment and Safety Engineering, School of Public Health, Hunan Key Laboratory for the Design and Application of Actinide Complexes, University of South China, Hengyang, Hunan 421001, P. R. China<&wdkj&>State Key Laboratory of Chemo/Biosensing and Chemometrics, Hunan University, Changsha, Hunan 410082, P. R. China
摘要：
A convenient and portable smartphone-assisted method for the colorimetric detection of uranyl ions (UO22+) in aqueous solutions is proposed using rifampicin and 2-(5-bromo-2-pyridylazo)-5-diethylaminophenol (Br-PADAP) as chromogenic agents. The addition of UO22+ would cause reaction with chromogenic agents to form complexes, changing the colour from orange to dark red in the rifampicin system and from yellow to light pink in the Br-PADAP system. To achieve the on-site estimation of the trace UO22+ concentration range, digital images of colour changes captured by the smartphone under fixed lighting conditions were imported into the built-in application named "Detect" to obtain HSV (hue, saturation, and value) and HSL (hue, saturation, lightness) information, which could be associated with the concentration of uranyl ions. For more precise laboratory-level detection, ultraviolet-visible (UV-vis) spectroscopy was employed as well. The absorbance of the rifampicin system exhibited strong linearity with the UO22+ concentration in the range from 4 to 50 mu M at 375 nm with a method detection limit (MDL) of 3.17 mu M by the UV-vis-based method, while that of Br-PADAP system had a linear relationship with the concentration from 0.9 to 7 mu M at 562 nm with an MDL of 0.89 mu M. The two strategies may be combined to detect UO22+ across a larger concentration range, and this method has been successfully used to analyze real samples including soil around uranium mines.
通讯机构：
[Li, CQ ] U;[Guo, MZ ] B;Univ South China, Natl Hlth Commiss, Key Lab Birth Defect Res & Prevent, Hengyang 421001, Hunan, Peoples R China.;Univ South China, Sch Comp, Hengyang 421001, Hunan, Peoples R China.;Beijing Univ Civil Engn & Architecture, Sch Elect & Informat Engn, Beijing 100044, Peoples R China.
摘要：
Transcription factors (TFs), transcription co-factors (TcoFs) and their target genes perform essential functions in diseases and biological processes. KnockTF 2.0 (http:////www.licpathway.net//KnockTF//index.html) aims to provide comprehensive gene expression profile datasets before//after T(co)F knockdown//knockout across multiple tissue//cell types of different species. Compared with KnockTF 1.0, KnockTF 2.0 has the following improvements: (i) Newly added T(co)F knockdown//knockout datasets in mice, Arabidopsis thaliana and Zea mays and also an expanded scale of datasets in humans. Currently, KnockTF 2.0 stores 1468 manually curated RNA-seq and microarray datasets associated with 612 TFs and 172 TcoFs disrupted by different knockdown//knockout techniques, which are 2.5 times larger than those of KnockTF 1.0. (ii) Newly added (epi)genetic annotations for T(co)F target genes in humans and mice, such as super-enhancers, common SNPs, methylation sites and chromatin interactions. (iii) Newly embedded and updated search and analysis tools, including T(co)F Enrichment (GSEA), Pathway Downstream Analysis and Search by Target Gene (BLAST). KnockTF 2.0 is a comprehensive update of KnockTF 1.0, which provides more T(co)F knockdown//knockout datasets and (epi)genetic annotations across multiple species than KnockTF 1.0. KnockTF 2.0 facilitates not only the identification of functional T(co)Fs and target genes but also the investigation of their roles in the physiological and pathological processes. Graphical Abstract
期刊：
Journal of Materials Chemistry A,2023年11(8):3771-3788 ISSN：2050-7488
通讯作者：
Han Zhang<&wdkj&>Ye Zhang
作者机构：
[Zhang, Ye; Jin, Linghua] Univ South China, Sch Chem & Chem Engn, Hengyang 421001, Peoples R China.;[Zhang, Han; Hao, Yabin] Shenzhen Univ, Inst Microscale Optoelect, Int Collaborat Lab 2D Mat Optoelect Sci & Technol, Minist Educ, Shenzhen 518060, Peoples R China.;[Khan, Karim; Tareen, Ayesha Khan] Dongguan Univ Technol, Sch Mech Engn, Dongguan 523808, Peoples R China.;[Al-Hartomy, Omar A.; Wageh, Swelm] King Abdulaziz Univ, Fac Sci, Dept Phys, Jeddah 21589, Saudi Arabia.;[Al-Sehemi, Abdullah G.] King Khalid Univ, Coll Sci, Res Ctr Adv Mat Sci RCAMS, Dept Chem, POB 9004, Abha 61413, Saudi Arabia.
通讯机构：
[Han Zhang] I;[Ye Zhang] S;School of Chemistry and Chemical Engineering, University of South China, Hengyang 421001, China<&wdkj&>International Collaborative Laboratory of 2D Materials for Optoelectronics Science and Technology of Ministry of Education, Institute of Microscale Optoelectronics, Shenzhen University, Shenzhen 518060, China
摘要：
As the heaviest chalcogen atom, tellurium (Te) is endowed with a high Seebeck coefficient and low lattice thermal conductivity, which are the key factors that contribute to a high ZT value in thermoelectricity. The most studied thermoelectric element is Te, and it was theoretically and experimentally studied to be an ideal thermoelectric element. However, the instability and mechanical endurance of Te thermoelectric modules cannot be guaranteed, especially in flexible electronic devices. A focused Te/polymer strategy was recently developed and implemented to address these problems, so combining nanostructured Te with flexible polymers can be an efficient way to construct stable, efficient and flexible thermoelectric generators. In this review, the use of nanostructured Te for thermoelectricity is summarized in brief, and then the preparation methods of Te/polymers are reviewed. Subsequently, the thermoelectric properties and applications of Te/polymers are highlighted, followed by detailed polymer types, including PEDOT:PSS, PANI, P3HT and PPy. Finally, based on current progress and achieved results, the prospects and future directions of Te/polymers are highlighted and discussed.
期刊：
International Journal of Biological Macromolecules,2023年238:124074 ISSN：0141-8130
通讯作者：
Hongqiang Wang
作者机构：
[Wang, Hongqiang; Wang, Qingliang; Gan, Jiali; Xin, Qi; Hu, Eming; Lei, Zhiwu] Univ South China, Sch Resource & Environm & Safety Engn, Hengyang 421001, Peoples R China.;[Zhang, Lieyu] Chinese Res Inst Environm Sci, State Key Lab Environm Criteria & Risk Assessment, Beijing 100012, Peoples R China.;[Xiong, Ying] Beijing Water Sci & Technol Inst, Beijing 100048, Peoples R China.;[Wang, Hongqing] Univ South China, Sch Chem & Chem Engn, Hengyang 421001, Peoples R China.
通讯机构：
[Hongqiang Wang] S;School of Resource & Environment and Safety Engineering, University of South China, Hengyang 421001, China
关键词：
Chitosan;Seawater;Uranium extraction
摘要：
A novel chitosan-based porous composite adsorbent with multifunctional groups, such as phosphoric acid, amidoxime, and quaternary ammonium groups, was prepared to improve the adsorption rate and competitive uranium‑vanadium adsorption of amidoxime group adsorbents. The maximum uranium adsorption capacity of PACNC was 962.226mgg(-1) at 308K and pH=7. The maximum adsorption rate constant of PACNC for uranium was 2.83E-2gmg(-1)min(-1), which is 2.38 times that of ACNC (1.19E-2gmg(-1)min(-1)). Moreover, the adsorption equilibrium time was shortened from 300 (ACNC) to 50 (PACNC) min. In simulated and real seawater, the K(d) and adsorption capacity of PACNC for uranium were approximately 8 and 6.62 times those for vanadium, respectively. These results suggest that phosphorylation significantly improved the competitive adsorption of uranium‑vanadium and uranium adsorption rate. PACNC also exhibited good recycling performance and maintained stable adsorption capacity after five cycles. DFT calculations were used to analyze and calculate the possible co-complex structure of PACNC and uranium. The binding structure of phosphate and amidoxime is the most stable, and its synergistic effect effectively improves the competitive adsorption of uranium-vanadium of amidoxime. All the results demonstrated that PACNC has substantial application potential for uranium extraction from seawater.
作者机构：
[Yang, Qian; Qiao, Jie; Li, Ningbo; Wang, Yuxin; Hu, Chuqian; Jin, Zhaohui] Shanxi Med Univ, Sch Basic Med Sci, Taiyuan 030001, Peoples R China.;[Gu, Shuo] Shanxi Med Univ, Sch Pharmaceut Sci, Taiyuan 030001, Peoples R China.;[He, Wei-Min; Ouyang, Wen-Tao] Univ South China, Sch Chem & Chem Engn, Hengyang 421001, Peoples R China.
通讯机构：
[Wei-Min He] S;School of Chemistry and Chemical Engineering, University of South China, Hengyang, China
摘要：
A concise and efficient ring-opening difluorination strategy was developed for the synthesis of highly functionalized hydroxy-containing alpha,alpha-difluoro-beta-ketoamides from the one-pot multicomponent reaction of 4-aminocoumarins, NFSI, and water in dimethyl carbonate (DMC) as a green solvent. The reactions were smoothly achieved under visible light irradiation in air at room temperature without the addition of any other external photocatalysts. With this protocol, various alpha,alpha-difluoro-beta-ketoamides were successfully synthesized under mild conditions (25 examples, 73-91% yields). This transition-metal-free synthetic procedure shows good functional group compatibility and attractive practical potential for large-scale synthesis.
期刊：
Asian Journal of Organic Chemistry,2023年12(1):e202200674- ISSN：2193-5807
通讯作者：
Cai, J.;Wang, D.;Deng, G.-J.
作者机构：
[Wang, Dahan; Liu, Jinbing] Shaoyang Univ, Dept Food & Chem Engn, ShaoShui Xi Rd, Shaoyang 422100, Peoples R China.;[Zhou, Yazheng; Deng, Guo-Jun; Wan, Xiaoyuan] Xiangtan Univ, Coll Chem, Key Lab Environmentally Friendly Chem, Hunan Prov Key Lab Green Organ Synth & Applicat, Xiangtan 411105, Peoples R China.;[Cai, Jinhui] Univ South China, Coll Chem & Chem Engn, Hengyang 421001, Hunan, Peoples R China.
通讯机构：
[Dr. Dahan Wang; Dr. Dahan Wang Dr. Dahan Wang Dr. Dahan Wang] D;[Dr. Jinhui Cai; Dr. Jinhui Cai Dr. Jinhui Cai Dr. Jinhui Cai] C;[Prof. Dr. Guo-Jun Deng; Prof. Dr. Guo-Jun Deng Prof. Dr. Guo-Jun Deng Prof. Dr. Guo-Jun Deng] K;College of Chemistry and Chemical Engineering, University of South China, Hengyang, 421001 Hunan, P. R. China<&wdkj&>Department of Food and Chemical Engineering, Shaoyang University, ShaoShui Xi Road, Shaoyang, 422100 P. R. China<&wdkj&>Key Laboratory of Environmentally Friendly Chemistry and Application of Ministry of Education, Hunan Province Key Laboratory of Green Organic Synthesis and Application, College of Chemistry, Xiangtan University, Xiangtan, 411105 P. R. China
关键词：
[3+2] cycloaddition;nitrileimines;transition metal-free;1,2,4-triazoles;trifluoromethyl groups
摘要：
An efficient synthesis of densely 1,2,4-triazoles has been achieved by [3+2] cycloaddition of nitrileimides with amidine hydrochlorides under transition metal-free conditions. This method features mild reaction conditions, wide substrate scope and good functional group tolerance. A series of aryl, heterocyclic and alkyl substituted 3-CF3-1,2,4-triazoles were synthesized smoothly under the promotion of NaHCO3 and yield up to 96%. In addition, both gram-scale reaction and synthetic transformations are smoothly elaborated to indicate the utility of this reaction.
作者机构：
[Zhao, Wei; Fu, Chao; Hu, Rong; Hu, R; Yin, Yuli; Yin, YL] Univ South China, Sch Chem & Chem Engn, Hengyang 421001, Peoples R China.;[Tang, Ben Zhong] Chinese Univ Hong Kong, Shenzhen Inst Aggregate Sci & Technol, Sch Sci & Engn, Shenzhen CUHK Shenzhen, Shenzhen 518172, Guangdong, Peoples R China.;[Yan, Caihong] Univ South China, Affiliated Hosp 2, Hengyang Med Sch, Hengyang 421001, Hunan, Peoples R China.;[Zhou, Yizhao] Hunan Normal Univ, Hunan Prov Peoples Hosp, Affiliated Hosp 1, Dept Orthoped, Changsha 410005, Peoples R China.;[Gao, Hanyi] Univ South China, Affiliated Hosp 7, Hunan Prov Vet Adm Hosp, Hengyang Med Sch, Hengyang 421001, Hunan, Peoples R China.
通讯机构：
[Tang, BZ ] C;[Hu, R ; Yin, YL] U;Univ South China, Sch Chem & Chem Engn, Hengyang 421001, Peoples R China.;Chinese Univ Hong Kong, Shenzhen Inst Aggregate Sci & Technol, Sch Sci & Engn, Shenzhen CUHK Shenzhen, Shenzhen 518172, Guangdong, Peoples R China.
摘要：
Ultrasound-triggered sonodynamic therapy (SDT) presents growing promise in deep-seated or unresectable tumor inhibition because of the perfect tissue penetration ability. However, its therapeutic efficacy is always restricted by the limited reactive oxygen species (ROS) generation ability of sonosensitizers. In this work, based on molecular engineering, we have fabricated aggregation-induced emission (AIE)-active organic sonosensitizers bearing efficient ROS generation with US irradiation for tumor treatment. By enhancing the intramolecular charge transfer strength and intermolecular interaction, an organic sonosensitizer with reduced energy gap and AIE features was developed, presenting enhanced oxygen sensitization behavior to produce ROS upon an ultrasound trigger compared to Ce 6. Moreover, the excellent mitochondrial enrichment of the obtained sonosensitizer enables effective tumor cell eradication via apoptotic and ferroptosis pathways with ultrasound irradiation. The efficient in vivo tumor inhibition was also achieved based on the SDT approach. Therefore, this work provided a generalized and promising strategy for deep-seated or unresectable tumor treatment in the clinic. An organic sonosensitizer bearing a low-energy gap and aggregation-induced emission features was constructed for efficient tumor therapy based on ultrasound irradiation triggered-ROS generation.
摘要：
A branched core-shell nanosphere composed of an anatase TiO 2 (a-TiO 2 ) core and a TiO 2 nanobranch shell with gradient-doped N (a-TiO 2 @N-TiO 2 ) is synthesized by a simple in situ doping method, in which mixed crystal anatase-rutile TiO 2 (ar-TiO 2 ) nanosphere is first prepared by oxidizing Ti using H 2 O 2 , and then is etched by NH 3 middotH 2 O to form (NH 4 ) 2 TiO 3 nanobranches, which is converted into a-TiO 2 @N-TiO 2 following an ambient annealing process. The diameter of a-TiO 2 core is similar to 500 nm, and the thickness of NTiO 2 branched shell is similar to 100 nm with gradually increased N concentration from the bottom to the edge. Ultra-thin amorphous coating layers on the branches are also observed. The morphology of the composites could be further tuned by the amount of NH 3 middotH 2 O, and its effect on the photocatalytic performance is also investigated. The optimized a-TiO 2 @N-TiO 2 shows an outstanding hydrogen evolution rate of 308.1 mu mol g -1 h -1 under air mass (AM) 1.5 illumination, and also exhibits highly active in photocatalytic degradation of various refractory organic pollutants, including organic dyes, phenols, antibiotics, and personal care products, with removal ratios higher than 96% after 2 h operation. This can be due to the gradient-doped N-TiO 2 nanobranches, which not only provide bending band structure and defect level derived from the N impurities and O vacancies, resulting the formation of n-n + heterojunctions to improve the charge separation, but also enhance the charge transfer at the liquid-solid interface due to the numerous nanobranches and amorphous coating layers.(c) 2023 Published by Elsevier B.V. on behalf of Chinese Chemical Society and Institute of Materia Medica, Chinese Academy of Medical Sciences.
