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NIR luminogen for low-temperature photothermal therapy by triggering HSP90α down-regulation

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成果类型:
期刊论文
作者:
Yang, Xinzhe;Ding, Keke;Zhang, Guiquan;Han, Pengbo;Hu, Rong;...
通讯作者:
Hu, Rong(hurong@usc.edu.cn);Qin, Anjun(msqinaj@scut.edu.cn);Tang, Ben Zhong(tangbenz@cuhk.edu.cn)
作者机构:
[Zhang, Guiquan; Qin, Anjun; Han, Pengbo; Hu, Rong; Yang, Xinzhe; Wang, Zhiming] South China Univ Technol, Guangdong Prov Key Lab Luminescence Mol Aggregates, State Key Lab Luminescent Mat & Devices, Guangzhou 510640, Peoples R China.
[Zhang, Guiquan; Qin, Anjun; Han, Pengbo; Hu, Rong; Yang, Xinzhe; Wang, Zhiming; Tang, Ben Zhong] South China Univ Technol, AIE Inst, Ctr Aggregat Induced Emiss, Guangzhou 510640, Peoples R China.
[Tang, Ben Zhong] Chinese Univ Hong Kong, Shenzhen Inst Aggregate Sci & Technol, Sch Sci & Engn, Shenzhen 518172, Guangdong, Peoples R China.
[Tang, Ben Zhong] Hong Kong Univ Sci & Technol, Chinese Natl Engn Res Ctr Tissue Restorat & Recons, Hong Kong Branch, Clear Water Bay, Hong Kong, Peoples R China.
[Hu, Rong] Univ South China, Sch Chem & Chem Engn, Hengyang 421001, Peoples R China.
通讯机构:
[Rong Hu; Anjun Qin] S
[Ben Zhong Tang] C
State Key Laboratory of Luminescent Materials and Devices, Guangdong Provincial Key Laboratory of Luminescence from Molecular Aggregates, South China University of Technology, Guangzhou, China<&wdkj&>Center for Aggregation-Induced Emission, AIE Institute, South China University of Technology, Guangzhou, China<&wdkj&>Center for Aggregation-Induced Emission, AIE Institute, South China University of Technology, Guangzhou, China<&wdkj&>School of Science and Engineering, Shenzhen Institute of Aggregate Science and Technology, The Chinese University of Hong Kong, Shenzhen, Guangdong, China<&wdkj&>Hong Kong Branch of Chinese National Engineering Research Centre for Tissue Restoration and Reconstruction, The Hong Kong University of Science & Technology, Clear Water Bay, Kowloon, Hong Kong, China<&wdkj&>State Key Laboratory of Luminescent Materials and Devices, Guangdong Provincial Key Laboratory of Luminescence from Molecular Aggregates, South China University of Technology, Guangzhou, China<&wdkj&>Center for Aggregation-Induced Emission, AIE Institute, South China University of Technology, Guangzhou, China<&wdkj&>School of Chemistry and Chemical Engineering, University of South China, Hengyang, China
语种:
英文
期刊:
Chemical Communications
ISSN:
1359-7345
年:
2023
卷:
59
期:
19
页码:
2743-2746
基金类别:
National Natural Science Foundation of China [21788102, 21907034]; Natural Science Foundation of Guangdong Province [2019B030301003]; National Key Research and Development Program of China [2017YFE0132200]; Innovation and Technology Commission of Hong Kong [ITC-CNERC14S01]
机构署名:
本校为其他机构
院系归属:
化学化工学院
摘要:
A near-infrared (NIR) luminogen TST was designed and used to efficiently trigger HSP90α protein knockdown through photo-thermal conversion based on a gene interference strategy, by which in vitro and in vivo tumor ablation were significantl...

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