A high performance AIE-active sonosensitizer for efficient sonodynamic tumor therapy

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成果类型：

期刊论文

作者：

Zhao, Wei;Fu, Chao;Gao, Hanyi;Zhou, Yizhao;Yan, Caihong;...

通讯作者：

Yin, Yuli;Hu, R;Tang, BZ

作者机构：

[Zhao, Wei; Fu, Chao; Hu, Rong; Hu, R; Yin, Yuli; Yin, YL] Univ South China, Sch Chem & Chem Engn, Hengyang 421001, Peoples R China.

[Tang, Ben Zhong] Chinese Univ Hong Kong, Shenzhen Inst Aggregate Sci & Technol, Sch Sci & Engn, Shenzhen CUHK Shenzhen, Shenzhen 518172, Guangdong, Peoples R China.

[Yan, Caihong] Univ South China, Affiliated Hosp 2, Hengyang Med Sch, Hengyang 421001, Hunan, Peoples R China.

[Zhou, Yizhao] Hunan Normal Univ, Hunan Prov Peoples Hosp, Affiliated Hosp 1, Dept Orthoped, Changsha 410005, Peoples R China.

[Gao, Hanyi] Univ South China, Affiliated Hosp 7, Hunan Prov Vet Adm Hosp, Hengyang Med Sch, Hengyang 421001, Hunan, Peoples R China.

通讯机构：

[Tang, BZ ] C

[Hu, R ; Yin, YL] U

Univ South China, Sch Chem & Chem Engn, Hengyang 421001, Peoples R China.

Chinese Univ Hong Kong, Shenzhen Inst Aggregate Sci & Technol, Sch Sci & Engn, Shenzhen CUHK Shenzhen, Shenzhen 518172, Guangdong, Peoples R China.

语种：

英文

期刊：

Materials Chemistry Frontiers

ISSN：

2052-1537

年：

2023

卷：

期：

页码：

6229-6235

DOI：

10.1039/d3qm00842h

基金类别：

This work is supported by the Hunan Provincial Natural Science Foundation of China (2022JJ40375, 2021JJ304060), Youth funding of Hunan Provincial Education Department (22B0404), and Scientific Research Foundation of University of South China (211RGC011 and [2022JJ40375, 2021JJ304060]; Hunan Provincial Natural Science Foundation of China [22B0404]; Hunan Provincial Education Department [211RGC011, 220XQD011]; Scientific Research Foundation of University of South China

机构署名：

本校为第一且通讯机构

院系归属：

化学化工学院

摘要：

Ultrasound-triggered sonodynamic therapy (SDT) presents growing promise in deep-seated or unresectable tumor inhibition because of the perfect tissue penetration ability. However, its therapeutic efficacy is always restricted by the limited reactive oxygen species (ROS) generation ability of sonosensitizers. In this work, based on molecular engineering, we have fabricated aggregation-induced emission (AIE)-active organic sonosensitizers bearing efficient ROS generation with US irradiation for tumor treatment. By enhancing the intramolecular charge transfer strength and intermolecular interacti...

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A high performance AIE-active sonosensitizer for efficient sonodynamic tumor therapy

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