KnockTF 2.0: a comprehensive gene expression profile database with knockdown/knockout of transcription (co-)factors in multiple species

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成果类型：

期刊论文

作者：

Feng, Chenchen;Song, Chao;Song, Shuang;Zhang, Guorui;Yin, Mingxue;...

通讯作者：

Li, CQ;Guo, MZ

作者机构：

[Feng, Chenchen; Wang, Qiuyu; Li, Chunquan] Univ South China, Natl Hlth Commiss, Key Lab Birth Defect Res & Prevent, Hengyang 421001, Hunan, Peoples R China.

[Feng, Chenchen; Wang, Qiuyu; Li, Chunquan] Univ South China, Sch Comp, Hengyang 421001, Hunan, Peoples R China.

[Feng, Chenchen; Zhang, Yuexin; Wang, Qiuyu; Yin, Mingxue; Song, Shuang; Zhang, Guorui; Li, Chunquan; Song, Chao; Qian, Fengcui] Univ South China, Affiliated Hosp 1, Hengyang Med Sch, Cardiovasc Lab Big Data & Imaging Artificial Intel, Hengyang 421001, Hunan, Peoples R China.

[Guo, Maozu] Beijing Univ Civil Engn & Architecture, Sch Elect & Informat Engn, Beijing 100044, Peoples R China.

[Feng, Chenchen; Zhang, Yuexin; Wang, Qiuyu; Yin, Mingxue; Li, Chunquan; Song, Shuang; Zhang, Guorui; Song, Chao; Qian, Fengcui] Univ South China, Hunan Prov Key Lab Multiom & Artificial Intelligen, Hengyang 421001, Hunan, Peoples R China.

通讯机构：

[Li, CQ ] U

[Guo, MZ ] B

Univ South China, Natl Hlth Commiss, Key Lab Birth Defect Res & Prevent, Hengyang 421001, Hunan, Peoples R China.

Univ South China, Sch Comp, Hengyang 421001, Hunan, Peoples R China.

Beijing Univ Civil Engn & Architecture, Sch Elect & Informat Engn, Beijing 100044, Peoples R China.

语种：

英文

关键词：

chromatin;gene expression profiling;methylation;single nucleotide polymorphism;genetics;mice;candidate disease gene;enhancer of transcription;basic local alignment search tool;datasets;arabidopsis;maize;rna-seq;transcription factor;genes;pathologic processes

期刊：

Nucleic Acids Research

ISSN：

0305-1048

年：

2024

卷：

期：

页码：

D183-D193

DOI：

10.1093/nar/gkad1016

基金类别：

National Natural Science Foundation of China [62171166, 62001145, 62302206, 62272212, 62031003]; Research Foundation of the First Affiliated Hospital of University of South China for Advanced Talents [20210002-1005 USCAT-2021-01]; China Postdoctoral Science Foundation [2019M661311]; Natural Science Foundation of Hunan Province [2023JJ40594, 2023JJ30536]; Scientific Research Fund Project of Hunan Provincial Health Commission [20201920]; Clinical Research 4310 Program of the University of South China [20224310NHYCG05]; and Natural Science Foundation of Heilongjiang Province [LH2021F044]. Funding for open access charge: National Natural Science Foundation of China [62171166, 62001145, 62302206, 62272212, 62031003]; Research Foundation of the First Affiliated Hospital of University of South China for Advanced Talents [20210002-1005 USCAT-2021-01]; China Postdoctoral Science Foundation [2019M661311]; Natural Science Foundation of Hunan Province [2023JJ40594, 2023JJ30536]; Scientific Research Fund Project of Hunan Provincial Health Commission [20201920]; Clinical Research 4310 Program of the University of South China [20224310NHYCG05]; and Natural Science Foundation of Heilongjiang Province [LH2021F044].

机构署名：

本校为第一且通讯机构

院系归属：

化学化工学院

医学院

药学与生物科学学院

摘要：

Transcription factors (TFs), transcription co-factors (TcoFs) and their target genes perform essential functions in diseases and biological processes. KnockTF 2.0 (http:////www.licpathway.net//KnockTF//index.html) aims to provide comprehensive gene expression profile datasets before//after T(co)F knockdown//knockout across multiple tissue//cell types of different species. Compared with KnockTF 1.0, KnockTF 2.0 has the following improvements: (i) Newly added T(co)F knockdown//knockout datasets in mice, Arabidopsis thaliana and Zea mays and also an expanded scale of datasets in humans. Currently...

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KnockTF 2.0: a comprehensive gene expression profile database with knockdown/knockout of transcription (co-)factors in multiple species

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