期刊：
Chemical Communications,2023年59(94):14029-14032 ISSN：1359-7345
通讯作者：
He, WM;Ou, LJ
作者机构：
[Wu, Chao; Zhou, Min-Hang; Hou, Jia-Cheng; Lu, Yu-Han; He, Wei-Min; Ji, Hong-Tao; Ouyang, Wen-Tao; Jiang, Jun; He, WM] Univ South China, Sch Chem & Chem Engn, Hengyang 421001, Peoples R China.;[Ou, Li-Juan] Hunan Inst Technol, Sch Mat Sci & Engn, Hengyang 421002, Peoples R China.
通讯机构：
[Ou, LJ ] H;[He, WM ] U;Univ South China, Sch Chem & Chem Engn, Hengyang 421001, Peoples R China.;Hunan Inst Technol, Sch Mat Sci & Engn, Hengyang 421002, Peoples R China.
摘要：
With both ferrocene and air as the redox catalysts, for the first time, the low-cost natural ilmenite (FeTiO3) was successfully used for photocatalytic bond formations. Under the assistance of a traceless H-bond, and HCHO as the methylene reagent, a variety of imidazo[1,5-a]quinoxalinones were semi-heterogeneously photosynthesized in high yields with good functional group compatibility.
摘要：
Additive strategy has been regarded as a promising approach for fabricating electronic copper patterns, since it has predominance over traditional lithography technology (subtractive strategy) in process simplicity, material economizing, and environmental protection. At present, the key challenge for additive strategy is how to precisely fabricate high-quality copper patterns adhering tightly to substrates, by facile and universally applicable process. Here a novel additive copper patterning process is explored by adopting a homogeneous Ag-based catalyst ink. The catalyst ink can be facilely patterned and tightly attached on various substrates by different patterning techniques, without any pre- and post-treatment procedures. In the catalyst ink formula, epoxy matrix contributes high adhesiveness and fixes ink form, valen Schiff base acts as a medium anchoring Ag catalyst, ethanol serves as both reductant and diluent, and polyethylene glycol improves hydrophility. The copper coating, forming on the catalyst layer by further electroless copper deposition process, exhibits compact structure and high electrical conductivity comparable to bulk copper. Moreover, the copper coating can be partially inserted into substrate body by porous surface design for substrates, thus achieving strong adhesion and high flexibility. This research contributes to the progress of next-generation copper patterning techniques.
通讯机构：
[Xinhua Xu] C;[Wei-Min He] S;College of Chemistry and Chemical Engineering, Hunan University, Changsha 410082, China<&wdkj&>School of Chemistry and Chemical Engineering, University of South China, Hengyang 421001, China
关键词：
Green chemistry;Electrochemistry;Cascade reaction;Multicomponent reaction;Thiocyanato
摘要：
A practical synthetic method for 4-thiocyanato-1H-pyrazoles through the electrochemical cascade reaction of hydrazines, 1,3-diones and NH4SCN under metal-, chemical oxidant- and external electrolyte-free conditions was established. Importantly, both a gram-scale synthesis of 4-thiocyanato-1H-pyrazoles and five one-pot sequential transformations starting from hydrazine were successfully accomplished.
作者机构：
[Zhang, Yuexin; Wang, Qiuyu; Zhang, Guorui; Song, Chao; Wang, Yuezhu; Zhou, Liwei; Zhao, Jun; Li, Chunquan; Qian, Fengcui] Univ South China, Affiliated Hosp 1, Hengyang Med Sch, Inst Cardiovasc Dis, Hengyang 421001, Hunan, Peoples R China.;[Zhao, Xilong; Feng, Chenchen; Wang, Qiuyu; Bai, Xuefeng; Zhang, Jian; Wang, Yuezhu; Ai, Bo; Liu, Xinyu; Zhou, Liwei; Zhao, Jun; Li, Chunquan; Zhu, Jiang; Wang, Fan] Harbin Med Univ, Sch Med Informat, Daqing Campus, Daqing 163319, Peoples R China.;[Zhang, Yuexin; Wang, Qiuyu; Zhang, Guorui; Song, Chao; Li, Chunquan; Qian, Fengcui] Univ South China, Sch Comp, Hengyang 421001, Hunan, Peoples R China.;[Zhang, Yuexin; Wang, Qiuyu; Song, Chao; Li, Chunquan; Qian, Fengcui] Univ South China, Affiliated Hosp 1, Hengyang Med Sch, Cardiovasc Lab Big Data & Imaging Artificial Inte, Hengyang 421001, Hunan, Peoples R China.;[Wang, Qiuyu; Li, Chunquan] Univ South China, Hunan Prov Base Sci & Technol Innovat Cooperat, Hengyang 421001, Hunan, Peoples R China.
通讯机构：
[Chunquan Li] T;The First Affiliated Hospital, Institute of Cardiovascular Disease, Hengyang Medical School, University of South China , Hengyang , Hunan 421001, China<&wdkj&>School of Medical Informatics, Daqing Campus, Harbin Medical University , Daqing 163319, China<&wdkj&>School of Computer, University of South China , Hengyang , Hunan 421001, China<&wdkj&>The First Affiliated Hospital, Cardiovascular Lab of Big Data and Imaging Artificial Intelligence, Hengyang Medical School, University of South China , Hengyang , Hunan 421001, China<&wdkj&>Hunan Provincial Base for Scientific and Technological Innovation Cooperation, University of South China , Hengyang , Hunan 421001, China<&wdkj&>The First Affiliated Hospital, Department of Cardiology, Hengyang Medical School, University of South China, Hengyang , Hunan 421001, China<&wdkj&>Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Hengyang Medical School, University of South China , Hengyang , Hunan 421001, China<&wdkj&>Department of Cell Biology and Genetics, School of Basic Medical Sciences, Hengyang Medical School, University of South China, Hengyang , Hunan 421001, China
摘要：
Super-enhancers (SEs) are cell-specific DNA cis-regulatory elements that can supervise the transcriptional regulation processes of downstream genes. SEdb 2.0 (http://www.licpathway.net/sedb) aims to provide a comprehensive SE resource and annotate their potential roles in gene transcriptions. Compared with SEdb 1.0, we have made the following improvements: (i) Newly added the mouse SEs and expanded the scale of human SEs. SEdb 2.0 contained 1 167 518 SEs from 1739 human H3K27ac chromatin immunoprecipitation sequencing (ChIP-seq) samples and 550 226 SEs from 931 mouse H3K27ac ChIP-seq samples, which was five times that of SEdb 1.0. (ii) Newly added transcription factor binding sites (TFBSs) in SEs identified by TF motifs and TF ChIP-seq data. (iii) Added comprehensive (epi)genetic annotations of SEs, including chromatin accessibility regions, methylation sites, chromatin interaction regions and topologically associating domains (TADs). (iv) Newly embedded and updated search and analysis tools, including ‘Search SE by TF-based’, ‘Differential-Overlapping-SE analysis’ and ‘SE-based TF–Gene analysis’. (v) Newly provided quality control (QC) metrics for ChIP-seq processing. In summary, SEdb 2.0 is a comprehensive update of SEdb 1.0, which curates more SEs and annotation information than SEdb 1.0. SEdb 2.0 provides a friendly platform for researchers to more comprehensively clarify the important role of SEs in the biological process.
摘要：
Early transition metals based 2D carbides, nitrides and carbonitrides nanomaterials are known as MXenes, a novel and extensive new class of 2D‐materials family. Due to its distinctive surface chemistry, graphene like shape, metallic conductivity, high hydrophilicity, outstanding mechanical and thermal properties, redox capacity and affordable with mass‐produced nature, this diverse MXenes are of tremendous scientific and technological significance. Abstract Early transition metals based 2D carbides, nitrides and carbonitrides nanomaterials are known as MXenes, a novel and extensive new class of 2D materials family. Since the first accidently synthesis based discovery of Ti3C2 in 2011, more than 50 additional compositions have been experimentally reported, including at least eight distinct synthesis methods and also more than 100 stoichiometries are theoretically studied. Due to its distinctive surface chemistry, graphene like shape, metallic conductivity, high hydrophilicity, outstanding mechanical and thermal properties, redox capacity and affordable with mass‐produced nature, this diverse MXenes are of tremendous scientific and technological significance. In this review, first we'll come across the MXene based nanomaterials possible synthesis methods, their advantages, limitations and future suggestions, new chemistry related to their selected properties and potential sensing applications, which will help us to explain why this family is growing very fast as compared to other 2D families. Secondly, problems that help to further improve commercialization of the MXene nanomaterials based sensors are examined, and many advances in the commercializing of the MXene nanomaterials based sensors are proposed. At the end, we'll go through the current challenges, limitations and future suggestions.
作者机构：
[Yu, Wenzhan; Xiao, Xilin] Univ South China, Sch Pharmaceut Sci, Hengyang 421001, Hunan, Peoples R China.;[Li, Qian; Liao, Lifu] Univ South China, Sch Chem & Chem Engn, Hengyang 421001, Hunan, Peoples R China.;[He, Liqiong; Zhou, Renlong; Xue, Jinhua] Univ South China, Sch Publ Hlth, Hengyang 421001, Hunan, Peoples R China.
通讯机构：
[Jinhua Xue; Xilin Xiao] S;School of Public Health, University of South China, Hengyang 421001, Hunan, PR China<&wdkj&>School of Pharmaceutical Science, University of South China, Hengyang 421001, Hunan, PR China
作者机构：
[Lin, Ying-Wu; Zhao, Shuangshuang; Wang, Chunhui; Xian, Keyi; Wang, Yanfei] Univ South China, Sch Chem & Chem Engn, Hengyang 421001, Peoples R China.;[Wang, Chunhui; Qin, Haozhe; Ou, Xing] Cent South Univ, Engn Res Ctr, Sch Met & Environm, Minist Educ Adv Battery Mat, 932 South Lushan Rd, Changsha 410083, Hunan, Peoples R China.;[Feng, Ming] Jilin Normal Univ, Key Lab Funct Mat Phys & Chem, Minist Educ, Changchun 130103, Peoples R China.;[Wang, Dong] Jilin Univ, Electron Microscopy Ctr, Sch Mat Sci & Engn, Key Lab Automobile Mat MOE,Jilin Prov Int Cooperat, Changchun 130012, Jilin, Peoples R China.;[Wang, Dong] Jilin Univ, Int Ctr Future Sci, Changchun 130012, Jilin, Peoples R China.
通讯机构：
[Feng, M ] J;[Lin, YW ] U;[Ou, X ] C;Univ South China, Sch Chem & Chem Engn, Hengyang 421001, Peoples R China.;Cent South Univ, Engn Res Ctr, Sch Met & Environm, Minist Educ Adv Battery Mat, 932 South Lushan Rd, Changsha 410083, Hunan, Peoples R China.
关键词：
Potassium ion battery;Cobaltous sulfide;Fe cluster;Interfacial engineering;Synergistic effect
摘要：
Interfacial engineering, especially atomic substitution at the interface or inside the nanomaterials, is a promising strategy for fabricating high-performance electrode materials. Herein, an interfacial modification strategy was reported to develop cobaltous sulfide (CoS2) nanomaterials with Fe clusters modified on their interface and Fe single atoms partially substituted Co atoms in CoS2 (Fe-CFS), which were further wrapped by graphene networks, forming highly active Fe-CFS@graphene nanomaterials (Fe-CFS@C) with triple reaction interfaces. As the 1st interface, graphene can decrease their electrical resistance. At the 2nd interface, partial substitution of Co atoms in CoS2 by Fe single atoms can reduce its band gap and boost the potassium ion (K+) diffusion rate. At the 3rd interface, anchoring Fe clusters on the surface of CoS2 results in the formation of Schottky junction and promotes the formation of built-in electric fields, which accelerates the K+ insertion/extraction kinetics and depresses the dynamic polarization. Acting as anode for K+ battery, Fe-CFS@C exhibits a high reversible capacity of 755.8 mA h g−1 at 0.05 A g−1. Even at 10 A g−1, it can maintain 178.3 mA h g−1 over 4000 cycles due to the greatly enhanced electrochemical reaction kinetics and effectively improved structural stability.
通讯机构：
[Yun Liao; Meng Wang] S;School of Chemistry and Chemical Engineering, University of South China, Hengyang, Hunan 421001, China<&wdkj&>Hunan Key Laboratory for the Design and Application of Actinide Complexes, University of South China, Hengyang, Hunan 421001, China<&wdkj&>School of Nuclear Science and Technology, University of South China, Hengyang, Hunan 421001, China
通讯机构：
[Linghua Jin; Ye Zhang] S;School of Chemistry and Chemical Engineering, University of South China, Hengyang 421001, China
关键词：
Prussian blue analogues;MnO2;Composite materials;Microstructure;Supercapacitor
摘要：
A composite supercapacitor electrode material, MnO2 decorated cobalt-iron Prussian blue analogue (CoPBA), has been rationally designed and fabricated through a facile precipitation method. The surface encapsulation of MnO2 onto CoPBA can result in improved electrochemical performances, because the uniformly covered MnO2 increases not only the electrical conductivity for faster ion transport but also the specific capacitance by providing more active sites. A maximum specific capacitance of 945F g(-1) at 1 A/g is observed for CoPBA@MnO2, which is 3.2-fold and 6.7-fold of those of pure CoPBA and MnO2, respectively. This study is expected to provide a good reference for designing high performance electrode materials with ease and low cost.
期刊：
Nuclear Engineering and Technology,2023年55(7):2556-2566 ISSN：1738-5733
通讯作者：
Nie, CM;Shi, WQ
作者机构：
[Liang, Ru-Ting; Nie, Chang-Ming; Nie, CM; Yin, Wan-Qiu] Univ South China, Sch Chem & Chem Engn, Hengyang 421001, Hunan, Peoples R China.;[Liang, Ru-Ting; Bo, Tao; Yin, Wan-Qiu; Zhang, Lei; Chai, Zhi-Fang] Chinese Acad Sci, Ningbo Inst Mat Technol & Engn, Engn Lab Adv Energy Mat, Ningbo 315201, Zhejiang, Peoples R China.;[Bo, Tao] Songshan Lake Mat Lab, Dongguan 523808, Guangdong, Peoples R China.;[Shi, Wei-Qun] Chinese Acad Sci, Inst High Energy Phys, Lab Nucl Energy Chem, Beijing 100049, Peoples R China.
通讯机构：
[Nie, CM ] U;[Shi, WQ ] C;Univ South China, Sch Chem & Chem Engn, Hengyang 421001, Hunan, Peoples R China.;Chinese Acad Sci, Inst High Energy Phys, Lab Nucl Energy Chem, Beijing 100049, Peoples R China.
摘要：
A first-principle approach within the framework of density functional theory was employed to study the effect of vacancy defects and fission products (FPs) doping on the mechanical, electronic, and thermodynamic properties of uranium monocarbide (UC). Firstly, the calculated vacancy formation energies confirm that the C vacancy is more stable than the U vacancy. The solution energies indicate that FPs prefer to occupying in U site rather than in C site. Zr, Mo, Th, and Pu atoms tend to directly replace U atom and dissolve into the UC lattice. Besides, the results of the mechanical properties show that U vacancy reduces the compressive and deformation resistance of UC while C vacancy has little effect. The doping of all FPs except He has a repairing effect on the mechanical properties of U1-xC. In addition, significant modifications are observed in the phonon dispersion curves and partial phonon density of states (PhDOS) of UC1-x, ZrxU1-xC, MoxU1-xC, and RhxU1-xC, including narrow frequency gaps and overlapping phonon modes, which increase the phonon scattering and lead to deterioration of thermal expansion coefficient (αV) and heat capacity (Cp) of UC predicted by the quasi harmonic approximation (QHA) method.
摘要：
Uranium, the primary fuel source for nuclear power reactors, is one of the most crucial components in new energy production. Currently, uranium is mainly mined from land ore, which will be exhausted within 200 years. As the world's largest uranium reservoir, the ocean is an ideal source for people to obtain these industrial resources. However, the low concentration of uranium (typically about 3.3 ug/L) in seawater poses a great challenge for the project uranium extraction from seawater. The porous aromatic framework (PAF) is a new type of porous nano-solid material with chemical stability, robust framework, and inherent porosity, making itself being the promising material for uranium capturing from aqueous solutions. The progress and advancements of PAFs and PAF-based materials as adsorbents for uranium extraction from aqueous solutions are detailed in this review. Then, several common utilized ways to enhance PAF-based materials' adsorption performance are discussed. Finally, the authors make a summary and perspective on the opportunities and challenges of this kind of nanomaterials to provide some relevant information on designing PAFs and PAF-based materials for Uranium Extraction from seawater.
作者机构：
[Yang, Xinyi; Wang, Xiao-Feng] Univ South China, Sch Chem & Chem Engn, Hengyang 421001, Peoples R China.;[Wang, Xiangke; Liu, Xiaolu; Yang, Xinyi; Chen, Zhongshan; Liu, Yanfang] North China Elect Power Univ, Coll Environm Sci & Engn, Beijing 102206, Peoples R China.
通讯机构：
[Xiao-Feng Wang] S;[Xiangke Wang] C;School of Chemistry and Chemical Engineering, University of South China, Hengyang, China<&wdkj&>College of Environmental Science and Engineering, North China Electric Power University, Beijing, China
作者机构：
[Shao, Dadong; Ouyang, Jiafeng; Shao, DD] Nanjing Univ Sci & Technol, Sch Environm & Biol Engn, Nanjing 210094, Peoples R China.;[Ouyang, Jiafeng; Yuan, Liyong; Shi, Weiqun; Guo, Wenlu; Wang, Lin] Chinese Acad Sci, Inst High Energy Phys, Beijing 100049, Peoples R China.;[Guo, Wenlu; Nie, Changming] Univ South China, Sch Chem & Chem Engn, Hengyang 421001, Peoples R China.
通讯机构：
[Shao, DD ] N;[Yuan, LY ] C;Nanjing Univ Sci & Technol, Sch Environm & Biol Engn, Nanjing 210094, Peoples R China.;Chinese Acad Sci, Inst High Energy Phys, Beijing 100049, Peoples R China.
关键词：
magnetic nanoparticle;3D mesoporous silica;amino functionalization;adsorption of U(VI);acid resistance
摘要：
Although mesoporous silica with magnetically hybridized two-dimensional channel structures has been well studied in recent years, it remains a challenge to fabricate the counterpart with macroporous three-dimensional cubic structures since the highly acidic preparation conditions lead to dissolution of magnetic particles. Herein, we successfully prepared magnetic KIT-6 nano-composite and its amino derivatives by bearing acid-resistant iron oxide. The prepared materials exhibited excellent properties for U(VI) ions removal from aqueous solutions under various conditions. The experimental data show that the U(VI) adsorption features fast adsorption kinetics, high adsorption capacity and ideal selectivity toward U(VI). The adsorption process is of spontaneous and endothermic nature and ionic strength independence, and the adsorbents can be easily regenerated by acid treatment. Compared to pristine KIT-6, the introduction of magnetism does not reduce the efficiency of the material to remove U(VI) while exerting its role as a recovery adsorbent. The findings of this work further demonstrate the potential broad application prospects of magnetic hybrid mesoporous silica in radionuclide chelation.
作者机构：
[Wang, Huamin; Cheng, Xiufang; Niu, Wenjin; Lin, Ying-Wu; Wang, HM] Univ South China, Sch Chem & Chem Engn, Hengyang, Peoples R China.;[Lin, Ying-Wu] Univ South China, Lab Prot Struct & Funct, Med Sch, Hengyang 421001, Peoples R China.
通讯机构：
[Lin, YW ; Wang, HM] U;Univ South China, Sch Chem & Chem Engn, Hengyang, Peoples R China.;Univ South China, Lab Prot Struct & Funct, Med Sch, Hengyang 421001, Peoples R China.
摘要：
Trifluoromethylated organic molecules are ubiquitous in pharmaceutics, materials science, and agrochemicals. In the past few decades, great efforts have been devoted to the development of convenient and efficient strategies for the synthesis of these compounds. beta-Trifluoromethylated enones are readily available building blocks, and are recognized as an attractive synthetic feedstock in organic transformations. Thus far, numerous new catalytic systems including novel chiral ligands and organocatalysts have been applied to asymmetric catalytic protocols using beta-trifluoromethylated enones and various optically active compounds containing CF3 motif have been synthesized. Hence, this minireview describes the applications of beta-trifluoromethylated enones in diverse asymmetric catalytic transformations since 2008, and incorporates the mechanistic aspects, involving the key mechanistic intermediates and the reaction pathways. Finally, the challenges of related fields and future perspectives are also pointed out. This minireview describes the applications of beta-trifluoromethylated enones in diverse asymmetric catalytic transformations since 2008, and incorporates the mechanistic aspects, involving the key mechanistic intermediates and the reaction pathways.
作者机构：
[Gao, Shu-Qin; Sun, Li-Juan; Wen, Ge-Bo; Lin, Ying-Wu] Univ South China, Hengyang Med Sch, Hengyang 421001, Peoples R China.;[Wang, Huamin; Lin, Ying-Wu] Univ South China, Sch Chem & Chem Engn, Hengyang 421001, Peoples R China.;[Xu, Jia-Kun] Chinese Acad Fishery Sci, Yellow Sea Fisheries Res Inst, Key Lab Sustainable Dev Polar Fishery, Qingdao 266071, Peoples R China.
通讯机构：
[Lin, YW ] U;Univ South China, Hengyang Med Sch, Hengyang 421001, Peoples R China.;Univ South China, Sch Chem & Chem Engn, Hengyang 421001, Peoples R China.
通讯机构：
[Xiao-Juan Wang; Ying-Wu Lin] S;School of Chemistry and Chemical Engineering, University of South China, Hengyang, 421001, China.;Key Lab of Protein Structure and Function of Universities in Hunan Province, University of South China, Hengyang, 421001, China.
摘要：
A facile and dual fluorescent chemosensor (named 7-IDF) based on a phenylalanine derivative with an indole group was designed and synthesized. 7-IDF can selectively and sensitively detect Zn(2+) via obvious fluorescence enhancement in an aqueous solution. Remarkably, the 7-IDF-Zn complex with blue luminescence has higher selectivity toward cysteine (Cys) and histidine (His) than for other amino acids. Intriguingly, 7-IDF can also be used as an excellent probe to detect Zn(2+) in real water samples. Moreover, 7-IDF and 7-IDF-Zn possess excellent biocompatibility and cell permeability, and 7-IDF can consecutively detect Zn(2+) and Cys/His in Hela cells through fluorescence imaging experiments. This study suggests that the phenylalanine-based chemosensor possesses great potential applications for the sequential detection of Zn(2+) and Cys/His in biosystems.
通讯机构：
[Li Feng; Lijun Hu] S;School of Civil and Transportation Engineering, Guangdong University of Technology, Guangzhou 510006, Guangdong, China<&wdkj&>School of Chemistry and Chemical Engineering, University of South China, Hengyang 421001, China
摘要：
Effort has been made in this study to examine how the rheological behaviors of asphalt binder and performances of Stone Matrix Asphalt (SMA) mixture are affected using lignin and soybean oil. In current research lignin (3%, 5%, 7% by weight of asphalt binder) and soybean oil (5% by weight of asphalt binder) were added to modify-two types of virgin binders (AC 60-70 and AC 85/100). To assess different binders' performance by checking their physical and rheological behavior, penetration grade, ductility, linear amplitude sweep, multiple stress creep recovery, Dynamic Shear Rheometer, rotational viscosity and softening point tests, and to evaluate asphalt mixtures' performance, fatigue, rutting, indirect tensile strength and resilient modulus performances were evaluated. ANOVA is applied for statistically analyzing data. Rheological behaviors' results showed the use of lignin additive increases the softening point and decrease the penetration grade. Using lignin decreases low temperature resistances of binder, whereas oil improves the bitumen's low-temperature resistance. Multiple Stress Creep Recovery (MSCR) experiment result demonstrated an enhance in high performance temperature of the virgin binder at different stress levels by the addition of lignin. While, the utilization of oil decreases the rutting strength of sample. According to Linear Amplitude Sweep (LAS) outcomes, the use of lignin additive decreases fatigue property of the binders. While, soybean oil enhanced it. The mixtures experiment outcomes reveal the use of lignin increased the lasting deformation resistances, resilient modulus (MR), Indirect tensile strength (ITS), fracture energies. While, addition of oil has negative effect. Fatigue test results indicated that addition of lignin decreases the fatigue life of specimens, while soybean oil increases it. The Mr of the oil modified mixture is 7% lower than original mixture. While addition of 3%, 5%, and 7% lignin leads to increase the Mr by 3%, 18%, and 25%, respectively. Through the outcomes, addition of oil to 3% lignin modified mixture lead to decrease the FE by 1% which has the same value like original binder. Adding oil to mixtures comprising 3%, 5%, and 7% lignin leads to increase the rut depth amounts about 5%, 10%, 12%, respectively.
摘要：
The histone deacetylase HDAC3 is associated with the NCoR/SMRT co-repressor complex, and its canonical function is in transcriptional repression, but it can also activate transcription. Here, we show that the repressor and activator functions of HDAC3 can be genetically separated in Drosophila. A lysine substitution in the N terminus (K26A) disrupts its catalytic activity and activator function, whereas a combination of substitutions (HEBI) abrogating the interaction with SMRTER enhances repressor activity beyond wild type in the early embryo. We conclude that the crucial functions of HDAC3 in embryo development involve catalytic-dependent gene activation and non-enzymatic repression by several mechanisms, including tethering of loci to the nuclear periphery.
摘要：
Tremendous progress in nanotechnology and nanomedicine has made a significant positive effect on cancer treatment by integrating multicomponents into a single multifunctional nanosized delivery system for combinatorial therapies. Although numerous nanocarriers developed so far have achieved excellent therapeutic performance in mouse models via elegant integration of chemotherapy, photothermal therapy, photodynamic therapy, sonodynamic therapy, and immunotherapy, their synthetic origin may still cause systemic toxicity, immunogenicity, and preferential detection or elimination by the immune system. Exosomes, endogenous nanosized particles secreted by multiple biological cells, could be absorbed by recipient cells to facilitate intercellular communication and content delivery. Therefore, exosomes have emerged as novel cargo delivery tools and attracted considerable attention for cancer diagnosis and treatment due to their innate stability, biological compatibility, and biomembrane penetration capacity. Exosome-related properties and functions have been well-documented; however, there are few reviews, to our knowledge, with a focus on the combination of exosomes and nanotechnology for the development of exosome-based theranostic platforms. To make a timely review on this hot subject of research, we summarize the basic information, isolation and functionalization methodologies, diagnostic and therapeutic potential of exosomes in various cancers with an emphasis on the description of exosome-related nanomedicine for cancer theranostics. The existing appealing challenges and outlook in exosome clinical translation are finally introduced. Advanced biotechnology and nanotechnology will definitely not only promote the integration of intrinsic advantages of natural nanosized exosomes with traditional synthetic nanomaterials for modulated precise cancer treatment but also contribute to the clinical translations of exosome-based nanomedicine as theranostic nanoplatforms.
