Separation of transcriptional repressor and activator functions in Drosophila HDAC3

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成果类型：

期刊论文

作者：

Tang, Min;Regadas, Isabel;Belikov, Sergey;Shilkova, Olga;Xu, Lei;...

通讯作者：

Mannervik, M

作者机构：

[Belikov, Sergey; Mannervik, M; Regadas, Isabel; Mannervik, Mattias; Tang, Min; Shilkova, Olga] Stockholm Univ, Wenner Gren Inst, Dept Mol Biosci, S-10691 Stockholm, Sweden.

[Wu, Hongmei; Liu, Xuewen; Tang, Min] Univ South China, Dept Biochem & Mol Biol, Hengyang 421001, Peoples R China.

[Shilkova, Olga] Karolinska Inst, Dept Biosci & Nutr, SE-14183 Huddinge, Sweden.

[Xu, Lei; Bienko, Magda; Wernersson, Erik] Karolinska Inst, Dept Med Biochem & Biophys, S-17165 Stockholm, Sweden.

[Xu, Lei; Bienko, Magda] Sci Life Lab, S-17165 Stockholm, Sweden.

通讯机构：

[Mannervik, M ] S

Stockholm Univ, Wenner Gren Inst, Dept Mol Biosci, S-10691 Stockholm, Sweden.

语种：

英文

关键词：

HDAC3;Histone deacetylase;Chromatin;Transcription;Embryo development;Drosophila

期刊：

DEVELOPMENT

ISSN：

0950-1991

年：

2023

卷：

150

期：

页码：

dev201548

DOI：

10.1242/dev.201548

基金类别：

Cancerfonden; Vetenskapsradet; National Natural Science Foundation of China [81711530050]; Swedish Foundation for International Cooperation in Research and Higher Education (STINT) [CH2016-6768]; Sven och Lilly Lawskis Fond for Naturvetenskaplig Forskning; Stockholm University

机构署名：

本校为其他机构

院系归属：

化学化工学院

药学与生物科学学院

摘要：

The histone deacetylase HDAC3 is associated with the NCoR/SMRT co-repressor complex, and its canonical function is in transcriptional repression, but it can also activate transcription. Here, we show that the repressor and activator functions of HDAC3 can be genetically separated in Drosophila. A lysine substitution in the N terminus (K26A) disrupts its catalytic activity and activator function, whereas a combination of substitutions (HEBI) abrogating the interaction with SMRTER enhances repressor activity beyond wild type in the early embryo. We conclude that the crucial functions of HDAC3 in...

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Separation of transcriptional repressor and activator functions in Drosophila HDAC3

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