摘要：
Sulfur dioxide (SO(2)), a novel endogenous gas signaling molecule, is involved in the regulation of cardiac function. Exerting a key role in progression of hyperthyroidism-induced cardiomyopathy (HTC), myocardial fibrosis is mainly caused by myocardial apoptosis, leading to poor treatment outcomes and prognoses. This study aimed to investigate the effect of SO(2) on the hyperthyroidism-induced myocardial fibrosis and the underlying regulatory mechanisms. Elisa, Masson staining, Western-Blot, transmission electron microscope, and immunofluorescence were employed to evaluate the myocardial interstitial collagen deposition, endoplasmic reticulum stress (ERS), apoptosis, changes in endogenous SO(2), and Hippo pathways from in vitro and in vivo experiments. The study results indicated that the hyperthyroidism-induced myocardial fibrosis was accompanied by decreased cardiac function, and down-regulated ERS, apoptosis, and endogenous SO(2)-producing enzyme aspartate aminotransferase (AAT)1/2 in cardiac myocytes. In contrast, exogenous SO(2) donors improved cardiac function, reduced myocardial interstitial collagen deposition, up-regulated AAT1/2, antagonized ERS and apoptosis, and inhibited excessive activation of Hippo pathway in hyperthyroid rats. In conclusion, the results herein suggested that SO(2) inhibited the overactivation of the Hippo pathway, antagonized ERS and apoptosis, and alleviated myocardial fibrosis in hyperthyroid rats. Therefore, this study was expected to identify intervention targets and new strategies for prevention and treatment of HTC.
摘要：
In this paper, we give six classes of permutation polynomials of the form (x(pm) - x + delta)(s) + a(x) over F-2(2m) and six classes of permutation polynomials of the form (x(pm) - x + delta)(s) + ax(pm) + a(pm) x over F-p(2m) (p being an odd prime), respectively. In addition, we also investigate permutation polynomials obtained from piecewise functions. Consequently, we find some complete permutation polynomials.
作者机构：
[Yu, B. X.; Yu, G.; Li, Xiaoyu; Hu, T.; Ning, Z.; Zhang, P.; Wen, S. P.; Shi, X.; Sun, G. X.; Ma, M. M.; Zhao, Ling; Chen, T.; Hou, X. T.; Zhu, Z. A.; Xu, G. F.; Wang, K.; Zhou, L. P.; Heng, Y. K.; Ji, Q.; Zhang, J. W.; Rong, G.; Guan, C. Y.; Qi, F. Z.; Wang, Y. F.; Wang, L. L.; Ouyang, Q.; Liao, Y. P.; Zhang, A. Q.; Ji, X. B.; Qian, S.; Dong, M. Y.; Zhang, Jiawei; Fang, S. S.; Chang, J. F.; Liu, Z. A.; Yan, X. Q.; Wu, J. F.; Wang, Yaqian; Sun, S. S.; Ding, B.; Fu, C. D.; Lou, X. C.; Lin, T.; Zhang, B. X.; Xing, T. Y.; Cao, G. F.; Wu, L. H.; Zhao, Y. B.; Fu, Y. W.; Zheng, J. P.; Jiang, X. S.; Kiuchi, R.; Gu, M. H.; Lu, Y. P.; Dong, L. Y.; Zhang, H. Q.; Zhao, G.; Wu, L. J.; Li, L. J.; Yang, Yifan; Yuan, Y.; Lu, X. L.; Wu, Z.; Fang, Y.; Luo, X. L.; Ji, X. L.; Zhang, X. M.; Li, L. K.; Li, H. B.; Liang, H.; Huang, Y. P.; Zhang, J. Y.; Yin, J. H.; Batozskaya, V.; Liu, Huanhuan; Chen, X. T.; Zhang, J. Z.; He, K. L.; Chen, G.; Ablikim, M.; Liu, C. X.; Chang, W. L.; Zhu, K.; Zhao, J. Z.; Yang, Tao; Mao, Z. P.; Xiao, S. Y.; Lu, J. G.; Liu, P. L.; Jing, M. Q.; Sun, H. K.; Chen, Y. B.; Zhang, Shuihan; Du, M. C.; Wang, Z.; Ablikim, M; Liu, Fang; Zhao, J. Y.; Dong, J.; Liu, K.; Shi, J. Y.; Wang, H. P.; Yuan, C. Z.; Tang, G. Y.; Yuan, S. C.; Zhang, H. Y.; Chen, M. L.; Zhang, Z. H.; Hou, G. Y.; Shen, H. F.; Shao, L. G.; Hou, Z. L.; Sun, Y. Z.; Liu, B. J.; Li, Ke; Zhu, K. J.; Liu, H. M.; Xu, C. F.; Ma, H. L.; Sun, T.; Ye, M.; Xie, Y. G.; Chen, H. S.; Cao, N.; Deng, Z. Y.; Ma, Q. M.; Wang, Z. Y.; Cai, X.; Yuan, X. Q.; Zhang, Y. H.; Ma, R. Q.; Shi, R. S.; Zheng, W. J.; Zou, J. H.; Zhang, Yao; Liu, J. Y.; Li, W. G.; Wang, Y. Q.; Mo, X. H.; Fang, J.; Shen, X. Y.; Ma, X. Y.; Hu, H. M.; Gong, W. X.; Xu, W.; Hu, Y.; Wang, B.; Zhang, B. L.; Ma, J. L.; Wang, Meng; Yang, Y. X.; Miao, H.; Li, F.; Lu, Z. H.; Yang, H. X.; Qin, Z. H.; Li, G.; Ping, R. G.; Qiu, J. F.; Dai, H. L.; Li, W. D.; Fang, W. X.; Zeng, Y. J.] Inst High Energy Phys, Beijing 100049, Peoples R China.;[Yuan, L.] Beihang Univ, Beijing 100191, Peoples R China.;[Li, Lei] Beijing Inst Petrochem Technol, Beijing 102617, Peoples R China.;[Jaeger, S.; Fritsch, M.; Kuessner, M.; Pelizaeus, M.; Kopf, B.; Wollenberg, L.; Holtmann, T.; de Boer, R. E.; Feldbauer, F.; Wiedner, U.; Heinsius, F. H. H.; Coen, S. C.; Wenzel, C. W.] Bochum Ruhr Univ, D-44780 Bochum, Germany.;[Achasov, M. N.; Nikolaev, I. B.; Muchnoi, N. Yu] Budker Inst Nucl Phys SB RAS BINP, Novosibirsk 630090, Russia.
通讯机构：
[Ablikim, M ] I;Inst High Energy Phys, Beijing 100049, Peoples R China.
摘要：
Based on data samples collected with the BESIII detector at the BEPCII collider, the process e+e- -> E+ E over bar - is studied at center -of -mass energies ffis ffi p = 2.3960, 2.6454, and 2.9000 GeV. Using a fully differential angular description of the final state particles, both the relative magnitude and phase information of the E+ electromagnetic form factors in the timelike region are extracted. The relative phase between the electric and magnetic form factors is determined to be sin AO = -0.67 +/- 0.29(stat) +/- 0.18(syst) at ffis ffi p = 2.3960 GeV, AO = 55 degrees +/- 19 degrees(stat) +/- 14 degrees(syst) at pffisffi = 2.6454 GeV, and 78 degrees +/- 22 degrees(stat) +/- 9 degrees(syst) at ffis ffi p = 2.9000 GeV. For the first time, the phase of the hyperon electromagnetic form factors is explored in a wide range of four -momentum transfer. The evolution of the phase along with fourmomentum transfer is an important input for understanding its asymptotic behavior and the dynamics of baryons.
摘要：
Background: Olfactory impairment has been reported in patients with depression and in rodent models of depression. Olfactory epithelium (OE) is the only peripheral neural tissue connected to the brain that has the potential for self-renewal. We hypothesized the olfactory deficit during depression may be related to the dysfunction of OE progenitor cells. The aim of the present study was therefore to evaluate the expansion and neuronal differentiation potency of cultured OE progenitor cells obtained from a rat model of depression. Methods: Rats were exposed to chronic unpredictable mild stress procedures to establish a depressive-like state. Depressive-like behavior and olfactory sensing function were then evaluated and compared with control rats. Primary OE progenitor cells were cultured in vitro. The proliferation potency and survival of OE progenitor cells were assessed by 5-Ethynyl-2 '-deoxyuridine staining and Cell Counting Kit-8 (CCK8), respectively, while cellular apoptosis was measured by flow cytometry. The neuronal differentiation potency of OE progenitor cells was evaluated by measurement of the protein and mRNA level of beta-3 tubulin, a marker of neural cells. mRNA expression associated with neural stemness was examined by quantitative reverse transcription polymerase chain reaction (RT-PCR). Results: Depressive-like rats showed decreased olfactory function. OE progenitor cells from depressive-like rats showed reduced cell proliferation/survival and neuronal differentiation potency. Moreover, OE progenitor cells from depressive-like rats showed decreased expression of mRNA related to neural stemness. Conclusions: These results indicate the impaired function of OE progenitor cells may contribute to the olfactory deficit observed during depression. The OE may therefore provide a window for the study of depression.
摘要：
Titanium (Ti) alloys are widely used in high-tech fields like aerospace and biomedical engineering. Laser additive manufacturing (LAM), as an innovative technology, is the key driver for the development of Ti alloys. Despite the significant advancements in LAM of Ti alloys, there remain challenges that need further research and development efforts. To recap the potential of LAM high-performance Ti alloy, this article systematically reviews LAM Ti alloys with up-to-date information on process, materials, and properties. Several feasible solutions to advance LAM Ti alloys are reviewed, including intelligent process parameters optimization, LAM process innovation with auxiliary fields and novel Ti alloys customization for LAM. The auxiliary energy fields (e.g. thermal, acoustic, mechanical deformation and magnetic fields) can affect the melt pool dynamics and solidification behaviour during LAM of Ti alloys, altering microstructures and mechanical performances. Different kinds of novel Ti alloys customized for LAM, like peritectic alpha-Ti, eutectoid (alpha + beta)-Ti, hybrid (alpha + beta)-Ti, isomorphous beta-Ti and eutectic beta-Ti alloys are reviewed in detail. Furthermore, machine learning in accelerating the LAM process optimization and new materials development is also outlooked. This review summarizes the material properties and performance envelops and benchmarks the research achievements in LAM of Ti alloys. In addition, the perspectives and further trends in LAM of Ti alloys are also highlighted. Substantive review of innovations in methodology, process and materials of AM Ti alloys.Novel titanium alloys designed for laser additive manufacturing.Machine learning assisted alloy design and process optimization.Field-assisted additive manufacturing for titanium alloys fabrications.
通讯作者：
Manbo Cai<&wdkj&>Xiaoming Xie<&wdkj&>Yutian Zou<&wdkj&>Manbo Cai Manbo Cai Manbo Cai<&wdkj&>Xiaoming Xie Xiaoming Xie Xiaoming Xie<&wdkj&>Yutian Zou Yutian Zou Yutian Zou
作者机构：
[Hongbo Zhu; Manbo Cai; Hongbo Zhu Hongbo Zhu Hongbo Zhu; Manbo Cai Manbo Cai Manbo Cai] The First Affiliated Hospital, Hengyang Medical School, University of South China, Hengyang, Hunan, China;[Jindong Xie; Xinpei Deng; Yi Xie; Peng Liu; Wei Deng; Li Ning; Yuhui Tang; Yuying Sun; Hailin Tang; Xiaoming Xie; Yutian Zou; Jindong Xie Jindong Xie Jindong Xie; Xinpei Deng Xinpei Deng Xinpei Deng; Yi Xie Yi Xie Yi Xie; Peng Liu Peng Liu Peng Liu; Wei Deng Wei Deng Wei Deng; Li Ning Li Ning Li Ning; Yuhui Tang Yuhui Tang Yuhui Tang; Yuying Sun Yuying Sun Yuying Sun; Hailin Tang Hailin Tang Hailin Tang; Xiaoming Xie Xiaoming Xie Xiaoming Xie; Yutian Zou Yutian Zou Yutian Zou] State Key Laboratory of Oncology in South China, Guangdong Provincial Clinical Research Center for Cancer, Sun Yat-Sen University Cancer Center, Guangzhou, Guangdong, China
通讯机构：
[Manbo Cai; Manbo Cai Manbo Cai Manbo Cai] T;[Xiaoming Xie; Yutian Zou; Xiaoming Xie Xiaoming Xie Xiaoming Xie; Yutian Zou Yutian Zou Yutian Zou] S;The First Affiliated Hospital, Hengyang Medical School, University of South China, Hengyang, Hunan, China<&wdkj&>State Key Laboratory of Oncology in South China, Guangdong Provincial Clinical Research Center for Cancer, Sun Yat-Sen University Cancer Center, Guangzhou, Guangdong, China
摘要：
Flowchart of our study. By utilizing multi‐omics pan‐cancer cohorts, our study firstly offers a pan‐cancer blueprint of the molecular and clinical characteristics of disulfidptosis regulators, as wells as disulfidptosis activity, which lay a solid foundation for the disulfidptosis‐targeting strategy in precision cancer treatment. Abstract Disruption of disulfide homeostasis during biological processes can have fatal consequences. Excess disulfides induce cell death in a novel manner, termed as “disulfidptosis.” However, the specific mechanism of disulfidptosis has not yet been elucidated. To determine the cancer types sensitive to disulfidptosis and outline the corresponding treatment strategies, we firstly investigated the crucial functions of disulfidptosis regulators pan‐cancer at multi‐omics levels. We found that different tumor types expressed dysregulated levels of disulfidptosis regulators, most of which had an impact on tumor prognosis. Moreover, we calculated the disulfidptosis activity score in tumors and validated it using multiple independent datasets. Additionally, we found that disulfidptosis activity was correlated with classic biological processes and pathways in various cancers. Disulfidptosis activity was also associated with tumor immune characteristics and could predict immunotherapy outcomes. Notably, the disulfidptosis regulator, glycogen synthase 1 (GYS1), was identified as a promising target for triple‐negative breast cancer and validated via in vitro and in vivo experiments. In conclusion, our study elucidated the complex molecular phenotypes and clinicopathological correlations of disulfidptosis regulators in tumors, laying a solid foundation for the development of disulfidptosis‐targeting strategies for cancer treatment.
通讯机构：
[Liu, M ] U;Univ South China, Coll Nucl Sci & Technol, Hengyang 421200, Hunan, Peoples R China.;Zhuhai Tsinghua Univ, Res Inst Innovat Ctr, 101 Univ Ave, Zhuhai 519000, Peoples R China.
摘要：
In this study, DyFe1-xCrxO3 (DFCO) was synthesized by sol-gel and underwent magnetic measurements and analysis. The experimental data were fitted and calculated by a four-sublattice molecular field model. Unlike previous studies, we found that in DyFe1-xCrxO3, the spin of the A-site rare earth ion Dy3+ also changed simultaneously with the spin reorientation of the Fe3+/Cr3+ ions. The effective spin is defined as the projection of the A site's total spin on the B site's spin plane, and the curve of temperature changes was obtained after fitting. This is convincing and, at the same time, provides a reference for the development of spintronic devices in the future.
摘要：
Cardiovascular disease (CVD) has a high incidence and low cure rate worldwide, and atherosclerosis (AS) is the main factor inducing cardiovascular disease, of which lipid deposition in the vessel wall is the main marker of AS. Currently, although statins can be used to lower lipids and low-density lipoprotein (LDL) in AS, the cure rate for AS remains low. Therefore, there is an urgent need to develop new therapeutic approaches, and stem cells are now widely studied, while stem cells are a class of cell types that always maintain the ability to differentiate and can differentiate to form other cells and tissues, and stem cell transplantation techniques have shown efficacy in the treatment of other diseases. With the establishment of cellular therapies and continued research in stem cell technology, stem cells are also being used to address the problem of AS. In this paper, we focus on recent research advances in stem cell therapy for AS and briefly summarize the relevant factors that induce the formation of AS. We mainly discuss the efficacy and application prospects of mesenchymal stem cells (MSCs) for the treatment of AS, in addition to the partial role and potential of exosomes in the treatment of AS. Further, provide new ideas for the clinical application of stem cells.
作者：
Ablikim, M.;Achasov, M. N.;Adlarson, P.;Ai, X. C.;Aliberti, R.;...
期刊：
Journal of High Energy Physics,2024年(1) ISSN：1029-8479
通讯作者：
Ablikim, M
作者机构：
[Yu, B. X.; Yu, G.; Hu, T.; Ning, Z.; Zhang, P.; Wen, S. P.; Shi, X.; Sun, G. X.; Yang, Y.; Ma, M. M.; Zhang, S.; Chen, T.; Hou, X. T.; Zhu, Z. A.; Xu, G. F.; Wang, K.; Zhou, L. P.; Heng, Y. K.; Ji, Q.; Zhang, J. W.; Rong, G.; Batozskaya, V; Guan, C. Y.; Qi, F. Z.; Wang, Y. F.; Wang, L. L.; Ouyang, Q.; Liao, Y. P.; Zhang, A. Q.; Ji, X. B.; Qian, S.; Dong, M. Y.; Fang, S. S.; Chang, J. F.; Liu, Z. A.; Yang, T.; Yan, X. Q.; Wu, J. F.; Sun, S. S.; Ding, B.; Fu, C. D.; Zhang, Y.; Lou, X. C.; Lin, T.; Zhang, B. X.; Xing, T. Y.; Cao, G. F.; Wu, L. H.; Zhao, Y. B.; Fu, Y. W.; Zheng, J. P.; Jiang, X. S.; Kiuchi, R.; Gu, M. H.; Lu, Y. P.; Dong, L. Y.; Zhang, H. Q.; Zhao, G.; Wu, L. J.; Li, L. J.; Yuan, Y.; Lu, X. L.; Wu, Z.; Fang, Y.; Luo, X. L.; Ji, X. L.; Zhang, X. M.; Li, L. K.; Li, H. B.; Liu, F.; Liang, H.; Huang, Y. P.; Zhang, J. Y.; Zhao, L.; Yin, J. H.; Song, W. M.; Chen, X. T.; Zhang, J. Z.; He, K. L.; Liu, H.; Chen, G.; Ablikim, M.; Liu, C. X.; Chang, W. L.; Li, X.; Zhu, K.; Zhao, J. Z.; Mao, Z. P.; Xiao, S. Y.; Lu, J. G.; Liu, P. L.; Jing, M. Q.; Sun, H. K.; Chen, Y. B.; Du, M. C.; Wang, Z.; Ablikim, M; Zhao, J. Y.; Dong, J.; Liu, K.; Shi, J. Y.; Wang, H. P.; Yuan, C. Z.; Wang, Y.; Tang, G. Y.; Yuan, S. C.; Zhang, H. Y.; Chen, M. L.; Zhang, Z. H.; Hou, G. Y.; Shen, H. F.; Shao, L. G.; Hou, Z. L.; Sun, Y. Z.; Liu, B. J.; Zhu, K. J.; Liu, H. M.; Xu, C. F.; Ma, H. L.; Sun, T.; Ye, M.; Xie, Y. G.; Chen, H. S.; Cao, N.; Deng, Z. Y.; Ma, Q. M.; Wang, Z. Y.; Cai, X.; Yuan, X. Q.; Zhang, Y. H.; Ma, R. Q.; Shi, R. S.; Zheng, W. J.; Zou, J. H.; Liu, J. Y.; Kui, X.; Li, W. G.; Wang, Y. Q.; Mo, X. H.; Fang, J.; Shen, X. Y.; Ma, X. Y.; Hu, H. M.; Li, K.; Gong, W. X.; Zhang, J.; Xu, W.; Hu, Y.; Wang, B.; Zhang, B. L.; Ma, J. L.; Wang, Meng; Yang, Y. X.; Miao, H.; Li, F.; Lu, Z. H.; Yang, H. X.; Qin, Z. H.; Li, G.; Ping, R. G.; Qiu, J. F.; Dai, H. L.; Li, W. D.; Fang, W. X.; Zeng, Y. J.] Inst High Energy Phys, Beijing 100049, Peoples R China.;[Yuan, L.] Beihang Univ, Beijing 100191, Peoples R China.;[Li, Lei] Beijing Inst Petrochem Technol, Beijing 102617, Peoples R China.;[Jaeger, S.; Fritsch, M.; Wiedner, U. W.; Pelizaeus, M.; Kuessner, M. K.; Kopf, B.; Wollenberg, L.; Holtmann, T.; de Boer, R. E.; Feldbauer, F.; Heinsius, F. H. H.; Coen, S. C.; Wenzel, C. W.] Bochum Ruhr Univ, D-44780 Bochum, Germany.;[Achasov, M. N.; Nikolaev, I. B.; Muchnoi, N. Yu] Budker Inst Nucl Phys SB RAS BINP, Novosibirsk 630090, Russia.
通讯机构：
[Ablikim, M ] I;Inst High Energy Phys, Beijing 100049, Peoples R China.
摘要：
Using (10087 +/- 44) x 10(6) J/psi events collected with the BESIII detector at the BEPCII e(+)e(-) storage ring at the center-of-mass energy of root s = 3.097 GeV, we present a search for the rare semi-muonic charmonium decay J/psi -> D-mu(+)nu(mu) + c.c.. Since no significant signal is observed, we set an upper limit of the branching fraction to be B (J/psi -> D-mu(+)nu(mu) + c.c.) < 5.6 x 10(-7) at 90% confidence level. This is the first search for the weak decay of charmonium with a muon in the final state.
摘要：
We calculate Alfvén eigenmodes within a magnetic island (MiAE) which have been conjectured over a decade ago. Starting from a cylindrical plasma equilibrium, we calculate the complete metric of the island interior assuming an iota profile with a constant shear for Wendelstein 7-X parameters. Then, we solve the resulting Magneto-Hydrodynamic equations inside the island optionally considering Finite Larmor Radius corrections. We find various eigenmodes in the lowest gaps for n = 0. The eigenmode with the lowest frequency shows a weakly non-linear dependence on the island width which deviates considerably from an earlier estimate.
期刊：
BRITISH JOURNAL OF OPHTHALMOLOGY,2024年108(3):329-335 ISSN：0007-1161
通讯作者：
Xiao, QG;Qi, L;Zhang, J
作者机构：
[He, Siqi; Jiang, Weijie; Liu, Logen; Zhang, Jia] Univ South China, Affiliated Hosp 2, Hengyang Med Sch, Clin Res Ctr, Hengyang, Hunan, Peoples R China.;[Chen, Tuo; Li, Juan; Meng, Xia; Xiao, Qiguo; Lu, Jing] Univ South China, Affiliated Hosp 2, Hengyang Med Sch, Dept Gastroenterol, Hengyang, Hunan, Peoples R China.;[Xu, Ying] Jinan Univ, Minist Educ, Guangdong Hong Kong Macau Inst Cent Nervous Syst, Key Lab Cent Nervous Syst Regenerat, Guangzhou, Peoples R China.;[Qi, Ling] Guangzhou Med Univ, Affiliated Hosp 6, Qingyuan Peoples Hosp, Inst Digest Dis, Qingyuan, Peoples R China.;[Zhang, Jia] Univ South China, Affiliated Hosp 2, Hengyang 421001, Hunan, Peoples R China.
通讯机构：
[Xiao, QG ; Zhang, J ] U;[Qi, L ] G;Univ South China, Affiliated Hosp 2, Hengyang Med Sch, Dept Gastroenterol, Hengyang, Hunan, Peoples R China.;Guangzhou Med Univ, Affiliated Hosp 6, Qingyuan Peoples Hosp, Inst Digest Dis, Qingyuan, Peoples R China.;Univ South China, Affiliated Hosp 2, Hengyang 421001, Hunan, Peoples R China.
关键词：
immunology;inflammation;retina
摘要：
MicroRNAs belong to the family of non-coding RNAs that participate in cell proliferation, cell death and development. The Müller glial cells are the inherent and specific neuroglia cells in the retinal organisation and play significant roles in retinal neuroprotection, organisational maintenance, inflammation and immunity, regeneration, and the occurrence and development of retinal diseases. However, only a few studies report the underlying mechanism of how miRNAs drive the function of Müller glial cells in the development of retinal diseases. This review aims to summarise the roles of miRNAs in retinal Müller glial cell function, including gliogenesis, inflammation and immunity, regeneration, the development of retinal diseases, and retinal development. This review may point out a novel miRNA-based insight into retinal repair and regeneration. MiRNAs in Müller glial cells may be considered a diagnostic and therapeutic target in the process of retinal repair and regeneration.
The data sets used and analysed during the current study are included within the article and its additional files. All material used in this review are from publicly available articles.
摘要：
BACKGROUND: Accurately predicting post-discharge mortality risk in patients with ST-segment elevation myocardial infarction (STEMI) undergoing primary percutaneous coronary intervention (PPCI) remains a complex and critical challenge. The primary objective of this study was to develop and validate a robust risk prediction model to assess the 12-month and 24-month mortality risk in STEMI patients after hospital discharge. METHODS: A retrospective study was conducted on 664 STEMI patients who underwent PPCI at Xiangtan Central Hospital Chest Pain Center between 2020 and 2022. The dataset was randomly divided into a training cohort (n = 464) and a validation cohort (n = 200) using a 7:3 ratio. The primary outcome was all-cause mortality following hospital discharge. The least absolute shrinkage and selection operator (LASSO) regression model was employed to identify the optimal predictive variables. Based on these variables, a regression model was constructed to determine the significant predictors of mortality. The performance of the model was evaluated using receiver operating characteristic (ROC) curve analysis and decision curve analysis (DCA). RESULTS: The prognostic model was developed based on the LASSO regression results and further validated using the independent validation cohort. LASSO regression identified five important predictors: age, Killip classification, B-type natriuretic peptide precursor (NTpro-BNP), left ventricular ejection fraction (LVEF), and the usage of angiotensin-converting enzyme inhibitors/angiotensin receptor blockers/angiotensin receptor-neprilysin inhibitors (ACEI/ARB/ARNI). The Harrell's concordance index (C-index) for the training and validation cohorts were 0.863 (95% CI: 0.792-0.934) and 0.888 (95% CI: 0.821-0.955), respectively. The area under the curve (AUC) for the training cohort at 12months and 24months was 0.785 (95% CI: 0.771-0.948) and 0.812 (95% CI: 0.772-0.940), respectively, while the corresponding values for the validation cohort were 0.864 (95% CI: 0.604-0.965) and 0.845 (95% CI: 0.705-0.951). These results confirm the stability and predictive accuracy of our model, demonstrating its reliable discriminative ability for post-discharge all-cause mortality risk. DCA analysis exhibited favorable net benefit of the nomogram. CONCLUSION: The developed nomogram shows potential as a tool for predicting post-discharge mortality in STEMI patients undergoing PPCI. However, its full utility awaits confirmation through broader external and temporal validation.
摘要：
This study utilizes both experimental and computational approaches to investigate the performance of Lu(2)Ti(2)O(7)(LTO) and Lu(1.5)Ce(0.5)Ti(2)O(7+x)(LCTO) pyrochlores under high pressure. The structural changes of LTO and LCTO pyrochlores were characterized usingin-situsynchrotron x-ray diffraction (SXRD) andin-situRaman spectroscopy at pressures up to 44.6 GPa. The kinks inP-aandP-Vcurves at around 5 GPa are mainly attributed to the interaction between the pressure medium and the isostructural changes. The onset pressures for transitioning from the cubic pyrochlore phase (Fd-3 m) to the monoclinic phase (P2(1)) are observed at 32.5 GPa and 38.1 GPa, respectively. It is important to note that at the highest measured pressures, the phase transition remains incomplete. This partial transition is likely the result of oriented disorder among cations and anions under high pressure. In addition, introducing Ce as a dopant significantly enhances structural stability. This can be explained by the larger ionic radius of Ce, which hinders the disordering process.
期刊：
RECENT PATENTS ON ANTI-CANCER DRUG DISCOVERY,2024年 ISSN：1574-8928
作者机构：
[Jiang, Baohong] Department of Pharmacy, the First Affiliated Hospital, Hengyang Medical School, University of South China, Hengyang, China;[Li, Na; Ye, Feng] State Key Laboratory of Oncology in South China, Guangdong Provincial Clinical Research Center for Cancer, Sun Yat-Sen University Cancer Center, Guangzhou, China;[Du, Wei] The First People's Hospital of Changde, Xiangya School of Medicine, Central South University, Changde, China;[Zeng, Lijun; Zhu, Hongbo; Tang, Yuanbin; Luo, Lunqi] Department of Oncology, The First Affiliated Hospital, Hengyang Medical School, University of South China, Hengyang, Hunan, People's Republic of China
关键词：
Ganoderma lucidum spore powder;prognosis;propensity score matching;triple-negative breast cancer
摘要：
BACKGROUND: Ganoderma lucidum extracts are widely used as adjuvants in the treatment of triple-negative breast cancers (TNBC) in China. However, its clinical value in TNBC remains unclear. Therefore, we investigated the clinical effect of Ganoderma lucidum spore powder (GLSP) on prognosis in patients with early-stage TNBC in this study. METHODS: A total of 388 patients who were diagnosed with TNBC at the Sun Yat-sen University Cancer Center from February 2012 to December 2017 were retrospectively reviewed. The propensity score matching (PSM) method was applied to balance baseline data. Kaplan-Meier method and Cox proportional hazards model were used to evaluate the relationship between GLSP and prognosis. RESULTS: Of the 388 patients, 72 (18.6%) patients took GLSP. After PSM, 208 patients were selected for analysis, including 71 (34.1%) patients who took the powder. The median followup period was 51 months. The patients who took GLSP (the treatment group) and those who did not take GLSP (the control group) were similar in most clinico-pathological features before being matched. However, the proportion of patients who received breast-conserving surgery in the treatment group was higher (27.8% vs. 16.1%; p =0.021) than in the control group. No significant difference was found in the baseline data between the two groups for the matched cohort (all p >0.05). Univariate analysis and multivariate analysis showed that patients taking GLSP benefited from improved overall survival (OS) (HR=0.159, p = 0.002) and disease-free survival (DFS) (HR=0.232, p = 0.005) before being matched. The main result of the survival analysis after matching was similar to that described above. Patients in the treatment group achieved both greater OS and DFS benefits than patients in the control group (all p < 0.05). In stratified analysis according to TNM stages, after adjusting for the significant prognostic factors, multivariate analysis revealed that the treatment group had better OS than the control group for patients in stages II and III (HR=0.172, p =0.004). CONCLUSIONS: The results of this real-world propensity-score-matched study suggest that GLSP can improve OS and DFS in early-stage TNBC patients. A higher OS was observed for patients taking GLSP, particularly in stage II and stage III.
期刊：
Frontiers in Pharmacology,2024年15:1352730 ISSN：1663-9812
通讯作者：
Zhuang, SG
作者机构：
[Xiong, Chongxiang; Wang, Xin; Hou, Qidi] Guangdong Med Univ, Affiliated Hosp Dongguan 1, Dept Nephrol, Dongguan, Guangdong, Peoples R China.;[Deng, Jin] Univ South China, Affiliated Hosp 1, Hengyang Med Sch, Dept Nephrol, Hengyang, Peoples R China.;[Zhuang, Shougang] Rhode Isl Hosp, Dept Med, Providence, RI 02903 USA.;[Zhuang, Shougang] Brown Univ, Sch Med, Providence, RI 02903 USA.;[Zhuang, Shougang] Tongji Univ, Sch Med, Shanghai East Hosp, Dept Nephrol, Shanghai, Peoples R China.
通讯机构：
[Zhuang, SG ] R;Rhode Isl Hosp, Dept Med, Providence, RI 02903 USA.;Brown Univ, Sch Med, Providence, RI 02903 USA.;Tongji Univ, Sch Med, Shanghai East Hosp, Dept Nephrol, Shanghai, Peoples R China.
关键词：
NF-κB;PP1;Src;Src family kinases;fibrosis;hyperuricemia;hyperuricemic nephropathy;kidney
摘要：
Hyperuricemia is an independent risk factor for chronic kidney disease and contributes to renal fibrosis. This study aims to investigate the effect of Src family kinase (SFK) inhibition on the development of hyperuricemic nephropathy (HN) and the mechanisms involved. In a rat model of HN, feeding rats a mixture of adenine and potassium oxonate increased Src phosphorylation, severe glomerular sclerosis, and renal interstitial fibrosis, accompanied by renal dysfunction and increased urine microalbumin excretion. Administration of PP1, a highly selective SFK inhibitor, prevented renal dysfunction, reduced urine microalbumin, and inhibited activation of renal interstitial fibroblasts and expression of extracellular proteins. PP1 treatment also inhibited hyperuricemia-induced activation of the TGF-β1/Smad3, STAT3, ERK1/2, and NF-κB signaling pathways and expression of multiple profibrogenic cytokines/chemokines in the kidney. Furthermore, PP1 treatment significantly reduced serum uric acid levels and xanthine oxidase activity. Thus, blocking Src can attenuate development of HN via a mechanism associated with the suppression of TGF-β1 signaling, inflammation, and uric acid production. The results suggest that Src inhibition might be a promising therapeutic strategy for HN.
