作者机构：
[Qiyuan Li; Xianglong Shi; Xiaoli Li; Jing Pang] Department of Radiology, The Affiliated Hospital of Qingdao University, No. 369, Shanghai Road, 266000, Qingdao, Qingdao, Shandong, China;[Yanmei Wang] GE Healthcare China, Pudong New Town, Shanghai, China;[Xia Zhao] Department of Radiology, The Affiliated Hospital of Shandong University of Traditional Chinese Medicine, Jinan, Shandong, China;[Yuchao Xu] School of Nuclear Science and Technology, University of South China, Hengyang, Hunan, China;[Ning Wang] Department of Radiology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, No. 324, Jingwu Road, 250021, Jinan, Shandong, China. 327242909@qq.com
通讯机构：
[Ning Wang; Feng Duan; Pei Nie] D;Department of Radiology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, China<&wdkj&>Department of Radiology, The Affiliated Hospital of Qingdao University, Qingdao, China<&wdkj&>Department of Radiology, The Affiliated Hospital of Qingdao University, Qingdao, China
摘要：
The preoperative identification of tumor grade in chondrosarcoma (CS) is crucial for devising effective treatment strategies and predicting outcomes. The study aims to build and validate a CT-based radiomics nomogram (RN) for the preoperative identification of tumor grade in CS, and to evaluate the correlation between the RN-predicted tumor grade and postoperative outcome. A total of 196 patients (139 in the training cohort and 57 in the external validation cohort) were derived from three different centers. A clinical model, radiomics signature (RS) and RN (which combines significant clinical factors and RS) were developed and validated to assess their ability to distinguish low-grade from high-grade CS with area under the curve (AUC). Additionally, Kaplan-Meier survival analysis was applied to examine the association between RN-predicted tumor grade and recurrence-free survival (RFS) of CS. The predictive accuracy of the RN was evaluated using Harrell’s concordance index (C-index), hazard ratio (HR) and AUC. Size, endosteal scalloping and active periostitis were selected to build the clinical model. Three radiomics features, based on CT images, were selected to construct the RS. Both the RN (AUC, 0.842) and RS (AUC, 0.835) were superior to the clinical model (AUC, 0.776) in the validation set (P = 0.003, 0.040, respectively). A correlation between Nomogram score (Nomo-score, derived from RN) and RFS was observed through Kaplan-Meier survival analysis in the training and test cohorts (log-rank P < 0.050). Patients with high Nomo-score tumors were 2.669 times more likely to suffer recurrence than those with low Nomo-score tumors (HR, 2.669, P < 0.001). The CT-based RN performed well in predicting both the histologic grade and outcome of CS.
摘要：
Capsaicin is the main active ingredient of chili peppers and the most pungent alkaloid. It is reported that capsaicin has many pharmacological effects such as analgesia, anticancer, anti-inflammatory, antibacterial, and anti-obesity. However, the application of capsaicin is limited by its adverse side effects, such as stomach irritation, stomach cramps, and burning sensation. In recent years, many capsaicin derivatives have been synthesized and their biological activities have been evaluated. Some capsaicin derivatives have shown promising activities in cells and animal models. Herein, we described the synthesis and biological activity of capsaicin and its derivatives. It is hoped that the insights obtained in this perspective will facilitate the synthesis of a second generation of capsaicin analogs with improved biological activities.
作者：
Di Zhang*;Li-Yan Zhang;Ke Zhang;Han Zhang;Huan-fang Zhang;...
期刊：
BMC Nursing,2024年23(1):1-10 ISSN：1472-6955
通讯作者：
Di Zhang
作者机构：
[Di Zhang] International Academy of Red Cross, Soochow University, Lvbo Lou, 1 Shizi Street, Jiangsu, China. dizhang@suda.edu.cn;[Li-Yan Zhang] International Academy of Red Cross, Soochow University, Lvbo Lou, 1 Shizi Street, Jiangsu, China;[Li-Yan Zhang] Disaster Nursing Committee, Chinese Nursing Association, Beijing, China;[Ke Zhang] School of Health Management, China Medical University, Shenyang, China;[Huan-fang Zhang] The First Affiliated Hospital of University of South China, Hengyang, Hunan, China
通讯机构：
[Zhang, Di] I;International Academy of Red Cross, Soochow University, Lvbo Lou, 1 Shizi Street, Jiangsu, China.
关键词：
Disaster literacy;Emergency management;Nurse;Qualitative research
摘要：
As the largest group of healthcare professionals, nurses play an indispensable and crucial role in disaster response. The enhancement of nurses’ disaster literacy is imperative for effective disaster emergency management. However, there is currently a lack of knowledge regarding nurses’ disaster literacy. This study represents the first attempt to explore the key components and characteristics of disaster literacy among nurses. A qualitative descriptive design was employed, and the reporting followed the Consolidated Criteria for Reporting Qualitative Research (COREQ) guidelines (refer to File S1). The purposive sampling method was utilized. Thirty-one rescue nurses from 31 medical institutions across 25 provinces and regions in China were recruited to participate in the study. The respondents were requested to share their experiences and insights regarding disaster rescue operations. Inductive content analysis was employed for data examination. The results indicated that rescue nurses universally recognized that there was a pressing need to enhance the level of disaster literacy among nurses. The disaster literacy of nurses encompasses nine dimensions: physical and mental quality, disaster rescue general knowledge, professional and technical competence, professional ethics, teamwork, emotional ability, information literacy, leadership, and knowledge transformation. To ensure national sustainability, government departments, healthcare organizations, and hospital administrators can accurately evaluate the disaster literacy of individual clinical nurses, groups, and the workforce as a whole through nine dimensions, which also can provide evidence to support the development of precision strategies to strengthen the disaster literacy of nurses.
关键词：
Composites aerogel;Colorimetry;Controllable catalysis;Recyclable and accurate detection;Visual and on -site sensing
摘要：
Colorimetric detection methods have been attracted and preferred for analytes assessment. Although simple and highly efficient colorimetric strategies based on nanozymes have been developed, there remain inherent problems of intrinsic color interference for accurate analysis and erratic activity to lose controllable, recyclable, and sensitive efficacies. Herein, we have prepared a novel composite aerogel named PACO that is rationally assembled by the poly (vinyl alcohol) aerogel (PVA aerogel) and copper oxide nanoparticles (CuO NPs) to address these challenges. PACO has been proved to exhibit the controllable peroxidase (POD)-like activity through separating the solid PACO from the aqueous solutions. Meanwhile, PACO can avoid intrinsic color interferences and provide more accurate detection performance for naked eye discrimination. Furthermore, PACO shows the recyclable and long lifetime performances for sensitive detection of water pollutants including hydroquinone (HQ) and catechol (CC) with the LOD of 0.084 mu M and 0.101 mu M, respectively. Finally, we have constructed a smartphone-based colorimetric detection platform to realize the on-site and visualanalysis of water pollutants in real water samples. Overall, PACO achieves the advanced detection performances to exhibit great potential in nanozymes based sensing method development and colorimetric-related analytical research.
摘要：
A deep framework for the accelerated multislice magnetic resonance imaging (MRI) reconstruction is proposed here. It exploits the non‐local interslice correlation information between adjacent slices in MRI image sequences to reconstruct high‐quality undersampled MRI images. A novel texture Transformer architecture for MRI reconstruction is designed. Such a framework enables united feature learning across target slice and adjacent slices, which encourages the exploration of deep features and transferring of accurate texture features across adjacent slices by the attention mechanism. The proposed multislice texture transformer network can be constructed in a cross‐scale way. It enables to recovery textures of MRI images via different levels, and enables to reserve more details in MRI reconstruction. Abstract Magnetic resonance imaging (MRI) is a non‐interposition imaging technique that provides rich anatomical and physiological information. Yet it is limited by the long imaging time. Recently, deep neural networks have shown potential to significantly accelerate MRI. However, most of these approaches ignore the correlation between adjacent slices in MRI image sequences. In addition, the existing deep learning‐based methods for MRI are mainly based on convolutional neural networks (CNNs). They fail to capture long‐distance dependencies due to the small receptive field. Inspired by the feature similarity in adjacent slices and impressive performance of Transformer for exploiting the long‐distance dependencies, a novel multislice texture transformer network is presented for undersampled MRI reconstruction (TTMRI). Specifically, the proposed TTMRI is consisted of four modules, namely the texture extraction, correlation calculation, texture transfer and texture synthesis. It takes three adjacent slices as inputs, in which the middle one is the target image to be reconstructed, and the other two are auxiliary images. The multiscale features are extracted by the texture extraction module and their inter‐dependencies are calculated by the correlation calculation module, respectively. Then the relevant features are transferred by the texture transfer module and fused by the texture synthesis module. By considering inter‐slice correlations and leveraging the Transformer architecture, the joint feature learning across target and adjacent slices are encouraged. Moreover, TTMRI can be stacked with multiple layers to recover more texture information at different levels. Extensive experiments demonstrate that the proposed TTMRI outperforms other state‐of‐the‐art methods in both quantitative and qualitative evaluationsions.
摘要：
Chronic wound healing is a class of diseases influenced by multiple complex factors, causing severe psychological and physiological impact on patients. It is an intractable clinical challenge and its possible mechanisms are not yet clear. It has been proven that adipose stem cell-derived exosomes (ADSC-Exos) can promote wound healing and inhibit scar formation by regulating inflammation, promoting cell proliferation, migration, and angiogenesis, regulating matrix remodeling, which provides a new approach for wound healing through biological treatment. This review focuses on the mechanism, treatment, and administration methods of ADSC-Exos in wound healing, providing a comprehensive understanding the mechanisms of ADSC-Exos on wound healing. This journal requires that authors assign a level of evidence to each article. For a full description of these Evidence-Based Medicine ratings, please refer to the Table of Contents or the online Instructions to Authors
www.springer.com/00266
.
作者：
Shao, Zuliang;Liu, He*;Lin, Qibin;Wu, Mingyang;Sun, Lei
期刊：
Fuel,2024年362:130790 ISSN：0016-2361
通讯作者：
Liu, He;Lin, QB
作者机构：
[Liu, He; Shao, Zuliang; Lin, QB; Lin, Qibin] Univ South China, Sch Resource Environm & Safety Engn, Hengyang 421001, Peoples R China.;[Liu, He] Wuhan Univ, Sch Civil Engn, Key Lab Safety Geotech & Struct Engn Hubei Prov, Wuhan 430072, Peoples R China.;[Wu, Mingyang] Chinese Acad Sci, Inst Rock & Soil Mech, State Key Lab Geomech & Geotech Engn, Wuhan 430071, Peoples R China.;[Sun, Lei] Univ Toronto, Dept Civil & Mineral Engn, Toronto, ON M5S 1A4, Canada.
通讯机构：
[Liu, H; Lin, QB ] U;Univ South China, Sch Resource Environm & Safety Engn, Hengyang 421001, Peoples R China.
关键词：
Natural gas hydrate;Thermal injection;Heat and mass transfer;Dissociation front;Temperature distribution
摘要：
Natural Gas Hydrate (NGH) is characterized by large reserves and cleanliness, which has attracted wide attention around the world. Thermal stimulation is considered to be one of the possible methods to facilitate hydrate dissociation. In this paper, the hydrate is dissociated through injecting hot water. In order to reveal the influence of the speed and the temperature of injected hot water on the temperature distribution, hydrate dissociation front, gas production rate, and cumulative gas production, a 2D cylindrical mathematical model of thermally-induced hydrate dissociation was established. The results show that the dissociation process can be regarded as a moving boundary ablation process. The dissociation front divides the whole reservoir into three sections: complete dissociation section, ongoing dissociation section, and undissociated section, and the range of ongoing dissociation section is a very narrow area characterized by a relatively intensive temperature contour, which indicates that the temperature drops rapidly during the hydrate dissociation. The temperature at the dissociation front is almost constant under different hot water injection speeds or temperatures. The injection speed and the temperature of hot water seem to have similar effects on hydrate dissociation. The enhanced hot water injection speed or hot water injection temperature will result in a faster gas production rate, a quicker movement of the dissociation front, and a shorter duration time of gas production, however, hot water injection speed and temperature have little impact on the final gas production. The results may provide a guidance for safely and efficiently exploiting NGH.
关键词：
autophagy;seizure-induced brain injury;SIRT3;Xyloketal B
摘要：
Brain damage in children due to seizures is irreversible and has been a major public health concern. The herbal monomer Xyloketal B (Xyl-B) can be used as a neuroprotective drug because of its antioxidant, antiapoptotic, and anti-inflammatory effects but with few adverse effects. In this article, we constructed a rat developmental convulsion model and a primary hippocampal neuronal cell convulsion model, through which we studied hippocampal neuronal morphology and neuronal apoptosis using H&E staining and TUNEL staining, respectively. Moreover, we measured TNF-α, IL-6, and IL-1β inflammatory factor levels using ELISA, MDA, and SOD kits. The expression of SIRT3 in hippocampal tissues was determined by qPCR and Western blotting. The expression of autophagy-related proteins such as LC3, p62, and Beclin-1 was evaluated by Western blotting or immunohistochemistry. The role of SIRT3 and autophagic activity with Xyl-B in convulsive seizure-induced brain injury was investigated by knocking down SIRT3 expression levels. Our results showed that Xyl-B plays a neuroprotective role in convulsive seizure-induced brain injury by increasing SIRT3 expression and activating the autophagy pathway. The regulatory role of SIRT3 in the autophagy pathway with Xyl-B treatment was explored by knocking down SIRT3 expression and inhibiting autophagy. Our results revealed that SIRT3 enhances the protective effect of Xyl-B against postconvulsive brain injury by regulating AMPK/mTOR signaling-mediated autophagy.
期刊：
Chinese Journal of Physics,2024年 ISSN：0577-9073
通讯作者：
Wenbin Lin
作者机构：
[Jie Li] School of Nuclear Science and Technology, University of South China, Hengyang 421001, China;[Bo Yang; Wenbin Lin] School of Mathematics and Physics, University of South China, Hengyang, 421001, China
通讯机构：
[Wenbin Lin] S;School of Mathematics and Physics, University of South China, Hengyang, 421001, China
摘要：
We investigate the hydrostatic equilibrium configurations of strange stars within the framework of Rastall-Rainbow theory of gravity. These stars are primarily composed of strange quark matter, with its distribution governed by the color-flavor-locked phase of quark matter equation of state (EoS). Using this EoS, we numerically solve the modified Tolman–Oppenheimer–Volkoff equation to obtain different quark star models. We find that the parameters from this modified gravity have specific contributions to the structure of quark stars and introduce new descriptions for massive celestial bodies. Aslo, the mass–radius relation strongly depends on the parameters from the considered EoS. Furthermore, we analyze the impact of these parameters on the gravitational redshift and compactness of quark stars.
摘要：
Diffusion study of the Ni-Si-V system is significant for the establishment of kinetic database of Ni-based alloys. In this work, the diffusion couple experiment combined with the numerical inverse method was adopted to evaluate the diffusivities and atomic mobilities for the Ni-Si-V fcc phase with high throughput. We prepared 12 fcc Ni-Si-V diffusion couples, which were annealed at 1273, 1373 and 1473 K, and their composition profiles after annealing were then measured by EPMA (Electron Probe Microanalysis). Subsequently, inputting the measured composition profiles as well as the available thermodynamic descriptions into the numerical inverse method incorporated in the CALTPP (CALculation of ThermoPhysical Properties) software, the composition- and temperature-dependent diffusivities and atomic mobilities for the Ni-Si-V fcc phase were simultaneously evaluated. In order to verify the reliability of the present evaluations, the CALTPP-simulated diffusion behaviors such as composition profiles and diffusion paths were compared with the measured ones, demonstrating reasonable agreements with each other. Meanwhile, the high-throughput determinations of diffusivities were confirmed by the ones obtained by the Matano-Kirkaldy method. Furthermore, applying the presently obtained diffusivities and atomic mobilities in combination with thermodynamic descriptions of the Ni-Si-V fcc phase, their diffusion flux, two-dimensional composition profile, activation energy and pre-frequency factor were predicted. It is expected that the presently obtained diffusivities and atomic mobilities of the Ni-Si-V fcc phase can contribute to the establishment of kinetic database of Ni-based alloys for their high-efficiency material design.
摘要：
Persistent photocatalysis has garnered significant attention due to its ability to sustain catalytic activity in dark by storing electrons. However, the practical application of persistent photocatalysis is hindered by limited electron storage capacity. Herein, we synthesized and demonstrated that Ti(3)C(2)/TiO(2)/Ag persistent photocatalyst has good electron storage capability. The electron storage capacity of Ti(3)C(2)/TiO(2)/Ag is up to 0.125μmol/mg, which is 2.5 times that of Ti(3)C(2)/TiO(2). The enhanced electron storage capacity resulted in improved dark-reaction activity because more electrons react with oxygen to form more radicals, as evidenced by degradation experiments of various organics. Especially, persistent photocatalytic degradation of tetracycline hydrochloride by Ti(3)C(2)/TiO(2)/Ag was achieved under natural outdoor conditions (from 2:00p.m. to 8:00p.m.). Additionally, the aid of oxidants such as peroxymonosulfate (PMS) can further improve the dark-reaction activity. TiO(2)/Ti(3)C(2)/Ag/PMS system exhibits excellent efficacy in removing tetracycline hydrochloride, oxytetracycline, rhodamine b, methyl orange, and methylene blue, with removal rates reaching 79.5 %, 81.4 %, 98.9 %, 99.1 %, and 99.2 %, respectively (15min of light-reaction and 45min of dark-reaction). This work provides a new strategy to enhance electron storage capacity and demonstrates that decoupling of light-reaction and dark-reaction may provide a new opportunity for photocatalytic removal of pollutants around the clock.
作者机构：
[Liang, Xianxiao; Zhao, Yang; Shi, Xuan; Shi, X; Deng, Xueyi] Chongqing Univ Posts & Telecommun, Sch Optoelect Engn, Chongqing 400065, Peoples R China.;[Liang, Xianxiao; Zhao, Yang; Shi, Xuan; Shi, X; Xiao, Zeyun; Peng, Xiaoyu; Deng, Xueyi] Chinese Acad Sci, Chongqing Inst Green & Intelligent Technol, Chongqing 400714, Peoples R China.;[Zhao, Hongquan] South China Univ, Sch Elect Engn, Hengyang, Peoples R China.;[Yuan, Hongkuan] Southwest Univ, Sch Phys Sci & Technol, Chongqing, Peoples R China.
通讯机构：
[Yuan, HK ; Zhao, HQ ] S;[Shi, X ] C;Chongqing Univ Posts & Telecommun, Sch Optoelect Engn, Chongqing 400065, Peoples R China.;Chinese Acad Sci, Chongqing Inst Green & Intelligent Technol, Chongqing 400714, Peoples R China.;South China Univ, Sch Elect Engn, Hengyang, Peoples R China.
关键词：
WSe2/Si2H heterojunction;first principles;extra electric field;optical absorption coefficient
摘要：
Van der Waals heterojunctions based on two-dimensional (2D) materials hold great potential applications in photodetectors. Using the density functional theory (DFT) method, the structures, electronic and optical properties of van der Waals WSe2/Si2H heterojunction are investigated. 1.32 eV of indirect bandgap is calculated from the WSe2/Si2H heterojunction, which is 0.3 eV and 0.1 eV smaller than those of its monolayer WSe2 and Si2H. This contributes to the photocarrier generations, and the Type-II heterojunction also benefits to the separation of the photogenerated electron and hole pairs. A significant hole mobility 1.05 x 10(4) cm(2) V-1 s(-1) of the heterojunction along the y-direction is obtained. Moreover, a high Ultraviolet light (UV) absorption coefficient is presented in the heterojunction. The heterojunction transforms to Type-I under a vertical electric field, with the bandgap, orientation and amount of transfer electrons modulated sufficiently. As a result, the optical absorption coefficient of the heterojunction is also improved significantly, leading to the red-shift of the absorption spectrum. These excellent properties address the WSe2/Si2H heterojunction one of the good candidates for UV detectors.
期刊：
JOURNAL OF COSMOLOGY AND ASTROPARTICLE PHYSICS,2024年2024(02):046 ISSN：1475-7516
作者机构：
[Hiroaki Nakajima] School of Mathematics and Physics, University of South China, Hengyang, 421001, China;School of Physical Science and Technology, Southwest Jiaotong University, Chengdu, 610031, China;[Ya Guo; Wenbin Lin] School of Mathematics and Physics, University of South China, Hengyang, 421001, China<&wdkj&>School of Physical Science and Technology, Southwest Jiaotong University, Chengdu, 610031, China
摘要：
We study an axisymmetric metric satisfying the Petrov type D property with some additional ansatze, but without assuming the vacuum condition. We find that our metric in turn becomes conformal to the Kerr metric deformed by one function of the radial coordinate. We then study the gravitational-wave equations on this background metric in the case that the conformal factor is unity. We find that under an appropriate gauge condition, the homogeneous wave equations admit the separation of the variables, which is also helpful for solving the nonhomogeneous equations. The resultant ordinary differential equation for the radial coordinate gives a natural extension of the Teukolsky equation.
关键词：
Space gravitational wave detection;Micro electric thruster;Hall thruster;Faraday probe;Response time
摘要：
An advanced Watt class Hall Micro Thruster (HMT) is offered for Space Gravitational Wave Detection (SGWD), and an investigation has been conducted on its start-up, shutdown, rise, and fall response times. The research involved creating a circuit for thruster discharge and signal acquisition, using a Faraday probe to measure the plasma plume signal generated by the thruster, and characterizing the thrust directly. Ultimately the response time of the thruster is extracted from the discharge current and Faraday current signals. The experimental results demonstrate that the HMT has a response time ranging from 1.08 ms to 16.76 ms at mass flow rates of 0.02 mg/s and 0.04 mg/s, meeting the SGWD requirements for micro thruster response time. This research provides a physical foundation and explanation for the variation of HMT response time with discharge voltage versus mass flow rate with several key parameters that affect HMT plasma discharge, such as neutral gas number density (n(n)) and ionization mean free path (lambda(i)). Furthermore, we have examined several anomalies in the signal. Overall, this research provides a brand-new method for measuring the thrust response time of electric thrusters.
关键词：
Ti alloys;surface nitriding;microhardness;wear resistance;high-temperature oxidation resistance
摘要：
Titanium alloys are considered lightweight alloys and are widely applied across various industries. However, their low hardness, poor wear resistance, and limited oxidation resistance restrict their prospects for wider application. In this paper, nitride coatings were prepared using three preparation processes, namely laser surface nitriding (LSN), physical vapor deposition (PVD), and plasma ion implantation (PII). Their microstructure, microhardness, tribological behavior, and high-temperature oxidation characteristics were compared. The experimental results revealed that nitrided coatings were successfully prepared using the three methods. However, a comparison of these data shows that the LSN coating exhibited superior comprehensive performance. It achieved the maximum thickness within the shortest preparation time: the thickness was about 280 mu m and the deposition rate of the LSN method was 2250 and 90,000 times higher than those of the PVD and PII methods. Nitrides have high hardness, but the carrying capacity could be attributed to the thickness of the coatings: the PVD coating could withstand a force of 500 g, while the PII coating only withstood a force of less than 25 g. In addition, as hardness is the most important factor for excellent wear resistance, the average volumetric wear rate of the LSN and PVD coatings was about 9 x 10-6 mm3/m center dot N, and their relative wear resistance was 49.2 times that of Ti6Al4V. Meanwhile, the excellent bond between the LSN coating and the substrate was evidenced by a high-temperature oxidation test during a rapid heating-cooling cycle.
