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SIRT3 enhances the protective effect of Xyloketal B on seizure-induced brain injury by regulating AMPK/mTOR signaling-mediated autophagy

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成果类型:
期刊论文
作者:
Chen, Fen-Fang;Liu, Jian-Feng;Zhou, Di-Mi
通讯作者:
Zhou, DM
作者机构:
[Chen, Fen-Fang; Liu, Jian-Feng] Univ South China, Affiliated Hosp 2, Dept Paediat, Hengyang, Hunan, Peoples R China.
[Zhou, Di-Mi] Univ South China, Affiliated Hosp 2, Dept Neurol, Hengyang, Hunan, Peoples R China.
[Zhou, Di-Mi] 35 Jiefang Dadao, Hengyang, Hunan, Peoples R China.
通讯机构:
[Zhou, DM ] 3
35 Jiefang Dadao, Hengyang, Hunan, Peoples R China.
语种:
英文
关键词:
autophagy;seizure-induced brain injury;SIRT3;Xyloketal B
期刊:
KAOHSIUNG JOURNAL OF MEDICAL SCIENCES
ISSN:
1607-551X
年:
2024
卷:
40
期:
1
页码:
74-85
基金类别:
Hengyang Science and Technology Plan Project Basic (Applied) Research Project [202150063524]; Hunan Province Clinical Medical Technology Innovation Guidance Project [2020SK51702]; Natural ScienceFoundation of Hunan Province Project (Joint Science and Health Foundation Project) [2021JJ70036]
机构署名:
本校为第一机构
院系归属:
医学院
摘要:
Brain damage in children due to seizures is irreversible and has been a major public health concern. The herbal monomer Xyloketal B (Xyl-B) can be used as a neuroprotective drug because of its antioxidant, antiapoptotic, and anti-inflammatory effects but with few adverse effects. In this article, we constructed a rat developmental convulsion model and a primary hippocampal neuronal cell convulsion model, through which we studied hippocampal neuronal morphology and neuronal apoptosis using H&E staining and TUNEL staining, respectively. Moreover,...

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