Pharmacological inhibition of Src family kinases attenuates hyperuricemic nephropathy

首页 > 成果 > 详情

认领

导出

Link by DOI

反馈

作者信息关键词期刊信息基础信息归属信息摘要

成果类型：

期刊论文

作者：

Xiong, Chongxiang;Deng, Jin;Wang, Xin;Hou, Qidi;Zhuang, Shougang

通讯作者：

Zhuang, SG

作者机构：

[Xiong, Chongxiang; Wang, Xin; Hou, Qidi] Guangdong Med Univ, Affiliated Hosp Dongguan 1, Dept Nephrol, Dongguan, Guangdong, Peoples R China.

[Deng, Jin] Univ South China, Affiliated Hosp 1, Hengyang Med Sch, Dept Nephrol, Hengyang, Peoples R China.

[Zhuang, Shougang] Rhode Isl Hosp, Dept Med, Providence, RI 02903 USA.

[Zhuang, Shougang] Brown Univ, Sch Med, Providence, RI 02903 USA.

[Zhuang, Shougang] Tongji Univ, Sch Med, Shanghai East Hosp, Dept Nephrol, Shanghai, Peoples R China.

通讯机构：

[Zhuang, SG ] R

Rhode Isl Hosp, Dept Med, Providence, RI 02903 USA.

Brown Univ, Sch Med, Providence, RI 02903 USA.

Tongji Univ, Sch Med, Shanghai East Hosp, Dept Nephrol, Shanghai, Peoples R China.

语种：

英文

关键词：

NF-κB;PP1;Src;Src family kinases;fibrosis;hyperuricemia;hyperuricemic nephropathy;kidney

期刊：

Frontiers in Pharmacology

ISSN：

1663-9812

年：

2024

卷：

页码：

1352730

DOI：

10.3389/fphar.2024.1352730

基金类别：

The author(s) declare that financial support was received for the research, authorship, and/or publication of this article. This study was supported by the Guangdong Basic and Applied Basic Research Foundation (2022A1515140177 to CX), the Dongguan Science and Technology of Social Development Program (20221800905662 to CX), the Talent Development Foundation of the First Dongguan Affiliated Hospital of Guangdong Medical University (GCC2022001 and PU2022001 to CX), the Natural Science Foundation of Hunan Province (2022JJ30525 to JD), and the Natural Science Foundation of China (82100804 to JD; 82370698 and 82070700 to SZ).

机构署名：

本校为其他机构

摘要：

Hyperuricemia is an independent risk factor for chronic kidney disease and contributes to renal fibrosis. This study aims to investigate the effect of Src family kinase (SFK) inhibition on the development of hyperuricemic nephropathy (HN) and the mechanisms involved. In a rat model of HN, feeding rats a mixture of adenine and potassium oxonate increased Src phosphorylation, severe glomerular sclerosis, and renal interstitial fibrosis, accompanied by renal dysfunction and increased urine microalbumin excretion. Administration of PP1, a highly se...

反馈

产权有误：本人成果被他人认领

数据有误：数据基本信息有误

归属有误：成果的院系归属、机构署名归属有误

其他原因：

验证码：

看不清楚，换一个

确定

取消

成果认领

标题：

用户	作者	通讯作者	--
	请选择	请选择	--

确定

取消

Pharmacological inhibition of Src family kinases attenuates hyperuricemic nephropathy

反馈

成果认领

提示

该栏目需要登录且有访问权限才可以访问