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Evaluation of the Expansion and Neuronal Differentiation Potency of Cultured Olfactory Epithelium Progenitor Cells from a Rat Model of Depression

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成果类型:
期刊论文
作者:
Chen, Liang;Xie, Yangzhi;Chen, Jiacheng;Luo, Yan
通讯作者:
Luo, Y
作者机构:
[Luo, Y; Chen, Liang; Luo, Yan; Xie, Yangzhi] Univ South China, Affiliated Nanhua Hosp, Hengyang Med Sch, Dept Neurol, Hengyang 421001, Hunan, Peoples R China.
[Chen, Jiacheng] Univ South China, Affiliated Nanhua Hosp, Hengyang Med Sch, Dept Intens Care Unit, Hengyang 421001, Hunan, Peoples R China.
通讯机构:
[Luo, Y ] U
Univ South China, Affiliated Nanhua Hosp, Hengyang Med Sch, Dept Neurol, Hengyang 421001, Hunan, Peoples R China.
语种:
英文
关键词:
depression;olfactory epithelium;progenitor cells;cell expansion;neuronal differentiation
期刊:
Journal of Integrative Neuroscience
ISSN:
0219-6352
年:
2024
卷:
23
期:
2
基金类别:
Key Project of Hunan Provincial Health Commission [202203074157]
机构署名:
本校为第一且通讯机构
摘要:
Background: Olfactory impairment has been reported in patients with depression and in rodent models of depression. Olfactory epithelium (OE) is the only peripheral neural tissue connected to the brain that has the potential for self-renewal. We hypothesized the olfactory deficit during depression may be related to the dysfunction of OE progenitor cells. The aim of the present study was therefore to evaluate the expansion and neuronal differentiation potency of cultured OE progenitor cells obtained from a rat model of depression. Methods: Rats were exposed to chronic unpredictable mild stress p...

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