通讯机构：
[Yin, XH ] U;Univ South China, Sch Nursing, Hengyang, Hunan, Peoples R China.
关键词：
Prehabilitation;Frailty;Aged;Meta-analysis
摘要：
Objective: The study investigates the impact of preoperative rehabilitation on the surgical prognosis of frail older patients. Method: The effect sizes of all studies retrieved and included by the nine databases were analyzed and expressed as RR and WMD. Results: 8 studies with 902 participants met the criteria for inclusion. A significant reduction in total complications (RR = 0.84, 95 % CI = 0.73 to 0.97, P = 0.021) and the 6MWT after surgery (WMD = 74.76, 95 % CI = 44.75 to 104.77, P = 0.000) was observed in the prehabilitation group. But it had no differences in mortality(RR = 1.89, 95 % CI = 0.75 to 4.72, P = 0.176), readmission rates(RR = 1.04, 95 % CI = 0.56 to 1.91, P = 0.906) and LOS(WMD = -0.24, 95 % CI = -1.00 to 0.52, P = 0.540). Conclusions: Prehabilitation had positive effect on postoperative complications and functional recovery in frail older patients. (c) 2023 The Authors. Published by Elsevier Inc. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/)
摘要：
BACKGROUND: We previously revealed that hydrogen sulfide (H(2)S) attenuates chronic stress-induced cognitive impairment, but the underlying mechanism needs to be further clarified. Growth differentiation factor 11 (GDF11) plays an important regulatory role in cognitive function and that hippocampal NLRP3/caspase-1-mediated pyroptosis contributes to the pathogenesis of cognitive impairment. Hence, this research aimed to explore whether promoting GDF11 levels and suppressing hippocampal NLRP3/caspase-1-mediated pyroptosis mediate H(2)S to alleviate chronic stress-induced cognitive impairment. METHODS: Sprague-Dawley rats were subjected to unpredictable chronic mild stress lasting four weeks to establish an animal model of chronic stress-induced cognitive impairment. Behavioral performance was assessed by the Y-maze test and the novel object recognition test. The expression levels of proteins were analyzed by Western blot analysis. The levels of IL-1β and IL-18 in the hippocampus were measured by ELISA. RESULTS: NaHS upregulated the expression of GDF11 in the hippocampus of chronic unpredictable mild stress (CUMS)-exposed rats. Silencing GDF11 blocked NaHS-improved cognitive impairment in CUMS-exposed rats, according to the Y-maze test and the novel object recognition test. Furthermore, NaHS mitigated NLRP3/caspase-1-mediated pyroptosis in the hippocampus of CUMS-exposed rats and this effect was reversed by silencing GDF11. Moreover, overexpression of GDF11 alleviated CUMS-induced cognitive impairment and NLRP3/caspase-1-mediated hippocampal pyroptosis. CONCLUSIONS: GDF11 mediates H(2)S to attenuate chronic stress-induced cognitive impairment via inhibiting hippocampal NLRP3/caspase-1-mediated pyroptosis.
期刊：
Western Journal of Nursing Research,2024年46(2):68-80 ISSN：0193-9459
通讯作者：
Ouyang, Xinping;He, PP
作者机构：
[Li, Junyi; Wen, Min; Chen, Yeshi; Wen, Xiaohui; He, Pingping] Univ South China, Sch Nursing, Hengyang Med Sch, Hengyang, Peoples R China.;[Wen, Min] Yueyang Vocat Tech Coll, Sch Nursing, Yueyang, Peoples R China.;[Yu, Juping] Univ South Wales, Fac Life Sci & Educ, Pontypridd, Wales.;[He, Pingping; Ouyang, Xinping] Hunan Normal Univ, Med Coll, Changsha, Peoples R China.;[Ouyang, Xinping; He, Pingping] Hunan Normal Univ, Med Coll, Changsha 410013, Hunan, Peoples R China.
通讯机构：
[Ouyang, XP; He, PP ] H;Hunan Normal Univ, Med Coll, Changsha 410013, Hunan, Peoples R China.
关键词：
coronary heart disease;fatigue;quality of life;self-management
摘要：
Western Journal of Nursing Research, Volume 46, Issue 2, Page 68-80, February 2024. <br/>Objective:This research aimed to determine how a 12-week PRECEDE-PROCEED model-based intervention affected fatigue in patients with coronary heart disease.Methods:This cluster randomized controlled trial recruited participants diagnosed with coronary heart disease at 2 community health centers in China. Participants in the control group (n = 36) received routine health education, whereas those in the intervention group (n = 38) were given a 12-week PRECEDE-PROCEED model-based intervention and routine health education. The intervention consisted of 6 training sessions on coronary heart disease, fatigue, fatigue management, self-management skills and social support. A primary outcome (fatigue) and 4 secondary outcomes (knowledge of fatigue, self-management, quality of life and body mass index) were assessed using the Fatigue Scale-14, Fatigue Cognitive Questionnaire for Patients with Coronary Heart Disease, Coronary Artery Disease Self-Management Scale, Chinese Cardiovascular Questionnaire of Quality of Life, and electronic weighing scale, respectively. Data were collected 3 times over 12 weeks.Results:Compared with the control group, the intervention group showed a statistically significant improvement in the level of fatigue (8.72 vs 7.06, P < .001), knowledge of fatigue (P < .001), self-management skills (P < .001), and quality of life (P < .001). However, there was no significant difference in body mass index between the 2 groups (P = .504).Conclusions:The findings suggest that a well-designed intervention based on the PRECEDE-PROCEED model could alleviate fatigue symptoms and increase knowledge of fatigue, self-management skills and quality of life in patients with coronary heart disease.
摘要：
There is a body of evidence to suggest that chronic stress modulates neurochemical homeostasis, alters neuronal structure, inhibits neurogenesis and contributes to development of mental disorders. Chronic stress-associated mental disorders present common symptoms of cognitive impairment and depression with complex disease mechanisms. P-coumaric acid (p-CA), a natural phenolic compound, is widely distributed in vegetables, cereals and fruits. p-CA exhibits a wide range of health-related effects, including anti-oxidative-stress, anti-mutagenesis, anti-inflammation and anti-cancer activities. The current study aims to evaluate the therapeutic potential of p-CA against stress-associated mental disorders. We assessed the effect of p-CA on cognitive deficits and depression-like behavior in mice exposed to chronic restraint stress (CRS); we used network pharmacology, biochemical and molecular biological approaches to elucidate the underlying molecular mechanisms. CRS exposure caused memory impairments and depression-like behavior in mice; p-CA administration attenuated these CRS-induced memory deficits and depression-like behavior. Network pharmacology analysis demonstrated that p-CA was possibly involved in multiple targets and a variety of signaling pathways. Among them, the protein kinase A (PKA) - cAMP-response element binding protein (CREB) - brain derived neurotrophic factor (BDNF) signaling pathway was predominant and further characterized. The levels of PKA, phosphorylated CREB (pCREB) and BDNF were significantly lowered in the hippocampus of CRS mice, suggesting disruption of the PKA-CREB-BDNF signaling pathway; p-CA treatment restored the signaling pathway. Furthermore, CRS upregulated expression of proinflammatory cytokines in hippocampus, while p-CA reversed the CRS-induced effects. Our findings suggest that p-CA will offer therapeutic benefit to patients with stress-associated mental disorders.
关键词：
Spiritual care needs;Attributes;Advanced breast cancer;Inpatients;Kano model
摘要：
Numerous previous research have established the need for spiritual care among patients with cancer globally. Nevertheless, there was limited research, primarily qualitative, on the spiritual care needs of Chinese inpatients with advanced breast cancer. Furthermore, the need for spiritual care was rarely explored using the Kano model. To better understand the spiritual care needs and attributes characteristics of inpatients with advanced breast cancer, this study examined the Kano model. A descriptive cross-sectional design study was conducted in the oncology departments of three tertiary grade-A hospitals in China from October 2022 to May 2023. To guarantee high-quality reporting of the study, the Strengthening the Reporting of Observational Studies in Epidemiology Checklist was used. Data on the demographic characteristics questionnaire, the Nurse Spiritual Therapeutics Scale (NSTS), and the Kano model-based Nurse Spiritual Therapeutics Attributes Scale (K-NSTAs) were collected through convenience sampling. The Kano model, descriptive statistics, two independent samples t-tests, and one-way analysis of variance were used to analyze the data. The overall score for spiritual care needs was 31.16 ± 7.85. The two dimensions with the highest average scores, “create a good atmosphere” (3.16 ± 0.95), and the lowest average scores, “help religious practice” (1.72 ± 0.73). The 12 items were distributed as follows: three attractive attributes were located in Reserving Area IV; five one-dimensional attributes were distributed as follows: three one-dimensional attributes were located in Predominance Area I, and two were found in Improving Area II; two must-be attributes were located in Improving Area II; and two indifference attributes were located in Secondary Improving Area III. The Chinese inpatients with advanced breast cancer had a middle level of spiritual care needs, which need to be further improved. Spiritual care needs attributes were defined, sorted, categorized, and optimized accurately and perfectly by the Kano model. And “create a good atmosphere” and “share self-perception” were primarily one-dimensional and must-be attributes. In contrast, the items in the dimensions of “share self-perception” and “help thinking” were principally attractive attributes. Nursing administrators are advised to optimize attractive attributes and transform indifference attributes by consolidating must-be and one-dimensional attributes, which will enable them to take targeted spiritual care measures based on each patient’s characteristics and unique personality traits.
关键词：
cancer;experiential avoidance;fear of cancer recurrence;generalized estimating equations;longitudinal study;newly diagnosed cancer patients;oncology;psycho-oncology
摘要：
Abstract Objective The fear of cancer recurrence (FCR) is an ongoing and common psychological problem faced by cancer patients. The objective of this study was to explore the variation trend of FCR and its influencing factors in Chinese newly diagnosed cancer patients from admission to 2 months after discharge. Demographic and tumor characteristics, as well as experiential avoidance (EA), were used as predictors. Method A longitudinal design and a consecutive sampling method were used to select 266 newly diagnosed cancer patients admitted to a tertiary cancer hospital in China from July to December 2022. Measurements of FCR and EA were obtained at admission (T1), 1 month after discharge (T2), and 2 months post‐discharge (T3). Generalized estimating equations were used to identify factors associated with FCR for longitudinal data analysis. Results A total of 266 participants completed the follow‐up. Both FCR and EA scores of patients with newly diagnosed cancer showed a significant trend of first increasing and then decreasing at baseline and follow‐up (p < 0.001). The junior secondary and less education level, rural residence, advanced tumor and high EA level were risk factors for higher FCR. Conclusions Our findings suggest that the FCR levels of most newly diagnosed cancer patients in China are different at the three time points and affected by different factors, with the highest level at 1 month after discharge. These results have significant implications for future identifying populations in need of targeted intervention based on their FCR trajectories.
作者机构：
[Peng, Tong; Huang, Li-li; Yue, Qian-qian; Feng, Ge-hui; Tang, Tian; Zeng, Ying; Meng, Xin-ru; Zhao, Ke-hao; Sun, Ying-xue] Univ South China, Sch Nursing, Hengyang Med Sch, Dept Int & Human Nursing Hunan Sci Popularizat Edu, Hengyang, Peoples R China.;[Zeng, Ying; Zeng, Xi] Univ South China, Canc Res Inst, Hunan Prov Key Lab Tumor Cellular & Mol Pathol, Hengyang, Peoples R China.;[Zeng, Ying; Zeng, Xi] Univ South China, Hengyang Med Sch, Hengyang, Peoples R China.;[Zeng, Ying] Univ South China, Sch Nursing, Dept Int & Humanist Nursing, Hengyang, Peoples R China.;[Zeng, Ying] Canc Res Inst Univ South China, Key Lab Tumor Cellular & Mol Pathol, Hengyang, Peoples R China.
通讯机构：
[Zeng, Y ] U;Univ South China, Hengyang Med Sch, Hengyang, Peoples R China.;Univ South China, Sch Nursing, Dept Int & Humanist Nursing, Hengyang, Peoples R China.;Canc Res Inst Univ South China, Key Lab Tumor Cellular & Mol Pathol, Hengyang, Peoples R China.
摘要：
BACKGROUND: Hepatocellular carcinoma (HCC) is the sixth most common cancer worldwide and the third leading cause of cancer mortality. HCC has high morbidity, high mortality, and low survival rates. Screening is one of the most significant methods of lowering incidence and death while also increasing survival. OBJECTIVES: The aim of this study was to identify the facilitators and barriers to participation in HCC screening among high-risk populations. METHODS: A comprehensive and systematic search was undertaken in PubMed, Web of Science, MEDLINE, EMBACE, EBSCOhost and the Cochrane Library. A combination of synonyms of the keywords including HCC, screening, factors and adherence were used for searching. Studies addressing the facilitators and barriers to HCC screening compliance in at-risk individuals were included. Data were synthesized using Review Manager version 5.4. A random/fixed effects model meta-analysis was performed to estimate the pooled data and expressed with odds ratio (OR) and 95% confidence interval (CI). RESULTS: A total of seven articles met the inclusion criteria. Qualitative (n=1) and quantitative (n=6) studies using various types of surgery were conducted. The most commonly mentioned barriers were insufficient knowledge and awareness of HCC screening, unawareness of the necessity for early detection of HCC and lack of physician recommendation. A meta-analysis of seven studies showed that individuals with a family history of HCC increased screening uptake by nearly three times (OR: 2.69, 95% CI: 1.93, 3.75). Other most frequently reported facilitators include age, education level, and perceived risk etal. CONCLUSIONS: Many barriers to HCC screening were found. Meanwhile, this review points out that improving the awareness of high-risk populations toward HCC screening is expected to enhance compliance, thereby promoting early diagnosis of liver cancer, reducing mortality, and alleviating the burden of HCC.
作者机构：
[Guo, Junchen; Xu, Xianghua; Chen, Yongyi; Wang, Ying; Liu, Chaoyi] Hunan Canc Hosp, Dept Palliat care, 283 Tongzipo Rd, Changsha 410006, Hunan, Peoples R China.;[Guo, Junchen] Univ South China, Sch Nursing, 28 Changsheng West Rd, Hengyang 421001, Hunan, Peoples R China.
通讯机构：
[Chen, YY ] H;Hunan Canc Hosp, Dept Palliat care, 283 Tongzipo Rd, Changsha 410006, Hunan, Peoples R China.
关键词：
Telemedicine;End of life;Family caregiver;Qualitative study
摘要：
Despite being driven by a strong sense of duty and familial obligation, providing care for patients nearing the end of life poses challenges for family caregivers. Telemedicine has rapidly gained traction as a transformative approach to healthcare delivery, offering an array of benefits that could be particularly valuable in end-of-life care. However, research on the perspectives of telemedicine-based services among family caregivers of patients with end-of-life cancer is limited. Therefore, this study aims to explore the perspectives and preferences of telemedicine-based services among family caregivers of patients with end-of-life cancer and provide a framework for developing and executing a tailored telemedicine-based end-of-life care program that addresses the unique needs of family caregivers in mainland China. A descriptive phenomenological approach was used. Family caregivers were selected using purposive sampling at a tertiary cancer hospital. One-on-one semi-structured interviews were conducted with the participants from November to December 2022. Colaizz’s method was used to analyze the interviews. Fourteen participants participated in interviews. Three themes and ten subthemes were identified: motivation to receive telemedicine services (relief from the burden of home care; access to professional health care services), supportive care needs for telemedicine services (support for symptom management; negative emotional adjustment; death education; daily life care guidance), and functional expectations of telemedicine service platforms (ease of use; real-time online guidance and response; personalized automatic reminder; targeted matching push of health knowledge). Family caregivers expressed interest in telemedicine-based services and identified various care needs before receiving telemedicine services. The findings of this study can help policymakers and healthcare providers develop more effective and culturally appropriate telemedicine-based service programs that can better support family caregivers of end-of-life cancer patients.
期刊：
Journal of Affective Disorders,2024年349:342-348 ISSN：0165-0327
通讯作者：
Zhao, JF
作者机构：
[Cao, Xueer; Li, Qingqi; Zhao, Jianfeng] Univ South China, Inst Neurosci, Hengyang Med Sch, Hengyang, Peoples R China.;[Wu, Hongrong; Tang, Shuangyang] Univ South China, Inst Pathogen Biol, Hengyang Med Sch, Hengyang, Peoples R China.;[Zhao, Jianfeng] Univ South China, Hengyang Med Sch, Dept Physiol, Hengyang, Peoples R China.;[Zhao, Jianfeng] Univ South China, Inst Neurosci, Med Sch, Hengyang 421001, Hunan, Peoples R China.
通讯机构：
[Zhao, JF ] U;Univ South China, Inst Neurosci, Med Sch, Hengyang 421001, Hunan, Peoples R China.
关键词：
Depression;Diabetes;Statin
摘要：
Background: Depression is a common mental disorder. Some studies have demonstrated that people with diabetes are more likely to suffer from depression. Statins are an everyday use for diabetes. Trials of statin therapy have had conflicting findings on the potential risk of depression. Methods: The National Health and Nutrition Examination Survey (NHANES) 2005-2018 was used to collect a representative sample. Weighted multivariate logistic regression models were used to evaluate odds ratios (ORs) and 95 % CIs for having depression symptoms. We performed stratified analyses to compare the effects of statins in subsamples with and without diabetes on depression symptoms. Results: Statin use showed a significant and strong decreasing effect on having depression symptoms in participants with diabetes (aOR (adjusted OR) 0.59, p = 0.014) compared with that in non -diabetics (aOR 0.78, p = 0.128). Diabetic individuals with statin use for >5 years had a lower risk of having depression symptoms (aOR 0.42, p = 0.002) than those with shorter -term statin use (1-5 years, aOR 0.69, p = 0.111; <1 year: aOR 0.83, p = 0.646). Atorvastatin was more effective in decreasing depression symptoms either in diabetes (aOR 0.49, p = 0.018) or in non -diabetes (aOR 0.58, p = 0.033). Limitations: First, the dosage of statins cannot be obtained from NHANES datasets. Second, after being stratified, the number of participants for several statins was insufficient. Third, recall bias may exist in the survey. Conclusions: Diabetics with depression symptoms may benefit from long-term statin therapy. Atorvastatin and pravastatin should be recommended for diabetic patients with depression.
摘要：
This paper examines a method and scheme for optimizing the allocation of nuclear radiation monitoring resources, based on the analysis of the risk of nuclear security events and the importance of facilities in a spent fuel reprocessing plant. By constructing a nuclear security radiation accident tree for a plant, the importance of different security events was calculated using fuzzy mathematics and expert scoring methods. The importance of each facility was determined by establishing a fuzzy comprehensive decision model, and a resource allocation scheme for nuclear radiation monitoring was proposed based on the importance level of facilities. The research findings demonstrated that the extraction process plant in the main process area, and the centralized control room in the front area of the plant, were of highest importance. Accordingly, three levels of nuclear radiation monitoring programs were established based on the importance of each facility. This study offers theoretical and technical support for the safety management and operation of a spent fuel reprocessing plant. Additionally, the analysis results can serve as a reference for allocating nuclear radiation monitoring resources in various facilities in a reasonable manner.
期刊：
Journal of Autism and Developmental Disorders,2024年54(2):749-764 ISSN：0162-3257
通讯作者：
Kun Xia<&wdkj&>Jinchen Li
作者机构：
[Wang, Xiaomeng; Zhao, Guihu; Li, Bin; Zhou, Qiao; Li, Jinchen] Cent South Univ, Xiangya Hosp, Dept Geriatr, Changsha 41008, Hunan, Peoples R China.;[Luo, Tengfei; Wang, Xiaomeng; Xia, Kun; Li, Jinchen; Ling, Zhengbao] Cent South Univ, Ctr Med Genet, Sch Life Sci, Hunan Key Lab Med Genet, Changsha 41008, Hunan, Peoples R China.;[Zhao, Guihu; Li, Bin; Li, Jinchen] Cent South Univ, Xiangya Hosp, Dept Neurol, Changsha, Hunan, Peoples R China.;[Zhao, Guihu; Li, Bin; Zhou, Qiao; Li, Jinchen] Cent South Univ, Xiangya Hosp, Bioinformat Ctr, Natl Clin Res Ctr Geriatr Disorders, Changsha, Hunan, Peoples R China.;[Xia, Kun] Univ South China, Hengyang, Hunan, Peoples R China.
通讯机构：
[Kun Xia] C;[Jinchen Li] D;Centre for Medical Genetics, Hunan Key Laboratory of Medical Genetics, School of Life Sciences, Central South University, Changsha, China<&wdkj&>University of South China, Hengyang, China<&wdkj&>Department of Geriatrics, Xiangya Hospital, Central South University, Changsha, China<&wdkj&>Centre for Medical Genetics, Hunan Key Laboratory of Medical Genetics, School of Life Sciences, Central South University, Changsha, China<&wdkj&>Department of Neurology, Xiangya Hospital, Central South University, Changsha, China<&wdkj&>Bioinformatics Center, National Clinical Research Centre for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, China
关键词：
Autism spectrum disorder;Symptoms;De novo variant;Pregnancy-induced hypertension;Gene ontology;Ubiquitin-dependent protein catabolic process
摘要：
Genetic factors, particularly, de novo variants (DNV), and an environment factor, exposure to pregnancy-induced hypertension (PIH), were reported to be associated with risk of autism spectrum disorder (ASD); however, how they jointly affect the severity of ASD symptom is unclear. We assessed the severity of core ASD symptoms affected by functional de novo variants or PIH. We selected phenotype data from Simon's Simplex Collection database, used genotypes from previous studies, and created linear regression models. We found that ASD patients carrying DNV with PIH exposure had increased adaptive and cognitive ability, decreased social problems, and enhanced repetitive behaviors; however, there was no difference in patients without DNV between those with or without PIH exposure. In addition, the DNV genes carried by patients exposed to PIH were enriched in ubiquitin-dependent proteolytic processes, highlighting how candidate genes in pathways and environments interact. The results indicate the joint contribution of DNV and PIH to ASD.
期刊：
Energy Economics,2024年130:107303 ISSN：0140-9883
通讯作者：
Li, YQ
作者机构：
[Yi, Yongxi; Li, Yuqiong; Zhang, Meng] Univ South China, Sch Econ Management & Law, Hengyang, Peoples R China.;[Zhang, Aoxiang] Xiamen Univ, China Inst Studies Energy Policy, Xiamen, Peoples R China.
通讯机构：
[Li, YQ ] U;Univ South China, Sch Econ Management & Law, Hengyang, Peoples R China.
关键词：
Energy saving and consumption reduction;Digital transformation;Double credit policy;Subsidy policy;Differential game
摘要：
Transportation is the second largest source of carbon emissions today, with more than 80% of the carbon emitted from automobile operations. Hence, reducing the fuel consumption per unit mileage while vigorously developing new energy vehicles has become an inevitable choice for carbon emission reduction. So, this paper applies the differential game approach to investigate the production trade-offs of fuel and new energy vehicles, fuel consumption reduction, and digital technology investment strategies in an automotive supply chain under a dynamic framework. In addition, it further analyzes whether the dual credit policy (DCP) can promote the healthy development of China's auto market after the withdrawal of the purchase subsidy policy for new energy vehicles (PSP). The results show that the implementation of DCP will reduce the sales of fuel vehicles with fuel consumption higher than the critical value (HFCV) but will not promote the willingness of manufacturers to invest in fuel consumption reduction of HFCV; the abolition of the PSP will not reduce the demand for fuel vehicles, nor will it affect the investment in fuel consumption reduction of fuel vehicles, but it will reduce the consumer demand for new energy vehicles. However, assuming that the government appropriately adjusts the intrinsic mechanism of the DCP, such as increasing the requirement for the proportion of new energy vehicles in the sales of cars by manufacturers and the value of the points per unit of new energy vehicles, it will be possible to promote the growth of new energy vehicles while discouraging the production of fuel-intensive vehicles. In addition, If the government abolishes PSP, the maximum rate of change in the profits of the manufacturer, retailer, and the entire supply chain in the parameter change intervals analyzed in our numerical example is only 1.6%, 0.04%, and 0.13%, respectively, which can be said to have minimal impact. The findings provide a theoretical basis for the government's choice of carbon regulation policy for the automotive supply chain.
通讯机构：
[Huang, ZH ] U;Univ South China, Coll Architecture & Design, Hengyang 421001, Peoples R China.
关键词：
multi-source data;spatial quality evaluation;living street
摘要：
Evaluating the spatial quality of a living street entails identifying and assessing the outdoor space that influences residents' leisure and recreation, which may contribute to urban renewal. The application of multi-source data and deep learning technology enables an objective evaluation of large-scale spatial quality as opposed to the traditional questionnaire survey or experts' subjective evaluation. Based on street view images, points of interest, and road network data, this study developed subjective and objective evaluation indicators for the central city of Hengyang using semantic segmentation and ArcGIS spatial analysis. This study then assigned weights to each indicator and calculated the spatial quality score for living streets. In addition, the subjective evaluations of the street view images were compared to test and verify the validation of the objective evaluation model. Finally, the study analyzed the accessibility within 500 m of the study area using Spatial Syntax and ArcGIS to overlay the low spatial quality score with the highest accessibility to identify the streets with the highest priority in the subsequent urban plan. The results indicate that the spatial quality of living in the west of Hengyang is higher than that in its northeast region. In addition, Xiao Xia Street, Guanghui Street, and Hengqi Road comprised the majority of the areas that required a priority update. Correspondingly, our research is expected to be a useful management tool for identifying urban street space issues and guiding urban renewal.
期刊：
Public Health Nursing,2023年40(5):782-789 ISSN：0737-1209
通讯作者：
Zeng, Y
作者机构：
[Huang, Yu-ting; Yue, Qian-qian; Tang, Tian; Zeng, Ying; Hu, Li-feng; Sun, Ying-xue; Zou, Jin-yu] Univ South China, Hengyang Med Sch, Dept Int & Humanist Nursing, Sch Nursing,Hunan Sci Popularizat Educ Base, Hengyang, Peoples R China.;[Zeng, Ying; Zeng, Xi] Univ South China, Canc Res Inst, Hengyang Med Sch, Key Lab Tumor Cellular & Mol Pathol, Hengyang, Peoples R China.;[Zeng, Ying] Univ South China, Hengyang Med Sch, Sch Nursing, Dept Int & Humanist Nursing, Hengyang, Peoples R China.
通讯机构：
[Zeng, Y ] U;Univ South China, Canc Res Inst, Hengyang Med Sch, Key Lab Tumor Cellular & Mol Pathol, Hengyang, Peoples R China.;Univ South China, Hengyang Med Sch, Sch Nursing, Dept Int & Humanist Nursing, Hengyang, Peoples R China.
摘要：
INTRODUCTION: Colorectal cancer (CRC) is associated with a high incidence and mortality rate. Fecal occult blood test (FOBT) is effective in the prevention of CRC. OBJECTIVE: This study aimed to assess knowledge and beliefs regarding FOBT-based screening. METHODS: This study used PubMed, Cochrane Library, MEDLINE Complete, and Web of Science to search for articles. Original full-text studies in English language focusing on knowledge and beliefs of FOBT screening were included. RESULTS: A total of 32 articles were included. This study indicated that the population in most studies had inadequate knowledge and lacked beliefs toward FOBT-based screening. Most of the extracted studies showed that less than half of the participants had heard of FOBT-based screening. Six studies showed that less than 50% of participants had knowledge of FOBT age. Three studies found that less than 40% of participants were aware of the screening interval. Some participants perceived the benefits of FOBT-based screening, while others perceived many barriers to the test. CONCLUSION: Participants' knowledge and belief in FOBT-based screening were insufficient. This review highlights the importance of educational programs to increase knowledge and beliefs regarding FOBT-based screening. It is important to include FOBT-based screening in the health care system to promote the secondary prevention of CRC.
期刊：
npj Science of Learning,2023年8(1):33 ISSN：2056-7936
通讯作者：
Yuan, Z
作者机构：
[Zhang, Juan; Gao, Fei; Yuan, Zhen; Hua, Lin; Li, Defeng; Armada-da-Silva, Paulo; Yuan, Z] Univ Macau, Ctr Cognit & Brain Sci, Macau, Peoples R China.;[Gao, Fei] Fudan Univ, Inst Modern Languages & Linguist, Shanghai, Peoples R China.;[Yuan, Zhen; Hua, Lin; Armada-da-Silva, Paulo; Yuan, Z] Univ Macau, Fac Hlth Sci, Macau, Peoples R China.;[Zhang, Juan] Univ Macau, Fac Educ, Macau, Peoples R China.;[Li, Defeng] Univ Macau, Fac Arts & Humanities, Macau, Peoples R China.
通讯机构：
[Yuan, Z ] U;Univ Macau, Ctr Cognit & Brain Sci, Macau, Peoples R China.;Univ Macau, Fac Hlth Sci, Macau, Peoples R China.
摘要：
While morphology constitutes a crucial component of the human language system, the neural bases of morphological processing in the human brain remains to be elucidated. The current study aims at exploring the extent to which the second language (L2) morphological processing would resemble or differ from that of their first language (L1) in adult Chinese-English bilinguals. Bilingual participants were asked to complete a morphological priming lexical decision task drawing on derivational morphology, which is present for both Chinese and English, when their electrophysiological and optical responses were recorded concurrently. Functional near-infrared spectroscopy (fNIRS) revealed a neural dissociation between morphological and semantic priming effects in the left fronto-temporal network, while L1 Chinese engaged enhanced activation in the left prefrontal cortex for morphological parsing relative to L2 English. In the early stage of lexical processing, cross-language morphological processing manifested a difference in degree, not in kind, as revealed by the early left anterior negativity (ELAN) effect. In addition, L1 and L2 shared both early and late structural parsing processes (P250 and 300 ~ 500 ms negativity, respectively). Therefore, the current results support a unified competition model for bilingual development, where bilinguals would primarily employ L1 neural resources for L2 morphological representation and processing.
摘要：
Background: Phosphatidylinositol 3-kinase (PI3K) and protein kinase B (AKT) are involved in the clearance of Mycobacterium tuberculosis (MTB) by macrophages.Aim: This study aimed to investigate the effects of polymorphisms in the PI3K/AKT genes and the gene-smoking interaction on susceptibility to TB.Methods: This case-control study used stratified sampling to randomly select 503 TB patients and 494 control subjects. Logistic regression analysis was used to determine the association between the polymorphisms and TB. Simultaneously, the marginal structure linear dominance model was used to estimate the gene-smoking interaction.Results: Genotypes GA (OR 1.562), AA (OR 2.282), and GA + AA (OR 1.650) at rs3730089 of the PI3KR1 gene were significantly associated with the risk to develop TB. Genotypes AG (OR 1.460), GG (OR 2.785), and AG + GG (OR 1.622) at rs1130233 of the AKT1 gene were significantly associated with the risk to develop TB. In addition, the relative excess risk of interaction (RERI) between rs3730089 and smoking was 0.9608 (95% CI: 0.5959, 1.3256, p < 0.05), which suggests a positive interaction.Conclusion: We conclude that rs3730089 and rs1130233 are associated with susceptibility to TB, and there was positive interaction between rs3730089 and smoking on susceptibility to TB.
通讯机构：
[Yangyang Wang] S;School of Economics Management and Law, University of South China, Hengyang, China
摘要：
This paper explores for the first time the manufacturers' joint energy reduction strategies for both new energy and fuel vehicles. Assume there is a Cournot car market with differentiated products consisting of one manufacturer producing fuel cars and one manufacturer producing fuel and new energy cars, and a double-points policy governs them. It shows that the double-points policy does not necessarily result in a contraction in the fuel vehicle market while leading to a boom in the new energy vehicle market; market competition and consumers' preference for low energy consumption can help incentive manufacturers to reduce vehicle energy consumption.
